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The map label for this gene is pncB2 [H]

Identifier: 197104114

GI number: 197104114

Start: 695852

End: 697228

Strand: Reverse

Name: pncB2 [H]

Synonym: PHZ_c0648

Alternate gene names: 197104114

Gene position: 697228-695852 (Counterclockwise)

Preceding gene: 197104115

Following gene: 197104113

Centisome position: 17.45

GC content: 74.29

Gene sequence:

>1377_bases
ATGACCGACCCGCCGCCCGTCCGGCCCGACCCGGCCGCCAGCCCGCTGCTCACCGACCTCTACCAGCTCAACATGCTGGA
GGCCTATCTCGACCACGGGTTCACCGAGCCGGCGGTGTTCGAGTTCTTTGTCCGCCGGCTGCCGCCCTCCCGGGGCTTCC
TGATGGCCGCGGGACTGGAGCAGGCCCTCGGCTTCCTGGAGGCCCTGGCCCCCTCGCCCGCCGAGCTCGACTGGCTGGAG
CGATCGGGCCGCTTCAGCCGCCGGGTGCTGGACTGGTTCGCCGAGCTGCGCTTCAGCGGCGACGTGGACGCCATGCCGGA
AGGCGCGGTGTTCTTCCGCGACGAGCCGATCCTGCGGGTGGTCGCGCCCCTGCCGGTCGCCCAACTGGTCGAGACCCGGC
TGATCAACATCCTGCACTTCCAGTCGCTGGTCGCCTCCAAGGCGGCGCGGATGGTGCTGGCCGCGCCCGGCCGCACGCTG
GTGGACTTCGGCCTGCGGCGCGCCCATGGCTCGGAGGCCGGCCTCTTCGCCGCCCGCGCCAGCTACCTCGCCGGCTTCAC
CGGCACCGCCACGACGCTGGCGGGGATGCTGTGGGACATCCCCCTCTTCGGCACCATGGCCCATTCGTTCGTCCAGGCGT
TCGAGGACGAGACGGCGGCCTTCGAGGCCTTCGCCCGCTCGCGTCCGGAGGGCCTCACCCTGCTGATCGACACCTACGAC
ACCGAAGCGGCCGCGCGGAAGGTCGTGGCGCTGGCCCCGCGCCTCGCCGCCGCCGGCGTGAAGGTCCGGGGCGTGCGGCT
GGACAGCGGCGACCTGCTGGCGCTGTCGCGCAGCGTCCGGGGGATCCTCGACGCGGGCGGCCTCTCCGACATCACCATCT
TCGCCAGCGGCGGCCTGGACGAGGGCGACCTGCAGGCGCTCGTCCGCGCGGGGGCCCCGATCGACGGCTTCGGGGTGGGC
ACCAGCCTGACCACCTCGTCCGACGCGCCCGGCCTCGACTGCGCCTACAAGCTCCAGGAATACGCCGGCGTCCCGCGCCG
CAAGCTCTCGACCGGCAAGGCCACCTGGCCCGGCCGCAAGCAGGTCTGGCGCAGCGTCGACGCGCGCGGCCGGATGCGCG
GCGACGTCGTCTCCACCCTGCACGACCGCCCGCTGGGCGAGCCCCTGCTGCAGCCTGTCATGCGTCAGGGACGGCGGACG
GGGCCGCCGCCCTCGCTGCCCGAGATCCGCGCCCGCGCCGCCCGCGAGCTCGCCGCCCTGCCCGAGCCCCTCCGGGCGCT
GGAGCCCCACGACTATCCGGTGCGGATCGCCGAGCCCCTGACGCGCCTCGCCGCCGAAGTGGACCGCCGGCTCGCCAAGC
AGGTCCAGCCGTCATGA

Upstream 100 bases:

>100_bases
GACGCGGCCGAGGAGGAAGCCTGGCGCATCCTCGGCGTGGACGACGTCATCAACGAGATCGAGGCGCCCTGACGCGCCGC
GCCGGTCCGAGGGGACGCCC

Downstream 100 bases:

>100_bases
TCCCCATCGCCCCCACCGACGCCCTGATCGTGATCGACGTGCAGAACGACTTCTGTCCCGGCGGTGCCCTGGCCGTGCCG
CGCGGAGACGAGGTGGTCGC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTDPPPVRPDPAASPLLTDLYQLNMLEAYLDHGFTEPAVFEFFVRRLPPSRGFLMAAGLEQALGFLEALAPSPAELDWLE
RSGRFSRRVLDWFAELRFSGDVDAMPEGAVFFRDEPILRVVAPLPVAQLVETRLINILHFQSLVASKAARMVLAAPGRTL
VDFGLRRAHGSEAGLFAARASYLAGFTGTATTLAGMLWDIPLFGTMAHSFVQAFEDETAAFEAFARSRPEGLTLLIDTYD
TEAAARKVVALAPRLAAAGVKVRGVRLDSGDLLALSRSVRGILDAGGLSDITIFASGGLDEGDLQALVRAGAPIDGFGVG
TSLTTSSDAPGLDCAYKLQEYAGVPRRKLSTGKATWPGRKQVWRSVDARGRMRGDVVSTLHDRPLGEPLLQPVMRQGRRT
GPPPSLPEIRARAARELAALPEPLRALEPHDYPVRIAEPLTRLAAEVDRRLAKQVQPS

Sequences:

>Translated_458_residues
MTDPPPVRPDPAASPLLTDLYQLNMLEAYLDHGFTEPAVFEFFVRRLPPSRGFLMAAGLEQALGFLEALAPSPAELDWLE
RSGRFSRRVLDWFAELRFSGDVDAMPEGAVFFRDEPILRVVAPLPVAQLVETRLINILHFQSLVASKAARMVLAAPGRTL
VDFGLRRAHGSEAGLFAARASYLAGFTGTATTLAGMLWDIPLFGTMAHSFVQAFEDETAAFEAFARSRPEGLTLLIDTYD
TEAAARKVVALAPRLAAAGVKVRGVRLDSGDLLALSRSVRGILDAGGLSDITIFASGGLDEGDLQALVRAGAPIDGFGVG
TSLTTSSDAPGLDCAYKLQEYAGVPRRKLSTGKATWPGRKQVWRSVDARGRMRGDVVSTLHDRPLGEPLLQPVMRQGRRT
GPPPSLPEIRARAARELAALPEPLRALEPHDYPVRIAEPLTRLAAEVDRRLAKQVQPS
>Mature_457_residues
TDPPPVRPDPAASPLLTDLYQLNMLEAYLDHGFTEPAVFEFFVRRLPPSRGFLMAAGLEQALGFLEALAPSPAELDWLER
SGRFSRRVLDWFAELRFSGDVDAMPEGAVFFRDEPILRVVAPLPVAQLVETRLINILHFQSLVASKAARMVLAAPGRTLV
DFGLRRAHGSEAGLFAARASYLAGFTGTATTLAGMLWDIPLFGTMAHSFVQAFEDETAAFEAFARSRPEGLTLLIDTYDT
EAAARKVVALAPRLAAAGVKVRGVRLDSGDLLALSRSVRGILDAGGLSDITIFASGGLDEGDLQALVRAGAPIDGFGVGT
SLTTSSDAPGLDCAYKLQEYAGVPRRKLSTGKATWPGRKQVWRSVDARGRMRGDVVSTLHDRPLGEPLLQPVMRQGRRTG
PPPSLPEIRARAARELAALPEPLRALEPHDYPVRIAEPLTRLAAEVDRRLAKQVQPS

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=535, Percent_Identity=33.2710280373832, Blast_Score=203, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997952, Length=525, Percent_Identity=30.0952380952381, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71997947, Length=525, Percent_Identity=30.0952380952381, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71997955, Length=217, Percent_Identity=39.1705069124424, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24581587, Length=527, Percent_Identity=30.1707779886148, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161076680, Length=299, Percent_Identity=31.1036789297659, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24581595, Length=299, Percent_Identity=31.1036789297659, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574709, Length=299, Percent_Identity=31.1036789297659, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24581593, Length=299, Percent_Identity=31.1036789297659, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24581591, Length=299, Percent_Identity=31.1036789297659, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49587; Mature: 49456

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPPPVRPDPAASPLLTDLYQLNMLEAYLDHGFTEPAVFEFFVRRLPPSRGFLMAAGLE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHH
QALGFLEALAPSPAELDWLERSGRFSRRVLDWFAELRFSGDVDAMPEGAVFFRDEPILRV
HHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHH
VAPLPVAQLVETRLINILHFQSLVASKAARMVLAAPGRTLVDFGLRRAHGSEAGLFAARA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCHHHHHHHH
SYLAGFTGTATTLAGMLWDIPLFGTMAHSFVQAFEDETAAFEAFARSRPEGLTLLIDTYD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
TEAAARKVVALAPRLAAAGVKVRGVRLDSGDLLALSRSVRGILDAGGLSDITIFASGGLD
CHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EGDLQALVRAGAPIDGFGVGTSLTTSSDAPGLDCAYKLQEYAGVPRRKLSTGKATWPGRK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCHH
QVWRSVDARGRMRGDVVSTLHDRPLGEPLLQPVMRQGRRTGPPPSLPEIRARAARELAAL
HHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
PEPLRALEPHDYPVRIAEPLTRLAAEVDRRLAKQVQPS
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDPPPVRPDPAASPLLTDLYQLNMLEAYLDHGFTEPAVFEFFVRRLPPSRGFLMAAGLE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHH
QALGFLEALAPSPAELDWLERSGRFSRRVLDWFAELRFSGDVDAMPEGAVFFRDEPILRV
HHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHH
VAPLPVAQLVETRLINILHFQSLVASKAARMVLAAPGRTLVDFGLRRAHGSEAGLFAARA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCCHHHHHHHH
SYLAGFTGTATTLAGMLWDIPLFGTMAHSFVQAFEDETAAFEAFARSRPEGLTLLIDTYD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
TEAAARKVVALAPRLAAAGVKVRGVRLDSGDLLALSRSVRGILDAGGLSDITIFASGGLD
CHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCC
EGDLQALVRAGAPIDGFGVGTSLTTSSDAPGLDCAYKLQEYAGVPRRKLSTGKATWPGRK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCHH
QVWRSVDARGRMRGDVVSTLHDRPLGEPLLQPVMRQGRRTGPPPSLPEIRARAARELAAL
HHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
PEPLRALEPHDYPVRIAEPLTRLAAEVDRRLAKQVQPS
CHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]