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The map label for this gene is fghA [H]

Identifier: 197105487

GI number: 197105487

Start: 2268278

End: 2269114

Strand: Reverse

Name: fghA [H]

Synonym: PHZ_c2024

Alternate gene names: 197105487

Gene position: 2269114-2268278 (Counterclockwise)

Preceding gene: 197105488

Following gene: 197105484

Centisome position: 56.78

GC content: 72.04

Gene sequence:

>837_bases
ATGGCGCTTGAGGTCGTCTCCACCGCCCGAAGCTTCGGCGGCGTCCAGGGCGTCTACCGGCACGACAGCCGCGAGACCGG
CACGCCGATGACCTTCAGCGTCTTCGTCCCGCCGCAGGCCGAGCGGGGACCCCGGCCGGTGGTCTGGTACCTGTCGGGCC
TGACCTGCACCCACGCCAATGTCACCGAGAAGGGCCAGTTCCAGCGCGCCTGCGCCGAGCTGGGCCTGATCCTGGTGGCT
CCCGACACCTCCCCGCGCGGCGAGGGGGTCCCCGACGACCCGGCCTACGACTTCGGCCAGGGCGCCGGCTTCTACGTCGA
TGCGACCCGGGAGCCCTGGGCGGCCAATTTCCGGATGGAGAGCTACATCGTCTCCGAGCTGCCCGGGCTGGTCGCCGCCG
AGTTCCCCGTGGACATGGCCCGCCAGGGGATCACCGGCCACTCCATGGGCGGCCACGGCGCCCTGACCCTGGCGCTGAAG
AATCCTGGCCGCTGGAAAAGCGTCTCGGCCTTCGCGCCGATCGCCTCGCCGATGCGCTGCCCCTGGGGCGAGAAGGCGCT
CTCGGGCTACCTCGGCGAGGACCGCAGCGCCTGGTGCCGCTACGACGCCACCGCCCTCCTGGAGGACGGCGCGCGCCTGC
CCGAGCTGCTGGTCGACCAGGGCGAGGCCGACACCTTCCTTGAAGACCAGCTCAAGCCGCACCTGCTGGCCCAGGCCTGC
GAGGCCGCCGGCGTGCCGCTGACCCTGCGCCTGCAGCCCGGCTACGACCACAGCTACTGGTTCGTCTCGACGTTCATGGC
CGACCACCTGGCCTGGCACGCCGAGCGCCTCGCCTAG

Upstream 100 bases:

>100_bases
TCGACCCCATGATCACCCACAAGCTGCCGCTGGAGCGGATCAACGAGGCCTTCGACCTCATGCACCGCGGCGAGAGCATC
CGCAGCGTGATCGTCTACTG

Downstream 100 bases:

>100_bases
AGCCCAAAAAGAAAGGCGGCCCGGATCGCTCCGGGCCGCCCGACCTGCCGGGGCAGGCCGTCCTCTTTCCTAGTACCGGA
AGCGGAGCGTCGCGCCCACG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MALEVVSTARSFGGVQGVYRHDSRETGTPMTFSVFVPPQAERGPRPVVWYLSGLTCTHANVTEKGQFQRACAELGLILVA
PDTSPRGEGVPDDPAYDFGQGAGFYVDATREPWAANFRMESYIVSELPGLVAAEFPVDMARQGITGHSMGGHGALTLALK
NPGRWKSVSAFAPIASPMRCPWGEKALSGYLGEDRSAWCRYDATALLEDGARLPELLVDQGEADTFLEDQLKPHLLAQAC
EAAGVPLTLRLQPGYDHSYWFVSTFMADHLAWHAERLA

Sequences:

>Translated_278_residues
MALEVVSTARSFGGVQGVYRHDSRETGTPMTFSVFVPPQAERGPRPVVWYLSGLTCTHANVTEKGQFQRACAELGLILVA
PDTSPRGEGVPDDPAYDFGQGAGFYVDATREPWAANFRMESYIVSELPGLVAAEFPVDMARQGITGHSMGGHGALTLALK
NPGRWKSVSAFAPIASPMRCPWGEKALSGYLGEDRSAWCRYDATALLEDGARLPELLVDQGEADTFLEDQLKPHLLAQAC
EAAGVPLTLRLQPGYDHSYWFVSTFMADHLAWHAERLA
>Mature_277_residues
ALEVVSTARSFGGVQGVYRHDSRETGTPMTFSVFVPPQAERGPRPVVWYLSGLTCTHANVTEKGQFQRACAELGLILVAP
DTSPRGEGVPDDPAYDFGQGAGFYVDATREPWAANFRMESYIVSELPGLVAAEFPVDMARQGITGHSMGGHGALTLALKN
PGRWKSVSAFAPIASPMRCPWGEKALSGYLGEDRSAWCRYDATALLEDGARLPELLVDQGEADTFLEDQLKPHLLAQACE
AAGVPLTLRLQPGYDHSYWFVSTFMADHLAWHAERLA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=53.7366548042705, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=53.4296028880866, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=47.2727272727273, Blast_Score=283, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=51.4184397163121, Blast_Score=279, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=41.554054054054, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=52.4822695035461, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=52.4822695035461, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30258; Mature: 30127

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEVVSTARSFGGVQGVYRHDSRETGTPMTFSVFVPPQAERGPRPVVWYLSGLTCTHAN
CCCHHHHHHHHHCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCEEEECCC
VTEKGQFQRACAELGLILVAPDTSPRGEGVPDDPAYDFGQGAGFYVDATREPWAANFRME
CCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
SYIVSELPGLVAAEFPVDMARQGITGHSMGGHGALTLALKNPGRWKSVSAFAPIASPMRC
HHHHHHCCCCEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
PWGEKALSGYLGEDRSAWCRYDATALLEDGARLPELLVDQGEADTFLEDQLKPHLLAQAC
CCCHHHHHCCCCCCCCCEECCCHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHH
EAAGVPLTLRLQPGYDHSYWFVSTFMADHLAWHAERLA
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALEVVSTARSFGGVQGVYRHDSRETGTPMTFSVFVPPQAERGPRPVVWYLSGLTCTHAN
CCHHHHHHHHHCCCCCHHCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCEEEECCC
VTEKGQFQRACAELGLILVAPDTSPRGEGVPDDPAYDFGQGAGFYVDATREPWAANFRME
CCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHH
SYIVSELPGLVAAEFPVDMARQGITGHSMGGHGALTLALKNPGRWKSVSAFAPIASPMRC
HHHHHHCCCCEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
PWGEKALSGYLGEDRSAWCRYDATALLEDGARLPELLVDQGEADTFLEDQLKPHLLAQAC
CCCHHHHHCCCCCCCCCEECCCHHHHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHH
EAAGVPLTLRLQPGYDHSYWFVSTFMADHLAWHAERLA
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]