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The map label for this gene is mpl [H]

Identifier: 197105385

GI number: 197105385

Start: 2152840

End: 2154252

Strand: Reverse

Name: mpl [H]

Synonym: PHZ_c1922

Alternate gene names: 197105385

Gene position: 2154252-2152840 (Counterclockwise)

Preceding gene: 197105388

Following gene: 197105383

Centisome position: 53.91

GC content: 73.39

Gene sequence:

>1413_bases
ATGCGCATCCATTTCACCGGCATCGCCGGCGCCGGCATGAGCGCCGCGGCCCTGATGATGCGCGAGGCCGGCCACCAGGT
CTCGGGCTCGGACCAGGACGTCTTCCCGCCCATGTCCACCTACGTGGAGGGGCTGGGCTTTCCCTTCTTCCGCGCCTTCG
ATCCGGCCAACCTGCCGCGGGATTTGGACGTGCTGGTGCTGGGCGCCTCGGCCAAGCTGGGCGGCGACGACAATCCCGAG
GTCGCCGAGGCGCGGCGGCGCGGCGTGCGCGTGACCACCTTCCCCGAGCTGGTGGGGGAGGCGACCGCCGGCAAGCTGAA
CACCGTCGTCGCCGGCTCGTTCGGCAAGTCCACCTGCACGGCGCTCCTGGCCCACGTGCTGCGCGAGGCGGGCTGCGACG
CCGGCTGGATGATCGGGGCGATCTCGCCCTCGCTTCCGGACACCGGCCACTGGGGCGCCGCTCCACAGGTCGTGCTGGAG
GGCGACGAGTACATCGTCGGGCCGTCCGACCACCGCTCGAAGTTCGTGCTCTACCACCCGCGCGACGTGCTGCTGACCTC
GCTGGTCCACGACCACGTCAACGTCTTCCCGACGTTCGCCGACTACGAGGCGCCGTTCCGCGAGCTGCTGCGGCTGCTGC
CGGCCGACGGGCTCCTCGTGGCGCGCGACCATCCGGCGATCCGCGCCGTCGCGGGCGAGGCCGCCTGCCGCATCGTCTGG
TACGACGTCGGCCCCTGCGAGGGCTGGTGCGCCGAGGACGTGGCGTTCGGCGACGTCACGCGCTTCACGCTGCGATCCCC
GGGCGGCGGCCGGCTGAAGCTCGCCACGACCCTGCTGGGCGCGCACAACATCGAGAACATCGTCGGCGTGGCGGCCTATG
TGCTGGAGCGCGGCCTAGCGACCGAGGCCCAGCTCGCCCGCGCCGTCGAGAGCTTCCAGGGCATCCGCCGCCGGCTCGAC
CGCCTGACCGCGGCCTCGCGCATCCCGCTCGTGGAGGGCTTCGGCTCGTCCTACGAGAAGGCCCGCTCGGCCATCGAGGC
GATGCGGCTGCACTATCCCGCGCGGCCCCTGACGGTGGTGTTCGAGCCGCACACCTTCTCGTGGCGCAACCGCGAGGCGC
TGCCCTGGTACGACACGGTGTTCGAGGGGGCGGCCAGGGTGCTGGTCGTCCCGCCGCCCAGCCACGGGGCGGCCAGCCAC
CAGCAGTCCAGCTTCGAGGAGATCCTCGCGCGGATCGAGCGGGCCGGCGTGCCGGCGGCCGGCGTGCGCACGGCCGAGGA
GGCCACCGCCGCCCTCGGCGGGCTCGCCGGCGACGAGGTCGTGCTGCTGCTCTCCTCGGGCCCGCTCCTGGGCCTGCCCG
ACAGCCTGCCGCCGGTCTTCGACCAGCTCTATGCCGAGCCCGCCGCGGCCTGA

Upstream 100 bases:

>100_bases
ATCAAAAGGCGCGAGGGGCGCCCGATTGTCGCGCCGGGCTGGACGGCGCCGATGGATCGGCTAACCAGCGGTCCTGGGAC
GTCTCGTCAGGGAAGGGCGC

Downstream 100 bases:

>100_bases
CCGCTAGCCGTGCCGGGCGGGGATGGGCTGGACGTAGTCCGTGCCCGCCTCGATCTCCTTGAACATCTGCCGCCGGGGGC
CGAGGTAGCCGAACAGGTAG

Product: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRIHFTGIAGAGMSAAALMMREAGHQVSGSDQDVFPPMSTYVEGLGFPFFRAFDPANLPRDLDVLVLGASAKLGGDDNPE
VAEARRRGVRVTTFPELVGEATAGKLNTVVAGSFGKSTCTALLAHVLREAGCDAGWMIGAISPSLPDTGHWGAAPQVVLE
GDEYIVGPSDHRSKFVLYHPRDVLLTSLVHDHVNVFPTFADYEAPFRELLRLLPADGLLVARDHPAIRAVAGEAACRIVW
YDVGPCEGWCAEDVAFGDVTRFTLRSPGGGRLKLATTLLGAHNIENIVGVAAYVLERGLATEAQLARAVESFQGIRRRLD
RLTAASRIPLVEGFGSSYEKARSAIEAMRLHYPARPLTVVFEPHTFSWRNREALPWYDTVFEGAARVLVVPPPSHGAASH
QQSSFEEILARIERAGVPAAGVRTAEEATAALGGLAGDEVVLLLSSGPLLGLPDSLPPVFDQLYAEPAAA

Sequences:

>Translated_470_residues
MRIHFTGIAGAGMSAAALMMREAGHQVSGSDQDVFPPMSTYVEGLGFPFFRAFDPANLPRDLDVLVLGASAKLGGDDNPE
VAEARRRGVRVTTFPELVGEATAGKLNTVVAGSFGKSTCTALLAHVLREAGCDAGWMIGAISPSLPDTGHWGAAPQVVLE
GDEYIVGPSDHRSKFVLYHPRDVLLTSLVHDHVNVFPTFADYEAPFRELLRLLPADGLLVARDHPAIRAVAGEAACRIVW
YDVGPCEGWCAEDVAFGDVTRFTLRSPGGGRLKLATTLLGAHNIENIVGVAAYVLERGLATEAQLARAVESFQGIRRRLD
RLTAASRIPLVEGFGSSYEKARSAIEAMRLHYPARPLTVVFEPHTFSWRNREALPWYDTVFEGAARVLVVPPPSHGAASH
QQSSFEEILARIERAGVPAAGVRTAEEATAALGGLAGDEVVLLLSSGPLLGLPDSLPPVFDQLYAEPAAA
>Mature_470_residues
MRIHFTGIAGAGMSAAALMMREAGHQVSGSDQDVFPPMSTYVEGLGFPFFRAFDPANLPRDLDVLVLGASAKLGGDDNPE
VAEARRRGVRVTTFPELVGEATAGKLNTVVAGSFGKSTCTALLAHVLREAGCDAGWMIGAISPSLPDTGHWGAAPQVVLE
GDEYIVGPSDHRSKFVLYHPRDVLLTSLVHDHVNVFPTFADYEAPFRELLRLLPADGLLVARDHPAIRAVAGEAACRIVW
YDVGPCEGWCAEDVAFGDVTRFTLRSPGGGRLKLATTLLGAHNIENIVGVAAYVLERGLATEAQLARAVESFQGIRRRLD
RLTAASRIPLVEGFGSSYEKARSAIEAMRLHYPARPLTVVFEPHTFSWRNREALPWYDTVFEGAARVLVVPPPSHGAASH
QQSSFEEILARIERAGVPAAGVRTAEEATAALGGLAGDEVVLLLSSGPLLGLPDSLPPVFDQLYAEPAAA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1790680, Length=350, Percent_Identity=28, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786279, Length=401, Percent_Identity=27.930174563591, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50226; Mature: 50226

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHFTGIAGAGMSAAALMMREAGHQVSGSDQDVFPPMSTYVEGLGFPFFRAFDPANLPR
CEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCC
DLDVLVLGASAKLGGDDNPEVAEARRRGVRVTTFPELVGEATAGKLNTVVAGSFGKSTCT
CCEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECHHHHCCCCCCCCEEEEECCCCHHHHH
ALLAHVLREAGCDAGWMIGAISPSLPDTGHWGAAPQVVLEGDEYIVGPSDHRSKFVLYHP
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCEEEECC
RDVLLTSLVHDHVNVFPTFADYEAPFRELLRLLPADGLLVARDHPAIRAVAGEAACRIVW
HHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEEE
YDVGPCEGWCAEDVAFGDVTRFTLRSPGGGRLKLATTLLGAHNIENIVGVAAYVLERGLA
EECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAQLARAVESFQGIRRRLDRLTAASRIPLVEGFGSSYEKARSAIEAMRLHYPARPLTVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEE
FEPHTFSWRNREALPWYDTVFEGAARVLVVPPPSHGAASHQQSSFEEILARIERAGVPAA
ECCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GVRTAEEATAALGGLAGDEVVLLLSSGPLLGLPDSLPPVFDQLYAEPAAA
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MRIHFTGIAGAGMSAAALMMREAGHQVSGSDQDVFPPMSTYVEGLGFPFFRAFDPANLPR
CEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCC
DLDVLVLGASAKLGGDDNPEVAEARRRGVRVTTFPELVGEATAGKLNTVVAGSFGKSTCT
CCEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECHHHHCCCCCCCCEEEEECCCCHHHHH
ALLAHVLREAGCDAGWMIGAISPSLPDTGHWGAAPQVVLEGDEYIVGPSDHRSKFVLYHP
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCEEEECC
RDVLLTSLVHDHVNVFPTFADYEAPFRELLRLLPADGLLVARDHPAIRAVAGEAACRIVW
HHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEEE
YDVGPCEGWCAEDVAFGDVTRFTLRSPGGGRLKLATTLLGAHNIENIVGVAAYVLERGLA
EECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
TEAQLARAVESFQGIRRRLDRLTAASRIPLVEGFGSSYEKARSAIEAMRLHYPARPLTVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCEEEE
FEPHTFSWRNREALPWYDTVFEGAARVLVVPPPSHGAASHQQSSFEEILARIERAGVPAA
ECCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GVRTAEEATAALGGLAGDEVVLLLSSGPLLGLPDSLPPVFDQLYAEPAAA
CCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA