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The map label for this gene is clpP [H]

Identifier: 197105280

GI number: 197105280

Start: 2035729

End: 2036346

Strand: Reverse

Name: clpP [H]

Synonym: PHZ_c1817

Alternate gene names: 197105280

Gene position: 2036346-2035729 (Counterclockwise)

Preceding gene: 197105281

Following gene: 197105279

Centisome position: 50.96

GC content: 65.05

Gene sequence:

>618_bases
ATGCGTGATCCCGTCACCACCGCCCTGGGCCTCGTGCCGATGGTCGTCGAGCAGACGAGCCGGGGCGAGCGCGCCTATGA
CATCTTCTCCCGCCTGCTGAAGGACCGGATCGTGTTCCTGGCGGGTCCGGTCGAGGACGGGATGGCCAGCCTGATCTGCG
CCCAGCTTCTCCATCTCGAGGCCGAGAACCCGAAGAAGGAGATCCAGATGTACATCAACTCCCCGGGGGGAGTGGTGACG
TCGGGCCTCGCGATCTACGACACCATGCAGTACATCAAGAGCCCGGTGATCACGCTGTGCCTCGGCATGGCCGCCTCGAT
GGGCTCGTTCCTGCTGATGGCCGGCGAGAAGGGCCAGCGGATCGCCCTGCCGAACTCGCGGATCATGGTCCACCAGCCGT
CGGGCGGGTACTCGGGCAAGGCGACCGACATCCAGCGCCACGCCGAGGACATCATCAAGACCAAGCGGCGGCTGAACGAG
ATCTACGCCAAGCACACCGGCCAGCCGATCGAGGCGGTCGAAGAAACCCTCGACCGCGACTTCTTCATGACCGCCCAGGA
GGCCAAGGACTGGGGCCTCGTGGACCACGTCTGGGAAAAGCGCGACAACGAAAGCTGA

Upstream 100 bases:

>100_bases
CCGCCTGACCCCGGCCTTGCGCGCGGGATAGGGGCGGGCGATATCGAAGGGACGGCGCGGGCCGCCCGCGCCCATCGACT
CTGAAGGAAGCCTCCTCTCC

Downstream 100 bases:

>100_bases
CGCGCCGATCCGGCACGCGCACGAGGGCCCGGGCGGCGACGCCCGGGCCCTCTTCGTTCCGGAGAAGCCTGGTGGCCCCG
CTCACATTAAGTTTAGCGGC

Product: ATP-dependent Clp protease, proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRDPVTTALGLVPMVVEQTSRGERAYDIFSRLLKDRIVFLAGPVEDGMASLICAQLLHLEAENPKKEIQMYINSPGGVVT
SGLAIYDTMQYIKSPVITLCLGMAASMGSFLLMAGEKGQRIALPNSRIMVHQPSGGYSGKATDIQRHAEDIIKTKRRLNE
IYAKHTGQPIEAVEETLDRDFFMTAQEAKDWGLVDHVWEKRDNES

Sequences:

>Translated_205_residues
MRDPVTTALGLVPMVVEQTSRGERAYDIFSRLLKDRIVFLAGPVEDGMASLICAQLLHLEAENPKKEIQMYINSPGGVVT
SGLAIYDTMQYIKSPVITLCLGMAASMGSFLLMAGEKGQRIALPNSRIMVHQPSGGYSGKATDIQRHAEDIIKTKRRLNE
IYAKHTGQPIEAVEETLDRDFFMTAQEAKDWGLVDHVWEKRDNES
>Mature_205_residues
MRDPVTTALGLVPMVVEQTSRGERAYDIFSRLLKDRIVFLAGPVEDGMASLICAQLLHLEAENPKKEIQMYINSPGGVVT
SGLAIYDTMQYIKSPVITLCLGMAASMGSFLLMAGEKGQRIALPNSRIMVHQPSGGYSGKATDIQRHAEDIIKTKRRLNE
IYAKHTGQPIEAVEETLDRDFFMTAQEAKDWGLVDHVWEKRDNES

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=61.4583333333333, Blast_Score=250, Evalue=6e-67,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=60.6965174129353, Blast_Score=270, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=61.2903225806452, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=61.2565445026178, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22811; Mature: 22811

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVTTALGLVPMVVEQTSRGERAYDIFSRLLKDRIVFLAGPVEDGMASLICAQLLHLE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEIQMYINSPGGVVTSGLAIYDTMQYIKSPVITLCLGMAASMGSFLLMAGEKGQR
CCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
IALPNSRIMVHQPSGGYSGKATDIQRHAEDIIKTKRRLNEIYAKHTGQPIEAVEETLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
FFMTAQEAKDWGLVDHVWEKRDNES
HHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MRDPVTTALGLVPMVVEQTSRGERAYDIFSRLLKDRIVFLAGPVEDGMASLICAQLLHLE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEIQMYINSPGGVVTSGLAIYDTMQYIKSPVITLCLGMAASMGSFLLMAGEKGQR
CCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
IALPNSRIMVHQPSGGYSGKATDIQRHAEDIIKTKRRLNEIYAKHTGQPIEAVEETLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
FFMTAQEAKDWGLVDHVWEKRDNES
HHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9755166 [H]