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The map label for this gene is fumC [H]

Identifier: 197104250

GI number: 197104250

Start: 863589

End: 864980

Strand: Reverse

Name: fumC [H]

Synonym: PHZ_c0784

Alternate gene names: 197104250

Gene position: 864980-863589 (Counterclockwise)

Preceding gene: 197104252

Following gene: 197104249

Centisome position: 21.64

GC content: 67.03

Gene sequence:

>1392_bases
GTGACCGCGACCCGCACCGAGACCGACACCTTCGGCCCGATCGAAGTCCCGTCCGACCGGTACTGGGGCGCGCAGACGCA
GCGCTCGATCGGCAACTTCAGGATCGGGTGGGAGAAGCAGCCGAAGCCGGTGATCCGCGCCCTGGGCGTGGTCAAGCGCG
CCGCCGCCGAGGCCAACATGGAGCTCGGCAAGCTCGATCCCGAGATCGGCAAGCACATCGTCGCCGCCGCCCAGGAGGTC
ATCGACGGCAAGCTGGACGACCATTTCCCGCTGGTGGTCTGGCAGACCGGGTCGGGCACCCAGTCGAACATGAACGCCAA
CGAGGTGATCTCGAACCGGGCCATCGAGATGATGGGCGGGCAGATGGGCTCGAAGAAGCCGGTCCACCCGAACGACCACG
TCAACATGAGCCAGTCGTCGAACGACACCTATCCGACGGCCATGCACATCGCCGCCGCCGAAGAGGTCGCCCGTTCGGTG
ATGCCGGCGCTGGAGCACCTGCACGCGGCGTTGAAGTACAAGGCCGAGGAGTTCGCCCACATCATCAAGATCGGGCGCAC
CCACACCCAGGACGCCACGCCCCTGACGCTGGGCCAGGAGTTCGGCGGCTACGCCCACCAGGTCGCCATGTCGGTGCGGC
GGATCAAGGAGACGCTGTACGGCCTCTACGAGCTGGCCCAGGGCGGCACGGCGGTGGGCACCGGCCTGAACGCCCCGGTG
GGCTTCGCCGAGCTGGTGGCCGAGAAGATCGCGAAGATCACCCACCTGCCGTTCGTCACCGCGCCGAACAAGTTCGAGGC
GCTGGCGGCGCACGACGCCATGGTGTTCAGCCACGGGGCGATCAACACGGCGGCGGCGGCGCTGTTCAAGATCGCCAACG
ACATCCGCTTCCTGGGCTCGGGGCCCCGTTCGGGCCTGGGCGAGCTGGCGCTCCCCGAGAACGAGCCGGGCTCGTCGATC
ATGCCCGGCAAGGTGAACCCCACCCAGGCCGAGGCCCTGACCATGGTCTGCGCCCACATCATGGGCAACCAGACGGCGAT
GACGGTGGCCGGGTCGCAGGGCCACTTCGAGCTGAACGTCTTCAACCCGGTGATGGCCTACAACTTCCTGCAGTCGTGCC
GGCTGATCTCGGACGCGGCGATCAGCTTCACCGACAACATGGTCAAGGGCATCGAGGCCCGCGAGGACAACATCAAGGCC
AACCTCGAGCGCTCGCTGATGCTGGTGACGGCGCTGGCGCCGAAGATCGGCTATGACAACGCCGCCAAGATCGCCAAGCT
GGCGCACAAGAACGGCACCACCCTGCGCGAGGAAGCCGTCGGCGGCGGCTACGTCACGAACGAGGAGTTCGACGAGGTCG
TCCGGCCTGAAAAAATGATCAGCCCGGGTTGA

Upstream 100 bases:

>100_bases
GGGGTCTCGGTCATTCCCGCCTGTCTAGCCCCAAGGGCGTCTTGCAGTCTCGGCCCACGTCGCTAAACCGGCCCGGCCAA
GACGTGAGGAGTGACTGCCC

Downstream 100 bases:

>100_bases
TCGGATGGCGCCCCGGCACCTCGAGCGGCACCAGATCGCCCGCATCGGCTGGCTGCGGGCGGCCGTGCTGGGCGCCAACG
ACGGCATCGTCTCCACAGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTATRTETDTFGPIEVPSDRYWGAQTQRSIGNFRIGWEKQPKPVIRALGVVKRAAAEANMELGKLDPEIGKHIVAAAQEV
IDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMMGGQMGSKKPVHPNDHVNMSQSSNDTYPTAMHIAAAEEVARSV
MPALEHLHAALKYKAEEFAHIIKIGRTHTQDATPLTLGQEFGGYAHQVAMSVRRIKETLYGLYELAQGGTAVGTGLNAPV
GFAELVAEKIAKITHLPFVTAPNKFEALAAHDAMVFSHGAINTAAAALFKIANDIRFLGSGPRSGLGELALPENEPGSSI
MPGKVNPTQAEALTMVCAHIMGNQTAMTVAGSQGHFELNVFNPVMAYNFLQSCRLISDAAISFTDNMVKGIEAREDNIKA
NLERSLMLVTALAPKIGYDNAAKIAKLAHKNGTTLREEAVGGGYVTNEEFDEVVRPEKMISPG

Sequences:

>Translated_463_residues
MTATRTETDTFGPIEVPSDRYWGAQTQRSIGNFRIGWEKQPKPVIRALGVVKRAAAEANMELGKLDPEIGKHIVAAAQEV
IDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMMGGQMGSKKPVHPNDHVNMSQSSNDTYPTAMHIAAAEEVARSV
MPALEHLHAALKYKAEEFAHIIKIGRTHTQDATPLTLGQEFGGYAHQVAMSVRRIKETLYGLYELAQGGTAVGTGLNAPV
GFAELVAEKIAKITHLPFVTAPNKFEALAAHDAMVFSHGAINTAAAALFKIANDIRFLGSGPRSGLGELALPENEPGSSI
MPGKVNPTQAEALTMVCAHIMGNQTAMTVAGSQGHFELNVFNPVMAYNFLQSCRLISDAAISFTDNMVKGIEAREDNIKA
NLERSLMLVTALAPKIGYDNAAKIAKLAHKNGTTLREEAVGGGYVTNEEFDEVVRPEKMISPG
>Mature_462_residues
TATRTETDTFGPIEVPSDRYWGAQTQRSIGNFRIGWEKQPKPVIRALGVVKRAAAEANMELGKLDPEIGKHIVAAAQEVI
DGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMMGGQMGSKKPVHPNDHVNMSQSSNDTYPTAMHIAAAEEVARSVM
PALEHLHAALKYKAEEFAHIIKIGRTHTQDATPLTLGQEFGGYAHQVAMSVRRIKETLYGLYELAQGGTAVGTGLNAPVG
FAELVAEKIAKITHLPFVTAPNKFEALAAHDAMVFSHGAINTAAAALFKIANDIRFLGSGPRSGLGELALPENEPGSSIM
PGKVNPTQAEALTMVCAHIMGNQTAMTVAGSQGHFELNVFNPVMAYNFLQSCRLISDAAISFTDNMVKGIEAREDNIKAN
LERSLMLVTALAPKIGYDNAAKIAKLAHKNGTTLREEAVGGGYVTNEEFDEVVRPEKMISPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=67.6086956521739, Blast_Score=621, Evalue=1e-178,
Organism=Homo sapiens, GI266458395, Length=68, Percent_Identity=54.4117647058823, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=56.0869565217391, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.4793926247288, Blast_Score=334, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=66.5948275862069, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=66.9724770642202, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=64.14686825054, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=65.7266811279826, Blast_Score=623, Evalue=1e-179,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=65.7266811279826, Blast_Score=622, Evalue=1e-178,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=61.4718614718615, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=60.6911447084233, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=51.8358531317495, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49806; Mature: 49675

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRTETDTFGPIEVPSDRYWGAQTQRSIGNFRIGWEKQPKPVIRALGVVKRAAAEANM
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
ELGKLDPEIGKHIVAAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMMGG
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
QMGSKKPVHPNDHVNMSQSSNDTYPTAMHIAAAEEVARSVMPALEHLHAALKYKAEEFAH
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAHQVAMSVRRIKETLYGLYELAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFAELVAEKIAKITHLPFVTAPNKFEALAAHDAMVFSHGAINTAAAALFKIANDIRFLGS
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
GPRSGLGELALPENEPGSSIMPGKVNPTQAEALTMVCAHIMGNQTAMTVAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
FNPVMAYNFLQSCRLISDAAISFTDNMVKGIEAREDNIKANLERSLMLVTALAPKIGYDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
AAKIAKLAHKNGTTLREEAVGGGYVTNEEFDEVVRPEKMISPG
HHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
TATRTETDTFGPIEVPSDRYWGAQTQRSIGNFRIGWEKQPKPVIRALGVVKRAAAEANM
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
ELGKLDPEIGKHIVAAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIEMMGG
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
QMGSKKPVHPNDHVNMSQSSNDTYPTAMHIAAAEEVARSVMPALEHLHAALKYKAEEFAH
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAHQVAMSVRRIKETLYGLYELAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFAELVAEKIAKITHLPFVTAPNKFEALAAHDAMVFSHGAINTAAAALFKIANDIRFLGS
CHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCC
GPRSGLGELALPENEPGSSIMPGKVNPTQAEALTMVCAHIMGNQTAMTVAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEE
FNPVMAYNFLQSCRLISDAAISFTDNMVKGIEAREDNIKANLERSLMLVTALAPKIGYDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
AAKIAKLAHKNGTTLREEAVGGGYVTNEEFDEVVRPEKMISPG
HHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]