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The map label for this gene is pdhA [H]

Identifier: 197105207

GI number: 197105207

Start: 1953866

End: 1954912

Strand: Reverse

Name: pdhA [H]

Synonym: PHZ_c1744

Alternate gene names: 197105207

Gene position: 1954912-1953866 (Counterclockwise)

Preceding gene: 197105208

Following gene: 197105206

Centisome position: 48.92

GC content: 68.48

Gene sequence:

>1047_bases
ATGGCGCGCGGGCAGACCGGTGAGGCCGGTCGGCGAAAAGCCAATGGGGCGGACGGGCGATCGGCCGCCGACAAGGACGA
GCTTCTCAAGTTCTACAGGGACATGCTGCTGATCCGCCGCTTCGAGGAGCGTGCAGGCCAGCTTTACGGCATGGGCCTGA
TCGGCGGCTTCTGCCACCTCTACATCGGCCAGGAGGCGATCGCGGTCGGCGTCCAGGCGATCAAGCAGCCGGGCGACCAG
GTGATCACCGGCTACCGCGACCACGGCCACATGCTGGCCTGCGGCATGGACCCGCGCGAGGTCATGGCCGAGCTGACCGG
CCGGGCCGGCGGCTCGTCCAAGGGCAAGGGCGGCTCGATGCACATGTTCTCGACCGAGGCCGACTTCTACGGCGGCCATG
GCATCGTGGGGGCGCAGGTCAGCCTCGGCACCGGCCTGGCGCTGGCCAACAAGTACCGCGACAACGGCAAGGTCAGCTTC
ACCTACTTCGGGGACGGCGCGGCCAACCAGGGGCAGGTCTACGAGAGCTTCAACATGGCCGAGCTCTGGAGCCTGCCGGT
CGTCTACGTGATCGAGAACAACCAGTACGCCATGGGCACGGCGGTGGAGCGGTCGTCGTCCGAGACCGAGCTGTTCCGGC
GCGGCGCGTCGTTCAAGATCCCTGGCGAGCAGGTCGACGGCATGGACGTGCTGGCGGTGAAGGCCGCCGCGGCCAAGGCG
GCCGAGCACGCCCGCTCGGGGAACGGCCCCTACATCCTCGAGATGAAGACCTACCGCTACCGCGGCCACTCCATGAGCGA
CCCGGCCAAGTACCGGACCCGCGAGGAGGTGGACGAGGTCCGCAAGACCCGCGATCCGATCGACCACGTCGAGGAGCTGC
TGGAGAAGCACGGCTGGGCCGACGAGGCGTCGCTGAAGGCGATCGACGCCGAGGTGAAGAAGATCGTCGCCGACGCGGCG
GAGTTCGCCCGCACCAGCCCCGAACCCGACCCGTCCGAACTCTACACCGACGTCTACACCGACGCTTCCCAGGGGGCGGC
CCAATGA

Upstream 100 bases:

>100_bases
GCTAGGCTTTGCTGACCCAAGGGACTATGTGATCCGCATGAAGCCCTAGCACCCCGTCGCGGGTTCTATCGGCTACCTGC
AAAGGATCACGGAGAGACGC

Downstream 100 bases:

>100_bases
CCGACATCCTGATGCCGGCCCTGTCGCCCACCATGGAGGAGGGCACCCTCGCCAAGTGGCACGTGAAGCCGGGCGACAAG
GTGCGCTCCGGCGACGTGAT

Product: pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MARGQTGEAGRRKANGADGRSAADKDELLKFYRDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGVQAIKQPGDQ
VITGYRDHGHMLACGMDPREVMAELTGRAGGSSKGKGGSMHMFSTEADFYGGHGIVGAQVSLGTGLALANKYRDNGKVSF
TYFGDGAANQGQVYESFNMAELWSLPVVYVIENNQYAMGTAVERSSSETELFRRGASFKIPGEQVDGMDVLAVKAAAAKA
AEHARSGNGPYILEMKTYRYRGHSMSDPAKYRTREEVDEVRKTRDPIDHVEELLEKHGWADEASLKAIDAEVKKIVADAA
EFARTSPEPDPSELYTDVYTDASQGAAQ

Sequences:

>Translated_348_residues
MARGQTGEAGRRKANGADGRSAADKDELLKFYRDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGVQAIKQPGDQ
VITGYRDHGHMLACGMDPREVMAELTGRAGGSSKGKGGSMHMFSTEADFYGGHGIVGAQVSLGTGLALANKYRDNGKVSF
TYFGDGAANQGQVYESFNMAELWSLPVVYVIENNQYAMGTAVERSSSETELFRRGASFKIPGEQVDGMDVLAVKAAAAKA
AEHARSGNGPYILEMKTYRYRGHSMSDPAKYRTREEVDEVRKTRDPIDHVEELLEKHGWADEASLKAIDAEVKKIVADAA
EFARTSPEPDPSELYTDVYTDASQGAAQ
>Mature_347_residues
ARGQTGEAGRRKANGADGRSAADKDELLKFYRDMLLIRRFEERAGQLYGMGLIGGFCHLYIGQEAIAVGVQAIKQPGDQV
ITGYRDHGHMLACGMDPREVMAELTGRAGGSSKGKGGSMHMFSTEADFYGGHGIVGAQVSLGTGLALANKYRDNGKVSFT
YFGDGAANQGQVYESFNMAELWSLPVVYVIENNQYAMGTAVERSSSETELFRRGASFKIPGEQVDGMDVLAVKAAAAKAA
EHARSGNGPYILEMKTYRYRGHSMSDPAKYRTREEVDEVRKTRDPIDHVEELLEKHGWADEASLKAIDAEVKKIVADAAE
FARTSPEPDPSELYTDVYTDASQGAAQ

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=324, Percent_Identity=52.7777777777778, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI291084742, Length=330, Percent_Identity=50.6060606060606, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI4505685, Length=330, Percent_Identity=50.6060606060606, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI291084744, Length=337, Percent_Identity=49.5548961424332, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI291084757, Length=330, Percent_Identity=45.1515151515152, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=30.5031446540881, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI258645172, Length=323, Percent_Identity=30.6501547987616, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=53.680981595092, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=53.680981595092, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI86563357, Length=318, Percent_Identity=29.2452830188679, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI86563355, Length=318, Percent_Identity=29.2452830188679, Blast_Score=121, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=50.7739938080495, Blast_Score=312, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=52.2012578616352, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=52.2012578616352, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=52.2012578616352, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24639746, Length=308, Percent_Identity=52.2727272727273, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24639748, Length=332, Percent_Identity=49.6987951807229, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI21355903, Length=315, Percent_Identity=26.984126984127, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37845; Mature: 37714

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARGQTGEAGRRKANGADGRSAADKDELLKFYRDMLLIRRFEERAGQLYGMGLIGGFCHL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
YIGQEAIAVGVQAIKQPGDQVITGYRDHGHMLACGMDPREVMAELTGRAGGSSKGKGGSM
HCCHHHHHHHHHHHHCCCHHEEECCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCE
HMFSTEADFYGGHGIVGAQVSLGTGLALANKYRDNGKVSFTYFGDGAANQGQVYESFNMA
EEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHH
ELWSLPVVYVIENNQYAMGTAVERSSSETELFRRGASFKIPGEQVDGMDVLAVKAAAAKA
HHHCCCEEEEEECCCEEECHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEHARSGNGPYILEMKTYRYRGHSMSDPAKYRTREEVDEVRKTRDPIDHVEELLEKHGWA
HHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
DEASLKAIDAEVKKIVADAAEFARTSPEPDPSELYTDVYTDASQGAAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARGQTGEAGRRKANGADGRSAADKDELLKFYRDMLLIRRFEERAGQLYGMGLIGGFCHL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHH
YIGQEAIAVGVQAIKQPGDQVITGYRDHGHMLACGMDPREVMAELTGRAGGSSKGKGGSM
HCCHHHHHHHHHHHHCCCHHEEECCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCE
HMFSTEADFYGGHGIVGAQVSLGTGLALANKYRDNGKVSFTYFGDGAANQGQVYESFNMA
EEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHH
ELWSLPVVYVIENNQYAMGTAVERSSSETELFRRGASFKIPGEQVDGMDVLAVKAAAAKA
HHHCCCEEEEEECCCEEECHHHHCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEHARSGNGPYILEMKTYRYRGHSMSDPAKYRTREEVDEVRKTRDPIDHVEELLEKHGWA
HHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
DEASLKAIDAEVKKIVADAAEFARTSPEPDPSELYTDVYTDASQGAAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]