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The map label for this gene is flp [H]

Identifier: 197104221

GI number: 197104221

Start: 830671

End: 832170

Strand: Reverse

Name: flp [H]

Synonym: PHZ_c0755

Alternate gene names: 197104221

Gene position: 832170-830671 (Counterclockwise)

Preceding gene: 197104223

Following gene: 197104219

Centisome position: 20.82

GC content: 72.07

Gene sequence:

>1500_bases
ATGAAGTTCGCAAGCTGTGCGGCGGCGCTGGCCGCGTTCTGCCTGGCCGGGTTCGGCCTGATCGGGCCGGTGGCGGCGCA
GACGGGGGACCAGAAGGCCGCCTTCGCCGAGATCGACCCGCTATTCGAGGCCTTCATGCGCGAGCAGAACGTCCCCGGCC
TCGTCTATGGCGTCGTGGCCGACGGCAAGCTGGCCTACGTCCGGACCCTGGGCGTGCAGGACGTGGAGACGAAGGCGCCG
GTCACGGCCGACACCGTCTTCCGCATCGCCTCGATGTCCAAGAACTTCACCGCGCTGGCGGCGCTGAAGCTCAGGGACGA
GGGCCGGCTGTCGCTGGACGCCCCCGCCGAGCAGTACGTGCCGGAGCTGAAGGCGCTGAAGTATCCCACGACGGACAGCC
CGAAGATCACCGTCCGCGACCTTCTCAGCCACGCCGGCGGCTTCGTCACCGACGACCCCTGGGGCGACCGCCATCTCGAC
ATGGCGGAGCCGGACTTCTCGCGCTTCGTCGCGGCGGGCGTCCCGTTCTCGCGAGCGCCCGGGACGGCGTTCGAATATTC
CAACTTCGGCTATGCGCTCGCCGGCCGGGTGGTCTCGAACGCCTCGGGGACGCCCTACGCCGACTACATCGGCGCCCGCT
TCCTCGCGCCGCTGGGCATGGCCTCGACCACGTTCGACATCGGCAAGGTCCCGGCCGGGCGCCTCGCCCGCGGCTATCGG
TGGGAGGACGGGCGCTGGACGCCCGAGCCGGCGCCGGGTCCCGGCGCCTTCGGGGCGATGGGCGGGCTCCTGACCAGCGC
TAACGACTACGCCCGCTACATGGCCTGGGAGCTCGCCGCCTGGCCGCCGCGCGATGGGCCCGAGGACGGGATCCTGGCCC
GCGCCAGCATCCGCGAGATCGCCCGTCCCCAGACCTACGCCACCGTGCAGCGGCGGTCCGATCCCGAGGGCTGCGACCGG
GCGGCCAGCTACGGCATGGGGACCATCCCCTACAGCGACTGCGTGCTCGGGCCGCACTTCGGCCATTCCGGCGGGCTGCC
GGGCTACGGCTCGAACGTCCTGATGCTGCCGCAGCGCGGCGTGGGCGTGTTCGCCTTCACGAACCGGACCTATGCGCCCG
CCTCCGTCGTCGTTCGCGAGGCGGCGACCCGGCTGGTGAAATCGGGGGCCTTCCCACAGCGCCAGGCGCCGCCCAGCGCG
GCGGTGACGGCCATGGCCGAGCGGGCCATGCGGATCTATGCGGCCGGCGACGTGCTGGCCGAGCCCGACGCCCTGGCCGT
CAACTTCCTGCTGGACGAGGACGCCGCCCACCGGAACGCGAAGATCGTCCCGATCAAGGAGAAGCTGGGCGCCTGTCGGG
GCGAGCTGCAGCCGGTGCGGACCGACAGCGCCATGGCGGCGATCCTGAAGTTCCCGTGCGAGCGGGGAACGCTGGAGGTC
CGCTTCCTCCTCGCGCCCACCACGCCCGCCAGCTTCCAGGCGCTGGAGTTCCGCGGCTAG

Upstream 100 bases:

>100_bases
GGGATGAGCCCGCGGCGCGACCCTGGCAACCTTGCCCCGACGTAACTTGACGAGGCGGGCCCCTGTCGGCGCTTCTGCCG
GTTCGGATGGGGGACGAGAG

Downstream 100 bases:

>100_bases
GCGCTAGAGCGACACCCAGTTGCCGTGGAAGCCGAAGGGCACGCGCCGCGGCATGGCCGCCGTCGCGACCGGCCCCCTGG
CGATGTCCTGCGCCTCGAAG

Product: beta-lactamase

Products: substituted beta-amino acid

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MKFASCAAALAAFCLAGFGLIGPVAAQTGDQKAAFAEIDPLFEAFMREQNVPGLVYGVVADGKLAYVRTLGVQDVETKAP
VTADTVFRIASMSKNFTALAALKLRDEGRLSLDAPAEQYVPELKALKYPTTDSPKITVRDLLSHAGGFVTDDPWGDRHLD
MAEPDFSRFVAAGVPFSRAPGTAFEYSNFGYALAGRVVSNASGTPYADYIGARFLAPLGMASTTFDIGKVPAGRLARGYR
WEDGRWTPEPAPGPGAFGAMGGLLTSANDYARYMAWELAAWPPRDGPEDGILARASIREIARPQTYATVQRRSDPEGCDR
AASYGMGTIPYSDCVLGPHFGHSGGLPGYGSNVLMLPQRGVGVFAFTNRTYAPASVVVREAATRLVKSGAFPQRQAPPSA
AVTAMAERAMRIYAAGDVLAEPDALAVNFLLDEDAAHRNAKIVPIKEKLGACRGELQPVRTDSAMAAILKFPCERGTLEV
RFLLAPTTPASFQALEFRG

Sequences:

>Translated_499_residues
MKFASCAAALAAFCLAGFGLIGPVAAQTGDQKAAFAEIDPLFEAFMREQNVPGLVYGVVADGKLAYVRTLGVQDVETKAP
VTADTVFRIASMSKNFTALAALKLRDEGRLSLDAPAEQYVPELKALKYPTTDSPKITVRDLLSHAGGFVTDDPWGDRHLD
MAEPDFSRFVAAGVPFSRAPGTAFEYSNFGYALAGRVVSNASGTPYADYIGARFLAPLGMASTTFDIGKVPAGRLARGYR
WEDGRWTPEPAPGPGAFGAMGGLLTSANDYARYMAWELAAWPPRDGPEDGILARASIREIARPQTYATVQRRSDPEGCDR
AASYGMGTIPYSDCVLGPHFGHSGGLPGYGSNVLMLPQRGVGVFAFTNRTYAPASVVVREAATRLVKSGAFPQRQAPPSA
AVTAMAERAMRIYAAGDVLAEPDALAVNFLLDEDAAHRNAKIVPIKEKLGACRGELQPVRTDSAMAAILKFPCERGTLEV
RFLLAPTTPASFQALEFRG
>Mature_499_residues
MKFASCAAALAAFCLAGFGLIGPVAAQTGDQKAAFAEIDPLFEAFMREQNVPGLVYGVVADGKLAYVRTLGVQDVETKAP
VTADTVFRIASMSKNFTALAALKLRDEGRLSLDAPAEQYVPELKALKYPTTDSPKITVRDLLSHAGGFVTDDPWGDRHLD
MAEPDFSRFVAAGVPFSRAPGTAFEYSNFGYALAGRVVSNASGTPYADYIGARFLAPLGMASTTFDIGKVPAGRLARGYR
WEDGRWTPEPAPGPGAFGAMGGLLTSANDYARYMAWELAAWPPRDGPEDGILARASIREIARPQTYATVQRRSDPEGCDR
AASYGMGTIPYSDCVLGPHFGHSGGLPGYGSNVLMLPQRGVGVFAFTNRTYAPASVVVREAATRLVKSGAFPQRQAPPSA
AVTAMAERAMRIYAAGDVLAEPDALAVNFLLDEDAAHRNAKIVPIKEKLGACRGELQPVRTDSAMAAILKFPCERGTLEV
RFLLAPTTPASFQALEFRG

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI26051231, Length=108, Percent_Identity=40.7407407407407, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26051233, Length=108, Percent_Identity=40.7407407407407, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1790593, Length=358, Percent_Identity=26.8156424581006, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786574, Length=331, Percent_Identity=25.3776435045317, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082101, Length=247, Percent_Identity=23.8866396761134, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=286, Percent_Identity=30.0699300699301, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550934, Length=343, Percent_Identity=27.1137026239067, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6

Molecular weight: Translated: 53233; Mature: 53233

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFASCAAALAAFCLAGFGLIGPVAAQTGDQKAAFAEIDPLFEAFMREQNVPGLVYGVVA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
DGKLAYVRTLGVQDVETKAPVTADTVFRIASMSKNFTALAALKLRDEGRLSLDAPAEQYV
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCHHHHH
PELKALKYPTTDSPKITVRDLLSHAGGFVTDDPWGDRHLDMAEPDFSRFVAAGVPFSRAP
HHHHHCCCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GTAFEYSNFGYALAGRVVSNASGTPYADYIGARFLAPLGMASTTFDIGKVPAGRLARGYR
CCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEE
WEDGRWTPEPAPGPGAFGAMGGLLTSANDYARYMAWELAAWPPRDGPEDGILARASIREI
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHH
ARPQTYATVQRRSDPEGCDRAASYGMGTIPYSDCVLGPHFGHSGGLPGYGSNVLMLPQRG
HCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VGVFAFTNRTYAPASVVVREAATRLVKSGAFPQRQAPPSAAVTAMAERAMRIYAAGDVLA
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCC
EPDALAVNFLLDEDAAHRNAKIVPIKEKLGACRGELQPVRTDSAMAAILKFPCERGTLEV
CCCCEEEEEEECCCCCCCCCEEEEHHHHHCCHHCCCCCCCCHHHHHHHHHCCCCCCCEEE
RFLLAPTTPASFQALEFRG
EEEEECCCCCCCCEEEECC
>Mature Secondary Structure
MKFASCAAALAAFCLAGFGLIGPVAAQTGDQKAAFAEIDPLFEAFMREQNVPGLVYGVVA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
DGKLAYVRTLGVQDVETKAPVTADTVFRIASMSKNFTALAALKLRDEGRLSLDAPAEQYV
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCHHHHH
PELKALKYPTTDSPKITVRDLLSHAGGFVTDDPWGDRHLDMAEPDFSRFVAAGVPFSRAP
HHHHHCCCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GTAFEYSNFGYALAGRVVSNASGTPYADYIGARFLAPLGMASTTFDIGKVPAGRLARGYR
CCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCEE
WEDGRWTPEPAPGPGAFGAMGGLLTSANDYARYMAWELAAWPPRDGPEDGILARASIREI
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHH
ARPQTYATVQRRSDPEGCDRAASYGMGTIPYSDCVLGPHFGHSGGLPGYGSNVLMLPQRG
HCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VGVFAFTNRTYAPASVVVREAATRLVKSGAFPQRQAPPSAAVTAMAERAMRIYAAGDVLA
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCC
EPDALAVNFLLDEDAAHRNAKIVPIKEKLGACRGELQPVRTDSAMAAILKFPCERGTLEV
CCCCEEEEEEECCCCCCCCCEEEEHHHHHCCHHCCCCCCCCHHHHHHHHHCCCCCCCEEE
RFLLAPTTPASFQALEFRG
EEEEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: beta-lactam; H2O

Specific reaction: A beta-lactam + H2O = a substituted beta-amino acid

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA