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The map label for this gene is adk

Identifier: 197104717

GI number: 197104717

Start: 1430258

End: 1430830

Strand: Direct

Name: adk

Synonym: PHZ_c1251

Alternate gene names: 197104717

Gene position: 1430258-1430830 (Clockwise)

Preceding gene: 197104716

Following gene: 197104718

Centisome position: 35.79

GC content: 72.25

Gene sequence:

>573_bases
ATGAACCTGATCCTGTTCGGACCGCCGGCGGCGGGGAAGGGGACCCAGGCCAAGCGCCTGGTCGAGCAGCGCCGGATGGT
GCAGCTCTCCACCGGCGACATGCTGCGCGCCGCCATCGCCTCGGGCTCGGAGCTGGGCCAGCGGGTGTCGGGCATCATGG
AGCGCGGCGAGCTCGTCTCGGACGCCATCGTCATCGAACTCATCGAACAGCGCCTGCCCGAGGCCGAGGCGGCGGGCGGG
GCGATCTTCGACGGCTTCCCGCGGACCCTGGCCCAGGCCGAGGCGCTGGACGCCATGCTGGCCGGCCGCGGCCGGCGGAT
CGACCTGGTCGTCCGCCTGAAGGTGGACGATGCGGCCCTGATGCAGCGCATCGCCGGGCGCTTCGCCGAATCGGGGCGCG
CCGACGACAACCCCGAGAGCTTCAAGGTCCGCCTGGACGCCTATAACCGCCAGACCGCGCCGCTGCTGCCGTACTACGAG
GGGCAGGGCAAGCTGGTCGAGGTGGACGGCATGGGCTCGATCGACCAGGTCGCCGCCGCGATCGACGCGGCCCTGACCGG
AGCTGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGGTCCAAGCTGCGCGGCGGGGGCCGCGGGCGCTGATCGGATAGACAGGGAAAGTGACGCCGGCGCCGGCAAGAGCGCC
GGCTCGGGGAGGGGTAGTCG

Downstream 100 bases:

>100_bases
TTCCCGCCGGCCCAGCCCACGCCCTGCGGCGCCAAGGCGCGCCTGTGGCCAAGTTGCGTGGCCGGGCGGCTCATGCTTTC
CTTAACCATCCCGAGGCTAC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MNLILFGPPAAGKGTQAKRLVEQRRMVQLSTGDMLRAAIASGSELGQRVSGIMERGELVSDAIVIELIEQRLPEAEAAGG
AIFDGFPRTLAQAEALDAMLAGRGRRIDLVVRLKVDDAALMQRIAGRFAESGRADDNPESFKVRLDAYNRQTAPLLPYYE
GQGKLVEVDGMGSIDQVAAAIDAALTGAAA

Sequences:

>Translated_190_residues
MNLILFGPPAAGKGTQAKRLVEQRRMVQLSTGDMLRAAIASGSELGQRVSGIMERGELVSDAIVIELIEQRLPEAEAAGG
AIFDGFPRTLAQAEALDAMLAGRGRRIDLVVRLKVDDAALMQRIAGRFAESGRADDNPESFKVRLDAYNRQTAPLLPYYE
GQGKLVEVDGMGSIDQVAAAIDAALTGAAA
>Mature_190_residues
MNLILFGPPAAGKGTQAKRLVEQRRMVQLSTGDMLRAAIASGSELGQRVSGIMERGELVSDAIVIELIEQRLPEAEAAGG
AIFDGFPRTLAQAEALDAMLAGRGRRIDLVVRLKVDDAALMQRIAGRFAESGRADDNPESFKVRLDAYNRQTAPLLPYYE
GQGKLVEVDGMGSIDQVAAAIDAALTGAAA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=41.1214953271028, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=41.1214953271028, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI4502011, Length=187, Percent_Identity=33.6898395721925, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=34.8717948717949, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=34.8717948717949, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI19923437, Length=194, Percent_Identity=32.4742268041237, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706497, Length=180, Percent_Identity=30, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=29.8969072164948, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=29.8969072164948, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=29.8969072164948, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=29.8969072164948, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=37.7880184331797, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=39.7129186602871, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=190, Percent_Identity=35.7894736842105, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=31.5508021390374, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=177, Percent_Identity=32.2033898305085, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=28.2178217821782, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=195, Percent_Identity=40, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=32.8282828282828, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=29.5698924731183, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=40, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17737899, Length=194, Percent_Identity=31.4432989690722, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645822, Length=194, Percent_Identity=31.4432989690722, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=32.1052631578947, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=32.1052631578947, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PHEZH (B4R8N8)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130094.1
- ProteinModelPortal:   B4R8N8
- GeneID:   6790754
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1251
- HOGENOM:   HBG630208
- OMA:   FQSILAC
- ProtClustDB:   PRK14532
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20180; Mature: 20180

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILFGPPAAGKGTQAKRLVEQRRMVQLSTGDMLRAAIASGSELGQRVSGIMERGELVS
CCEEEECCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DAIVIELIEQRLPEAEAAGGAIFDGFPRTLAQAEALDAMLAGRGRRIDLVVRLKVDDAAL
HHHHHHHHHHHCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHH
MQRIAGRFAESGRADDNPESFKVRLDAYNRQTAPLLPYYEGQGKLVEVDGMGSIDQVAAA
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEECCCCCEEEECCCCCHHHHHHH
IDAALTGAAA
HHHHHHCCCC
>Mature Secondary Structure
MNLILFGPPAAGKGTQAKRLVEQRRMVQLSTGDMLRAAIASGSELGQRVSGIMERGELVS
CCEEEECCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DAIVIELIEQRLPEAEAAGGAIFDGFPRTLAQAEALDAMLAGRGRRIDLVVRLKVDDAAL
HHHHHHHHHHHCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHH
MQRIAGRFAESGRADDNPESFKVRLDAYNRQTAPLLPYYEGQGKLVEVDGMGSIDQVAAA
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEECCCCCEEEECCCCCHHHHHHH
IDAALTGAAA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA