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The map label for this gene is gmk [H]

Identifier: 197105026

GI number: 197105026

Start: 1764523

End: 1765188

Strand: Direct

Name: gmk [H]

Synonym: PHZ_c1563

Alternate gene names: 197105026

Gene position: 1764523-1765188 (Clockwise)

Preceding gene: 197105025

Following gene: 197105027

Centisome position: 44.15

GC content: 70.27

Gene sequence:

>666_bases
GTGAGCCCGCATGACGAACACGCCCGGCCCTGGGAGACCGTCCGCCGCGGCCTGCTGCTGCTGATCTCGAGCCCCGCGGG
GGCGGGCAAGACCTCGCTGTCGCGCCGGCTCGTGGCGGACCACTCGGACCTGACGCTGTCGATCTCGGCGACCACCCGCG
ATCCGCGGCCGGGCGAGGAGGAAGGGCGGGAGTACTTCTTCAAGACCCGCGCCGAGTTCGAGGCGATGATCGAGGCGGGC
GAGTTCCTGGAGTGGGCGACCGTCAACGGCAACTACTACGGCACCCCGAAAACGCCCGTGATCGAGGCGCTGGAAGGCGG
CCACGACGTGCTGTTCGACATCGACTGGCAGGGCGCGCGGCAGATCGCCGAGAAGCAGCCCGACGACAGCGTGCGGGTGT
TCATCCTGCCGCCGGTGTGGAGCGACCTGGAGCGGCGCCTGCGGGCCCGGGCCCAGGACAGCGAGGAGATCATCGACGCC
CGGCTGCGGCTGGGGCGCGAGGAGATCGCCCACTGGACCGAGTACGACTACGTCATCGTCAACAAGAACTTCGACCGCGC
CTACGCCGACCTCGGCCACATCTACCGCGCCGAACGGATGAAGCCCGGCCGCAACCCGTGGCTGCCCGAGTTCGTCGACG
GGCTGCTGGAGGACGCGGCGGGGTAG

Upstream 100 bases:

>100_bases
ATCGGGGCGCGGGGTGTGCCAGAGAGGCGCGCGTTCGTGTGGTTCGTGTGGTGCGTGGACGACGTCCGCGCCGCGCGTGC
GATTGGAGGATGGACCACTG

Downstream 100 bases:

>100_bases
GGGGGGCTTCGACAGCTCACATCGCGACAAACAAGGGCTGTGCCCCCAGGCGCTCTCGGATGTTAATGCGCCCCGCGCCG
CGAAGGCGGCCGATGCCGCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MSPHDEHARPWETVRRGLLLLISSPAGAGKTSLSRRLVADHSDLTLSISATTRDPRPGEEEGREYFFKTRAEFEAMIEAG
EFLEWATVNGNYYGTPKTPVIEALEGGHDVLFDIDWQGARQIAEKQPDDSVRVFILPPVWSDLERRLRARAQDSEEIIDA
RLRLGREEIAHWTEYDYVIVNKNFDRAYADLGHIYRAERMKPGRNPWLPEFVDGLLEDAAG

Sequences:

>Translated_221_residues
MSPHDEHARPWETVRRGLLLLISSPAGAGKTSLSRRLVADHSDLTLSISATTRDPRPGEEEGREYFFKTRAEFEAMIEAG
EFLEWATVNGNYYGTPKTPVIEALEGGHDVLFDIDWQGARQIAEKQPDDSVRVFILPPVWSDLERRLRARAQDSEEIIDA
RLRLGREEIAHWTEYDYVIVNKNFDRAYADLGHIYRAERMKPGRNPWLPEFVDGLLEDAAG
>Mature_220_residues
SPHDEHARPWETVRRGLLLLISSPAGAGKTSLSRRLVADHSDLTLSISATTRDPRPGEEEGREYFFKTRAEFEAMIEAGE
FLEWATVNGNYYGTPKTPVIEALEGGHDVLFDIDWQGARQIAEKQPDDSVRVFILPPVWSDLERRLRARAQDSEEIIDAR
LRLGREEIAHWTEYDYVIVNKNFDRAYADLGHIYRAERMKPGRNPWLPEFVDGLLEDAAG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=38.2198952879581, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=38.2198952879581, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=38.2198952879581, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI21361598, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI38570142, Length=200, Percent_Identity=28, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI52630447, Length=206, Percent_Identity=29.126213592233, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4505237, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118255, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118263, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI262118259, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=48.9583333333333, Blast_Score=183, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=36.8131868131868, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=36.8131868131868, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.2513661202186, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356141, Length=177, Percent_Identity=38.9830508474576, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077626, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007136, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85724806, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554489, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640542, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330166, Length=145, Percent_Identity=32.4137931034483, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330162, Length=147, Percent_Identity=32.6530612244898, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221330164, Length=147, Percent_Identity=32.6530612244898, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25234; Mature: 25103

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHDEHARPWETVRRGLLLLISSPAGAGKTSLSRRLVADHSDLTLSISATTRDPRPGEE
CCCCCCCCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHH
EGREYFFKTRAEFEAMIEAGEFLEWATVNGNYYGTPKTPVIEALEGGHDVLFDIDWQGAR
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCHHHHHHCCCCEEEEEECCHHHH
QIAEKQPDDSVRVFILPPVWSDLERRLRARAQDSEEIIDARLRLGREEIAHWTEYDYVIV
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCEEEE
NKNFDRAYADLGHIYRAERMKPGRNPWLPEFVDGLLEDAAG
ECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SPHDEHARPWETVRRGLLLLISSPAGAGKTSLSRRLVADHSDLTLSISATTRDPRPGEE
CCCCCCCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHH
EGREYFFKTRAEFEAMIEAGEFLEWATVNGNYYGTPKTPVIEALEGGHDVLFDIDWQGAR
HHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCHHHHHHCCCCEEEEEECCHHHH
QIAEKQPDDSVRVFILPPVWSDLERRLRARAQDSEEIIDARLRLGREEIAHWTEYDYVIV
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCCCEEEE
NKNFDRAYADLGHIYRAERMKPGRNPWLPEFVDGLLEDAAG
ECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]