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The map label for this gene is czcD [H]

Identifier: 197104899

GI number: 197104899

Start: 1627408

End: 1628349

Strand: Direct

Name: czcD [H]

Synonym: PHZ_c1434

Alternate gene names: 197104899

Gene position: 1627408-1628349 (Clockwise)

Preceding gene: 197104898

Following gene: 197104900

Centisome position: 40.72

GC content: 68.37

Gene sequence:

>942_bases
ATGAGCGAGGCGAGCGCCGGGCATGAGCCGATCGGTCATGACCATGGGCCGGGCGGCCACGCCCACAGCCACACGGCCAA
CGCCAACGCCCGGCAGCTGACGCTCGCCCTAGCGCTGACCTCGGCCTTCCTGGTCGCCGAGGTCATCGGGGGGCTGGTGT
TCGGCAGCCTCGCCTTGCTGTCCGACGCAGCCCACATGTTCACCGACACGGCCGCGTTGGCGATCGCCCTGGCCGCGATC
AAGATCGGGCAGCGAAAGGCCGATGAGCGTCGGACCTTCGGCTACCGTCGCTTCGAGATCCTGGCCGCGGCGTTCAACGC
CGTGCTGCTGTTCGGGGTCGCGCTCTACGTCCTGATCGAAGGCGCGAGACGGATTTTCGAGCCGGCACCGGTGCAATCCA
CCGGCATGCTGATCGTGGCCGGGCTCGGCTTGGCGGTGAACCTCATCTCCATGCGGGTCCTCGCAGGCGGCAAGGACAAG
AGCCTCAACGTCAAGGGCGCCTATCTCGAAGTCTGGGCCGACATGGTGGGCTCCGTCGGTGTGATCGCCGGCGCCCTGGT
CATCCAGTTCACCGGCTGGAGCTGGGTCGACCCGGTGGTCGCCATCGCAATCGGGCTCTGGGTGCTTCCTCGCACCTGGG
TCCTCCTGCGGGACAGCACCAACATCCTGCTTGAAGGCGCCCCTTCCGGAATCGCCCTGGCAGGCATTCGCACGACCATC
GCCGAGACGCCGGGTGTCGCCGGGGTGCACGACCTGCATCTTTGGGTCTCCGGCGCCGATCAGCCGAGCTGCACAGCCCA
CGTCGTCCTGGCCGCTGGCGCCGACGGGGAGTCCGTCCGACGGCATGTCGCCGCGCGGCTCGAGGCGGACTTCGATGTCC
ACCACGTCACCATCCAAACCGAGACGGCGCCCTGCGACGCGGCGGAGCCCCTTCATCCATGA

Upstream 100 bases:

>100_bases
GCTGGCGCGCCGCCTCCGGACAGCCGCCGGCGAGGCCTCGCGGCCGGCCGCCCAGCCCTTGTCTTGAGGGTTGGTTCGTG
ACGAGCGGAGGGATGAGAGC

Downstream 100 bases:

>100_bases
AGCCCGGTGACCTAATTTGCGAAAGGCGCCTGTTCGGTGCAAGACATCCCGACCCAGCTGCGGAGTTCCTCATGAAGATG
ATCGTCCAGTCGGCCTTCGC

Product: cobalt-zinc-cadmium resistance protein CzcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSEASAGHEPIGHDHGPGGHAHSHTANANARQLTLALALTSAFLVAEVIGGLVFGSLALLSDAAHMFTDTAALAIALAAI
KIGQRKADERRTFGYRRFEILAAAFNAVLLFGVALYVLIEGARRIFEPAPVQSTGMLIVAGLGLAVNLISMRVLAGGKDK
SLNVKGAYLEVWADMVGSVGVIAGALVIQFTGWSWVDPVVAIAIGLWVLPRTWVLLRDSTNILLEGAPSGIALAGIRTTI
AETPGVAGVHDLHLWVSGADQPSCTAHVVLAAGADGESVRRHVAARLEADFDVHHVTIQTETAPCDAAEPLHP

Sequences:

>Translated_313_residues
MSEASAGHEPIGHDHGPGGHAHSHTANANARQLTLALALTSAFLVAEVIGGLVFGSLALLSDAAHMFTDTAALAIALAAI
KIGQRKADERRTFGYRRFEILAAAFNAVLLFGVALYVLIEGARRIFEPAPVQSTGMLIVAGLGLAVNLISMRVLAGGKDK
SLNVKGAYLEVWADMVGSVGVIAGALVIQFTGWSWVDPVVAIAIGLWVLPRTWVLLRDSTNILLEGAPSGIALAGIRTTI
AETPGVAGVHDLHLWVSGADQPSCTAHVVLAAGADGESVRRHVAARLEADFDVHHVTIQTETAPCDAAEPLHP
>Mature_312_residues
SEASAGHEPIGHDHGPGGHAHSHTANANARQLTLALALTSAFLVAEVIGGLVFGSLALLSDAAHMFTDTAALAIALAAIK
IGQRKADERRTFGYRRFEILAAAFNAVLLFGVALYVLIEGARRIFEPAPVQSTGMLIVAGLGLAVNLISMRVLAGGKDKS
LNVKGAYLEVWADMVGSVGVIAGALVIQFTGWSWVDPVVAIAIGLWVLPRTWVLLRDSTNILLEGAPSGIALAGIRTTIA
ETPGVAGVHDLHLWVSGADQPSCTAHVVLAAGADGESVRRHVAARLEADFDVHHVTIQTETAPCDAAEPLHP

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=309, Percent_Identity=31.0679611650485, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI64762489, Length=331, Percent_Identity=31.1178247734139, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI289803013, Length=287, Percent_Identity=32.404181184669, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803009, Length=287, Percent_Identity=32.404181184669, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803007, Length=287, Percent_Identity=32.404181184669, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803003, Length=287, Percent_Identity=32.404181184669, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI21359890, Length=318, Percent_Identity=27.9874213836478, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=29.4498381877023, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI20070323, Length=320, Percent_Identity=25.625, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI14210520, Length=226, Percent_Identity=28.7610619469027, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI52352803, Length=118, Percent_Identity=40.6779661016949, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI52351208, Length=125, Percent_Identity=33.6, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786966, Length=281, Percent_Identity=40.9252669039146, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1790349, Length=221, Percent_Identity=24.4343891402715, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193210990, Length=311, Percent_Identity=32.7974276527331, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17555794, Length=323, Percent_Identity=30.030959752322, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17555796, Length=254, Percent_Identity=32.6771653543307, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=300, Percent_Identity=30, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17550442, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=239, Percent_Identity=30.1255230125523, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=129, Percent_Identity=32.5581395348837, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=117, Percent_Identity=34.1880341880342, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583858, Length=341, Percent_Identity=26.6862170087977, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656728, Length=323, Percent_Identity=27.8637770897833, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656724, Length=323, Percent_Identity=27.8637770897833, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656720, Length=323, Percent_Identity=27.8637770897833, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656715, Length=323, Percent_Identity=27.8637770897833, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357035, Length=323, Percent_Identity=27.8637770897833, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=36.0544217687075, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=36.0544217687075, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=36.0544217687075, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=36.0544217687075, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24645863, Length=124, Percent_Identity=39.5161290322581, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584409, Length=137, Percent_Identity=35.036496350365, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574430, Length=137, Percent_Identity=35.036496350365, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32675; Mature: 32544

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00059 ADH_ZINC ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASAGHEPIGHDHGPGGHAHSHTANANARQLTLALALTSAFLVAEVIGGLVFGSLALL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDAAHMFTDTAALAIALAAIKIGQRKADERRTFGYRRFEILAAAFNAVLLFGVALYVLIE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GARRIFEPAPVQSTGMLIVAGLGLAVNLISMRVLAGGKDKSLNVKGAYLEVWADMVGSVG
HHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCHH
VIAGALVIQFTGWSWVDPVVAIAIGLWVLPRTWVLLRDSTNILLEGAPSGIALAGIRTTI
HHHHHHHEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCEEEEHHHHHH
AETPGVAGVHDLHLWVSGADQPSCTAHVVLAAGADGESVRRHVAARLEADFDVHHVTIQT
HCCCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEE
ETAPCDAAEPLHP
CCCCCCCCCCCCC
>Mature Secondary Structure 
SEASAGHEPIGHDHGPGGHAHSHTANANARQLTLALALTSAFLVAEVIGGLVFGSLALL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDAAHMFTDTAALAIALAAIKIGQRKADERRTFGYRRFEILAAAFNAVLLFGVALYVLIE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GARRIFEPAPVQSTGMLIVAGLGLAVNLISMRVLAGGKDKSLNVKGAYLEVWADMVGSVG
HHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHCCHH
VIAGALVIQFTGWSWVDPVVAIAIGLWVLPRTWVLLRDSTNILLEGAPSGIALAGIRTTI
HHHHHHHEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCEEEEHHHHHH
AETPGVAGVHDLHLWVSGADQPSCTAHVVLAAGADGESVRRHVAARLEADFDVHHVTIQT
HCCCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEE
ETAPCDAAEPLHP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]