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The map label for this gene is copA [H]

Identifier: 197104518

GI number: 197104518

Start: 1184924

End: 1186756

Strand: Reverse

Name: copA [H]

Synonym: PHZ_c1052

Alternate gene names: 197104518

Gene position: 1186756-1184924 (Counterclockwise)

Preceding gene: 197104520

Following gene: 197104517

Centisome position: 29.7

GC content: 72.39

Gene sequence:

>1833_bases
ATGCGAGCCCGCGCGAGCGACCTCGATAGACGCAAGCTCCTGAAAGGGGCGGCCGCCCTCGGCGGCGGGGCGGCCCTTGC
GGGCCTCCTGCCCGGCTGGGCGCAGAGCGCCGCGGCCGGCCTGCCGGCCCTCACCGGCGAGGACATCCGCCTGACCGCCG
GCCACTTCCCGCACCGGGTCGAGGGCCGCGTCGGCCACGCCGTGGGCATCAACGGCACGGTGCCGGCCCCGCTGATCCGG
CTGAAGGAAGGCCAGAACGTCCGGCTGCACCTGACCAACAACCTGGCCGAGGACACCTCGATCCACTGGCACGGCCTGCT
GCTGCCGTTCGAGATGGACGGCGTGCCGGGCGTCGCCTTCCCCGGCGTGCGGCCGGGCGAGACCTTCACCTACGAGTTCC
CGGTCATCCAGAGCGGCACCTACTGGTACCACAGCCACTCGGGCCTCCAGGAGCCGATGGGCCACTACGGCCCGATCATC
ATCGATCCGGCCGGCCCCGACCCCGTCGCCTACGACCGCGAGCACGTGGTGGTCCTCTCGGACTTCAGCTTCGTCCATCC
GCACACGATCTTCCGCCGGATGAAGGCCCAGGGCGGGGTGTTCAACTTCCAGAAGCAGACCGTGGCGGGTCTGCTCGCCG
GCCGCGACCAGACCCTGGCCGAGCGGCTGGAGTGGGCGAAGATGCGGATGGATCCCACCGACATCTCCGACGTCACCGGC
GCGGTCTACACCTACCTGATCAACGGCCACGGCCCGGCCGACAACTGGACCGCCCTCTTCCGCCCGGGCGAGCGGGTGCG
CCTGCGGTTCATCAACGCCGCGGCCCAGACCATCTTCAACGTCCGCATCCCGGGCCTGAAGCTGACCATCGTGGCCGCCG
ACGGCCAGGACGTGCGCCCCGTCGCGGTGGACGAGTTCCAGATCGGCAACGCCGAGACCTACGACGTGATCGTCACGCCC
GCCGACGACCGCGCCTTCGCCCTGGTGGCCGAGGCGGTGGACCGCTCGGGCATGGCCCTGGCCACCCTCGCCCCCCGGGC
GGGCATGCGCGCCGAGGCCCCGCCCCTGCGCGAACGCCCCCTCGGGACGATGAAGGACATGGGCATGGACATGTCGGCCC
ACGGCGGCGGGCACGGCGCAGGCCATGCCGCCCCGGCCGCCGCCGATCCGCACGCCGGCCACGGCTCCGGCGGACACGCC
GGCCACGCCATGGCCGCCGCCGCCGCTCCGGTCCCCGGCATGGCCCCGCCCCGCGTCCGCGGCTCGGACGTCATGGGGCA
CGAGATGGACATGCTCGACTTCTCCAAGGCGCCCCAGGTCGAGCCCGGCCCCGGCGTGCAGTCGATCGCGCCCATGCCCC
AGGACCGCACCGGCGAGCCCGGCCAGGGCCTGGAGAGCGTCGGCCACCGCGTGCTCGTCTACACCGACCTCGAGGCGCTG
CACCCGAACCCGGACACCCGCCCGCCGGAGCGCGCGCTGGAGATCCGGCTCACCGGCAACATGGAGCGGTTCATGTGGGG
CTTCGACGGGAAGAAGTATTCCGACGGCCCGCCGCCCTACACCTTCCGGACCGGGGAGCGCGTCCGGGTCACCCTGGTGA
ACGACACCATGATGACCCACCCGATCCACCTGCACGGCCACTTCTTCGAGCTGGTCCACGCGCCCGTCGGCCGCCTGCCG
CGCAAGCACACGGTCAACGTCGCCCCCGGCGGCAAGGTGACCTTCGACTTCACCGCCGAGGCGGGCGACTGGGCCTTCCA
CTGCCACATGATGTTCCACATGCACGCCGGGATGTTCCAGGTGTTCGCCGTCCGCGACGGAGCCGCCGCATGA

Upstream 100 bases:

>100_bases
CCCAGCACCTGCAGGCCGACCACCAGGGCCAGCCACTTATGGATCTGGGTCGACCAACGAAGCATCCGATTCCCCCCGTT
CACTGACCAGGACATTACCC

Downstream 100 bases:

>100_bases
TCCGCCCCGCCCTCCTCGCGCTCGTGCCCGCGGCCCTCGCCGCCCCGGCCCTCGCTCAGGACCCGCACGCCCACCACCAC
CCGGCGCCCGCCGCCGAGGC

Product: copper-resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MRARASDLDRRKLLKGAAALGGGAALAGLLPGWAQSAAAGLPALTGEDIRLTAGHFPHRVEGRVGHAVGINGTVPAPLIR
LKEGQNVRLHLTNNLAEDTSIHWHGLLLPFEMDGVPGVAFPGVRPGETFTYEFPVIQSGTYWYHSHSGLQEPMGHYGPII
IDPAGPDPVAYDREHVVVLSDFSFVHPHTIFRRMKAQGGVFNFQKQTVAGLLAGRDQTLAERLEWAKMRMDPTDISDVTG
AVYTYLINGHGPADNWTALFRPGERVRLRFINAAAQTIFNVRIPGLKLTIVAADGQDVRPVAVDEFQIGNAETYDVIVTP
ADDRAFALVAEAVDRSGMALATLAPRAGMRAEAPPLRERPLGTMKDMGMDMSAHGGGHGAGHAAPAAADPHAGHGSGGHA
GHAMAAAAAPVPGMAPPRVRGSDVMGHEMDMLDFSKAPQVEPGPGVQSIAPMPQDRTGEPGQGLESVGHRVLVYTDLEAL
HPNPDTRPPERALEIRLTGNMERFMWGFDGKKYSDGPPPYTFRTGERVRVTLVNDTMMTHPIHLHGHFFELVHAPVGRLP
RKHTVNVAPGGKVTFDFTAEAGDWAFHCHMMFHMHAGMFQVFAVRDGAAA

Sequences:

>Translated_610_residues
MRARASDLDRRKLLKGAAALGGGAALAGLLPGWAQSAAAGLPALTGEDIRLTAGHFPHRVEGRVGHAVGINGTVPAPLIR
LKEGQNVRLHLTNNLAEDTSIHWHGLLLPFEMDGVPGVAFPGVRPGETFTYEFPVIQSGTYWYHSHSGLQEPMGHYGPII
IDPAGPDPVAYDREHVVVLSDFSFVHPHTIFRRMKAQGGVFNFQKQTVAGLLAGRDQTLAERLEWAKMRMDPTDISDVTG
AVYTYLINGHGPADNWTALFRPGERVRLRFINAAAQTIFNVRIPGLKLTIVAADGQDVRPVAVDEFQIGNAETYDVIVTP
ADDRAFALVAEAVDRSGMALATLAPRAGMRAEAPPLRERPLGTMKDMGMDMSAHGGGHGAGHAAPAAADPHAGHGSGGHA
GHAMAAAAAPVPGMAPPRVRGSDVMGHEMDMLDFSKAPQVEPGPGVQSIAPMPQDRTGEPGQGLESVGHRVLVYTDLEAL
HPNPDTRPPERALEIRLTGNMERFMWGFDGKKYSDGPPPYTFRTGERVRVTLVNDTMMTHPIHLHGHFFELVHAPVGRLP
RKHTVNVAPGGKVTFDFTAEAGDWAFHCHMMFHMHAGMFQVFAVRDGAAA
>Mature_610_residues
MRARASDLDRRKLLKGAAALGGGAALAGLLPGWAQSAAAGLPALTGEDIRLTAGHFPHRVEGRVGHAVGINGTVPAPLIR
LKEGQNVRLHLTNNLAEDTSIHWHGLLLPFEMDGVPGVAFPGVRPGETFTYEFPVIQSGTYWYHSHSGLQEPMGHYGPII
IDPAGPDPVAYDREHVVVLSDFSFVHPHTIFRRMKAQGGVFNFQKQTVAGLLAGRDQTLAERLEWAKMRMDPTDISDVTG
AVYTYLINGHGPADNWTALFRPGERVRLRFINAAAQTIFNVRIPGLKLTIVAADGQDVRPVAVDEFQIGNAETYDVIVTP
ADDRAFALVAEAVDRSGMALATLAPRAGMRAEAPPLRERPLGTMKDMGMDMSAHGGGHGAGHAAPAAADPHAGHGSGGHA
GHAMAAAAAPVPGMAPPRVRGSDVMGHEMDMLDFSKAPQVEPGPGVQSIAPMPQDRTGEPGQGLESVGHRVLVYTDLEAL
HPNPDTRPPERALEIRLTGNMERFMWGFDGKKYSDGPPPYTFRTGERVRVTLVNDTMMTHPIHLHGHFFELVHAPVGRLP
RKHTVNVAPGGKVTFDFTAEAGDWAFHCHMMFHMHAGMFQVFAVRDGAAA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=357, Percent_Identity=26.6106442577031, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321067, Length=275, Percent_Identity=29.4545454545455, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=300, Percent_Identity=24, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=169, Percent_Identity=34.3195266272189, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650186, Length=302, Percent_Identity=25.8278145695364, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18859919, Length=280, Percent_Identity=28.9285714285714, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28574104, Length=323, Percent_Identity=27.8637770897833, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 65650; Mature: 65650

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARASDLDRRKLLKGAAALGGGAALAGLLPGWAQSAAAGLPALTGEDIRLTAGHFPHRV
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCCCCEEEECCCCCCCC
EGRVGHAVGINGTVPAPLIRLKEGQNVRLHLTNNLAEDTSIHWHGLLLPFEMDGVPGVAF
CCCCCEEECCCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCC
PGVRPGETFTYEFPVIQSGTYWYHSHSGLQEPMGHYGPIIIDPAGPDPVAYDREHVVVLS
CCCCCCCEEEEECCEEECCEEEEECCCCCHHHHHCCCCEEECCCCCCCCCCCCCEEEEEE
DFSFVHPHTIFRRMKAQGGVFNFQKQTVAGLLAGRDQTLAERLEWAKMRMDPTDISDVTG
CCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCC
AVYTYLINGHGPADNWTALFRPGERVRLRFINAAAQTIFNVRIPGLKLTIVAADGQDVRP
EEEEEEECCCCCCCCCEEEECCCCEEEEEEEEHHHHEEEEEECCCEEEEEEECCCCCCCC
VAVDEFQIGNAETYDVIVTPADDRAFALVAEAVDRSGMALATLAPRAGMRAEAPPLRERP
EEECEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
LGTMKDMGMDMSAHGGGHGAGHAAPAAADPHAGHGSGGHAGHAMAAAAAPVPGMAPPRVR
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
GSDVMGHEMDMLDFSKAPQVEPGPGVQSIAPMPQDRTGEPGQGLESVGHRVLVYTDLEAL
CCCCCCCCCCHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHCCEEEEEECHHHH
HPNPDTRPPERALEIRLTGNMERFMWGFDGKKYSDGPPPYTFRTGERVRVTLVNDTMMTH
CCCCCCCCCCCEEEEEEECCHHHEEEECCCCCCCCCCCCEEEECCCEEEEEEECCCEEEC
PIHLHGHFFELVHAPVGRLPRKHTVNVAPGGKVTFDFTAEAGDWAFHCHMMFHMHAGMFQ
EEEECHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCEEEEEEEEEHHHCCEEE
VFAVRDGAAA
EEEECCCCCC
>Mature Secondary Structure
MRARASDLDRRKLLKGAAALGGGAALAGLLPGWAQSAAAGLPALTGEDIRLTAGHFPHRV
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCCCCCEEEECCCCCCCC
EGRVGHAVGINGTVPAPLIRLKEGQNVRLHLTNNLAEDTSIHWHGLLLPFEMDGVPGVAF
CCCCCEEECCCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCC
PGVRPGETFTYEFPVIQSGTYWYHSHSGLQEPMGHYGPIIIDPAGPDPVAYDREHVVVLS
CCCCCCCEEEEECCEEECCEEEEECCCCCHHHHHCCCCEEECCCCCCCCCCCCCEEEEEE
DFSFVHPHTIFRRMKAQGGVFNFQKQTVAGLLAGRDQTLAERLEWAKMRMDPTDISDVTG
CCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCC
AVYTYLINGHGPADNWTALFRPGERVRLRFINAAAQTIFNVRIPGLKLTIVAADGQDVRP
EEEEEEECCCCCCCCCEEEECCCCEEEEEEEEHHHHEEEEEECCCEEEEEEECCCCCCCC
VAVDEFQIGNAETYDVIVTPADDRAFALVAEAVDRSGMALATLAPRAGMRAEAPPLRERP
EEECEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
LGTMKDMGMDMSAHGGGHGAGHAAPAAADPHAGHGSGGHAGHAMAAAAAPVPGMAPPRVR
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
GSDVMGHEMDMLDFSKAPQVEPGPGVQSIAPMPQDRTGEPGQGLESVGHRVLVYTDLEAL
CCCCCCCCCCHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHCCEEEEEECHHHH
HPNPDTRPPERALEIRLTGNMERFMWGFDGKKYSDGPPPYTFRTGERVRVTLVNDTMMTH
CCCCCCCCCCCEEEEEEECCHHHEEEECCCCCCCCCCCCEEEECCCEEEEEEECCCEEEC
PIHLHGHFFELVHAPVGRLPRKHTVNVAPGGKVTFDFTAEAGDWAFHCHMMFHMHAGMFQ
EEEECHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCEEEEEEEEEHHHCCEEE
VFAVRDGAAA
EEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]