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The map label for this gene is mmsB [H]

Identifier: 197105141

GI number: 197105141

Start: 1882680

End: 1883576

Strand: Reverse

Name: mmsB [H]

Synonym: PHZ_c1678

Alternate gene names: 197105141

Gene position: 1883576-1882680 (Counterclockwise)

Preceding gene: 197105142

Following gene: 197105140

Centisome position: 47.13

GC content: 72.8

Gene sequence:

>897_bases
ATGACCCGTATCGCATTCATCGGCCTGGGCAACATGGGCGGGGGCATGGCGGCGAACCAGGCGAAGGCCGGCCGCACGGT
CGCCGCGTTCGACCTCTCGGCCGCGGCGCTGGAGAAGGCGGCCGGCGCCGGCTGCACGCCCGCCGGCTCGGTGGCCGAGG
CCGTGAAGGACGCCGAGGCGGTCATCACCATGCTGCCGGCCGGGCCGCATGTCCGTTCCGTCTACGCCGAGCAGGTGCTC
CCGCACGCGCCCAAGTCGGCCCTGCTGATCGACTGCTCCACCATCGACGTGGAAAGCGCGCGCGCGGTGGCCGGGCAGGC
CAAGGCCCAGGGCTTCCGTTTCGCCGATGCGCCGGTCTCCGGCGGGACGGCGGCGGCCGAGGCTGGGACGCTGGCTTTCA
TGGTCGGCTGCGACGAGGCCGACTTCGCCGAGGTGGAGCGAATCATCGCGCCGATGAGCCGCGCCACGATCCGCGCCGGC
GACCACGGGGCGGGGCAGGCGGCCAAGATCTGCAACAACATGGTGCTCGGCATCTCGATGATAGGGGTGTGCGAGGCCCT
GGCGCTGGCCGAGAAGCTCGGGCTGGACCCGGTGAAGTTCTACGAGATCAGCTCCCAGTCCTCCGGCCAGTGCTGGAGCC
TGACGAGCTACTGCCCCTGGCCGGGGCCGGTGCCGGCCGCGCCGTCCAACCGCGGCTACGAGGGCGGCTTCGCCACGGCC
ATGATGCTGAAGGACCTCAAGCTGGCGCAGGAGGCGGCGGCCAGGGCCGGCGCGGCGGCGCCGCTGGGGGCGGCGGCGGA
AGGCCTCTATGCGCTGTTCGACCGCCTCGGCGGGGGCGGCAAGGACTTCTCGGCCATCCTCGAGCTGCTGCGGGGCAATG
CGCCGCAGGGGACCTGA

Upstream 100 bases:

>100_bases
CATGCTGGACGAGATCTTCGCGCCGCTGCCGGCCGACCAGGAATGGTCGCCGCTGCCCTGAGGATTCGGCCGCCAACAGA
CTGAAATTCATGAGGAAGCC

Downstream 100 bases:

>100_bases
GGACGCTCCCCGGCTCCTGATCGCCGTTCACGAATTCTCAGGGTCCGTCCACGAAGCCTCGGACGACCCGCGACCCGATT
TTATGGACAATGTGAAATCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTRIAFIGLGNMGGGMAANQAKAGRTVAAFDLSAAALEKAAGAGCTPAGSVAEAVKDAEAVITMLPAGPHVRSVYAEQVL
PHAPKSALLIDCSTIDVESARAVAGQAKAQGFRFADAPVSGGTAAAEAGTLAFMVGCDEADFAEVERIIAPMSRATIRAG
DHGAGQAAKICNNMVLGISMIGVCEALALAEKLGLDPVKFYEISSQSSGQCWSLTSYCPWPGPVPAAPSNRGYEGGFATA
MMLKDLKLAQEAAARAGAAAPLGAAAEGLYALFDRLGGGGKDFSAILELLRGNAPQGT

Sequences:

>Translated_298_residues
MTRIAFIGLGNMGGGMAANQAKAGRTVAAFDLSAAALEKAAGAGCTPAGSVAEAVKDAEAVITMLPAGPHVRSVYAEQVL
PHAPKSALLIDCSTIDVESARAVAGQAKAQGFRFADAPVSGGTAAAEAGTLAFMVGCDEADFAEVERIIAPMSRATIRAG
DHGAGQAAKICNNMVLGISMIGVCEALALAEKLGLDPVKFYEISSQSSGQCWSLTSYCPWPGPVPAAPSNRGYEGGFATA
MMLKDLKLAQEAAARAGAAAPLGAAAEGLYALFDRLGGGGKDFSAILELLRGNAPQGT
>Mature_297_residues
TRIAFIGLGNMGGGMAANQAKAGRTVAAFDLSAAALEKAAGAGCTPAGSVAEAVKDAEAVITMLPAGPHVRSVYAEQVLP
HAPKSALLIDCSTIDVESARAVAGQAKAQGFRFADAPVSGGTAAAEAGTLAFMVGCDEADFAEVERIIAPMSRATIRAGD
HGAGQAAKICNNMVLGISMIGVCEALALAEKLGLDPVKFYEISSQSSGQCWSLTSYCPWPGPVPAAPSNRGYEGGFATAM
MLKDLKLAQEAAARAGAAAPLGAAAEGLYALFDRLGGGGKDFSAILELLRGNAPQGT

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=42.1232876712329, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI40556376, Length=296, Percent_Identity=25.3378378378378, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1790315, Length=302, Percent_Identity=35.4304635761589, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=31.1188811188811, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=28.8659793814433, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789092, Length=296, Percent_Identity=25.3378378378378, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=38.9830508474576, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=43.2525951557093, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=43.2525951557093, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28574115, Length=292, Percent_Identity=21.9178082191781, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30047; Mature: 29915

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIAFIGLGNMGGGMAANQAKAGRTVAAFDLSAAALEKAAGAGCTPAGSVAEAVKDAEA
CCEEEEEEECCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VITMLPAGPHVRSVYAEQVLPHAPKSALLIDCSTIDVESARAVAGQAKAQGFRFADAPVS
HEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCC
GGTAAAEAGTLAFMVGCDEADFAEVERIIAPMSRATIRAGDHGAGQAAKICNNMVLGISM
CCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHH
IGVCEALALAEKLGLDPVKFYEISSQSSGQCWSLTSYCPWPGPVPAAPSNRGYEGGFATA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
MMLKDLKLAQEAAARAGAAAPLGAAAEGLYALFDRLGGGGKDFSAILELLRGNAPQGT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TRIAFIGLGNMGGGMAANQAKAGRTVAAFDLSAAALEKAAGAGCTPAGSVAEAVKDAEA
CEEEEEEECCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VITMLPAGPHVRSVYAEQVLPHAPKSALLIDCSTIDVESARAVAGQAKAQGFRFADAPVS
HEEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCC
GGTAAAEAGTLAFMVGCDEADFAEVERIIAPMSRATIRAGDHGAGQAAKICNNMVLGISM
CCCCHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHH
IGVCEALALAEKLGLDPVKFYEISSQSSGQCWSLTSYCPWPGPVPAAPSNRGYEGGFATA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
MMLKDLKLAQEAAARAGAAAPLGAAAEGLYALFDRLGGGGKDFSAILELLRGNAPQGT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]