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The map label for this gene is pepA [H]

Identifier: 197105167

GI number: 197105167

Start: 1909953

End: 1911395

Strand: Reverse

Name: pepA [H]

Synonym: PHZ_c1704

Alternate gene names: 197105167

Gene position: 1911395-1909953 (Counterclockwise)

Preceding gene: 197105177

Following gene: 197105166

Centisome position: 47.83

GC content: 70.2

Gene sequence:

>1443_bases
ATGGAGATCGAGTTCGTCGCCGCCTCGGCCGCGACGCCCGCGAAGACCGCCCTGGCCCGGATCGTGTTCGAGGGGGAGGC
GCAGGATACGACGCTCACCCAGGCGAGCCGCTTCACCGGCGCCAAGGGCCAGACCCTCGACATCCTCGCGCCGGCCAGCG
TGGACGCCGCCCGGCTGGTGCTCGTGGGCGCCGGCAAGCGGGAGGCCTTCGACGCCCTTGCGGCCGAGCACGCCGCGGCG
ACCGCCTACAACGCGGTGAAGACCTCGGGTCTGGAGGTCCTGCGGGTCGAGACGCCCAACGGCGACGCCGAACTCGCCGC
CCGCGTGGCCCTGGGGGTGCGGCTGGCCTGCTACCGCTTCGACAAGTACCGGACCAAGGAGCCGGCCGAGAAGAAGCCTT
CGATCGTCAAGACCCAGGTGGCGACCGCCGACCCCGACGGCGCCCTGGCGGCCTTCCCGCCGCTGGCCGCCCTGGCCGAT
GCGGTGAGCTTCAGCCGCGACCTGGTCTCCGAACCCGCCAACGTCCTCTATCCGGCCGAGTTCGCGCGGCGGGTGAAGGA
GCTGGAGCGCCTCGGCCTCGAGGTCGAGATCCTGGGCGAGGACGCCATGAAGGCCCTCGGCATGGGCAGCCTGCTCGGGG
TGGGGCAGGGCAGCGTGCGCGAGAGCCAGCTGGTGGTGATCCGCTGGAACGGCGCGCAGGATCCGAACGCCCAGCCCGTC
GCCTTCGTCGGCAAGGGCGTCTGCTTCGACACCGGCGGCATCTCCATCAAGCCCGCCGAGGGCATGGAGGACATGAAGTG
GGACATGGGCGGCGCCGGCGCCGTCGCGGGCCTGATGTACGCGCTGGCCGGCCGCAAGGCCAAGGTCAACGCCGTCGGGA
TCCTCGGCCTCGTCGAGAACATGCCTGACGGCAACGCCCAGCGTCCGGGCGACGTGGTGACCTCCATGTCGGGGCAGACG
GTCGAGGTGATCAACACCGACGCCGAGGGCCGCCTCGTGCTGGCCGACGCCATCTGGTACTGCCAGGACCGCTTCAAGCC
GAAGTTCATCGTCGACCTGGCCACCCTGACCGGCGCGATCATCATCAGCCTGGGCAACGACTACGCCGGCCTGTTCTCCA
ACAACGACGAGCTGGCCGGGAACCTGCTGGATGCGTCGGGCAAGGAGGGCGAGCCCCTGTGGCGGCTGCCGCTGCCCGAG
GCCTACAACAAGCAGCTGGAATCCCCGATCGCCGACATGAAGAACATCGGCGGCCGTCCGGCCGGCTCGATCACCGCGGC
CCTGTTCATCCAGAAGTTCGTCAACAACGTCCCCTGGGCGCACCTCGACATCGCGTCCACCGCCTGGAAGAAGCCCTCGA
CCGTGCCGACCATCCCGGAAGGCGCCACCGGCTTCGGCGTGCGGCTGCTGAACCGCATGGTCCAGGAGAAGTACGAGGGC
TGA

Upstream 100 bases:

>100_bases
ATTAGGGCCTGCCCCGGCCGCGGAGGTGTTCTAAATCATGCGTCGCCGCGACGCACAACCGCACCGCACAGACGTCCACT
TAAGCTGACGAGAGAGTTTC

Downstream 100 bases:

>100_bases
GGCGTGACCGAGGTCTGGTTCTACCACCTGGAGAGGACCGGCCTGGACCAGGCCCTTCCCGAGCTGCTTGAGAAGACCCT
GCAGCGCGGCTGGAAGGCGA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MEIEFVAASAATPAKTALARIVFEGEAQDTTLTQASRFTGAKGQTLDILAPASVDAARLVLVGAGKREAFDALAAEHAAA
TAYNAVKTSGLEVLRVETPNGDAELAARVALGVRLACYRFDKYRTKEPAEKKPSIVKTQVATADPDGALAAFPPLAALAD
AVSFSRDLVSEPANVLYPAEFARRVKELERLGLEVEILGEDAMKALGMGSLLGVGQGSVRESQLVVIRWNGAQDPNAQPV
AFVGKGVCFDTGGISIKPAEGMEDMKWDMGGAGAVAGLMYALAGRKAKVNAVGILGLVENMPDGNAQRPGDVVTSMSGQT
VEVINTDAEGRLVLADAIWYCQDRFKPKFIVDLATLTGAIIISLGNDYAGLFSNNDELAGNLLDASGKEGEPLWRLPLPE
AYNKQLESPIADMKNIGGRPAGSITAALFIQKFVNNVPWAHLDIASTAWKKPSTVPTIPEGATGFGVRLLNRMVQEKYEG

Sequences:

>Translated_480_residues
MEIEFVAASAATPAKTALARIVFEGEAQDTTLTQASRFTGAKGQTLDILAPASVDAARLVLVGAGKREAFDALAAEHAAA
TAYNAVKTSGLEVLRVETPNGDAELAARVALGVRLACYRFDKYRTKEPAEKKPSIVKTQVATADPDGALAAFPPLAALAD
AVSFSRDLVSEPANVLYPAEFARRVKELERLGLEVEILGEDAMKALGMGSLLGVGQGSVRESQLVVIRWNGAQDPNAQPV
AFVGKGVCFDTGGISIKPAEGMEDMKWDMGGAGAVAGLMYALAGRKAKVNAVGILGLVENMPDGNAQRPGDVVTSMSGQT
VEVINTDAEGRLVLADAIWYCQDRFKPKFIVDLATLTGAIIISLGNDYAGLFSNNDELAGNLLDASGKEGEPLWRLPLPE
AYNKQLESPIADMKNIGGRPAGSITAALFIQKFVNNVPWAHLDIASTAWKKPSTVPTIPEGATGFGVRLLNRMVQEKYEG
>Mature_480_residues
MEIEFVAASAATPAKTALARIVFEGEAQDTTLTQASRFTGAKGQTLDILAPASVDAARLVLVGAGKREAFDALAAEHAAA
TAYNAVKTSGLEVLRVETPNGDAELAARVALGVRLACYRFDKYRTKEPAEKKPSIVKTQVATADPDGALAAFPPLAALAD
AVSFSRDLVSEPANVLYPAEFARRVKELERLGLEVEILGEDAMKALGMGSLLGVGQGSVRESQLVVIRWNGAQDPNAQPV
AFVGKGVCFDTGGISIKPAEGMEDMKWDMGGAGAVAGLMYALAGRKAKVNAVGILGLVENMPDGNAQRPGDVVTSMSGQT
VEVINTDAEGRLVLADAIWYCQDRFKPKFIVDLATLTGAIIISLGNDYAGLFSNNDELAGNLLDASGKEGEPLWRLPLPE
AYNKQLESPIADMKNIGGRPAGSITAALFIQKFVNNVPWAHLDIASTAWKKPSTVPTIPEGATGFGVRLLNRMVQEKYEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=429, Percent_Identity=38.2284382284382, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI47155554, Length=323, Percent_Identity=36.8421052631579, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1790710, Length=453, Percent_Identity=40.6181015452539, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=41.5384615384615, Blast_Score=210, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17556903, Length=332, Percent_Identity=33.7349397590361, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=437, Percent_Identity=25.858123569794, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24662227, Length=346, Percent_Identity=32.3699421965318, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24661038, Length=384, Percent_Identity=33.0729166666667, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129969, Length=377, Percent_Identity=30.2387267904509, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355725, Length=358, Percent_Identity=34.3575418994413, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161077148, Length=372, Percent_Identity=29.0322580645161, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20130057, Length=372, Percent_Identity=29.0322580645161, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357381, Length=357, Percent_Identity=35.0140056022409, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI221379063, Length=357, Percent_Identity=35.0140056022409, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221379062, Length=357, Percent_Identity=35.0140056022409, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129963, Length=377, Percent_Identity=31.8302387267904, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI19922386, Length=383, Percent_Identity=29.7650130548303, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355645, Length=372, Percent_Identity=27.4193548387097, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24662223, Length=372, Percent_Identity=27.4193548387097, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646701, Length=169, Percent_Identity=33.7278106508876, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646703, Length=169, Percent_Identity=33.7278106508876, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358201, Length=169, Percent_Identity=33.7278106508876, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50698; Mature: 50698

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEFVAASAATPAKTALARIVFEGEAQDTTLTQASRFTGAKGQTLDILAPASVDAARLV
CCEEEEECCCCCHHHHHHHHEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
LVGAGKREAFDALAAEHAAATAYNAVKTSGLEVLRVETPNGDAELAARVALGVRLACYRF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEH
DKYRTKEPAEKKPSIVKTQVATADPDGALAAFPPLAALADAVSFSRDLVSEPANVLYPAE
HHHCCCCCCCCCCCEEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEEEHHH
FARRVKELERLGLEVEILGEDAMKALGMGSLLGVGQGSVRESQLVVIRWNGAQDPNAQPV
HHHHHHHHHHCCCEEEEECHHHHHHHCCCHHEECCCCCCCCCEEEEEEECCCCCCCCCCE
AFVGKGVCFDTGGISIKPAEGMEDMKWDMGGAGAVAGLMYALAGRKAKVNAVGILGLVEN
EEEECCEEEECCCEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHHHC
MPDGNAQRPGDVVTSMSGQTVEVINTDAEGRLVLADAIWYCQDRFKPKFIVDLATLTGAI
CCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEEHHHHCCEE
IISLGNDYAGLFSNNDELAGNLLDASGKEGEPLWRLPLPEAYNKQLESPIADMKNIGGRP
EEEECCCCCCCCCCCHHHCCCEECCCCCCCCCEEECCCCHHHHHHHHCHHHHHHHCCCCC
AGSITAALFIQKFVNNVPWAHLDIASTAWKKPSTVPTIPEGATGFGVRLLNRMVQEKYEG
CCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEIEFVAASAATPAKTALARIVFEGEAQDTTLTQASRFTGAKGQTLDILAPASVDAARLV
CCEEEEECCCCCHHHHHHHHEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEEE
LVGAGKREAFDALAAEHAAATAYNAVKTSGLEVLRVETPNGDAELAARVALGVRLACYRF
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHEEEEH
DKYRTKEPAEKKPSIVKTQVATADPDGALAAFPPLAALADAVSFSRDLVSEPANVLYPAE
HHHCCCCCCCCCCCEEEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCCEEEHHH
FARRVKELERLGLEVEILGEDAMKALGMGSLLGVGQGSVRESQLVVIRWNGAQDPNAQPV
HHHHHHHHHHCCCEEEEECHHHHHHHCCCHHEECCCCCCCCCEEEEEEECCCCCCCCCCE
AFVGKGVCFDTGGISIKPAEGMEDMKWDMGGAGAVAGLMYALAGRKAKVNAVGILGLVEN
EEEECCEEEECCCEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHHHC
MPDGNAQRPGDVVTSMSGQTVEVINTDAEGRLVLADAIWYCQDRFKPKFIVDLATLTGAI
CCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEEHHHHCCEE
IISLGNDYAGLFSNNDELAGNLLDASGKEGEPLWRLPLPEAYNKQLESPIADMKNIGGRP
EEEECCCCCCCCCCCHHHCCCEECCCCCCCCCEEECCCCHHHHHHHHCHHHHHHHCCCCC
AGSITAALFIQKFVNNVPWAHLDIASTAWKKPSTVPTIPEGATGFGVRLLNRMVQEKYEG
CCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]