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The map label for this gene is purM [H]

Identifier: 197105156

GI number: 197105156

Start: 1898222

End: 1899247

Strand: Direct

Name: purM [H]

Synonym: PHZ_c1693

Alternate gene names: 197105156

Gene position: 1898222-1899247 (Clockwise)

Preceding gene: 197105154

Following gene: 197105157

Centisome position: 47.5

GC content: 70.66

Gene sequence:

>1026_bases
ATGTCCGAGCGTCCGAACGGTCTCACCTACGCCCAGGCGGGCGTCGACATAGACGCCGGAAACGCGCTCGTCGAGCGTAT
CAAGCCGCTGGCGAAGTCCACGCGCCGCTCGGGGGCCGAACCTTCGCTGGGCGGATTCGGCGCGCTCTTCGACCTGAAGG
CGGCCGGCTACGACGATCCGCTGCTGGTCACGACGACCGACGGGGTGGGCACCAAGCTGAAGGTCGCCATCGAGACCGGC
ATCCACGACACGGTCGGCGTCGACCTCGTCGGCATGTGCGTCAACGACCTGCTGGCCCAGGGCGCCGAGCCGCTGATGTT
CCTGGACTACTACGCCACCGGGAAGCTCGACGTGGAGGCCGCCGCCGCCGTGGTGGCCGGCATCGCCGAAGGCTGTCGCC
AGGCCGGCTGCGCCCTCGTCGGCGGCGAGACGGCCGAGATGCCGGGCATGTACGCCGAGGGCGACTACGACATGGCCGGC
TTCTGCGTCGGCGCCGTCGACCGCGACAAGGTGCTGCCGCGCCTGGGCGACCAGAAGCCCGGGGACATCCTGATCGGCCT
CGCCTCGTCGGGCCCGCACTCGAACGGCTATTCGCTGATCCGGCGCATCGTCGAGCGCTCGGGCCTGGCCTGGAACTCGC
CGGCGCCGTTCGCCGAGGGCAAGACCCTGGCCGCCGCCCTGCTCGAGCCGACGCGCATCTACATCAAGACGGTGCTGCCG
CACCTGAAGGCGGGCCGCGTGAAGGGCCTGGCCCACATCACCGGCGGCGGGTTGATCGAGAACCCGCCCCGGGCCATCGC
CGAGGGGCTGGAGGCGAAGTTCGACTGGAGCGCCTGGACCCTTCCCCCGGTTTTCGAATGGCTGCAGGCGGCCGGCGGCG
TCGCCGAGCAGGAGATGCGCCGCACCTTCAACTGCGGCGTGGGCTTGGTGCTGATCGTCGGTCCCGAGGACCTGCCAGAC
GTGCTGGAAGGGCTGGTCCGCGACGGCGAGGACGCCTTCGTCGTGGGCGAACTCGCCAAGGCTTGA

Upstream 100 bases:

>100_bases
GTGGTTGTGATGGGCGTCATCGATTAGCTATAGCCCCGCGCGCGACCGAGTCTGCAAGTGCGCGATGCACGCGGCTCCAA
TTCCTTTATAGGCTTCCTGA

Downstream 100 bases:

>100_bases
CCTGACGAAAGGCGGATTTGCGCGTTCACTCAGCCTGCATCCCTCCGGCAAAGGCTGACGTACCGCGCATATGAGGATCC
TTCTCGCCGCCCCCGCGCTG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSERPNGLTYAQAGVDIDAGNALVERIKPLAKSTRRSGAEPSLGGFGALFDLKAAGYDDPLLVTTTDGVGTKLKVAIETG
IHDTVGVDLVGMCVNDLLAQGAEPLMFLDYYATGKLDVEAAAAVVAGIAEGCRQAGCALVGGETAEMPGMYAEGDYDMAG
FCVGAVDRDKVLPRLGDQKPGDILIGLASSGPHSNGYSLIRRIVERSGLAWNSPAPFAEGKTLAAALLEPTRIYIKTVLP
HLKAGRVKGLAHITGGGLIENPPRAIAEGLEAKFDWSAWTLPPVFEWLQAAGGVAEQEMRRTFNCGVGLVLIVGPEDLPD
VLEGLVRDGEDAFVVGELAKA

Sequences:

>Translated_341_residues
MSERPNGLTYAQAGVDIDAGNALVERIKPLAKSTRRSGAEPSLGGFGALFDLKAAGYDDPLLVTTTDGVGTKLKVAIETG
IHDTVGVDLVGMCVNDLLAQGAEPLMFLDYYATGKLDVEAAAAVVAGIAEGCRQAGCALVGGETAEMPGMYAEGDYDMAG
FCVGAVDRDKVLPRLGDQKPGDILIGLASSGPHSNGYSLIRRIVERSGLAWNSPAPFAEGKTLAAALLEPTRIYIKTVLP
HLKAGRVKGLAHITGGGLIENPPRAIAEGLEAKFDWSAWTLPPVFEWLQAAGGVAEQEMRRTFNCGVGLVLIVGPEDLPD
VLEGLVRDGEDAFVVGELAKA
>Mature_340_residues
SERPNGLTYAQAGVDIDAGNALVERIKPLAKSTRRSGAEPSLGGFGALFDLKAAGYDDPLLVTTTDGVGTKLKVAIETGI
HDTVGVDLVGMCVNDLLAQGAEPLMFLDYYATGKLDVEAAAAVVAGIAEGCRQAGCALVGGETAEMPGMYAEGDYDMAGF
CVGAVDRDKVLPRLGDQKPGDILIGLASSGPHSNGYSLIRRIVERSGLAWNSPAPFAEGKTLAAALLEPTRIYIKTVLPH
LKAGRVKGLAHITGGGLIENPPRAIAEGLEAKFDWSAWTLPPVFEWLQAAGGVAEQEMRRTFNCGVGLVLIVGPEDLPDV
LEGLVRDGEDAFVVGELAKA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=57.566765578635, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=57.566765578635, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=57.566765578635, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=55.5891238670695, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=339, Percent_Identity=44.2477876106195, Blast_Score=291, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=55.0595238095238, Blast_Score=384, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=47.887323943662, Blast_Score=272, Evalue=3e-73,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35627; Mature: 35496

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERPNGLTYAQAGVDIDAGNALVERIKPLAKSTRRSGAEPSLGGFGALFDLKAAGYDDP
CCCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
LLVTTTDGVGTKLKVAIETGIHDTVGVDLVGMCVNDLLAQGAEPLMFLDYYATGKLDVEA
EEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
AAAVVAGIAEGCRQAGCALVGGETAEMPGMYAEGDYDMAGFCVGAVDRDKVLPRLGDQKP
HHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCC
GDILIGLASSGPHSNGYSLIRRIVERSGLAWNSPAPFAEGKTLAAALLEPTRIYIKTVLP
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHH
HLKAGRVKGLAHITGGGLIENPPRAIAEGLEAKFDWSAWTLPPVFEWLQAAGGVAEQEMR
HHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
RTFNCGVGLVLIVGPEDLPDVLEGLVRDGEDAFVVGELAKA
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHCC
>Mature Secondary Structure 
SERPNGLTYAQAGVDIDAGNALVERIKPLAKSTRRSGAEPSLGGFGALFDLKAAGYDDP
CCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCC
LLVTTTDGVGTKLKVAIETGIHDTVGVDLVGMCVNDLLAQGAEPLMFLDYYATGKLDVEA
EEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
AAAVVAGIAEGCRQAGCALVGGETAEMPGMYAEGDYDMAGFCVGAVDRDKVLPRLGDQKP
HHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCC
GDILIGLASSGPHSNGYSLIRRIVERSGLAWNSPAPFAEGKTLAAALLEPTRIYIKTVLP
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHH
HLKAGRVKGLAHITGGGLIENPPRAIAEGLEAKFDWSAWTLPPVFEWLQAAGGVAEQEMR
HHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
RTFNCGVGLVLIVGPEDLPDVLEGLVRDGEDAFVVGELAKA
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA