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The map label for this gene is adhI [H]

Identifier: 197105488

GI number: 197105488

Start: 2269114

End: 2270223

Strand: Reverse

Name: adhI [H]

Synonym: PHZ_c2025

Alternate gene names: 197105488

Gene position: 2270223-2269114 (Counterclockwise)

Preceding gene: 197105489

Following gene: 197105487

Centisome position: 56.81

GC content: 68.65

Gene sequence:

>1110_bases
ATGAAGACTCGCGCCGCCGTTGCGTTCGAGGCGAAGAAGCCGCTGGAGATCGTGGAGCTCGACCTCGAGGGCCCCCGCGC
CGGCGAGGTGCTGGTGGAGATCAAGGCGACGGGCGTCTGCCACACCGACGCCTACACGCTGGACGGCCTCGATTCCGAGG
GGATCTTCCCCTCGATCCTGGGCCACGAGGGCGCGGGCGTGGTGGTCGAGGTCGGGCCGGGGGTGACCTCGGTCGCGCCG
GGCGACCACGTGATCCCGCTCTACACGCCCGAATGCCGGCAGTGCAAAAGCTGCCTCTCGCGCAAGACCAACCTGTGCAC
CGCCATCCGGGGCACGCAAGGGCGGGGCCTGATGCCCGACGGGACCAGCCGGTTCTCGTACAAGGGCCAGACGATCCATC
ACTACATGGGCTGCTCGACGTTCTCGAACTACACGGTGCTGCCCGAGATCGCGGTGGCGAAGATCCGCAAGGACGCGCCG
TTCGAGACCGCCTGCTACGTCGGCTGCGGCGTGACCACGGGCGTCGGGGCGGTGGTCAACACCGCCCATGTGGAGCCGGG
CGCCAACTGCATCGTCTTCGGCCTGGGCGGCATCGGCCTGAACGTCATCCAGGGCCTGAAGCTGGTGGGCGCGGGCATGA
TCGTCGGCGTCGACATCAATCCCGCCCGCGAGGAATGGGGCCGCCGCTTCGGCATGACCCACTTCGTCAATCCGAAGAAC
GTGCAGGGCGACCTCGTGGCCCATCTCGTCGAGCTGACCGGCGGCGGGGCCGACTACACCTTCGACGCCACCGGCAACAC
CGACGTCATGCGCCAGGCGCTCGAGGCCTGTCACCGCGGCTGGGGCGAGAGCATCATCATCGGCGTCGCCGAGGCCGGCC
GCGAGATCGCCACCCGCCCGTTCCAGCTGGTCACCGGCCGGGTCTGGAAGGGCACCGCCTTCGGCGGCGCGCGCGGCCGC
ACCGACACGCCGAAGATCGTCGACTGGTACATGGAGGGGAAGATCGAGATCGACCCCATGATCACCCACAAGCTGCCGCT
GGAGCGGATCAACGAGGCCTTCGACCTCATGCACCGCGGCGAGAGCATCCGCAGCGTGATCGTCTACTGA

Upstream 100 bases:

>100_bases
GCCCGATCCGAACGCGCCGGTGGTCACGCGCTCGCCCTACTAGGCTTGGCCGGCCCGGCGGGGTTAGAAGGCCCATCCCC
TTAAGGTTCGGAGAGGCCCC

Downstream 100 bases:

>100_bases
TGGCGCTTGAGGTCGTCTCCACCGCCCGAAGCTTCGGCGGCGTCCAGGGCGTCTACCGGCACGACAGCCGCGAGACCGGC
ACGCCGATGACCTTCAGCGT

Product: alcohol dehydrogenase, class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKTRAAVAFEAKKPLEIVELDLEGPRAGEVLVEIKATGVCHTDAYTLDGLDSEGIFPSILGHEGAGVVVEVGPGVTSVAP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRGTQGRGLMPDGTSRFSYKGQTIHHYMGCSTFSNYTVLPEIAVAKIRKDAP
FETACYVGCGVTTGVGAVVNTAHVEPGANCIVFGLGGIGLNVIQGLKLVGAGMIVGVDINPAREEWGRRFGMTHFVNPKN
VQGDLVAHLVELTGGGADYTFDATGNTDVMRQALEACHRGWGESIIIGVAEAGREIATRPFQLVTGRVWKGTAFGGARGR
TDTPKIVDWYMEGKIEIDPMITHKLPLERINEAFDLMHRGESIRSVIVY

Sequences:

>Translated_369_residues
MKTRAAVAFEAKKPLEIVELDLEGPRAGEVLVEIKATGVCHTDAYTLDGLDSEGIFPSILGHEGAGVVVEVGPGVTSVAP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRGTQGRGLMPDGTSRFSYKGQTIHHYMGCSTFSNYTVLPEIAVAKIRKDAP
FETACYVGCGVTTGVGAVVNTAHVEPGANCIVFGLGGIGLNVIQGLKLVGAGMIVGVDINPAREEWGRRFGMTHFVNPKN
VQGDLVAHLVELTGGGADYTFDATGNTDVMRQALEACHRGWGESIIIGVAEAGREIATRPFQLVTGRVWKGTAFGGARGR
TDTPKIVDWYMEGKIEIDPMITHKLPLERINEAFDLMHRGESIRSVIVY
>Mature_369_residues
MKTRAAVAFEAKKPLEIVELDLEGPRAGEVLVEIKATGVCHTDAYTLDGLDSEGIFPSILGHEGAGVVVEVGPGVTSVAP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRGTQGRGLMPDGTSRFSYKGQTIHHYMGCSTFSNYTVLPEIAVAKIRKDAP
FETACYVGCGVTTGVGAVVNTAHVEPGANCIVFGLGGIGLNVIQGLKLVGAGMIVGVDINPAREEWGRRFGMTHFVNPKN
VQGDLVAHLVELTGGGADYTFDATGNTDVMRQALEACHRGWGESIIIGVAEAGREIATRPFQLVTGRVWKGTAFGGARGR
TDTPKIVDWYMEGKIEIDPMITHKLPLERINEAFDLMHRGESIRSVIVY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=58.58310626703, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=44.7721179624665, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=44.4444444444444, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=44.0540540540541, Blast_Score=342, Evalue=2e-94,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=44.0540540540541, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=43.6314363143631, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=43.6314363143631, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=41.5760869565217, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=41.8282548476454, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=60.7046070460705, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=27.6712328767123, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=377, Percent_Identity=26.2599469496021, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=25.3481894150418, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=24.0837696335079, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=26.7955801104972, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=27.445652173913, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081918, Length=344, Percent_Identity=27.0348837209302, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=379, Percent_Identity=23.7467018469657, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=54.4235924932976, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=54.1333333333333, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=54.2274052478134, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=28.8409703504043, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=27.2237196765499, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=354, Percent_Identity=27.4011299435028, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=367, Percent_Identity=23.433242506812, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=55.7951482479784, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6323099, Length=385, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=25.6756756756757, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=27.4011299435028, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=27.4011299435028, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=24.4623655913978, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=25.1336898395722, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=352, Percent_Identity=23.2954545454545, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=58.695652173913, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39540; Mature: 39540

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVAFEAKKPLEIVELDLEGPRAGEVLVEIKATGVCHTDAYTLDGLDSEGIFPSIL
CCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTSVAPGDHVIPLYTPECRQCKSCLSRKTNLCTAIRGTQGRGLMPD
CCCCCEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCC
GTSRFSYKGQTIHHYMGCSTFSNYTVLPEIAVAKIRKDAPFETACYVGCGVTTGVGAVVN
CCCCEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHEE
TAHVEPGANCIVFGLGGIGLNVIQGLKLVGAGMIVGVDINPAREEWGRRFGMTHFVNPKN
EEECCCCCCEEEEECCCCHHHHHHHHHEECCCEEEEECCCHHHHHHHHHCCCEEECCCCC
VQGDLVAHLVELTGGGADYTFDATGNTDVMRQALEACHRGWGESIIIGVAEAGREIATRP
CCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCCC
FQLVTGRVWKGTAFGGARGRTDTPKIVDWYMEGKIEIDPMITHKLPLERINEAFDLMHRG
EEHHCCCEEECCCCCCCCCCCCCCCEEEEEECCEEEECCEEECCCCHHHHHHHHHHHHCC
ESIRSVIVY
CCHHEEECC
>Mature Secondary Structure
MKTRAAVAFEAKKPLEIVELDLEGPRAGEVLVEIKATGVCHTDAYTLDGLDSEGIFPSIL
CCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGPGVTSVAPGDHVIPLYTPECRQCKSCLSRKTNLCTAIRGTQGRGLMPD
CCCCCEEEEEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCC
GTSRFSYKGQTIHHYMGCSTFSNYTVLPEIAVAKIRKDAPFETACYVGCGVTTGVGAVVN
CCCCEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCEEEEEECCCHHCCHHHEE
TAHVEPGANCIVFGLGGIGLNVIQGLKLVGAGMIVGVDINPAREEWGRRFGMTHFVNPKN
EEECCCCCCEEEEECCCCHHHHHHHHHEECCCEEEEECCCHHHHHHHHHCCCEEECCCCC
VQGDLVAHLVELTGGGADYTFDATGNTDVMRQALEACHRGWGESIIIGVAEAGREIATRP
CCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCCC
FQLVTGRVWKGTAFGGARGRTDTPKIVDWYMEGKIEIDPMITHKLPLERINEAFDLMHRG
EEHHCCCEEECCCCCCCCCCCCCCCEEEEEECCEEEECCEEECCCCHHHHHHHHHHHHCC
ESIRSVIVY
CCHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]