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The map label for this gene is mycA [H]

Identifier: 197105513

GI number: 197105513

Start: 2291990

End: 2293681

Strand: Direct

Name: mycA [H]

Synonym: PHZ_c2050

Alternate gene names: 197105513

Gene position: 2291990-2293681 (Clockwise)

Preceding gene: 197105512

Following gene: 197105514

Centisome position: 57.35

GC content: 74.88

Gene sequence:

>1692_bases
TTGACCCCTACCCCCACCGCTCCCGACCGGCCCTTCCGACTGGGCGGGTTCGCCACCCTGACCGAGGCGCTGGACTTCGC
CGCCCAGGGGCCCACGGGCGTGAACCTCTACGGCCTGCGCGGCGAGCTGGTGCTCGCCCTGTCCTACGCCGAGCTGCGCG
AGCGGGCCCGCGCCCTGGCCGCGCGCATCCTGGCGGCCGGGATCCGGCCGTTCGACCGCGTGGGCCTCGTCGCCGAGACC
GACGCCGACTTCGTGGTCGCCTTCTTCGCCTGCCAGCACGCCCGGGTGACGCCCGCGCCGCTGGGCGGCCGCGAGGCCTA
TGTGGAGCAGATCGGCCGGATGCTGGGCTCGGCGCAGGCCTCGGCCGTGTTCGGCCCCGAGGCCCTGATCCCGTGGCTGC
AGGAGGCGGCGCAGGCCGCCGGCGTGAGGCTCGCGGCCCGCGTCCAGGACCTGCCCGAGGCGCCCGCCGCCGACCTGCCC
GCGCCGACGCCGGACGATCCCTGCTACGTGCAGTTCTCCTCGGGCAGCACGCGGCACCCGACGGGCGTCCTCTGCACCCA
CAGCGCCTTGATGGCCAACACCACCGCGATCACCCGCGACGGGCTGAAGGTGGTCCCGGCCGACCGGGCGTTCTCGTGGC
TGCCGCTCTATCACGACATGGGCCTGGTGGGCTTCCTGATGGCCCCGCTGGCCAGCCAGATGACCGTGGACCTGATGCCC
ACGGGCGCCTTCGTGCGCCGGCCGCTGCTGTGGCTGGACCTGATGTCGAAGAACCGGGCGACGATCTCGTACAGCCCGAC
CTTCGGCTACGAGCTGTGCGCCCGCCGCGGCGACGGCACGCGCGAGGGGCTGGACCTGTCGGCCTGGCGGATCGCCGGCT
GCGGCGGCGACATGGTGCGGCCGGGCCCGCTGATGGCCTTCGCCGAGACGTTCGCGCCCGCCGGCTTCTCCCCCACGGCC
TTCGTCGCCAGCTACGGCATGGCCGAGGCGACGCTGGCGCTGACCATGGCGCCGCTGGGCCAGGGACTGCGGTTCGAGAC
CGTCGACGTCGACCGGATGGAGCGCGACGGCGTGGTCGTCGGCGGCCGGGAAGGCCGCAGCCGGGCCTTCGTCCGCTGCG
GGCCGGTGCTGCCCGGCCACGAGCTGGAGGTCCGCGACGAGGCGGGCGCCGCCCTGCCCGAGCTGAAGGTCGGCCGGGTG
TTCGTGCGGGGCCCCAGCCTGATGCGCGGCTATTTCGGCGAGCCCGAGGCCTCGGCCAAGGTGCTGGGGCCGGACGGCTG
GCTCGACACCGGCGACCTGGGCTTCCTGGTCGAGGGCGAGATCGTGCCGACGGGCCGCGCCAAGGACCTGATCCTGCTGA
ACGGCCGGAACGTCTGGCCGCAGGACCTGGAATGGTCCGCCGAGAGCGAGATCGGCAAGCTGCGCAGCGGCGACGTGGCC
GCGTTCTCGGTCGACCGCGACGAGGGCGAGCAGCTGGTCGTGCTGGTGCAGGCGCGCACCAGCGATCCCGAGGCGCGCCG
GGCGCTGGCCGACGACGTCGCCGCCCTGCTCCGGGCCCGGCACGGCGTGGAGGCCCACGTGGAGCTGGTGGGGGCGCACG
CCCTGCCGCAGACCTCGTCGGGCAAGCTCAGCCGGTCCAAGGCCAAGGCGCTGTACCTGGCGGGCGCCTTCCGGGCGGAG
GAGCCGGCCTGA

Upstream 100 bases:

>100_bases
TGGCCCTGGGCCTGCTCGGGTTCATCCTGAGGGAGAACGGGACCCGGCGCCGGGAGACGCCGCCCCCCTCCGGTTCCGAC
GACAGTCTGAAAGGCGAAGC

Downstream 100 bases:

>100_bases
CGCGGCTCGCCGCCGTCACCGGCGCCACCGGCTTCCTCGGCCGCCGGATCGTCCGCGCGCTGGCCGAGGACGGCTGGCGC
GTGCGCATCCTGGCGCGGCG

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Glutamate-1-semialdehyde aminotransferase; GSA-AT; ATP-dependent asparagine adenylase 1; AsnA 1; Asparagine activase 1 [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTPTPTAPDRPFRLGGFATLTEALDFAAQGPTGVNLYGLRGELVLALSYAELRERARALAARILAAGIRPFDRVGLVAET
DADFVVAFFACQHARVTPAPLGGREAYVEQIGRMLGSAQASAVFGPEALIPWLQEAAQAAGVRLAARVQDLPEAPAADLP
APTPDDPCYVQFSSGSTRHPTGVLCTHSALMANTTAITRDGLKVVPADRAFSWLPLYHDMGLVGFLMAPLASQMTVDLMP
TGAFVRRPLLWLDLMSKNRATISYSPTFGYELCARRGDGTREGLDLSAWRIAGCGGDMVRPGPLMAFAETFAPAGFSPTA
FVASYGMAEATLALTMAPLGQGLRFETVDVDRMERDGVVVGGREGRSRAFVRCGPVLPGHELEVRDEAGAALPELKVGRV
FVRGPSLMRGYFGEPEASAKVLGPDGWLDTGDLGFLVEGEIVPTGRAKDLILLNGRNVWPQDLEWSAESEIGKLRSGDVA
AFSVDRDEGEQLVVLVQARTSDPEARRALADDVAALLRARHGVEAHVELVGAHALPQTSSGKLSRSKAKALYLAGAFRAE
EPA

Sequences:

>Translated_563_residues
MTPTPTAPDRPFRLGGFATLTEALDFAAQGPTGVNLYGLRGELVLALSYAELRERARALAARILAAGIRPFDRVGLVAET
DADFVVAFFACQHARVTPAPLGGREAYVEQIGRMLGSAQASAVFGPEALIPWLQEAAQAAGVRLAARVQDLPEAPAADLP
APTPDDPCYVQFSSGSTRHPTGVLCTHSALMANTTAITRDGLKVVPADRAFSWLPLYHDMGLVGFLMAPLASQMTVDLMP
TGAFVRRPLLWLDLMSKNRATISYSPTFGYELCARRGDGTREGLDLSAWRIAGCGGDMVRPGPLMAFAETFAPAGFSPTA
FVASYGMAEATLALTMAPLGQGLRFETVDVDRMERDGVVVGGREGRSRAFVRCGPVLPGHELEVRDEAGAALPELKVGRV
FVRGPSLMRGYFGEPEASAKVLGPDGWLDTGDLGFLVEGEIVPTGRAKDLILLNGRNVWPQDLEWSAESEIGKLRSGDVA
AFSVDRDEGEQLVVLVQARTSDPEARRALADDVAALLRARHGVEAHVELVGAHALPQTSSGKLSRSKAKALYLAGAFRAE
EPA
>Mature_562_residues
TPTPTAPDRPFRLGGFATLTEALDFAAQGPTGVNLYGLRGELVLALSYAELRERARALAARILAAGIRPFDRVGLVAETD
ADFVVAFFACQHARVTPAPLGGREAYVEQIGRMLGSAQASAVFGPEALIPWLQEAAQAAGVRLAARVQDLPEAPAADLPA
PTPDDPCYVQFSSGSTRHPTGVLCTHSALMANTTAITRDGLKVVPADRAFSWLPLYHDMGLVGFLMAPLASQMTVDLMPT
GAFVRRPLLWLDLMSKNRATISYSPTFGYELCARRGDGTREGLDLSAWRIAGCGGDMVRPGPLMAFAETFAPAGFSPTAF
VASYGMAEATLALTMAPLGQGLRFETVDVDRMERDGVVVGGREGRSRAFVRCGPVLPGHELEVRDEAGAALPELKVGRVF
VRGPSLMRGYFGEPEASAKVLGPDGWLDTGDLGFLVEGEIVPTGRAKDLILLNGRNVWPQDLEWSAESEIGKLRSGDVAA
FSVDRDEGEQLVVLVQARTSDPEARRALADDVAALLRARHGVEAHVELVGAHALPQTSSGKLSRSKAKALYLAGAFRAEE
PA

Specific function: This protein is a multifunctional enzyme, able to activate a long chain fatty acid and link it with the amino acid Asn as part of the synthesis of mycosubtilin. The activation sites consist of individual domains [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI44888818, Length=467, Percent_Identity=26.5524625267666, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI55749758, Length=573, Percent_Identity=23.9092495636998, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI156151445, Length=562, Percent_Identity=22.0640569395018, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI45827692, Length=475, Percent_Identity=22.5263157894737, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225735629, Length=475, Percent_Identity=22.5263157894737, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI225735625, Length=592, Percent_Identity=23.6486486486486, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI145693145, Length=536, Percent_Identity=25.7462686567164, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI221142682, Length=202, Percent_Identity=30.1980198019802, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560308, Length=558, Percent_Identity=23.4767025089606, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=473, Percent_Identity=24.3128964059197, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=546, Percent_Identity=22.8937728937729, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=568, Percent_Identity=22.3591549295775, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581924, Length=568, Percent_Identity=24.2957746478873, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922652, Length=426, Percent_Identity=24.8826291079812, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24653035, Length=181, Percent_Identity=27.0718232044199, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356947, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076582, Length=180, Percent_Identity=27.2222222222222, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR005814
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00202 Aminotran_3; PF00501 AMP-binding; PF00668 Condensation; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: NA

Molecular weight: Translated: 59986; Mature: 59855

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTPTAPDRPFRLGGFATLTEALDFAAQGPTGVNLYGLRGELVLALSYAELRERARALA
CCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEHHHHHHHHHHHH
ARILAAGIRPFDRVGLVAETDADFVVAFFACQHARVTPAPLGGREAYVEQIGRMLGSAQA
HHHHHHCCCCHHHCCEEEECCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
SAVFGPEALIPWLQEAAQAAGVRLAARVQDLPEAPAADLPAPTPDDPCYVQFSSGSTRHP
CEECCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
TGVLCTHSALMANTTAITRDGLKVVPADRAFSWLPLYHDMGLVGFLMAPLASQMTVDLMP
CCEEEECHHHHHCCCEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCEEEEEEC
TGAFVRRPLLWLDLMSKNRATISYSPTFGYELCARRGDGTREGLDLSAWRIAGCGGDMVR
CCHHHHCHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCCC
PGPLMAFAETFAPAGFSPTAFVASYGMAEATLALTMAPLGQGLRFETVDVDRMERDGVVV
CCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHEEEEHHCCCCCEEEEECHHHHCCCCEEE
GGREGRSRAFVRCGPVLPGHELEVRDEAGAALPELKVGRVFVRGPSLMRGYFGEPEASAK
ECCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEECEEEEECCHHHHCCCCCCCCCCE
VLGPDGWLDTGDLGFLVEGEIVPTGRAKDLILLNGRNVWPQDLEWSAESEIGKLRSGDVA
EECCCCCCCCCCCCEEEECEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCEE
AFSVDRDEGEQLVVLVQARTSDPEARRALADDVAALLRARHGVEAHVELVGAHALPQTSS
EEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCC
GKLSRSKAKALYLAGAFRAEEPA
CCCCHHHCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TPTPTAPDRPFRLGGFATLTEALDFAAQGPTGVNLYGLRGELVLALSYAELRERARALA
CCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEHHHHHHHHHHHH
ARILAAGIRPFDRVGLVAETDADFVVAFFACQHARVTPAPLGGREAYVEQIGRMLGSAQA
HHHHHHCCCCHHHCCEEEECCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
SAVFGPEALIPWLQEAAQAAGVRLAARVQDLPEAPAADLPAPTPDDPCYVQFSSGSTRHP
CEECCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
TGVLCTHSALMANTTAITRDGLKVVPADRAFSWLPLYHDMGLVGFLMAPLASQMTVDLMP
CCEEEECHHHHHCCCEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCEEEEEEC
TGAFVRRPLLWLDLMSKNRATISYSPTFGYELCARRGDGTREGLDLSAWRIAGCGGDMVR
CCHHHHCHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCCC
PGPLMAFAETFAPAGFSPTAFVASYGMAEATLALTMAPLGQGLRFETVDVDRMERDGVVV
CCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHEEEEHHCCCCCEEEEECHHHHCCCCEEE
GGREGRSRAFVRCGPVLPGHELEVRDEAGAALPELKVGRVFVRGPSLMRGYFGEPEASAK
ECCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEECEEEEECCHHHHCCCCCCCCCCE
VLGPDGWLDTGDLGFLVEGEIVPTGRAKDLILLNGRNVWPQDLEWSAESEIGKLRSGDVA
EECCCCCCCCCCCCEEEECEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCEE
AFSVDRDEGEQLVVLVQARTSDPEARRALADDVAALLRARHGVEAHVELVGAHALPQTSS
EEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCC
GKLSRSKAKALYLAGAFRAEEPA
CCCCHHHCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10557314 [H]