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The map label for this gene is luxQ [H]

Identifier: 197104629

GI number: 197104629

Start: 1335366

End: 1337774

Strand: Direct

Name: luxQ [H]

Synonym: PHZ_c1163

Alternate gene names: 197104629

Gene position: 1335366-1337774 (Clockwise)

Preceding gene: 197104628

Following gene: 197104632

Centisome position: 33.42

GC content: 72.48

Gene sequence:

>2409_bases
ATGAAGCGCAAGGCGCGGACCGTCGCGGGCAGACCGCCCGGCCTGGAGCAGTCCGGGCCGGTGTTCGATCGCGCGACCCG
CCTCCTGCGCACGCTCTTCGGCGGCGACGTCGAGGCCCAGATCACCCTCGTCGAGGGCGAGGGGGAGGGCGTGTGGCACA
GCCGCGGGGGCGGAACTCCCAGCGCCGCCCAGGCCGCCGGCGTGCGCGAATTGATGCGAACCGGCGCGCCCGTCTGGTCC
GAGGACTGCCGCGAGGATCCGCGTTTCCTGGACGACGCCTCGGTGGTGGGGCCGCCCTACGTCCGCTTCTTCGCCGCCGC
GCCGATCCGGCTCGAGGACGGCTCCACCCCCGGCGCGCTCTGGGTGGGCGGCCTGGAGCCGCGGCCGTACGACCGGGTGC
TGGCGGCCCGCCTCCAGGACCTGGCCGACACCGTCGCCGACGAGTGGGCCCGGCTCCGGGAGACCGATGCCCGTCGCACC
TACGAGAAGACGCTGAACGCCATCATTGAGGCGCTGCCGATCTCGTTGGTGCTGACCGACCGCGAGATGCGCGTGCTCTA
CGCCAGCCCGCCCTGGATCACCGGGCGGGGGCTGGCCGGCCGGCAGGTGACCGGCAAGACGCTCTACGAGCTGCGGCCGG
ACATGTTCGAGCAGTGGCGCGAGGGGCTGGAGGCGGCCGTCGCCGCCGGAACCGGCTACAAGCTCGACCGGCGCGCGCTG
CCGGGGCCGGACGGCTCTGTCGAATGGGTGAAGTTCGAGGTCACGCCCTGGCGCGACACCGAAGGCCAGGTCGGCGGACT
GATCCTGGCCTCGTACGACATCACCGAAATGGTCGAGGCGCTGGAGCGGACCGAACGCTCCGAGGAGCGGCTGCGGATCG
CGATGCAGATCGCCGACCTGCACGTCTACGAACTGGACTATGTGCGGCGCGAGCTGACCAAGGTCGGCGCCGAGGACACG
TTCTTCGACCGACCGCGAACGTACGCCGACCTCGCAGCCAACATCTGGAACGCGATCGATCCGCGGGATGTCGCGAAGGT
CCAGGCTGCGTGGAAAGCGCATGTCCGGGACGGGGCGCCCTACTATCCCGAGTATCGGCTGCGGCGCGGCGACGGCAGGG
AGGTCTGGGCGGCCGGCACGGCGCGCCTCACCACCGGCGAGGACGGCCGGCCCCTGCGCCTGGTGGGCGCCATGCAGAAC
GTCACGGTGCGAAAGGCCCAGGAGCGGGCGCTGGTCCGCGCCAAGGAGGAGGCCGAGGCCGCCAACCGCGCCAAGAGCGC
CTTCCTGGCCACCATGAGCCACGAGATCCGCACGCCGCTGAACGGCGTGCTGGGCATGGCGCAGGCCATGGCCATGGACG
AGCTGTCGCCCGCCCAGCGCGAGCGCCTCGACGTGATCCGCCAGTCGGGCGAGAGCCTGCTGGCCATCCTCAACGACGTG
CTGGACCTGTCCAAGATCGAGGCCGGCAAGCTCGACCTGGAGGAAGCCGAGTTCGACGTCGAGGAGCTGGTTCGGACCGT
CCACGCGACCTTCGCCGCCGTGGCGGAGGCGAAGGGGCTCGGCTTCGAGATCGCCGTCGCCCGCAACGCCCGCGGACTCT
ACCGGGGCGATCCGATCCGTGTGCGGCAGATCCTCTGGAACCTCGTCTCCAACGGCCTGAAGTTCACCGACCGCGGCGCG
GTGGAGGTGCGGGTGCGGCGCGCGCAGGGCCTGCTGGCCTTCGAGGTGCGCGACACCGGCATCGGCATCGCGCCCGAACA
GCTCGCCAACCTGTTCCGCAAGTTCGAGCAGGCCGACGCCTCGACCACGCGCCGGTTCGGCGGCACGGGCCTTGGCCTGG
CCATCTGCCGCGAGCTGGCGGGCCTGATGGGGGGCGAGATCGCCGCCGAGAGCGCCCGCGGGCAGGGGGCGAGGTTCACC
GTCAGCCTGCCGCTGGAGAAGGTCCGCCGCCGCGCCGTGAAGGCGAAGCGGGCGCCCGCCGAGCGCACCCCCGCCGAGCC
GGACCGTCCCCTGCGCATCCTCGCCGCCGAGGACAACGCCATGAACCAGCTGGTGCTCAAGACCCTGCTGGCCCAGGTCG
GCGTGGATCCGGTGATCGTGCCCGACGGGCGCGAGGCGGTGGCCGCCTGGGAGCAGGGCGACTGGGACGTGATCCTGATG
GACGTGCAGATGCCGGTGATGGACGGCCCCACCGCCACGGCCATGATCCGCACGCGCGAGCTGTCGCTGGGGCGGCCCCG
GACGCCGATCGTGGCGCTGACCGCCAACGCCATGGCCCACCAGGTGGCCGAGTACCTGGACGTCGGCATGGACGGCTACG
TCGCCAAGCCGATCGAAGCCGCGCGCCTCTACGAGGCCCTGCAGGCGGCGCTGGAGCGGTCCGAGGCGGCGCGCTCGGCG
GCCGCCTAG

Upstream 100 bases:

>100_bases
TGCACCACCTGACCGCAAAGGGTGCGGCCTAAAGCCAAGTTTAACCTCGCGGTGCGATCCTAGACCGTCGCGGCGCATGT
CTGCCGTGGGCGGGAGGAAC

Downstream 100 bases:

>100_bases
CGGCTCAGGCGGCCGCCATCTGGGGTTCGCCGAATTCGAAGGCCGAGATCACCACGTCCATGACGGTGTCGCGGAACACG
GCGCGCGCAGGCTCGCCCTC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MKRKARTVAGRPPGLEQSGPVFDRATRLLRTLFGGDVEAQITLVEGEGEGVWHSRGGGTPSAAQAAGVRELMRTGAPVWS
EDCREDPRFLDDASVVGPPYVRFFAAAPIRLEDGSTPGALWVGGLEPRPYDRVLAARLQDLADTVADEWARLRETDARRT
YEKTLNAIIEALPISLVLTDREMRVLYASPPWITGRGLAGRQVTGKTLYELRPDMFEQWREGLEAAVAAGTGYKLDRRAL
PGPDGSVEWVKFEVTPWRDTEGQVGGLILASYDITEMVEALERTERSEERLRIAMQIADLHVYELDYVRRELTKVGAEDT
FFDRPRTYADLAANIWNAIDPRDVAKVQAAWKAHVRDGAPYYPEYRLRRGDGREVWAAGTARLTTGEDGRPLRLVGAMQN
VTVRKAQERALVRAKEEAEAANRAKSAFLATMSHEIRTPLNGVLGMAQAMAMDELSPAQRERLDVIRQSGESLLAILNDV
LDLSKIEAGKLDLEEAEFDVEELVRTVHATFAAVAEAKGLGFEIAVARNARGLYRGDPIRVRQILWNLVSNGLKFTDRGA
VEVRVRRAQGLLAFEVRDTGIGIAPEQLANLFRKFEQADASTTRRFGGTGLGLAICRELAGLMGGEIAAESARGQGARFT
VSLPLEKVRRRAVKAKRAPAERTPAEPDRPLRILAAEDNAMNQLVLKTLLAQVGVDPVIVPDGREAVAAWEQGDWDVILM
DVQMPVMDGPTATAMIRTRELSLGRPRTPIVALTANAMAHQVAEYLDVGMDGYVAKPIEAARLYEALQAALERSEAARSA
AA

Sequences:

>Translated_802_residues
MKRKARTVAGRPPGLEQSGPVFDRATRLLRTLFGGDVEAQITLVEGEGEGVWHSRGGGTPSAAQAAGVRELMRTGAPVWS
EDCREDPRFLDDASVVGPPYVRFFAAAPIRLEDGSTPGALWVGGLEPRPYDRVLAARLQDLADTVADEWARLRETDARRT
YEKTLNAIIEALPISLVLTDREMRVLYASPPWITGRGLAGRQVTGKTLYELRPDMFEQWREGLEAAVAAGTGYKLDRRAL
PGPDGSVEWVKFEVTPWRDTEGQVGGLILASYDITEMVEALERTERSEERLRIAMQIADLHVYELDYVRRELTKVGAEDT
FFDRPRTYADLAANIWNAIDPRDVAKVQAAWKAHVRDGAPYYPEYRLRRGDGREVWAAGTARLTTGEDGRPLRLVGAMQN
VTVRKAQERALVRAKEEAEAANRAKSAFLATMSHEIRTPLNGVLGMAQAMAMDELSPAQRERLDVIRQSGESLLAILNDV
LDLSKIEAGKLDLEEAEFDVEELVRTVHATFAAVAEAKGLGFEIAVARNARGLYRGDPIRVRQILWNLVSNGLKFTDRGA
VEVRVRRAQGLLAFEVRDTGIGIAPEQLANLFRKFEQADASTTRRFGGTGLGLAICRELAGLMGGEIAAESARGQGARFT
VSLPLEKVRRRAVKAKRAPAERTPAEPDRPLRILAAEDNAMNQLVLKTLLAQVGVDPVIVPDGREAVAAWEQGDWDVILM
DVQMPVMDGPTATAMIRTRELSLGRPRTPIVALTANAMAHQVAEYLDVGMDGYVAKPIEAARLYEALQAALERSEAARSA
AA
>Mature_802_residues
MKRKARTVAGRPPGLEQSGPVFDRATRLLRTLFGGDVEAQITLVEGEGEGVWHSRGGGTPSAAQAAGVRELMRTGAPVWS
EDCREDPRFLDDASVVGPPYVRFFAAAPIRLEDGSTPGALWVGGLEPRPYDRVLAARLQDLADTVADEWARLRETDARRT
YEKTLNAIIEALPISLVLTDREMRVLYASPPWITGRGLAGRQVTGKTLYELRPDMFEQWREGLEAAVAAGTGYKLDRRAL
PGPDGSVEWVKFEVTPWRDTEGQVGGLILASYDITEMVEALERTERSEERLRIAMQIADLHVYELDYVRRELTKVGAEDT
FFDRPRTYADLAANIWNAIDPRDVAKVQAAWKAHVRDGAPYYPEYRLRRGDGREVWAAGTARLTTGEDGRPLRLVGAMQN
VTVRKAQERALVRAKEEAEAANRAKSAFLATMSHEIRTPLNGVLGMAQAMAMDELSPAQRERLDVIRQSGESLLAILNDV
LDLSKIEAGKLDLEEAEFDVEELVRTVHATFAAVAEAKGLGFEIAVARNARGLYRGDPIRVRQILWNLVSNGLKFTDRGA
VEVRVRRAQGLLAFEVRDTGIGIAPEQLANLFRKFEQADASTTRRFGGTGLGLAICRELAGLMGGEIAAESARGQGARFT
VSLPLEKVRRRAVKAKRAPAERTPAEPDRPLRILAAEDNAMNQLVLKTLLAQVGVDPVIVPDGREAVAAWEQGDWDVILM
DVQMPVMDGPTATAMIRTRELSLGRPRTPIVALTANAMAHQVAEYLDVGMDGYVAKPIEAARLYEALQAALERSEAARSA
AA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=400, Percent_Identity=35.25, Blast_Score=223, Evalue=5e-59,
Organism=Escherichia coli, GI1788713, Length=386, Percent_Identity=34.9740932642487, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=42.8571428571429, Blast_Score=196, Evalue=6e-51,
Organism=Escherichia coli, GI87081816, Length=387, Percent_Identity=35.4005167958656, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=37.8486055776892, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1786600, Length=275, Percent_Identity=31.2727272727273, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=28.3898305084746, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=258, Percent_Identity=29.0697674418605, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=28.9915966386555, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=25.8555133079848, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=91, Percent_Identity=41.7582417582418, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322000, Length=117, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88132; Mature: 88132

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKARTVAGRPPGLEQSGPVFDRATRLLRTLFGGDVEAQITLVEGEGEGVWHSRGGGTP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCC
SAAQAAGVRELMRTGAPVWSEDCREDPRFLDDASVVGPPYVRFFAAAPIRLEDGSTPGAL
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCEE
WVGGLEPRPYDRVLAARLQDLADTVADEWARLRETDARRTYEKTLNAIIEALPISLVLTD
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
REMRVLYASPPWITGRGLAGRQVTGKTLYELRPDMFEQWREGLEAAVAAGTGYKLDRRAL
CCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCC
PGPDGSVEWVKFEVTPWRDTEGQVGGLILASYDITEMVEALERTERSEERLRIAMQIADL
CCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVYELDYVRRELTKVGAEDTFFDRPRTYADLAANIWNAIDPRDVAKVQAAWKAHVRDGAP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
YYPEYRLRRGDGREVWAAGTARLTTGEDGRPLRLVGAMQNVTVRKAQERALVRAKEEAEA
CCCCHHEECCCCCEEEECCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ANRAKSAFLATMSHEIRTPLNGVLGMAQAMAMDELSPAQRERLDVIRQSGESLLAILNDV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
LDLSKIEAGKLDLEEAEFDVEELVRTVHATFAAVAEAKGLGFEIAVARNARGLYRGDPIR
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
VRQILWNLVSNGLKFTDRGAVEVRVRRAQGLLAFEVRDTGIGIAPEQLANLFRKFEQADA
HHHHHHHHHHCCCEECCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCH
STTRRFGGTGLGLAICRELAGLMGGEIAAESARGQGARFTVSLPLEKVRRRAVKAKRAPA
HHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCC
ERTPAEPDRPLRILAAEDNAMNQLVLKTLLAQVGVDPVIVPDGREAVAAWEQGDWDVILM
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCEEEE
DVQMPVMDGPTATAMIRTRELSLGRPRTPIVALTANAMAHQVAEYLDVGMDGYVAKPIEA
EEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHH
ARLYEALQAALERSEAARSAAA
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRKARTVAGRPPGLEQSGPVFDRATRLLRTLFGGDVEAQITLVEGEGEGVWHSRGGGTP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCCC
SAAQAAGVRELMRTGAPVWSEDCREDPRFLDDASVVGPPYVRFFAAAPIRLEDGSTPGAL
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCEE
WVGGLEPRPYDRVLAARLQDLADTVADEWARLRETDARRTYEKTLNAIIEALPISLVLTD
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEC
REMRVLYASPPWITGRGLAGRQVTGKTLYELRPDMFEQWREGLEAAVAAGTGYKLDRRAL
CCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCC
PGPDGSVEWVKFEVTPWRDTEGQVGGLILASYDITEMVEALERTERSEERLRIAMQIADL
CCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVYELDYVRRELTKVGAEDTFFDRPRTYADLAANIWNAIDPRDVAKVQAAWKAHVRDGAP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
YYPEYRLRRGDGREVWAAGTARLTTGEDGRPLRLVGAMQNVTVRKAQERALVRAKEEAEA
CCCCHHEECCCCCEEEECCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ANRAKSAFLATMSHEIRTPLNGVLGMAQAMAMDELSPAQRERLDVIRQSGESLLAILNDV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHH
LDLSKIEAGKLDLEEAEFDVEELVRTVHATFAAVAEAKGLGFEIAVARNARGLYRGDPIR
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHH
VRQILWNLVSNGLKFTDRGAVEVRVRRAQGLLAFEVRDTGIGIAPEQLANLFRKFEQADA
HHHHHHHHHHCCCEECCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCH
STTRRFGGTGLGLAICRELAGLMGGEIAAESARGQGARFTVSLPLEKVRRRAVKAKRAPA
HHHHHCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCC
ERTPAEPDRPLRILAAEDNAMNQLVLKTLLAQVGVDPVIVPDGREAVAAWEQGDWDVILM
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCCEEEE
DVQMPVMDGPTATAMIRTRELSLGRPRTPIVALTANAMAHQVAEYLDVGMDGYVAKPIEA
EEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHH
ARLYEALQAALERSEAARSAAA
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]