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The map label for this gene is trpE [H]

Identifier: 197105220

GI number: 197105220

Start: 1965690

End: 1967222

Strand: Direct

Name: trpE [H]

Synonym: PHZ_c1757

Alternate gene names: 197105220

Gene position: 1965690-1967222 (Clockwise)

Preceding gene: 197105219

Following gene: 197105221

Centisome position: 49.19

GC content: 70.91

Gene sequence:

>1533_bases
GTGACGCCGGAGCCGTCGTTCGAGGCGTTCCGGTCGACCTACGACGGCGGCGCTCCGCAGGTCGTCTGGACGCGGCTGGT
CGACGACCTGGAGACCCCCGTCTCCGCGTTCCTGAAGATCGGTCACGGCCGGCCGTACGCCTTCCTGTTCGAATCGGTGG
AAGGCGGCGCCTGGCGCGGCCGCTATTCGATCATCACCCTGGCGCCCGACCTCGTCTGGCGCTGTCGCGGCGACGTGGCC
GAGGCGGCCGAGGGCGAAGACATCGCCGCCGGCCGGTTCACCACCCAGCCCGGCGGGGCGCTGGATTCGCTGCGCGACCT
GCTGGCCGCCTCGCGCATCGAGCTGCCCCCGGGCCTGCCGCCCATGGCCGCGGGCGTCTTCGGGGCGATCGGCTACGACA
TGATCCGGCTGGTCGAGCGCCTGCCGAACGTGAATCCCGACCCGTTGGGCCTGCCCGACTCGGTGCTGGCGCGTCCCTCG
ATCGTGGCGATCTTCGACGCCATCGCCCAGGAGATCATCCTGGTGACGCCGGTCCGTCCGGGCATGGCGTCGGCCGAACA
GGCCTATGAGGCCGCCCGCGCGCGGCTGCAGGCGGTCGTCGACGACCTGCGAAGGCCCGCGCCGCCGCTCACCGGGACGG
CCACGCCCGAGCCCGACAGCTTCACGACCCCGGTCAGCCGCGAGGCGTACCGCGAGATCGTCGAAAAGGCGAAGGGCTAC
ATCCGCGCCGGCGACATCTTTCAGGTCGTCCCCAGCCACCGCTTCCGCGCGCCGTTCACCCGCGATCCATTCGCGCTCTA
CCGCTCGCTGCGCCGGACCAACCCGTCGCCGTTCCTGTTCTTCCTGGACTTCGGCGGTTTCCAGCTCGCCGGCTCGAGCC
CCGAGATCCTGGTGCGCCTGCGCGACGGCAAGATCACCATCCGGCCGATCGCGGGCACCCGCCCCCGCGGCGCGACGCCC
GAGGAGGACCTGCGGCTCGAACAGGAGCTCGTGAACGATCCCAAGGAACGCGCCGAACACCTGATGCTGCTGGACCTCGG
CCGCAACGACGTCGGCCGGGTGGCGATGCTGAAGGAACAGGGCGCCAACCAGCCGGCGCCCGCGTCGCGCCAGCCGCGCG
TGCGGGTCACGAACAGCTTCTTCGTCGAGCGCTACAGCCACGTCATGCACCTCGTCTCAAACGTCGAGGGGGATGCGCCC
GATGGCCTCGATCCGGTGGACGTGGTGATGGCCGCCCTGCCGGCCGGCACGCTCTCCGGCGCGCCGAAGGTGCGGGCGAT
GGAGATCATCGACGAGTTGGAGATCGAGAAGCGCGGCATCGGCTACGCAGGCGGCGTCGGCTACTTCGGCTGCGACGGAT
CGGTGGACACCTGCATCGTCCTGCGCACCGCGCTGTTCAAGGACGAGGTGATGTACGTGCAGGCCGGCGGCGGCGTCGTG
GCCGACAGCGATCCCGACGCCGAGTACGATGAAACCCTCCACAAGGCCCGCGCATTGCGGCGGGCGGCCGAGGAGAGCTG
GCGCTTCGTCTGA

Upstream 100 bases:

>100_bases
CGGCGCGCGACAAGCTGAAGGTGCGCGTGGATGTGAACCGCGCCCGCGCCGCGGTCGGCTTCGAGCCCCTCGACGCCAAG
GCCCCGGCGGAGAAGAAGAA

Downstream 100 bases:

>100_bases
GCCGCGTTAACTGCGATCGCTCAATGCGGGTAGGCCCGCGCTTGCATAACTTCGTCGGCTCGCGAACGTGATCGTGCGTT
CGCCGACCGGCGCACGCCGG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTPEPSFEAFRSTYDGGAPQVVWTRLVDDLETPVSAFLKIGHGRPYAFLFESVEGGAWRGRYSIITLAPDLVWRCRGDVA
EAAEGEDIAAGRFTTQPGGALDSLRDLLAASRIELPPGLPPMAAGVFGAIGYDMIRLVERLPNVNPDPLGLPDSVLARPS
IVAIFDAIAQEIILVTPVRPGMASAEQAYEAARARLQAVVDDLRRPAPPLTGTATPEPDSFTTPVSREAYREIVEKAKGY
IRAGDIFQVVPSHRFRAPFTRDPFALYRSLRRTNPSPFLFFLDFGGFQLAGSSPEILVRLRDGKITIRPIAGTRPRGATP
EEDLRLEQELVNDPKERAEHLMLLDLGRNDVGRVAMLKEQGANQPAPASRQPRVRVTNSFFVERYSHVMHLVSNVEGDAP
DGLDPVDVVMAALPAGTLSGAPKVRAMEIIDELEIEKRGIGYAGGVGYFGCDGSVDTCIVLRTALFKDEVMYVQAGGGVV
ADSDPDAEYDETLHKARALRRAAEESWRFV

Sequences:

>Translated_510_residues
MTPEPSFEAFRSTYDGGAPQVVWTRLVDDLETPVSAFLKIGHGRPYAFLFESVEGGAWRGRYSIITLAPDLVWRCRGDVA
EAAEGEDIAAGRFTTQPGGALDSLRDLLAASRIELPPGLPPMAAGVFGAIGYDMIRLVERLPNVNPDPLGLPDSVLARPS
IVAIFDAIAQEIILVTPVRPGMASAEQAYEAARARLQAVVDDLRRPAPPLTGTATPEPDSFTTPVSREAYREIVEKAKGY
IRAGDIFQVVPSHRFRAPFTRDPFALYRSLRRTNPSPFLFFLDFGGFQLAGSSPEILVRLRDGKITIRPIAGTRPRGATP
EEDLRLEQELVNDPKERAEHLMLLDLGRNDVGRVAMLKEQGANQPAPASRQPRVRVTNSFFVERYSHVMHLVSNVEGDAP
DGLDPVDVVMAALPAGTLSGAPKVRAMEIIDELEIEKRGIGYAGGVGYFGCDGSVDTCIVLRTALFKDEVMYVQAGGGVV
ADSDPDAEYDETLHKARALRRAAEESWRFV
>Mature_509_residues
TPEPSFEAFRSTYDGGAPQVVWTRLVDDLETPVSAFLKIGHGRPYAFLFESVEGGAWRGRYSIITLAPDLVWRCRGDVAE
AAEGEDIAAGRFTTQPGGALDSLRDLLAASRIELPPGLPPMAAGVFGAIGYDMIRLVERLPNVNPDPLGLPDSVLARPSI
VAIFDAIAQEIILVTPVRPGMASAEQAYEAARARLQAVVDDLRRPAPPLTGTATPEPDSFTTPVSREAYREIVEKAKGYI
RAGDIFQVVPSHRFRAPFTRDPFALYRSLRRTNPSPFLFFLDFGGFQLAGSSPEILVRLRDGKITIRPIAGTRPRGATPE
EDLRLEQELVNDPKERAEHLMLLDLGRNDVGRVAMLKEQGANQPAPASRQPRVRVTNSFFVERYSHVMHLVSNVEGDAPD
GLDPVDVVMAALPAGTLSGAPKVRAMEIIDELEIEKRGIGYAGGVGYFGCDGSVDTCIVLRTALFKDEVMYVQAGGGVVA
DSDPDAEYDETLHKARALRRAAEESWRFV

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=383, Percent_Identity=40.2088772845953, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1788114, Length=472, Percent_Identity=31.5677966101695, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1786809, Length=234, Percent_Identity=27.3504273504274, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=492, Percent_Identity=37.3983739837398, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6324361, Length=409, Percent_Identity=22.9828850855746, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55649; Mature: 55518

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEPSFEAFRSTYDGGAPQVVWTRLVDDLETPVSAFLKIGHGRPYAFLFESVEGGAWRG
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSIITLAPDLVWRCRGDVAEAAEGEDIAAGRFTTQPGGALDSLRDLLAASRIELPPGLP
CEEEEEECHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGAIGYDMIRLVERLPNVNPDPLGLPDSVLARPSIVAIFDAIAQEIILVTPVRP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHEEEEECCCC
GMASAEQAYEAARARLQAVVDDLRRPAPPLTGTATPEPDSFTTPVSREAYREIVEKAKGY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
IRAGDIFQVVPSHRFRAPFTRDPFALYRSLRRTNPSPFLFFLDFGGFQLAGSSPEILVRL
EECCCHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCEEEEEE
RDGKITIRPIAGTRPRGATPEEDLRLEQELVNDPKERAEHLMLLDLGRNDVGRVAMLKEQ
ECCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCHHHHHHHC
GANQPAPASRQPRVRVTNSFFVERYSHVMHLVSNVEGDAPDGLDPVDVVMAALPAGTLSG
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCC
APKVRAMEIIDELEIEKRGIGYAGGVGYFGCDGSVDTCIVLRTALFKDEVMYVQAGGGVV
CCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEECCCEE
ADSDPDAEYDETLHKARALRRAAEESWRFV
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TPEPSFEAFRSTYDGGAPQVVWTRLVDDLETPVSAFLKIGHGRPYAFLFESVEGGAWRG
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSIITLAPDLVWRCRGDVAEAAEGEDIAAGRFTTQPGGALDSLRDLLAASRIELPPGLP
CEEEEEECHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGAIGYDMIRLVERLPNVNPDPLGLPDSVLARPSIVAIFDAIAQEIILVTPVRP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHEEEEECCCC
GMASAEQAYEAARARLQAVVDDLRRPAPPLTGTATPEPDSFTTPVSREAYREIVEKAKGY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
IRAGDIFQVVPSHRFRAPFTRDPFALYRSLRRTNPSPFLFFLDFGGFQLAGSSPEILVRL
EECCCHHEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCEEEEEE
RDGKITIRPIAGTRPRGATPEEDLRLEQELVNDPKERAEHLMLLDLGRNDVGRVAMLKEQ
ECCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCHHHHHHHC
GANQPAPASRQPRVRVTNSFFVERYSHVMHLVSNVEGDAPDGLDPVDVVMAALPAGTLSG
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCC
APKVRAMEIIDELEIEKRGIGYAGGVGYFGCDGSVDTCIVLRTALFKDEVMYVQAGGGVV
CCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCEEEEEECCCEE
ADSDPDAEYDETLHKARALRRAAEESWRFV
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA