Click here to switch to the map view.

The map label for this gene is nhoA [H]

Identifier: 197104658

GI number: 197104658

Start: 1369268

End: 1370011

Strand: Direct

Name: nhoA [H]

Synonym: PHZ_c1192

Alternate gene names: 197104658

Gene position: 1369268-1370011 (Clockwise)

Preceding gene: 197104656

Following gene: 197104659

Centisome position: 34.26

GC content: 72.58

Gene sequence:

>744_bases
TTGCACGCGCTGCAGGCGCACCACCTCGCTGCGATCCCGTTCGAGGCCATCGACGTGCTGCTTGGCCGCCACGTCGACAT
CTCGCCGGCGGCGGTCGACGCGAAGCTCATCGCGCGCGGGCGAGGCGGCTACTGCTACGAGCAGAACGGCCTCTTCAAGC
GCGTCCTGACCGCGATCGGCTTCGAGGTGGACGCGCTCGTCGCCAGCGTGCGCTGGCAGGCGCCGGCGGGCGCGCCTCCC
CCGCCTCGCACCCACATGGCGCTGCGGGTCACGGTCGACGGCGCGCCGTGGCTCGTGGATGTGGGCTTCGGCTCCGCCGT
GCCGGCGGCGCCGCTGCGGCTCGACCGCAGAGATCCGCAGTCCGCCGGCGACGGCCGCTACCGGGTGACCCCGCTCGGGG
CCGGCTTCCTTGTGCGAACGGAGGCGGATGGGCAGTGGCTGCCGCTCTACGACGTCTCGCCGGAGCCGTTGCTGGACAGC
CACTACGAGCTGTTCAACTGGTTCACCTCGACCCACCCCTCGTCGCACTTCCGTCGCCAGTTGATCGTCACCAAGGCGAC
GCCGGAGGCGCGCTTCGCCCTGCTGGACTCGAAGCTCACCATCCGGGCGCGGACCGGTGAAGCTGAGCGCCGGCGCCTCG
ATGCGGACGGGATCGCGCACGTGCTGGAGTCGGTGTTCGGTCTCACGCCGGCGCCGGACTGGCGGCCGGTGTTGGCGGCC
GCCGCCGAGCGTGGCGCCTCCTGA

Upstream 100 bases:

>100_bases
GGCGGCGGTCGGCGCCGCGGCGTCGGCCGAGACCCTGGACCTGAAGGCCTACTGCCGGCGCATCGGCTACGGTGGCCCCC
TGGAGCCCACTCTGGAGACC

Downstream 100 bases:

>100_bases
CCAAGGGCGGCGCGAGCCGCCGTTCGCAGGTCGGCTGCTCCCGCCCCAGGTTGCGCCGCCGGCGCCCCGCCATCGCGATG
GAGCGCGGTAATATAACGAC

Product: N-hydroxyarylamine O-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MHALQAHHLAAIPFEAIDVLLGRHVDISPAAVDAKLIARGRGGYCYEQNGLFKRVLTAIGFEVDALVASVRWQAPAGAPP
PPRTHMALRVTVDGAPWLVDVGFGSAVPAAPLRLDRRDPQSAGDGRYRVTPLGAGFLVRTEADGQWLPLYDVSPEPLLDS
HYELFNWFTSTHPSSHFRRQLIVTKATPEARFALLDSKLTIRARTGEAERRRLDADGIAHVLESVFGLTPAPDWRPVLAA
AAERGAS

Sequences:

>Translated_247_residues
MHALQAHHLAAIPFEAIDVLLGRHVDISPAAVDAKLIARGRGGYCYEQNGLFKRVLTAIGFEVDALVASVRWQAPAGAPP
PPRTHMALRVTVDGAPWLVDVGFGSAVPAAPLRLDRRDPQSAGDGRYRVTPLGAGFLVRTEADGQWLPLYDVSPEPLLDS
HYELFNWFTSTHPSSHFRRQLIVTKATPEARFALLDSKLTIRARTGEAERRRLDADGIAHVLESVFGLTPAPDWRPVLAA
AAERGAS
>Mature_247_residues
MHALQAHHLAAIPFEAIDVLLGRHVDISPAAVDAKLIARGRGGYCYEQNGLFKRVLTAIGFEVDALVASVRWQAPAGAPP
PPRTHMALRVTVDGAPWLVDVGFGSAVPAAPLRLDRRDPQSAGDGRYRVTPLGAGFLVRTEADGQWLPLYDVSPEPLLDS
HYELFNWFTSTHPSSHFRRQLIVTKATPEARFALLDSKLTIRARTGEAERRRLDADGIAHVLESVFGLTPAPDWRPVLAA
AAERGAS

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649126, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649124, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649122, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649119, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI42741671, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649009, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649132, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI237649130, Length=247, Percent_Identity=27.1255060728745, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1787736, Length=230, Percent_Identity=33.4782608695652, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 26888; Mature: 26888

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHALQAHHLAAIPFEAIDVLLGRHVDISPAAVDAKLIARGRGGYCYEQNGLFKRVLTAIG
CCCCCCCCEEECCHHHHHHHHCCCCCCCHHHHCHHHEECCCCCEEECCCCHHHHHHHHHC
FEVDALVASVRWQAPAGAPPPPRTHMALRVTVDGAPWLVDVGFGSAVPAAPLRLDRRDPQ
CHHHHHHHHHEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCEEECCCCCC
SAGDGRYRVTPLGAGFLVRTEADGQWLPLYDVSPEPLLDSHYELFNWFTSTHPSSHFRRQ
CCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHEE
LIVTKATPEARFALLDSKLTIRARTGEAERRRLDADGIAHVLESVFGLTPAPDWRPVLAA
EEEEECCCCCEEEEECCEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHH
AAERGAS
HHHCCCC
>Mature Secondary Structure
MHALQAHHLAAIPFEAIDVLLGRHVDISPAAVDAKLIARGRGGYCYEQNGLFKRVLTAIG
CCCCCCCCEEECCHHHHHHHHCCCCCCCHHHHCHHHEECCCCCEEECCCCHHHHHHHHHC
FEVDALVASVRWQAPAGAPPPPRTHMALRVTVDGAPWLVDVGFGSAVPAAPLRLDRRDPQ
CHHHHHHHHHEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCEEECCCCCC
SAGDGRYRVTPLGAGFLVRTEADGQWLPLYDVSPEPLLDSHYELFNWFTSTHPSSHFRRQ
CCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHEE
LIVTKATPEARFALLDSKLTIRARTGEAERRRLDADGIAHVLESVFGLTPAPDWRPVLAA
EEEEECCCCCEEEEECCEEEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHH
AAERGAS
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]