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The map label for this gene is cysG1 [H]

Identifier: 197105507

GI number: 197105507

Start: 2287062

End: 2287913

Strand: Reverse

Name: cysG1 [H]

Synonym: PHZ_c2044

Alternate gene names: 197105507

Gene position: 2287913-2287062 (Counterclockwise)

Preceding gene: 197105510

Following gene: 197105506

Centisome position: 57.25

GC content: 76.17

Gene sequence:

>852_bases
ATGGCACAGCGAGACCTGAAGCGAAGGCGCGCCGACCGGCTCGTGGTGCTGGGCGGCGGAACCCGCGCCGCGCAGCCGGG
TGCGGTCTGGCTCGTGGGCGCCGGCCCGGGCGATCCCGAGCTGCTCACCCTCAAGGCGCTGAAGGCCCTGCAGGCCGCCG
ACGTCGTCGTCCACGACGGCCTCGTCTCGGACGAGATCCTGGACCTCGCGCCCGCCTCGGCGCGGCGCATCTCGGTCGCC
AAGCGCAAGTCGCGCCATTCCTACGCCCAGGACGAGATCAACCGCATGCTGGTCGCCTTCGCCCAGGACGGCCTGCGCGT
CGTGCGCCTGAAGGGCGGCGATCCCTTCATCTTCGGGCGCGGCGGCGAGGAGCTGGAGGCCTGCCGCGCGGCGGGCGTCG
AATGCCACGTCGTCCCCGGCGTCACCGCGGCCCTGGCGGCCGGGGCCAGCGCCGGCGCGCCCCTGACCCACCGCGGCTCG
GCTCAGGCGGTCACCTTCGTCACCGGCCACGCCGCGCAGGGCGCCGAGCCCGACCTCGACTGGGCCAGCCTGGCGCGGGC
CAACCAGACCGTCGTGATCTACATGGGCCTGTCGCAGGCCGCCGCGATCGCCGGGCGCCTGATGGCCGCCGGCCGCGATG
GGGCGACGCCGGCCCTGATCGTCGAGAACGCCTCGCGCGCCGACGAGCGCCGCCTCACCACCACCCTGTCCGGCCTGGCC
GAGGCCGCCGCCGCCCTGCGCGGCCCGGCCCTGCTGATCGTCGGCGAGGCCATGGCCCTGGCCCAGGAGCAGGGGGCGGC
CGGGGAGGGGGCGACGCAGACCGAAACCCTGATCCGGGAGGCCCGCGCATGA

Upstream 100 bases:

>100_bases
CTGGTGTATCGGCCCTTTTCGCCGGCGGGCGAAAGGCGGGGCGGGCGCAAGTCCGTCCCGCTCTGATTCCAGAGTACAGC
GCTTTTAGAGAACCTAAAAT

Downstream 100 bases:

>100_bases
AGGTGCTGACCGCCAACCGCCTCTCCGACGGGGAGGTCGTCTTCTGGAAGGCCGGCCACTGGGTCGAGCGCTTCGCCGAG
GCCGAGCTGTTCGACGAGCC

Product: sirohaem synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAQRDLKRRRADRLVVLGGGTRAAQPGAVWLVGAGPGDPELLTLKALKALQAADVVVHDGLVSDEILDLAPASARRISVA
KRKSRHSYAQDEINRMLVAFAQDGLRVVRLKGGDPFIFGRGGEELEACRAAGVECHVVPGVTAALAAGASAGAPLTHRGS
AQAVTFVTGHAAQGAEPDLDWASLARANQTVVIYMGLSQAAAIAGRLMAAGRDGATPALIVENASRADERRLTTTLSGLA
EAAAALRGPALLIVGEAMALAQEQGAAGEGATQTETLIREARA

Sequences:

>Translated_283_residues
MAQRDLKRRRADRLVVLGGGTRAAQPGAVWLVGAGPGDPELLTLKALKALQAADVVVHDGLVSDEILDLAPASARRISVA
KRKSRHSYAQDEINRMLVAFAQDGLRVVRLKGGDPFIFGRGGEELEACRAAGVECHVVPGVTAALAAGASAGAPLTHRGS
AQAVTFVTGHAAQGAEPDLDWASLARANQTVVIYMGLSQAAAIAGRLMAAGRDGATPALIVENASRADERRLTTTLSGLA
EAAAALRGPALLIVGEAMALAQEQGAAGEGATQTETLIREARA
>Mature_282_residues
AQRDLKRRRADRLVVLGGGTRAAQPGAVWLVGAGPGDPELLTLKALKALQAADVVVHDGLVSDEILDLAPASARRISVAK
RKSRHSYAQDEINRMLVAFAQDGLRVVRLKGGDPFIFGRGGEELEACRAAGVECHVVPGVTAALAAGASAGAPLTHRGSA
QAVTFVTGHAAQGAEPDLDWASLARANQTVVIYMGLSQAAAIAGRLMAAGRDGATPALIVENASRADERRLTTTLSGLAE
AAAALRGPALLIVGEAMALAQEQGAAGEGATQTETLIREARA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=52.5641025641026, Blast_Score=231, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=37.1794871794872, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 29099; Mature: 28967

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRDLKRRRADRLVVLGGGTRAAQPGAVWLVGAGPGDPELLTLKALKALQAADVVVHDG
CCHHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHEEECC
LVSDEILDLAPASARRISVAKRKSRHSYAQDEINRMLVAFAQDGLRVVRLKGGDPFIFGR
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECC
GGEELEACRAAGVECHVVPGVTAALAAGASAGAPLTHRGSAQAVTFVTGHAAQGAEPDLD
CCHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
WASLARANQTVVIYMGLSQAAAIAGRLMAAGRDGATPALIVENASRADERRLTTTLSGLA
HHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
EAAAALRGPALLIVGEAMALAQEQGAAGEGATQTETLIREARA
HHHHHHCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AQRDLKRRRADRLVVLGGGTRAAQPGAVWLVGAGPGDPELLTLKALKALQAADVVVHDG
CHHHHHHHHHCEEEEEECCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHEEECC
LVSDEILDLAPASARRISVAKRKSRHSYAQDEINRMLVAFAQDGLRVVRLKGGDPFIFGR
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECC
GGEELEACRAAGVECHVVPGVTAALAAGASAGAPLTHRGSAQAVTFVTGHAAQGAEPDLD
CCHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
WASLARANQTVVIYMGLSQAAAIAGRLMAAGRDGATPALIVENASRADERRLTTTLSGLA
HHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
EAAAALRGPALLIVGEAMALAQEQGAAGEGATQTETLIREARA
HHHHHHCCCEEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA