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The map label for this gene is fdh [H]

Identifier: 197104524

GI number: 197104524

Start: 1192798

End: 1193973

Strand: Reverse

Name: fdh [H]

Synonym: PHZ_c1058

Alternate gene names: 197104524

Gene position: 1193973-1192798 (Counterclockwise)

Preceding gene: 197104525

Following gene: 197104523

Centisome position: 29.88

GC content: 69.22

Gene sequence:

>1176_bases
ATGAAAGCCATCTGCTGGCAAGGCAAGAAGGACCTCCGCTGCGAGGAGGTGCCCGATCCGGTCATCGAGGATCCGAAGGA
CGCGATCATCCGCGTCACCTCGACCTGCATCTGCGGCTCGGACCTGCACCTGATGAACGGCTTCGTGCCGACCATGTGCA
AGGGCGACGTAATGGGCCACGAGCCCATGGGCGAGGTCGTCGAGGTAGGCGCCGAGGCCCGCGCCGCCGGCCTCAACGTG
GGCGACCGGGTGGTGGTCCCCTTCCAGATGATCTGCGGCCAGTGCGAGCAGTGCCGGGCCGGCAACTTTTCGGTCTGCCA
GGTCACCAACCGCAACGCCGACCTCGCCAAGGCCTTCTTCGGCGACACCACCGCGGGCCTGTTCGGCTACTCGCACATCA
CCGGCGGCTACGCCGGCGGCCAGGCCGAGTACATGCGCGTGCCGTTCGCCGCCACGACGGTCATCAAGGTCCCCAAGACC
GGCGCCGACGAGAAGTACGTCTTCCTCTCCGACATCCTGCCCACCGGCTGGCAGGCGGCGGCCTTCGCCGACATCCAGCC
CACCGACACGGTCGCCGTCTGGGGCTGCGGGCCCGTGGGCCTCTTCACCGTCCTGTCGGCGATCGCCATGGGCGCCGAGC
GGGTCATCGCCATCGACGACGTGCCCGAGCGGCTGGAGATGGCCGCCACCCTGGGCGCCCAGGTGCTGGACCGGCGCGGG
ACCAACGTCATCCAGGCGCTGAAGGACATGACCGGCGGCCACGGCCCCGAGAAGTGCATCGACGCCGTGGGCATCGAGGC
GCACGGCCCCACCGCCGTGCTCGAGCTGATCGACCGCGTGCAGACCGCCCTCAAGCTCGAGACCGAGCGGCCGATCGCCC
TGCGCGAGGCGATCATGGCCTGCAAGTCGGCCGGCACGGTCTCGATCCCCGGCGTCTACGGCGGGATGTCCAACTCCATC
CCCATGGGCGCGGCCATGAACAAGGGCCTGACCATCCGCACCGGCCAGACCCACGTGAAGCGCTGGGCCGACGACCTGCT
GCGGCGGATCGACGAGGGCGAAATCGACCCCACCTTCCTGATCACCCACACCGCCCCGCTCGGCCAGGCGCCCGAGCTCT
ACAAGCTGTTCCGCGACAAGCAGGACGGCTGCGTGAAGGTGGTGCTGAAGCCGTAG

Upstream 100 bases:

>100_bases
TCGCCATGGGGGTCGTGCTCGCCGTCACCGCCCTCGACGTGCTCGCCGCCGTGCGCATGAGCACCGTCAAGCGCACCTGC
GACTGAAGGAGGACACCGCG

Downstream 100 bases:

>100_bases
GCCGCCGCTCCGCCCGGGACGTCATTTGACGCCCCGGGCAACGATGGGCCCGGTCCGCCGGTTACCTTCCCAGGAATAGG
AGACTGCGCATGAAGTGGCT

Product: glutathione-dependent formaldehyde dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKAICWQGKKDLRCEEVPDPVIEDPKDAIIRVTSTCICGSDLHLMNGFVPTMCKGDVMGHEPMGEVVEVGAEARAAGLNV
GDRVVVPFQMICGQCEQCRAGNFSVCQVTNRNADLAKAFFGDTTAGLFGYSHITGGYAGGQAEYMRVPFAATTVIKVPKT
GADEKYVFLSDILPTGWQAAAFADIQPTDTVAVWGCGPVGLFTVLSAIAMGAERVIAIDDVPERLEMAATLGAQVLDRRG
TNVIQALKDMTGGHGPEKCIDAVGIEAHGPTAVLELIDRVQTALKLETERPIALREAIMACKSAGTVSIPGVYGGMSNSI
PMGAAMNKGLTIRTGQTHVKRWADDLLRRIDEGEIDPTFLITHTAPLGQAPELYKLFRDKQDGCVKVVLKP

Sequences:

>Translated_391_residues
MKAICWQGKKDLRCEEVPDPVIEDPKDAIIRVTSTCICGSDLHLMNGFVPTMCKGDVMGHEPMGEVVEVGAEARAAGLNV
GDRVVVPFQMICGQCEQCRAGNFSVCQVTNRNADLAKAFFGDTTAGLFGYSHITGGYAGGQAEYMRVPFAATTVIKVPKT
GADEKYVFLSDILPTGWQAAAFADIQPTDTVAVWGCGPVGLFTVLSAIAMGAERVIAIDDVPERLEMAATLGAQVLDRRG
TNVIQALKDMTGGHGPEKCIDAVGIEAHGPTAVLELIDRVQTALKLETERPIALREAIMACKSAGTVSIPGVYGGMSNSI
PMGAAMNKGLTIRTGQTHVKRWADDLLRRIDEGEIDPTFLITHTAPLGQAPELYKLFRDKQDGCVKVVLKP
>Mature_391_residues
MKAICWQGKKDLRCEEVPDPVIEDPKDAIIRVTSTCICGSDLHLMNGFVPTMCKGDVMGHEPMGEVVEVGAEARAAGLNV
GDRVVVPFQMICGQCEQCRAGNFSVCQVTNRNADLAKAFFGDTTAGLFGYSHITGGYAGGQAEYMRVPFAATTVIKVPKT
GADEKYVFLSDILPTGWQAAAFADIQPTDTVAVWGCGPVGLFTVLSAIAMGAERVIAIDDVPERLEMAATLGAQVLDRRG
TNVIQALKDMTGGHGPEKCIDAVGIEAHGPTAVLELIDRVQTALKLETERPIALREAIMACKSAGTVSIPGVYGGMSNSI
PMGAAMNKGLTIRTGQTHVKRWADDLLRRIDEGEIDPTFLITHTAPLGQAPELYKLFRDKQDGCVKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501939, Length=268, Percent_Identity=28.7313432835821, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI156523966, Length=396, Percent_Identity=26.010101010101, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71565154, Length=234, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71743840, Length=399, Percent_Identity=25.31328320802, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073058, Length=392, Percent_Identity=23.7244897959184, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786825, Length=403, Percent_Identity=43.9205955334988, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1787863, Length=396, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082125, Length=230, Percent_Identity=31.304347826087, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI226510992, Length=375, Percent_Identity=27.2, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790045, Length=397, Percent_Identity=26.1964735516373, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=225, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786552, Length=208, Percent_Identity=29.8076923076923, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788075, Length=404, Percent_Identity=25.7425742574257, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=355, Percent_Identity=23.6619718309859, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=28.82096069869, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788407, Length=301, Percent_Identity=25.9136212624585, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=281, Percent_Identity=28.1138790035587, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=239, Percent_Identity=29.7071129707113, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=241, Percent_Identity=29.4605809128631, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=209, Percent_Identity=28.2296650717703, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=311, Percent_Identity=27.3311897106109, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=417, Percent_Identity=25.4196642685851, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=299, Percent_Identity=25.4180602006689, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=396, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17137530, Length=396, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737895, Length=403, Percent_Identity=25.5583126550869, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 41792; Mature: 41792

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAICWQGKKDLRCEEVPDPVIEDPKDAIIRVTSTCICGSDLHLMNGFVPTMCKGDVMGH
CCCCCCCCCCCCCHHCCCCCCCCCCHHHHEEEHHHEECCCCHHHHCCCCCCCCCCCCCCC
EPMGEVVEVGAEARAAGLNVGDRVVVPFQMICGQCEQCRAGNFSVCQVTNRNADLAKAFF
CCHHHHHHHCCHHHHCCCCCCCEEEEEHHHHCCCHHHCCCCCEEEEEEECCCCHHHHHHH
GDTTAGLFGYSHITGGYAGGQAEYMRVPFAATTVIKVPKTGADEKYVFLSDILPTGWQAA
CCCHHHHHHHHHHCCCCCCCCCCEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCE
AFADIQPTDTVAVWGCGPVGLFTVLSAIAMGAERVIAIDDVPERLEMAATLGAQVLDRRG
EEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
TNVIQALKDMTGGHGPEKCIDAVGIEAHGPTAVLELIDRVQTALKLETERPIALREAIMA
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
CKSAGTVSIPGVYGGMSNSIPMGAAMNKGLTIRTGQTHVKRWADDLLRRIDEGEIDPTFL
HHCCCCEECCCCCCCCCCCCCCCHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCEEE
ITHTAPLGQAPELYKLFRDKQDGCVKVVLKP
EEECCCCCCCHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAICWQGKKDLRCEEVPDPVIEDPKDAIIRVTSTCICGSDLHLMNGFVPTMCKGDVMGH
CCCCCCCCCCCCCHHCCCCCCCCCCHHHHEEEHHHEECCCCHHHHCCCCCCCCCCCCCCC
EPMGEVVEVGAEARAAGLNVGDRVVVPFQMICGQCEQCRAGNFSVCQVTNRNADLAKAFF
CCHHHHHHHCCHHHHCCCCCCCEEEEEHHHHCCCHHHCCCCCEEEEEEECCCCHHHHHHH
GDTTAGLFGYSHITGGYAGGQAEYMRVPFAATTVIKVPKTGADEKYVFLSDILPTGWQAA
CCCHHHHHHHHHHCCCCCCCCCCEEECCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCE
AFADIQPTDTVAVWGCGPVGLFTVLSAIAMGAERVIAIDDVPERLEMAATLGAQVLDRRG
EEECCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
TNVIQALKDMTGGHGPEKCIDAVGIEAHGPTAVLELIDRVQTALKLETERPIALREAIMA
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
CKSAGTVSIPGVYGGMSNSIPMGAAMNKGLTIRTGQTHVKRWADDLLRRIDEGEIDPTFL
HHCCCCEECCCCCCCCCCCCCCCHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCEEE
ITHTAPLGQAPELYKLFRDKQDGCVKVVLKP
EEECCCCCCCHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]