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The map label for this gene is gor [H]

Identifier: 197105451

GI number: 197105451

Start: 2221308

End: 2222696

Strand: Reverse

Name: gor [H]

Synonym: PHZ_c1988

Alternate gene names: 197105451

Gene position: 2222696-2221308 (Counterclockwise)

Preceding gene: 197105452

Following gene: 197105450

Centisome position: 55.62

GC content: 69.55

Gene sequence:

>1389_bases
TTGGCCGGATACGACTACGACCTCTTCGTCATCGGCGCCGGTTCGGGCGGCGTGCGCGCGGCCCGGGTGGCGGCGCTGTC
GGGCGCCCGCGTGGCCGTCGCCGAGGAGCACCGCGTCGGCGGCACCTGCGTGATCCGCGGCTGCGTGCCCAAGAAGTTCA
TGGTCTACGCCTCGGAGTTCGCGCACCACTTCAAGACCGCCGAAGGCTACGGCTGGACGGTCGAGGGCGCGCGGTTCGAC
TGGCCCGCCTTCCTGGCCGAAAAGGACAAGGAGATCGCCCGGCTTTCCGGCATCTATGTCCGTAACCTGCAGAACGCCGG
CGCCGAGCTGGTGCACGGCAAGGCTCGCCTCGTGGACCGCCACACGGTCGAGGTCGAGGGGCGCGGCCAGGTCACGGCCG
ACAAGATCCTGATCGCCACCGGCGGCCGGCCCTGGATGCCGAAGGACCTGCCCGGGATCGAGCACGCCATCACCTCCAAC
GAGGCGTTCCATATCGCCGAGCTGCCGAAGCGGATCATCATCGCCGGCGGCGGCTACATCGCCGTCGAGTTCGCCGGCAT
CTTCAACGGCCTGGGCGTCGATACGACCCTGGTCCATCGCGGCCCCAACATCCTGCGCGGCTTCGACGACGACGTGCGCG
CCCACGTGGCCGAGGAGATGGAGAAGCGCGGGATCAAGGTCCTGCTCGGCACGCAGCATTCCGCCATCGAGCAGACCGCG
ACGGGTCTCGTGAGCCGGCTCACCAACGGCATGTCGCCGTGCGAGAGCGACCTGGTGCTCTTCGCCCTTGGCCGCGAGCC
CTATGTCGAAGGCCTCGGCCTCGAGGCGGCCGGCGTCGAGCTGGACGCGCGCGGCGCGGTGAAGGTGGACGAGTACTCCC
GCACCAGCGTCGACAACATCTGGGCCGTGGGCGACGTCACCGACCGGATCAACCTGACGCCGGTGGCGATCCGGGAGGGC
CACGCCTTCGCCGACACCGTGTTCAACGACCGGCCCACGACCTTCGACCACGAGATGGTGGCCTCGGCGGTCTTCTCGCA
GCCGCCGATCGGCTCGGTGGGCCTCTCCGAGGCCGAGGCCCGGCACAGCCACGGCGGCAAGGTGGACATCTACCTCGCAC
GCTTCAGGCCGATGAAGTACGCCTTCACGGGCGGCGACGAGCGGTGCCTGGTGAAGCTGGTGGTGGAGCAGGGGACCGAG
AAGATCCTCGGCTGCCACGTCGTCGCGCCCGATGCGCCCGAGATCATCCAGATGGCCGCCATCGCCATGAAGATGGGGGT
GACCAAGCCGCAGTGGGATTCCACCTGCGCCGTCCACCCGACCCTGGCCGAGGAGCTGGTCACCCTGCGTGAGAAGCAGG
CGCCGCCCGCCCTGGGTCAGGTGGCCTGA

Upstream 100 bases:

>100_bases
TGGTGGACCACGGCCTCTTCCTCGACCTCGCCGACCGGGCTTTGATCGGCGGCCCCGGCGGCGTCACGACGCTGGAGCCC
TAGACCCCAAGGAGTCCGCG

Downstream 100 bases:

>100_bases
TGCCTGCGGCCGCCGCGGCGTCCGACCGGCTGGCGGTCTGGTGCGGCTGGGTGCTGGTGGGCGCCGCGGCGCTGGTCCCG
CTGCTGGCCTGGCTGGGGCC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAGYDYDLFVIGAGSGGVRAARVAALSGARVAVAEEHRVGGTCVIRGCVPKKFMVYASEFAHHFKTAEGYGWTVEGARFD
WPAFLAEKDKEIARLSGIYVRNLQNAGAELVHGKARLVDRHTVEVEGRGQVTADKILIATGGRPWMPKDLPGIEHAITSN
EAFHIAELPKRIIIAGGGYIAVEFAGIFNGLGVDTTLVHRGPNILRGFDDDVRAHVAEEMEKRGIKVLLGTQHSAIEQTA
TGLVSRLTNGMSPCESDLVLFALGREPYVEGLGLEAAGVELDARGAVKVDEYSRTSVDNIWAVGDVTDRINLTPVAIREG
HAFADTVFNDRPTTFDHEMVASAVFSQPPIGSVGLSEAEARHSHGGKVDIYLARFRPMKYAFTGGDERCLVKLVVEQGTE
KILGCHVVAPDAPEIIQMAAIAMKMGVTKPQWDSTCAVHPTLAEELVTLREKQAPPALGQVA

Sequences:

>Translated_462_residues
MAGYDYDLFVIGAGSGGVRAARVAALSGARVAVAEEHRVGGTCVIRGCVPKKFMVYASEFAHHFKTAEGYGWTVEGARFD
WPAFLAEKDKEIARLSGIYVRNLQNAGAELVHGKARLVDRHTVEVEGRGQVTADKILIATGGRPWMPKDLPGIEHAITSN
EAFHIAELPKRIIIAGGGYIAVEFAGIFNGLGVDTTLVHRGPNILRGFDDDVRAHVAEEMEKRGIKVLLGTQHSAIEQTA
TGLVSRLTNGMSPCESDLVLFALGREPYVEGLGLEAAGVELDARGAVKVDEYSRTSVDNIWAVGDVTDRINLTPVAIREG
HAFADTVFNDRPTTFDHEMVASAVFSQPPIGSVGLSEAEARHSHGGKVDIYLARFRPMKYAFTGGDERCLVKLVVEQGTE
KILGCHVVAPDAPEIIQMAAIAMKMGVTKPQWDSTCAVHPTLAEELVTLREKQAPPALGQVA
>Mature_461_residues
AGYDYDLFVIGAGSGGVRAARVAALSGARVAVAEEHRVGGTCVIRGCVPKKFMVYASEFAHHFKTAEGYGWTVEGARFDW
PAFLAEKDKEIARLSGIYVRNLQNAGAELVHGKARLVDRHTVEVEGRGQVTADKILIATGGRPWMPKDLPGIEHAITSNE
AFHIAELPKRIIIAGGGYIAVEFAGIFNGLGVDTTLVHRGPNILRGFDDDVRAHVAEEMEKRGIKVLLGTQHSAIEQTAT
GLVSRLTNGMSPCESDLVLFALGREPYVEGLGLEAAGVELDARGAVKVDEYSRTSVDNIWAVGDVTDRINLTPVAIREGH
AFADTVFNDRPTTFDHEMVASAVFSQPPIGSVGLSEAEARHSHGGKVDIYLARFRPMKYAFTGGDERCLVKLVVEQGTEK
ILGCHVVAPDAPEIIQMAAIAMKMGVTKPQWDSTCAVHPTLAEELVTLREKQAPPALGQVA

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=41.6846652267819, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=35.4564755838641, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=33.1223628691983, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=33.1223628691983, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=33.1223628691983, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=33.1223628691983, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=33.1223628691983, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=31.5010570824524, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=29.5983086680761, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI91199540, Length=476, Percent_Identity=27.7310924369748, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=39.9538106235566, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=28.8546255506608, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=27.5938189845475, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=27.3127753303965, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789065, Length=187, Percent_Identity=30.4812834224599, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=453, Percent_Identity=39.9558498896247, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71983419, Length=453, Percent_Identity=39.9558498896247, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=33.5403726708075, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=490, Percent_Identity=29.3877551020408, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=30, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17559934, Length=208, Percent_Identity=29.3269230769231, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=38.177874186551, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=29.1576673866091, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=27.7542372881356, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=35.531914893617, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=35.531914893617, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=35.531914893617, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=36.5750528541226, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=30.4439746300211, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49725; Mature: 49594

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYDYDLFVIGAGSGGVRAARVAALSGARVAVAEEHRVGGTCVIRGCVPKKFMVYASEF
CCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHH
AHHFKTAEGYGWTVEGARFDWPAFLAEKDKEIARLSGIYVRNLQNAGAELVHGKARLVDR
HHHHCCCCCCCEEECCCCCCCHHHHHHCCHHHHHHHHHHEEHHHHCCHHHHCCHHEEEEC
HTVEVEGRGQVTADKILIATGGRPWMPKDLPGIEHAITSNEAFHIAELPKRIIIAGGGYI
EEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCEEHHHCCCEEEEECCCEE
AVEFAGIFNGLGVDTTLVHRGPNILRGFDDDVRAHVAEEMEKRGIKVLLGTQHSAIEQTA
EEEEEHHHCCCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
TGLVSRLTNGMSPCESDLVLFALGREPYVEGLGLEAAGVELDARGAVKVDEYSRTSVDNI
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHCCCCEECCEEECCCCCEEECCCCCCCCCCE
WAVGDVTDRINLTPVAIREGHAFADTVFNDRPTTFDHEMVASAVFSQPPIGSVGLSEAEA
EEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
RHSHGGKVDIYLARFRPMKYAFTGGDERCLVKLVVEQGTEKILGCHVVAPDAPEIIQMAA
HHCCCCEEEEEEEECCCEEEEECCCCCCEEHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
IAMKMGVTKPQWDSTCAVHPTLAEELVTLREKQAPPALGQVA
HHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AGYDYDLFVIGAGSGGVRAARVAALSGARVAVAEEHRVGGTCVIRGCVPKKFMVYASEF
CCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHH
AHHFKTAEGYGWTVEGARFDWPAFLAEKDKEIARLSGIYVRNLQNAGAELVHGKARLVDR
HHHHCCCCCCCEEECCCCCCCHHHHHHCCHHHHHHHHHHEEHHHHCCHHHHCCHHEEEEC
HTVEVEGRGQVTADKILIATGGRPWMPKDLPGIEHAITSNEAFHIAELPKRIIIAGGGYI
EEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCEEHHHCCCEEEEECCCEE
AVEFAGIFNGLGVDTTLVHRGPNILRGFDDDVRAHVAEEMEKRGIKVLLGTQHSAIEQTA
EEEEEHHHCCCCCCEEEEECCCHHHCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
TGLVSRLTNGMSPCESDLVLFALGREPYVEGLGLEAAGVELDARGAVKVDEYSRTSVDNI
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHCCCCEECCEEECCCCCEEECCCCCCCCCCE
WAVGDVTDRINLTPVAIREGHAFADTVFNDRPTTFDHEMVASAVFSQPPIGSVGLSEAEA
EEECCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
RHSHGGKVDIYLARFRPMKYAFTGGDERCLVKLVVEQGTEKILGCHVVAPDAPEIIQMAA
HHCCCCEEEEEEEECCCEEEEECCCCCCEEHHHHHHCCCCEEEEEEEECCCCHHHHHHHH
IAMKMGVTKPQWDSTCAVHPTLAEELVTLREKQAPPALGQVA
HHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]