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The map label for this gene is thrC [H]

Identifier: 197104015

GI number: 197104015

Start: 580431

End: 581819

Strand: Direct

Name: thrC [H]

Synonym: PHZ_c0549

Alternate gene names: 197104015

Gene position: 580431-581819 (Clockwise)

Preceding gene: 197104014

Following gene: 197104016

Centisome position: 14.52

GC content: 71.71

Gene sequence:

>1389_bases
ATGCGCTACGTCTCGACCCGCGGGCAGTGCCCCGCGGTCGGCTTCACCGATGCGGTCCTCTCGGGCCTGGCCCCCGACGG
CGGGCTCTATGTGCCCGAGGCCTGGCCGACGTTCAGCCGCGCCCGGATCGAGGGCTTCGCCGGCAAGCCGTATGCCGAGG
TCGCCGCCGCGGTGATCGGCGCCTTCGCGGGCGACGAGATCCCCGCCGCCGACCTGCGCGAGATGTGCGAGGAGGCCTAC
GCCACCTTCAACCACAAGGCCGTCGTGCCGCTGGTCCAGATCGGGCCCGACGCGTTCCTGGCCGAGCTGTTCCATGGGCC
CTCGCTCGCGTTCAAGGACGTGGCGATGCAGATCCTGGCGCGGCTGTACGACCACCTGCTGGGCGCGCAGGGGCGGACGC
AGACGATCCTCTGCGCCACCTCGGGCGACACGGGCGGGGCGGCGGTGGAGGCCTTCCGCGGCCGGAAGAACGTGAAGATC
GTGGCGCTCTTCCCCGAGGGCCGGATCTCGGAGGTCCAGCGCCGGTTCATGACCACGGCCGAGGAGGACAACGTCGCCTG
CGTGGCGGTGACGGGCACCTTCGACGACTGCCAGGCCATCGTGAAGCAGGCCTTCCAGGACCAGTCCCTGCGCCAGGCCG
TGGACCTGACGGGCGTCAATTCGATCAACTTCGCCCGCATCGCCGCCCAGGCGGTCTACTACTTCACCACCGCCGTCGCG
CTCGGGGCCCCGCACCGGAAGGTCAGCTTCTGCGTCCCGTCGGGCAATTTCGGCGACGCCTTCGCCGGCTACGTGGCCAT
GCGCATGGGGCTGCCGGTGGCGCGCATCGCCACGGCGACCAATGCGAACGACATCCTGGCCCGCGCGTTCGAGACCGGCC
GCTACGTGCGCGGCGCGGTCCAACCCACCATCTCTCCGGCCATGGACATCCAGTCGGCGTCGAACTTCGAGCGGCTCTAC
TTCGAGACCGTCAAGCGCGAGCCGGTCGAGACGGCCCGCGCCTTCCAGGCGTTCGCCGAGGCCGGCGCCATCGACATCCC
GCCCAGCGCCTACGCCGCCATGCGCGAGGTCTTCCGGGGCGTGAGCATCGGCGAGGACGAGACGGCCCGCACGATCGTCT
CGACGCTGAACGAGACGGGCGAGCTGATCGACCCGCACACCGCCGTGGGCGTCGCCGCCCTGCGCCACGTGGACCTGCCC
GGGCCCGTGGTCGTGCTTTCCACCGCCCACGCCGCCAAGTTCCCGGACGACGTGGCCAAGGCCTGCGGCGCCATGCCGGC
CCTGCCGCGGGGCGTCGCCAACCTCGCCGACCGACGCGAGCGCTTCGACCGGCTGCCGGCCGAGGCCGAGACCATCAAGG
CCTATGTCCGCGCGTTCGCCGAGCGCTGA

Upstream 100 bases:

>100_bases
TCTCCAACCGTCACCTCGAGTACGCCGTGACCTGGTACGGCCTTGCCGCCGCCCTGCTCGGCGTCTATGCGGCCATGCTC
CTCAAGCGGCGGAAGACCTG

Downstream 100 bases:

>100_bases
GGCGCGCCTGCCCCGGGTCCACCGGCTAGCGAACGGGGTGCGGGTGGTCTGCGACCCGATCCCCGGCTGGCAGACCGTGG
CGCTGTCGGTCGTGGCCGGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRYVSTRGQCPAVGFTDAVLSGLAPDGGLYVPEAWPTFSRARIEGFAGKPYAEVAAAVIGAFAGDEIPAADLREMCEEAY
ATFNHKAVVPLVQIGPDAFLAELFHGPSLAFKDVAMQILARLYDHLLGAQGRTQTILCATSGDTGGAAVEAFRGRKNVKI
VALFPEGRISEVQRRFMTTAEEDNVACVAVTGTFDDCQAIVKQAFQDQSLRQAVDLTGVNSINFARIAAQAVYYFTTAVA
LGAPHRKVSFCVPSGNFGDAFAGYVAMRMGLPVARIATATNANDILARAFETGRYVRGAVQPTISPAMDIQSASNFERLY
FETVKREPVETARAFQAFAEAGAIDIPPSAYAAMREVFRGVSIGEDETARTIVSTLNETGELIDPHTAVGVAALRHVDLP
GPVVVLSTAHAAKFPDDVAKACGAMPALPRGVANLADRRERFDRLPAEAETIKAYVRAFAER

Sequences:

>Translated_462_residues
MRYVSTRGQCPAVGFTDAVLSGLAPDGGLYVPEAWPTFSRARIEGFAGKPYAEVAAAVIGAFAGDEIPAADLREMCEEAY
ATFNHKAVVPLVQIGPDAFLAELFHGPSLAFKDVAMQILARLYDHLLGAQGRTQTILCATSGDTGGAAVEAFRGRKNVKI
VALFPEGRISEVQRRFMTTAEEDNVACVAVTGTFDDCQAIVKQAFQDQSLRQAVDLTGVNSINFARIAAQAVYYFTTAVA
LGAPHRKVSFCVPSGNFGDAFAGYVAMRMGLPVARIATATNANDILARAFETGRYVRGAVQPTISPAMDIQSASNFERLY
FETVKREPVETARAFQAFAEAGAIDIPPSAYAAMREVFRGVSIGEDETARTIVSTLNETGELIDPHTAVGVAALRHVDLP
GPVVVLSTAHAAKFPDDVAKACGAMPALPRGVANLADRRERFDRLPAEAETIKAYVRAFAER
>Mature_462_residues
MRYVSTRGQCPAVGFTDAVLSGLAPDGGLYVPEAWPTFSRARIEGFAGKPYAEVAAAVIGAFAGDEIPAADLREMCEEAY
ATFNHKAVVPLVQIGPDAFLAELFHGPSLAFKDVAMQILARLYDHLLGAQGRTQTILCATSGDTGGAAVEAFRGRKNVKI
VALFPEGRISEVQRRFMTTAEEDNVACVAVTGTFDDCQAIVKQAFQDQSLRQAVDLTGVNSINFARIAAQAVYYFTTAVA
LGAPHRKVSFCVPSGNFGDAFAGYVAMRMGLPVARIATATNANDILARAFETGRYVRGAVQPTISPAMDIQSASNFERLY
FETVKREPVETARAFQAFAEAGAIDIPPSAYAAMREVFRGVSIGEDETARTIVSTLNETGELIDPHTAVGVAALRHVDLP
GPVVVLSTAHAAKFPDDVAKACGAMPALPRGVANLADRRERFDRLPAEAETIKAYVRAFAER

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=452, Percent_Identity=32.0796460176991, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=32.8918322295806, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1786185, Length=450, Percent_Identity=37.5555555555556, Blast_Score=254, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6319901, Length=483, Percent_Identity=38.7163561076605, Blast_Score=311, Evalue=1e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 49405; Mature: 49405

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVSTRGQCPAVGFTDAVLSGLAPDGGLYVPEAWPTFSRARIEGFAGKPYAEVAAAVIG
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHH
AFAGDEIPAADLREMCEEAYATFNHKAVVPLVQIGPDAFLAELFHGPSLAFKDVAMQILA
HHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHH
RLYDHLLGAQGRTQTILCATSGDTGGAAVEAFRGRKNVKIVALFPEGRISEVQRRFMTTA
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
EEDNVACVAVTGTFDDCQAIVKQAFQDQSLRQAVDLTGVNSINFARIAAQAVYYFTTAVA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRKVSFCVPSGNFGDAFAGYVAMRMGLPVARIATATNANDILARAFETGRYVRGAV
HCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCHHHHCCC
QPTISPAMDIQSASNFERLYFETVKREPVETARAFQAFAEAGAIDIPPSAYAAMREVFRG
CCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
VSIGEDETARTIVSTLNETGELIDPHTAVGVAALRHVDLPGPVVVLSTAHAAKFPDDVAK
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCHHHHH
ACGAMPALPRGVANLADRRERFDRLPAEAETIKAYVRAFAER
HHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYVSTRGQCPAVGFTDAVLSGLAPDGGLYVPEAWPTFSRARIEGFAGKPYAEVAAAVIG
CCCCCCCCCCCCCCHHHHHHHCCCCCCCEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHH
AFAGDEIPAADLREMCEEAYATFNHKAVVPLVQIGPDAFLAELFHGPSLAFKDVAMQILA
HHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHH
RLYDHLLGAQGRTQTILCATSGDTGGAAVEAFRGRKNVKIVALFPEGRISEVQRRFMTTA
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
EEDNVACVAVTGTFDDCQAIVKQAFQDQSLRQAVDLTGVNSINFARIAAQAVYYFTTAVA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRKVSFCVPSGNFGDAFAGYVAMRMGLPVARIATATNANDILARAFETGRYVRGAV
HCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCHHHHCCC
QPTISPAMDIQSASNFERLYFETVKREPVETARAFQAFAEAGAIDIPPSAYAAMREVFRG
CCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
VSIGEDETARTIVSTLNETGELIDPHTAVGVAALRHVDLPGPVVVLSTAHAAKFPDDVAK
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCHHHHH
ACGAMPALPRGVANLADRRERFDRLPAEAETIKAYVRAFAER
HHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]