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The map label for this gene is glmU [H]

Identifier: 197105453

GI number: 197105453

Start: 2223397

End: 2224755

Strand: Reverse

Name: glmU [H]

Synonym: PHZ_c1990

Alternate gene names: 197105453

Gene position: 2224755-2223397 (Counterclockwise)

Preceding gene: 197105455

Following gene: 197105452

Centisome position: 55.67

GC content: 71.67

Gene sequence:

>1359_bases
ATGACCGCGAGAGCCGCCGTAATCATGGCCGCCGGCCAAGGCACGCGGATGAAGTCTCCGGTCCCCAAGGTGCTGCACAA
GGTGGGCGGACGCACGCTGCTGGACCGGATCATCGACACGGTCCAGGCGGCCGGCTGCGAGCGCATCCACGTCATCGTCG
GGAACCACAGTCCCGAGGTGCGGGCGCTGGTCGCCCGGCGCCTAGGCGAGGGCGCCGCCGTGCTGCAGGACCCGCCGCTC
GGCACCGGCCACGCCGTACTCTGCGCCGCCGACACCCTGGCCGACTACGACGGCGACGTGCTGGTGGTGAACGGCGACTG
CCCGCTGCTGCAGGCGTCGGACCTGGAGCCGCTGTTCGAGCTGCGCGCGGGCGGCGCGGCGCTGGCGATCATGGGCTTCG
AGCCGCAGGACCAGCTGCTCTACGGCCGGCTGATCCGCGGGGCGGACGGCCACGTCCTGCGCATCGTCGAGCCCAGCCAG
TGCAGCGAGCAGGAGCGGGCGGTCCGCCTCTGCAACGCCGGCATGTACGTGGCCGACCGCGCCGACCTGTTCCGGTGGCT
GTCGCGGCTGACCAACGACAATCCGAAGGGCGAGTATTTCCTCACCGGGATCGTCGCCGAGGCGAACGCCGAGGAGCTGA
CGGTGCGGGCGCACATCGCCTCCGAAACCGCGGTGATGGGCGCCGACACCCAGATGCAGCTCTCCCAGGCCGAGGCGGTC
TTCCAGCAGCGCCGGCGGGCCCACTTCCTGGCCGAGGGCGTGGGGATGCCGGCGCCCGAGACCGTGCACTTCGCCTGGGA
CACCGAGATCGCGCCGGGCGCCGTGGTCGAACAGTTCGTGGTCTTCGCGCCCGGCGTGAAGGTCGAGACCGGCGCCGTGA
TCCGGGCGTTCAGCCATCTGGAAGGCGCGGTGGTCCGGGAGGGCGCCCTCGTCGGCCCCTACGCCCGCCTGCGGCCCGGG
GCCGAGATCGGGCCGGACGCCCACATAGGCAACTTCGTCGAGGTGAAGAACGTCGCGGTGGGCAAGGGCGCCAAGGCCAA
CCACCTGTCCTACCTGGGGGACGGCGAGGTCGGCGCGGGCGCGAACATCGGCGCCGGCACGATCTTCTGCAACTACGACG
GCTTCTTCAAATACCGGACGGTGGTGGGCGAGGGCGCCTTCATCGGCTCGAACACGGCCCTCGTCGCGCCGGTCACGATC
GGCGCGGGGGCCATGACCGGCTCCGGCTCGGTGATCACCAGGGACGTGCCGGACCACGCCCTGGCGCTCGAGCGCAGCCC
CCAGGCCGACAAGGCCGGATGGGCGCGGGCGTTCCGTGAGAAGAAGTCGGCCGAGAAGGCGGCGAGGGGGAAGAAATGA

Upstream 100 bases:

>100_bases
CCGGAAACGTGCCGAAAGCTAGCCTCTTGTCGCGCGGCGCCACAAGGCTTGCTAAGGCGTTCGGCATCGTTGACTCGTCG
CCGCCCGGGAGCCCAGCCGC

Downstream 100 bases:

>100_bases
GCGACGCCGAGGCGCAGAAGAAGGCCGCGGGCGAAGCCGCCGCGGCGCTGGTCGAGAGCGGCATGGTGGTGGGCCTGGGC
ACCGGTTCCACCGCCGCCTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTARAAVIMAAGQGTRMKSPVPKVLHKVGGRTLLDRIIDTVQAAGCERIHVIVGNHSPEVRALVARRLGEGAAVLQDPPL
GTGHAVLCAADTLADYDGDVLVVNGDCPLLQASDLEPLFELRAGGAALAIMGFEPQDQLLYGRLIRGADGHVLRIVEPSQ
CSEQERAVRLCNAGMYVADRADLFRWLSRLTNDNPKGEYFLTGIVAEANAEELTVRAHIASETAVMGADTQMQLSQAEAV
FQQRRRAHFLAEGVGMPAPETVHFAWDTEIAPGAVVEQFVVFAPGVKVETGAVIRAFSHLEGAVVREGALVGPYARLRPG
AEIGPDAHIGNFVEVKNVAVGKGAKANHLSYLGDGEVGAGANIGAGTIFCNYDGFFKYRTVVGEGAFIGSNTALVAPVTI
GAGAMTGSGSVITRDVPDHALALERSPQADKAGWARAFREKKSAEKAARGKK

Sequences:

>Translated_452_residues
MTARAAVIMAAGQGTRMKSPVPKVLHKVGGRTLLDRIIDTVQAAGCERIHVIVGNHSPEVRALVARRLGEGAAVLQDPPL
GTGHAVLCAADTLADYDGDVLVVNGDCPLLQASDLEPLFELRAGGAALAIMGFEPQDQLLYGRLIRGADGHVLRIVEPSQ
CSEQERAVRLCNAGMYVADRADLFRWLSRLTNDNPKGEYFLTGIVAEANAEELTVRAHIASETAVMGADTQMQLSQAEAV
FQQRRRAHFLAEGVGMPAPETVHFAWDTEIAPGAVVEQFVVFAPGVKVETGAVIRAFSHLEGAVVREGALVGPYARLRPG
AEIGPDAHIGNFVEVKNVAVGKGAKANHLSYLGDGEVGAGANIGAGTIFCNYDGFFKYRTVVGEGAFIGSNTALVAPVTI
GAGAMTGSGSVITRDVPDHALALERSPQADKAGWARAFREKKSAEKAARGKK
>Mature_451_residues
TARAAVIMAAGQGTRMKSPVPKVLHKVGGRTLLDRIIDTVQAAGCERIHVIVGNHSPEVRALVARRLGEGAAVLQDPPLG
TGHAVLCAADTLADYDGDVLVVNGDCPLLQASDLEPLFELRAGGAALAIMGFEPQDQLLYGRLIRGADGHVLRIVEPSQC
SEQERAVRLCNAGMYVADRADLFRWLSRLTNDNPKGEYFLTGIVAEANAEELTVRAHIASETAVMGADTQMQLSQAEAVF
QQRRRAHFLAEGVGMPAPETVHFAWDTEIAPGAVVEQFVVFAPGVKVETGAVIRAFSHLEGAVVREGALVGPYARLRPGA
EIGPDAHIGNFVEVKNVAVGKGAKANHLSYLGDGEVGAGANIGAGTIFCNYDGFFKYRTVVGEGAFIGSNTALVAPVTIG
AGAMTGSGSVITRDVPDHALALERSPQADKAGWARAFREKKSAEKAARGKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=459, Percent_Identity=39.4335511982571, Blast_Score=318, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001228
- InterPro:   IPR011004 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47713; Mature: 47582

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARAAVIMAAGQGTRMKSPVPKVLHKVGGRTLLDRIIDTVQAAGCERIHVIVGNHSPEV
CCCCEEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
RALVARRLGEGAAVLQDPPLGTGHAVLCAADTLADYDGDVLVVNGDCPLLQASDLEPLFE
HHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHHCCCCCEEEECCCCCEEECCCCCHHHH
LRAGGAALAIMGFEPQDQLLYGRLIRGADGHVLRIVEPSQCSEQERAVRLCNAGMYVADR
HCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECH
ADLFRWLSRLTNDNPKGEYFLTGIVAEANAEELTVRAHIASETAVMGADTQMQLSQAEAV
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEECCCEEEECCCCHHHHHHHHHH
FQQRRRAHFLAEGVGMPAPETVHFAWDTEIAPGAVVEQFVVFAPGVKVETGAVIRAFSHL
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHH
EGAVVREGALVGPYARLRPGAEIGPDAHIGNFVEVKNVAVGKGAKANHLSYLGDGEVGAG
CCCEEECCCEECCHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCCCCCC
ANIGAGTIFCNYDGFFKYRTVVGEGAFIGSNTALVAPVTIGAGAMTGSGSVITRDVPDHA
CCCCCCEEEECCCCCEEEEEEECCCEEECCCCEEEEEEEECCCCCCCCCCEEEECCCCHH
LALERSPQADKAGWARAFREKKSAEKAARGKK
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARAAVIMAAGQGTRMKSPVPKVLHKVGGRTLLDRIIDTVQAAGCERIHVIVGNHSPEV
CCCEEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
RALVARRLGEGAAVLQDPPLGTGHAVLCAADTLADYDGDVLVVNGDCPLLQASDLEPLFE
HHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHHCCCCCEEEECCCCCEEECCCCCHHHH
LRAGGAALAIMGFEPQDQLLYGRLIRGADGHVLRIVEPSQCSEQERAVRLCNAGMYVADR
HCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECH
ADLFRWLSRLTNDNPKGEYFLTGIVAEANAEELTVRAHIASETAVMGADTQMQLSQAEAV
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEECCCEEEECCCCHHHHHHHHHH
FQQRRRAHFLAEGVGMPAPETVHFAWDTEIAPGAVVEQFVVFAPGVKVETGAVIRAFSHL
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHH
EGAVVREGALVGPYARLRPGAEIGPDAHIGNFVEVKNVAVGKGAKANHLSYLGDGEVGAG
CCCEEECCCEECCHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCCCCCC
ANIGAGTIFCNYDGFFKYRTVVGEGAFIGSNTALVAPVTIGAGAMTGSGSVITRDVPDHA
CCCCCCEEEECCCCCEEEEEEECCCEEECCCCEEEEEEEECCCCCCCCCCEEEECCCCHH
LALERSPQADKAGWARAFREKKSAEKAARGKK
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA