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The map label for this gene is guaB [H]

Identifier: 197104881

GI number: 197104881

Start: 1603172

End: 1604632

Strand: Direct

Name: guaB [H]

Synonym: PHZ_c1415

Alternate gene names: 197104881

Gene position: 1603172-1604632 (Clockwise)

Preceding gene: 197104880

Following gene: 197104882

Centisome position: 40.12

GC content: 68.72

Gene sequence:

>1461_bases
ATGGAGATTCGCGAAGGGCTCACCTTCGACGATGTTTTGCTCGAACCCGGCGCGTCCGATGTGATGCCCACGCAGGTGGA
TGTCTCCACCAGGTTCACGCGAGAGATCAATCTGAACATCCCGCTCGTGTCGGCCGCCATGGACACGGTCACCGAAAGCC
GGCTGGCGATCGCCATGGCCCAGGCTGGCGGCATCGGGGTGCTTCACCGCAACCTGACGGTCGACGAACAGGCCGACCAG
GTCCGCGAGGTGAAGCGCTACGAGAGCGGCATGGTCATCAACCCGCTGACCATCGGCCCCGACACCACCCTGGGCGAGGT
CCGCCAGATCAAGGCGCGCAAGCGGATCTCGGGCTTCCCCGTGGTGGACGAGGCCGGCAAGCTCTGCGGCATCTTGACCA
ACCGGGACATGCGCTTCGAGAGTCGTGACGACATCCCGGCCAAGGCGCTGATGACCCGGGAGAACCTGGTCACCGTCAAG
GAGGGCGTCAGCCAGGCCGAGGCGCGAGACTTGCTGCGCCGGCACAAGATCGAGCGCCTGATCGTCGTCGACGACGAGTA
CCACGCCGTCGGCCTGATCACCGTCAAGGACATGGAGAAGGCTCAGGCCCATCCGTTCGCGGCCAAGGACGCCCAGGGCC
GTCTGCTGGTGGCGGCGGCCTCGACGGTCGGCGATGCGGGCTACGAGCGCTCAATGGCCCTCGTGGACGCCGGCGTCGAC
GTGGTGGTGATCGACACCGCCCACGGCCACAATGCCTCGGTGGCCGACGCCGTCCAGCGGGTGAAGCGCGAGACCAACCG
CGTCCAGATCGTCGCCGGCAACGTGGCGACCTACGACGGGGCGCGCGCGCTGATCGACGCCGGCGCCGACGCCGTGAAGG
TGGGGATCGGGCCCGGGTCGATCTGCACCACGCGGATCGTGGCGGGCGTAGGCGTGCCGCAGCTGACCGCCATCGCCGAT
GCGGTGCGCGCGGCGCAGGGCTCGGACGTTCCGGTCGTCGCCGACGGCGGCATCAAGTACTCGGGGGATCTCGCCAAGGC
GCTCGCCATGGGCGCCTCGGTGGCGATGATGGGCTCGGTGTTCGCGGGCGTCGACGAGGCGCCGGGCGAGGTGTTCCTGT
ACCAGGGCCGCTCGTACAAGGCGTACCGCGGCATGGGTTCGCTGGGCGCCATGGGCCAGGGCTCGGCGGACCGCTACTTC
CAGAAGGACGTGAAGGACGCGCTGAAGCTGGTGCCTGAAGGCATCGAGGGACAGGTCCCCTACAAGGGCCCGATCGCCCC
CATCCTGCACCAGATGATCGGCGGCCTGCGCGCGGCCATGGGTTATGTCGGCGGCGCCGACCTGGCCGAGTTCCGCAAGC
GGGCCCGGTTCATCCGCATCACCAACGCCGGCCTTCGCGAGAGCCACGTCCACGACGTGATGATCACCCGCGAGGCGCCG
AACTACCCCAGCGCCGTCTAG

Upstream 100 bases:

>100_bases
CGGCGCCGCAGGAGACCGTAATCGCATGAAGCAGCTCACCTCGCCCCTTGCCCCGGGGTCGGCCTTACCCCTATACCCGC
GCCGCAAAACGGAGAGTCTC

Downstream 100 bases:

>100_bases
GCCGCCTCATGCGCGACGGCGGACGGCTGGCGGCGGCCATTGAAGTTCTGACGGAGATCGAGGCTCGCCACCGCCCCGTC
CGCCTGGCGCTGAAGGCCTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MEIREGLTFDDVLLEPGASDVMPTQVDVSTRFTREINLNIPLVSAAMDTVTESRLAIAMAQAGGIGVLHRNLTVDEQADQ
VREVKRYESGMVINPLTIGPDTTLGEVRQIKARKRISGFPVVDEAGKLCGILTNRDMRFESRDDIPAKALMTRENLVTVK
EGVSQAEARDLLRRHKIERLIVVDDEYHAVGLITVKDMEKAQAHPFAAKDAQGRLLVAAASTVGDAGYERSMALVDAGVD
VVVIDTAHGHNASVADAVQRVKRETNRVQIVAGNVATYDGARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIAD
AVRAAQGSDVPVVADGGIKYSGDLAKALAMGASVAMMGSVFAGVDEAPGEVFLYQGRSYKAYRGMGSLGAMGQGSADRYF
QKDVKDALKLVPEGIEGQVPYKGPIAPILHQMIGGLRAAMGYVGGADLAEFRKRARFIRITNAGLRESHVHDVMITREAP
NYPSAV

Sequences:

>Translated_486_residues
MEIREGLTFDDVLLEPGASDVMPTQVDVSTRFTREINLNIPLVSAAMDTVTESRLAIAMAQAGGIGVLHRNLTVDEQADQ
VREVKRYESGMVINPLTIGPDTTLGEVRQIKARKRISGFPVVDEAGKLCGILTNRDMRFESRDDIPAKALMTRENLVTVK
EGVSQAEARDLLRRHKIERLIVVDDEYHAVGLITVKDMEKAQAHPFAAKDAQGRLLVAAASTVGDAGYERSMALVDAGVD
VVVIDTAHGHNASVADAVQRVKRETNRVQIVAGNVATYDGARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIAD
AVRAAQGSDVPVVADGGIKYSGDLAKALAMGASVAMMGSVFAGVDEAPGEVFLYQGRSYKAYRGMGSLGAMGQGSADRYF
QKDVKDALKLVPEGIEGQVPYKGPIAPILHQMIGGLRAAMGYVGGADLAEFRKRARFIRITNAGLRESHVHDVMITREAP
NYPSAV
>Mature_486_residues
MEIREGLTFDDVLLEPGASDVMPTQVDVSTRFTREINLNIPLVSAAMDTVTESRLAIAMAQAGGIGVLHRNLTVDEQADQ
VREVKRYESGMVINPLTIGPDTTLGEVRQIKARKRISGFPVVDEAGKLCGILTNRDMRFESRDDIPAKALMTRENLVTVK
EGVSQAEARDLLRRHKIERLIVVDDEYHAVGLITVKDMEKAQAHPFAAKDAQGRLLVAAASTVGDAGYERSMALVDAGVD
VVVIDTAHGHNASVADAVQRVKRETNRVQIVAGNVATYDGARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAIAD
AVRAAQGSDVPVVADGGIKYSGDLAKALAMGASVAMMGSVFAGVDEAPGEVFLYQGRSYKAYRGMGSLGAMGQGSADRYF
QKDVKDALKLVPEGIEGQVPYKGPIAPILHQMIGGLRAAMGYVGGADLAEFRKRARFIRITNAGLRESHVHDVMITREAP
NYPSAV

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.6265560165975, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=38.5416666666667, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=38.5416666666667, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=38.5416666666667, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=38.5416666666667, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=38.3966244725738, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=37.7083333333333, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=35.8333333333333, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=37.3076923076923, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541954, Length=271, Percent_Identity=35.4243542435424, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541952, Length=271, Percent_Identity=35.4243542435424, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541948, Length=271, Percent_Identity=35.4243542435424, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541956, Length=271, Percent_Identity=35.4243542435424, Blast_Score=162, Evalue=8e-40,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=56.6115702479339, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1786293, Length=248, Percent_Identity=36.2903225806452, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=505, Percent_Identity=35.4455445544554, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=431, Percent_Identity=37.8190255220418, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=245, Percent_Identity=37.9591836734694, Blast_Score=164, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=39.8357289527721, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=40.041067761807, Blast_Score=335, Evalue=9e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=38.9690721649485, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.6432748538012, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=36.9747899159664, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=38.0165289256198, Blast_Score=321, Evalue=9e-88,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=38.0165289256198, Blast_Score=321, Evalue=9e-88,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=37.5565610859729, Blast_Score=282, Evalue=3e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51740; Mature: 51740

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIREGLTFDDVLLEPGASDVMPTQVDVSTRFTREINLNIPLVSAAMDTVTESRLAIAMA
CCCCCCCCHHHHEECCCCCCCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHHHEEEEE
QAGGIGVLHRNLTVDEQADQVREVKRYESGMVINPLTIGPDTTLGEVRQIKARKRISGFP
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC
VVDEAGKLCGILTNRDMRFESRDDIPAKALMTRENLVTVKEGVSQAEARDLLRRHKIERL
CHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCEE
IVVDDEYHAVGLITVKDMEKAQAHPFAAKDAQGRLLVAAASTVGDAGYERSMALVDAGVD
EEECCCCCEEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECHHCCCCHHCCEEEEECCCC
VVVIDTAHGHNASVADAVQRVKRETNRVQIVAGNVATYDGARALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCEEECCCCHHHHHCCCCEEEEECCCCC
ICTTRIVAGVGVPQLTAIADAVRAAQGSDVPVVADGGIKYSGDLAKALAMGASVAMMGSV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHH
FAGVDEAPGEVFLYQGRSYKAYRGMGSLGAMGQGSADRYFQKDVKDALKLVPEGIEGQVP
HHCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YKGPIAPILHQMIGGLRAAMGYVGGADLAEFRKRARFIRITNAGLRESHVHDVMITREAP
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCC
NYPSAV
CCCCCC
>Mature Secondary Structure
MEIREGLTFDDVLLEPGASDVMPTQVDVSTRFTREINLNIPLVSAAMDTVTESRLAIAMA
CCCCCCCCHHHHEECCCCCCCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHHHEEEEE
QAGGIGVLHRNLTVDEQADQVREVKRYESGMVINPLTIGPDTTLGEVRQIKARKRISGFP
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC
VVDEAGKLCGILTNRDMRFESRDDIPAKALMTRENLVTVKEGVSQAEARDLLRRHKIERL
CHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCEE
IVVDDEYHAVGLITVKDMEKAQAHPFAAKDAQGRLLVAAASTVGDAGYERSMALVDAGVD
EEECCCCCEEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECHHCCCCHHCCEEEEECCCC
VVVIDTAHGHNASVADAVQRVKRETNRVQIVAGNVATYDGARALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCEEECCCCHHHHHCCCCEEEEECCCCC
ICTTRIVAGVGVPQLTAIADAVRAAQGSDVPVVADGGIKYSGDLAKALAMGASVAMMGSV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHH
FAGVDEAPGEVFLYQGRSYKAYRGMGSLGAMGQGSADRYFQKDVKDALKLVPEGIEGQVP
HHCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YKGPIAPILHQMIGGLRAAMGYVGGADLAEFRKRARFIRITNAGLRESHVHDVMITREAP
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCC
NYPSAV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA