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The map label for this gene is bdhA [H]

Identifier: 197105019

GI number: 197105019

Start: 1757366

End: 1758439

Strand: Reverse

Name: bdhA [H]

Synonym: PHZ_c1556

Alternate gene names: 197105019

Gene position: 1758439-1757366 (Counterclockwise)

Preceding gene: 197105029

Following gene: 197105017

Centisome position: 44.0

GC content: 72.16

Gene sequence:

>1074_bases
ATGAGGGCCGTCATCCGGCGCAACAGGCAACTCGTCTGCGACGAGATCGAGGACCTGACGCCCGCAGAGGGGCAGGTGCT
CGTGAGGACGCTCGCCTGCGGGATCTGCGGCTCGGACCTGCACGCCCTGCACCACATGGAGCACATGATCGACCTGTCGC
GGCGGGCAGGTTCGCCGGACAACGGCTTCGATCCGCGCGCGGACACCGTCTTCGGCCACGAGTTCTGCGCCGAGATCCTC
GATCACGGGCCGGGGGCGGCGAAGACCCTCAAGGCCGGCGCTCGGGTCGTCAGCATGCCGGCCGTCATGACGCCCAGCGG
CGTCGAGCTGCTGGGCTTCTCCAACCGCCTGCCCGGCGGCTTCGCCGAGCGCATGGTGCTCACCGAGGCGATGCTGCTGG
AAGTGCCCAACGGCCTGCCCACCGACCAGGCCGCGATGACCGAGCCGTTCGCCGTCGGAGCCCACGCCGTGGCCAAGGCG
CGCCTGGAGCCCGGCTCGGCCTCGCTGGTCGTAGGCTGCGGCCCGGTGGGACTGGCGGTCATCGGCGCGCTGAAGGCCGC
CGGCCACGGCCCGGTGATCGCCGCCGACTACTCGCCCCGGCGCCGCGCCGCCGCCGAGCGGCTGGGCGCGGACATCGTGG
TCGATCCGGCCGTGGAATCTCCGCACGCCCGCTGGGAGGCCCTGGGCGTTCCCACGTCGCGGGCGGCGCAGAGCATGGTC
CAGATGATGGGCGGCAGCTTCGCCCGGCCGGTGGTCTTCGAGTGCGTCGGCGCGCCCGGCGTCCTGCAGGCGCTCATCGA
GGCCGCACCGGCCGGCGCGCAGATCGTCGTCGCCGGCGTCTGCATGGAGACCGACCGCATCGAGCCCTCGATCGCGGTCA
CCAAGGAGATCGAGCTGACGTTCGTGCTGGGCTACACGCCGCAGGAGTTCGCCGACACCCTGCGGAACCTTGCCGAGGGG
GTCATCGACGTCTCGCACCTGGTCACCGGCAAGGTGGGGCTGGACGGCGTCGCCGGCGCGTTCGAGGCGCTCGGCGATCC
CGAGGCCCACGTGAAGATTCTGGTCGAGCCCTAG

Upstream 100 bases:

>100_bases
CTGATTGCTTGATTCCGAGGCGCGAGGGTTAGGGGATTAGGCTAGGCTGGACAAGCAGAGGACGTCGCGGCCGCCAAGAG
CCGCCTTTGGAGGGGAACGC

Downstream 100 bases:

>100_bases
GGACCCGCAACCGAAACCCTGGCGATCTCCGGGGCCTGGCTGCGCCGGTAGGCCTCCACGGCCTCGCGATAGGACTCGGT
CTCCCGACCATCCGTCGGGC

Product: threonine dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRAVIRRNRQLVCDEIEDLTPAEGQVLVRTLACGICGSDLHALHHMEHMIDLSRRAGSPDNGFDPRADTVFGHEFCAEIL
DHGPGAAKTLKAGARVVSMPAVMTPSGVELLGFSNRLPGGFAERMVLTEAMLLEVPNGLPTDQAAMTEPFAVGAHAVAKA
RLEPGSASLVVGCGPVGLAVIGALKAAGHGPVIAADYSPRRRAAAERLGADIVVDPAVESPHARWEALGVPTSRAAQSMV
QMMGGSFARPVVFECVGAPGVLQALIEAAPAGAQIVVAGVCMETDRIEPSIAVTKEIELTFVLGYTPQEFADTLRNLAEG
VIDVSHLVTGKVGLDGVAGAFEALGDPEAHVKILVEP

Sequences:

>Translated_357_residues
MRAVIRRNRQLVCDEIEDLTPAEGQVLVRTLACGICGSDLHALHHMEHMIDLSRRAGSPDNGFDPRADTVFGHEFCAEIL
DHGPGAAKTLKAGARVVSMPAVMTPSGVELLGFSNRLPGGFAERMVLTEAMLLEVPNGLPTDQAAMTEPFAVGAHAVAKA
RLEPGSASLVVGCGPVGLAVIGALKAAGHGPVIAADYSPRRRAAAERLGADIVVDPAVESPHARWEALGVPTSRAAQSMV
QMMGGSFARPVVFECVGAPGVLQALIEAAPAGAQIVVAGVCMETDRIEPSIAVTKEIELTFVLGYTPQEFADTLRNLAEG
VIDVSHLVTGKVGLDGVAGAFEALGDPEAHVKILVEP
>Mature_357_residues
MRAVIRRNRQLVCDEIEDLTPAEGQVLVRTLACGICGSDLHALHHMEHMIDLSRRAGSPDNGFDPRADTVFGHEFCAEIL
DHGPGAAKTLKAGARVVSMPAVMTPSGVELLGFSNRLPGGFAERMVLTEAMLLEVPNGLPTDQAAMTEPFAVGAHAVAKA
RLEPGSASLVVGCGPVGLAVIGALKAAGHGPVIAADYSPRRRAAAERLGADIVVDPAVESPHARWEALGVPTSRAAQSMV
QMMGGSFARPVVFECVGAPGVLQALIEAAPAGAQIVVAGVCMETDRIEPSIAVTKEIELTFVLGYTPQEFADTLRNLAEG
VIDVSHLVTGKVGLDGVAGAFEALGDPEAHVKILVEP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=27.2189349112426, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI226510992, Length=353, Percent_Identity=28.0453257790368, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=25.8160237388724, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787863, Length=364, Percent_Identity=25.2747252747253, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790718, Length=345, Percent_Identity=24.9275362318841, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=358, Percent_Identity=25.1396648044693, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082125, Length=210, Percent_Identity=29.0476190476191, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=22.1556886227545, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788407, Length=355, Percent_Identity=24.2253521126761, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=25.9587020648968, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=24.6290801186944, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=365, Percent_Identity=29.3150684931507, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=369, Percent_Identity=28.1842818428184, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=346, Percent_Identity=25.7225433526012, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=323, Percent_Identity=26.0061919504644, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=323, Percent_Identity=26.0061919504644, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17737897, Length=335, Percent_Identity=25.6716417910448, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37186; Mature: 37186

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVIRRNRQLVCDEIEDLTPAEGQVLVRTLACGICGSDLHALHHMEHMIDLSRRAGSPD
CCCHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
NGFDPRADTVFGHEFCAEILDHGPGAAKTLKAGARVVSMPAVMTPSGVELLGFSNRLPGG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCEECCCCCEEEECCCCCCCH
FAERMVLTEAMLLEVPNGLPTDQAAMTEPFAVGAHAVAKARLEPGSASLVVGCGPVGLAV
HHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
IGALKAAGHGPVIAADYSPRRRAAAERLGADIVVDPAVESPHARWEALGVPTSRAAQSMV
HHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEECCCCCCCCCCEECCCCHHHHHHHHH
QMMGGSFARPVVFECVGAPGVLQALIEAAPAGAQIVVAGVCMETDRIEPSIAVTKEIELT
HHHCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEE
FVLGYTPQEFADTLRNLAEGVIDVSHLVTGKVGLDGVAGAFEALGDPEAHVKILVEP
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MRAVIRRNRQLVCDEIEDLTPAEGQVLVRTLACGICGSDLHALHHMEHMIDLSRRAGSPD
CCCHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
NGFDPRADTVFGHEFCAEILDHGPGAAKTLKAGARVVSMPAVMTPSGVELLGFSNRLPGG
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCEECCCCCEEEECCCCCCCH
FAERMVLTEAMLLEVPNGLPTDQAAMTEPFAVGAHAVAKARLEPGSASLVVGCGPVGLAV
HHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
IGALKAAGHGPVIAADYSPRRRAAAERLGADIVVDPAVESPHARWEALGVPTSRAAQSMV
HHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEEECCCCCCCCCCEECCCCHHHHHHHHH
QMMGGSFARPVVFECVGAPGVLQALIEAAPAGAQIVVAGVCMETDRIEPSIAVTKEIELT
HHHCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEE
FVLGYTPQEFADTLRNLAEGVIDVSHLVTGKVGLDGVAGAFEALGDPEAHVKILVEP
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]