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The map label for this gene is parE [H]

Identifier: 197105032

GI number: 197105032

Start: 1769361

End: 1771415

Strand: Reverse

Name: parE [H]

Synonym: PHZ_c1569

Alternate gene names: 197105032

Gene position: 1771415-1769361 (Counterclockwise)

Preceding gene: 197105033

Following gene: 197105031

Centisome position: 44.33

GC content: 70.56

Gene sequence:

>2055_bases
ATGTCTCCCAAGTCCACCGCCCAGGCCTCCCTGTTCGACGAAGCGCTGAATCCCGCGCCGGCCGCGCCGCTGGCCGAGAG
CCACGAGCCGCGCCCCGATCCCGCCGTCGTCGGCGTGAAGACCAGCGGCTACTCGGCGGCCGACATCGAGGTCCTCGAAG
GGCTGGAGCCGGTGCGCAAGCGGCCCGGCATGTACATCGGCGGCACCGACGAGCGGGCGCTGCACCACCTGTTCGCCGAA
GTCCTCGACAACGCCATGGACGAGGCCGTCGCCGGCCACGCCAAGGTCATCGAGGTCAGCCTCGACGCCGACGGCGCCCT
GACCGTCCGCGACGACGGCCGCGGCATCCCGGTCGATCCGCACCCCAAGCACCCAGGCAAGTCGGCCCTGGAAGTGATCA
TGACCGTCCTGCACTCGGGCGGGAAGTTCTCGGGCAAGGCCTACGAGACCTCGGGCGGCCTGCACGGCGTCGGCGTCTCG
GTGGTCAACGCCCTGTCCGAGCGCGTCGAGGTCACCGTCTTCAAGGACGGCTTCGAGTGGCGCCAGGCCTTCACCCGCGG
CAAGCCGCTGGGCGGCATCGAGAAGATCGGCCCCACCCGCAAGAAGGGCACGGCCATCAGCTTCCTGCCCGACCCGGTGA
TCTTCGGCGACGGCGCGGCGTTCAAGCCCGCCCGCCTCTACCGGATGGCCCGCTCCAAGGCCTACCTGTTCGGCGGGGTC
GAGATCCGCTGGAAGTGCGACCCGGCCCGCATCCACGACCAGACCCCGGCCGAGGCGGTGTTCCGCTTCCCCAACGGCCT
GGCCGACTTCCTGGCCGAGCGGATCAAGGGCCTGGAGACCGTCACCCCCGAGCCCTTCACCGGCCGCTACGAGCGTCCAG
GCGAGGCCGGCAAGGTCGAGTGGGCCATCGCCTGGACCCCCGCCGGCTTCGGCGAGGCCGACAGCTTCATGCAGTCCTAC
TGCAACACCGTGCCGACCCCCGAGGGCGGCACGCACGAGTCCGGCCTGCGCGCGGCGCTGACCAAGGGCCTGAAGCAGTA
CGCCGAGCTGGTCGGCGAGAAGCGCGGCGGCCTGATCACCGCCGACGACGTGGTCGCCCAGGCCGGCGCCCTCGTCAGCG
TCTTCATCCGCGACCCCGAGTTCCAGGGCCAGACCAAGGAGAAGCTCTCCTCCACCGAGGCCCAGCGCCTGGTCGAGAAG
GCCCTGGCCGACCCGTTCGACCACTGGCTGACCGCCCAGCCCAAGGCCGCGGGCGCCCTCCTGCAGTTCGTGGTCGAGCG
CGCCGAGGAGCGCCTGAAGCGCCGCCGCGACAAGGAGGTCGCCCGCGCCTCGGCCACCCGCAAGCTGCGCCTGCCGGGCA
AGCTCGCCGACTGCGCCGGCAACGCCATCGACGGCGCCGAGCTGTTCCTGGTCGAGGGCGATTCCGCCGGCGGCTCGGCC
AAGCAGGCCCGCGACCGCAAGAACCAGGCGATCCTGCCCCTGCGCGGCAAGATCCTGAACGTCGCCTCGGCCTCCACCGA
CAAGTTCGGCGGCAACAAGGAGCTGTCCGACCTGCTGCTGGCCCTCGGCGTCCAGCCCGGTTCGAAGTTCAAGGAAGACG
ACCTGCGCTACGAGCGCATCATCATCATGACGGACGCCGACGTCGACGGCGCCCACATCGCCAGCCTGCTGATCACCTTC
TTCTTCCGCACCATGCCCGACATGATCCGCGCCGGGCGCCTGTACCTGGCCCTGCCGCCGCTCTACCGGATCAGCCACGG
CGGCAAGGCGGTCTACGCCCGCGACGACGCGCACCGCGACGAGCTGCTGGCCACCGAGTTCAAGGGCAAGAAGCCCGAGA
TCAGCCGCTTCAAGGGCCTCGGCGAGATGATGCCGAACCAGCTCAAGGAAACCACCATGGACCCGAAGACGCGGACCCTG
GCCCGCGTCACCCTGCCCCGGGCCGAGGAGACGGTGGAGGACCTGGTCGAGGCGCTGATGGGCCGCAAGCCCGAGCTGCG
CTTCCGCTTCATCCAGGAAAACGCTGAGTTCGCCGCCGCCGACCTCGACATCTAG

Upstream 100 bases:

>100_bases
CCCGGAAATAGGTCGCAGGGCCCCGGGACCGGCCGGCATTGATCCGCCGGTCCCGGGGGGCCATACGGGGTCGCTCCAGA
ATCGCCGCAAACTCGGGCCC

Downstream 100 bases:

>100_bases
GGCGGCGCCGAACGAACACGGCTCCGCCCGCGTTCCCGTGGGGTTCAGGCTCCGACGGAGGAACGGCGATGGAAGACCAC
GGCCGGATGGGGAAGATGGG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSPKSTAQASLFDEALNPAPAAPLAESHEPRPDPAVVGVKTSGYSAADIEVLEGLEPVRKRPGMYIGGTDERALHHLFAE
VLDNAMDEAVAGHAKVIEVSLDADGALTVRDDGRGIPVDPHPKHPGKSALEVIMTVLHSGGKFSGKAYETSGGLHGVGVS
VVNALSERVEVTVFKDGFEWRQAFTRGKPLGGIEKIGPTRKKGTAISFLPDPVIFGDGAAFKPARLYRMARSKAYLFGGV
EIRWKCDPARIHDQTPAEAVFRFPNGLADFLAERIKGLETVTPEPFTGRYERPGEAGKVEWAIAWTPAGFGEADSFMQSY
CNTVPTPEGGTHESGLRAALTKGLKQYAELVGEKRGGLITADDVVAQAGALVSVFIRDPEFQGQTKEKLSSTEAQRLVEK
ALADPFDHWLTAQPKAAGALLQFVVERAEERLKRRRDKEVARASATRKLRLPGKLADCAGNAIDGAELFLVEGDSAGGSA
KQARDRKNQAILPLRGKILNVASASTDKFGGNKELSDLLLALGVQPGSKFKEDDLRYERIIIMTDADVDGAHIASLLITF
FFRTMPDMIRAGRLYLALPPLYRISHGGKAVYARDDAHRDELLATEFKGKKPEISRFKGLGEMMPNQLKETTMDPKTRTL
ARVTLPRAEETVEDLVEALMGRKPELRFRFIQENAEFAAADLDI

Sequences:

>Translated_684_residues
MSPKSTAQASLFDEALNPAPAAPLAESHEPRPDPAVVGVKTSGYSAADIEVLEGLEPVRKRPGMYIGGTDERALHHLFAE
VLDNAMDEAVAGHAKVIEVSLDADGALTVRDDGRGIPVDPHPKHPGKSALEVIMTVLHSGGKFSGKAYETSGGLHGVGVS
VVNALSERVEVTVFKDGFEWRQAFTRGKPLGGIEKIGPTRKKGTAISFLPDPVIFGDGAAFKPARLYRMARSKAYLFGGV
EIRWKCDPARIHDQTPAEAVFRFPNGLADFLAERIKGLETVTPEPFTGRYERPGEAGKVEWAIAWTPAGFGEADSFMQSY
CNTVPTPEGGTHESGLRAALTKGLKQYAELVGEKRGGLITADDVVAQAGALVSVFIRDPEFQGQTKEKLSSTEAQRLVEK
ALADPFDHWLTAQPKAAGALLQFVVERAEERLKRRRDKEVARASATRKLRLPGKLADCAGNAIDGAELFLVEGDSAGGSA
KQARDRKNQAILPLRGKILNVASASTDKFGGNKELSDLLLALGVQPGSKFKEDDLRYERIIIMTDADVDGAHIASLLITF
FFRTMPDMIRAGRLYLALPPLYRISHGGKAVYARDDAHRDELLATEFKGKKPEISRFKGLGEMMPNQLKETTMDPKTRTL
ARVTLPRAEETVEDLVEALMGRKPELRFRFIQENAEFAAADLDI
>Mature_683_residues
SPKSTAQASLFDEALNPAPAAPLAESHEPRPDPAVVGVKTSGYSAADIEVLEGLEPVRKRPGMYIGGTDERALHHLFAEV
LDNAMDEAVAGHAKVIEVSLDADGALTVRDDGRGIPVDPHPKHPGKSALEVIMTVLHSGGKFSGKAYETSGGLHGVGVSV
VNALSERVEVTVFKDGFEWRQAFTRGKPLGGIEKIGPTRKKGTAISFLPDPVIFGDGAAFKPARLYRMARSKAYLFGGVE
IRWKCDPARIHDQTPAEAVFRFPNGLADFLAERIKGLETVTPEPFTGRYERPGEAGKVEWAIAWTPAGFGEADSFMQSYC
NTVPTPEGGTHESGLRAALTKGLKQYAELVGEKRGGLITADDVVAQAGALVSVFIRDPEFQGQTKEKLSSTEAQRLVEKA
LADPFDHWLTAQPKAAGALLQFVVERAEERLKRRRDKEVARASATRKLRLPGKLADCAGNAIDGAELFLVEGDSAGGSAK
QARDRKNQAILPLRGKILNVASASTDKFGGNKELSDLLLALGVQPGSKFKEDDLRYERIIIMTDADVDGAHIASLLITFF
FRTMPDMIRAGRLYLALPPLYRISHGGKAVYARDDAHRDELLATEFKGKKPEISRFKGLGEMMPNQLKETTMDPKTRTLA
RVTLPRAEETVEDLVEALMGRKPELRFRFIQENAEFAAADLDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=654, Percent_Identity=25.2293577981651, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI19913408, Length=682, Percent_Identity=24.3401759530792, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789408, Length=647, Percent_Identity=43.7403400309119, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI48994957, Length=566, Percent_Identity=43.2862190812721, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=635, Percent_Identity=24.4094488188976, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212645845, Length=571, Percent_Identity=24.3432574430823, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=646, Percent_Identity=25.077399380805, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136538, Length=590, Percent_Identity=25.7627118644068, Blast_Score=133, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 74369; Mature: 74237

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKSTAQASLFDEALNPAPAAPLAESHEPRPDPAVVGVKTSGYSAADIEVLEGLEPVRK
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHH
RPGMYIGGTDERALHHLFAEVLDNAMDEAVAGHAKVIEVSLDADGALTVRDDGRGIPVDP
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCCCCC
HPKHPGKSALEVIMTVLHSGGKFSGKAYETSGGLHGVGVSVVNALSERVEVTVFKDGFEW
CCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHEEEEEEECCHHH
RQAFTRGKPLGGIEKIGPTRKKGTAISFLPDPVIFGDGAAFKPARLYRMARSKAYLFGGV
HHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCEEEEECE
EIRWKCDPARIHDQTPAEAVFRFPNGLADFLAERIKGLETVTPEPFTGRYERPGEAGKVE
EEEEECCHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEE
WAIAWTPAGFGEADSFMQSYCNTVPTPEGGTHESGLRAALTKGLKQYAELVGEKRGGLIT
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
ADDVVAQAGALVSVFIRDPEFQGQTKEKLSSTEAQRLVEKALADPFDHWLTAQPKAAGAL
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHH
LQFVVERAEERLKRRRDKEVARASATRKLRLPGKLADCAGNAIDGAELFLVEGDSAGGSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCEEEEEECCCCCCCH
KQARDRKNQAILPLRGKILNVASASTDKFGGNKELSDLLLALGVQPGSKFKEDDLRYERI
HHHHHHCCCEECCCCCCEEEHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEE
IIMTDADVDGAHIASLLITFFFRTMPDMIRAGRLYLALPPLYRISHGGKAVYARDDAHRD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHEECCCCCEEEECCCCCHH
ELLATEFKGKKPEISRFKGLGEMMPNQLKETTMDPKTRTLARVTLPRAEETVEDLVEALM
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCHHHHHHHHHHHHH
GRKPELRFRFIQENAEFAAADLDI
CCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SPKSTAQASLFDEALNPAPAAPLAESHEPRPDPAVVGVKTSGYSAADIEVLEGLEPVRK
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHH
RPGMYIGGTDERALHHLFAEVLDNAMDEAVAGHAKVIEVSLDADGALTVRDDGRGIPVDP
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCCCCCCC
HPKHPGKSALEVIMTVLHSGGKFSGKAYETSGGLHGVGVSVVNALSERVEVTVFKDGFEW
CCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHEEEEEEECCHHH
RQAFTRGKPLGGIEKIGPTRKKGTAISFLPDPVIFGDGAAFKPARLYRMARSKAYLFGGV
HHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCEEEEECE
EIRWKCDPARIHDQTPAEAVFRFPNGLADFLAERIKGLETVTPEPFTGRYERPGEAGKVE
EEEEECCHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEE
WAIAWTPAGFGEADSFMQSYCNTVPTPEGGTHESGLRAALTKGLKQYAELVGEKRGGLIT
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
ADDVVAQAGALVSVFIRDPEFQGQTKEKLSSTEAQRLVEKALADPFDHWLTAQPKAAGAL
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHH
LQFVVERAEERLKRRRDKEVARASATRKLRLPGKLADCAGNAIDGAELFLVEGDSAGGSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCEEEEEECCCCCCCH
KQARDRKNQAILPLRGKILNVASASTDKFGGNKELSDLLLALGVQPGSKFKEDDLRYERI
HHHHHHCCCEECCCCCCEEEHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEE
IIMTDADVDGAHIASLLITFFFRTMPDMIRAGRLYLALPPLYRISHGGKAVYARDDAHRD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHEECCCCCEEEECCCCCHH
ELLATEFKGKKPEISRFKGLGEMMPNQLKETTMDPKTRTLARVTLPRAEETVEDLVEALM
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCHHHHHHHHHHHHH
GRKPELRFRFIQENAEFAAADLDI
CCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647; 9426128 [H]