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The map label for this gene is lpxD

Identifier: 197105233

GI number: 197105233

Start: 1979945

End: 1980976

Strand: Reverse

Name: lpxD

Synonym: PHZ_c1770

Alternate gene names: 197105233

Gene position: 1980976-1979945 (Counterclockwise)

Preceding gene: 197105234

Following gene: 197105232

Centisome position: 49.57

GC content: 73.45

Gene sequence:

>1032_bases
ATGCCCGATCCGCGCTTCTACGAAGACCTGGGACCGGTTCCCCTCGCCGAGCTGGCCAAGCTCGGCGGGGCGGACCTGCC
CGCAGGCGCCGACGGCGCCCGCCTGATCCGCGCCGCGGCGGTGCTGGCCCACGCGGGGCCCGACACCGTCACCTTCCTGA
CCGACCGCAAGCACCTGCCGGGCCTCGCTCGCCTGGAAGGCGCCTGCTTCGTCCAGGCCAGGGACGCAAGCGTCTTGCCC
GATGGCTGCATCCCGCTCGTCACCCGCAACCCGCACGGCGCCTATGCGCTGGCGGCGCAGACGCTGCACCGGCCCCGTGC
GGTCGGATCGGACGCCATTGCGCCCGACGTGGTGCTGGAGCCGGGCGTCGAGCTGGGCGCGGGGGTCGTGCTGGGGCCGG
GGGTCAAGGTGGGACGCGGGACCCGGATCGGCCCAAACGCCGTGGTCGGCGCCGGCGTCGCGATCGGCCGCGAGTGCGAC
ATCGGGGCGAACGTCACCCTCGGCTTCGCCCTGCTCGGCGACCGGGTGCGGATCCTGGCCGGCGCGGTCATCGGCGAGCC
GGGCTTCGGCGCGACGGCCGGGGCGCAGGGCCTGATCGACATCCCGCAGCTCGGCCGGGTGATCATCCAGGACGGGGTGA
CCATCGGGGCGAACACCACCATCGACCGCGGCGCCTTCGACGACACCGTGATCGGCGAGAACACCAAGATCGACAACCTC
GTGCAGATCGCCCACAACGTCCGCGTGGGACGAAACTGCGTCATGGCCGCCCACACCGGCATCTCGGGCAGCGTGGAGAT
CGGCGAGGGCGCCCAGTTCGGCGGCCGCGCCGGCGTGGCCGACCATGTGACCATCGGCGCCGGCGCCCGGGTGGGCGCGG
CGGCCGGCGTGATGAAGGACATCCCGGCCGGAGAGACATGGGGGGGCATGCCCGCCCGTCCGATCCGGCACTGGCTGAAG
GAAACGGCGTGGCTCGCCCGGATGGCGAACCGCAGGGGGCCGGACGGTAAAGGGGCTGGGAATGACGCGTAA

Upstream 100 bases:

>100_bases
CTGGACCAGCCGGCGGCCCAGCCCGCTCCGGCCGCCCAGACGCAACAGCCGCGCCGCTAGTCGGCCGACGGAGCGCGGAG
CGAGCCCGCCAAGGCGCACC

Downstream 100 bases:

>100_bases
GGCGCCGGCGGGGCAGGACCCGACGCAGATCGACATCACCGAGGTGCTGGAGCGGATCCCGCACCGCTATCCGTTCCTGC
TGGTGGACCGTTGCGAGGAG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLPGLARLEGACFVQARDASVLP
DGCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLEPGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECD
IGANVTLGFALLGDRVRILAGAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNL
VQIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKDIPAGETWGGMPARPIRHWLK
ETAWLARMANRRGPDGKGAGNDA

Sequences:

>Translated_343_residues
MPDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLPGLARLEGACFVQARDASVLP
DGCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLEPGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECD
IGANVTLGFALLGDRVRILAGAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNL
VQIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKDIPAGETWGGMPARPIRHWLK
ETAWLARMANRRGPDGKGAGNDA
>Mature_342_residues
PDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLPGLARLEGACFVQARDASVLPD
GCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLEPGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECDI
GANVTLGFALLGDRVRILAGAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNLV
QIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKDIPAGETWGGMPARPIRHWLKE
TAWLARMANRRGPDGKGAGNDA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=324, Percent_Identity=34.2592592592593, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786378, Length=218, Percent_Identity=30.2752293577982, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PHEZH (B4RBY4)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130610.1
- ProteinModelPortal:   B4RBY4
- GeneID:   6791283
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1770
- HOGENOM:   HBG469615
- OMA:   TIGANSC
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34749; Mature: 34618

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLP
CCCCCCHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GLARLEGACFVQARDASVLPDGCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLE
CHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHCCCCCCCCCEEEC
PGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECDIGANVTLGFALLGDRVRILA
CCCCCCCCEEECCCEEECCCCCCCCCCEEECCEEECCCCCCCCCCEEEHHHHCCHHHHHH
GAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNL
HHHCCCCCCCCCCCCCCCEEHHHHHHEEHHCCEEECCCCCCCCCCCCCCCCCCCCCHHHH
VQIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKD
HHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHC
IPAGETWGGMPARPIRHWLKETAWLARMANRRGPDGKGAGNDA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PDPRFYEDLGPVPLAELAKLGGADLPAGADGARLIRAAAVLAHAGPDTVTFLTDRKHLP
CCCCCHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GLARLEGACFVQARDASVLPDGCIPLVTRNPHGAYALAAQTLHRPRAVGSDAIAPDVVLE
CHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHCCCCCCCCCEEEC
PGVELGAGVVLGPGVKVGRGTRIGPNAVVGAGVAIGRECDIGANVTLGFALLGDRVRILA
CCCCCCCCEEECCCEEECCCCCCCCCCEEECCEEECCCCCCCCCCEEEHHHHCCHHHHHH
GAVIGEPGFGATAGAQGLIDIPQLGRVIIQDGVTIGANTTIDRGAFDDTVIGENTKIDNL
HHHCCCCCCCCCCCCCCCEEHHHHHHEEHHCCEEECCCCCCCCCCCCCCCCCCCCCHHHH
VQIAHNVRVGRNCVMAAHTGISGSVEIGEGAQFGGRAGVADHVTIGAGARVGAAAGVMKD
HHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHC
IPAGETWGGMPARPIRHWLKETAWLARMANRRGPDGKGAGNDA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA