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The map label for this gene is ywrD [H]

Identifier: 197103989

GI number: 197103989

Start: 548442

End: 550103

Strand: Reverse

Name: ywrD [H]

Synonym: PHZ_c0523

Alternate gene names: 197103989

Gene position: 550103-548442 (Counterclockwise)

Preceding gene: 197103992

Following gene: 197103988

Centisome position: 13.77

GC content: 72.44

Gene sequence:

>1662_bases
GTGGGGCCCGGCGACCGGATCGACGGCGCCACCTTCGCCAGCCGTTCGGCGGCCTGGGGCCTGCACGGGGCGGCGGCCAC
CGCCCACCCCCTCGCCACCCTCGCCGCCATCGAGATCCTCAAGGCCGGTGGCTCGGCGGTGGACGCCGCCGTGGCCGCCA
ATGCGGTGCTGGGCTTCGCCGAGCCCATCGCCTGCGGCATCGGCGGCGACTGTTTCGTGATGCTGTGGGATCCGAAGCAG
GGGAAGGTCGTCGGCCTGAACGGCTCGGGCCGCAGCCCGCGCGGGCTGTCGCTGGCGACCGTCCGGGCGCGGGCGAAGAA
CGGCTTCATCCCCAGCCACGGCGCCATCTCGGTCAGCGTGCCGGGCGCCGTCGACGCCTGGTGGAGCCTGCACCAGCGCT
ACGGCAAGCTGCCGTGGAAGAGCCTGTTCGAGCCGGCGATCCGCCACGCCACCGAGGGCGCGCCGATCACCCAGAACGTC
GCCTACTACCTGGAGCGCTCGTTCAGCGCCTTCACCCGGCCCGGCTCGGGCATCGAGGAGGTGGAGAACTTCAAGGCCGT
CTGGGCCCCCGAGGGCCGGGTCCCCGTCGAGGGCGAGGTGTTCAGGAACCCGCGCCTGGCGGCCACCTACCGCCGGATCG
CCGAGGGCGGCGGGCGCGAGTTCTACGAGGGCGAGACCGCCCGGGCCATCGAGGCCTACTTCAAGCGCATCGGCGGCTGG
ATGACCCGCGCCGACCTCGCCGCCCACCGGTCGGAGTGGGTGGCCCCGGTCTCGTCCAGCTACCGCGGGGTCGACGTCTG
GGCCCTGCCGCCCAACAGCCAGGGGATCGCCACCCTGCAGCTGCTGAACATCCTCGAGCAGTTCGACGTGAAGGCGATGG
GCTTCCAGTCGGCGGCGGCGATCCACCACGCGGTGGAGGCCAAGCGGCTGGCCTTCGAGGACCGCGCCCGCCACTACGCC
GATCCCGCCTTCTACAAGGCGCCGATCGAGCACCTGGTCTCCAAGGCCTATGCGAAGGAGCGCGCGGCCCTGATCCGGCC
TGACCGCATCCTGCGGGAGATCGCCCCCTTCCAGGCCCCCAGCCGCGGCGACACCACCTACTTCACCACCGCCGACGCCG
ACGGGATGATGGTCTCGATCATCCAGTCCAACTACCGGGGCATGGGCTCGGGCCTGTCGCCCGACGACCTGGGCTTCATG
TTCCAGGACCGCGGCGAGCTGTTCGCCCTGCAGGACGGCCATCCGAACCTCTACGCGCCCGGCAAGCGGCCCTTCCAGAC
CATCATCCCGGGCTTCGCCACGCGCGAGGGCAAGCCGTGGCTGTCGTTCGGGGTCATGGGCGGCGACATGCAGCCCCAGG
GCCAGGCGCAGATCATCTCCAACATGGTCGACCACGGCCTGTCCCTGCAGGAGGCGGGCGATGCGCCCCGCTGGCATCAC
GAGGGCGGCTCCGAGCCCACCGGGCAGAAGCTGGACCCGCTGGGCCTGCTGCGGCTGGAGACCGGCGTGCCCGCCAGGAC
CAAGGCGGCCCTCGCCGCCCTCGGCTGGAAGCTGGGCGAGCCCGACGGCGGCTTCGGCGGCTACCAGGCGGTCGAGCGCT
GGCCCGGCCGCTACGCCGCGGCCAGCGAGATGCGCAAGGACGGCATGGCTCTGGCCTACTAG

Upstream 100 bases:

>100_bases
CCTGCCCGCCGCCGCCCTGGCCGCGCCCCTGGCCGGGCCTCTGGCCGCGCCCGCGTTAGCGGACAGCCGCAGCCAGAACC
CCAACCGGAACCGGCCCGAC

Downstream 100 bases:

>100_bases
GGACGTCCCCGATGACCTACGAGGAGATGCGCGCCATCGTGCTGGCCTTCCCCGGCGCCGAGGAGGGCAAGAGCTACGGC
AAGCCCGCCTTCCTGGTGAA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MGPGDRIDGATFASRSAAWGLHGAAATAHPLATLAAIEILKAGGSAVDAAVAANAVLGFAEPIACGIGGDCFVMLWDPKQ
GKVVGLNGSGRSPRGLSLATVRARAKNGFIPSHGAISVSVPGAVDAWWSLHQRYGKLPWKSLFEPAIRHATEGAPITQNV
AYYLERSFSAFTRPGSGIEEVENFKAVWAPEGRVPVEGEVFRNPRLAATYRRIAEGGGREFYEGETARAIEAYFKRIGGW
MTRADLAAHRSEWVAPVSSSYRGVDVWALPPNSQGIATLQLLNILEQFDVKAMGFQSAAAIHHAVEAKRLAFEDRARHYA
DPAFYKAPIEHLVSKAYAKERAALIRPDRILREIAPFQAPSRGDTTYFTTADADGMMVSIIQSNYRGMGSGLSPDDLGFM
FQDRGELFALQDGHPNLYAPGKRPFQTIIPGFATREGKPWLSFGVMGGDMQPQGQAQIISNMVDHGLSLQEAGDAPRWHH
EGGSEPTGQKLDPLGLLRLETGVPARTKAALAALGWKLGEPDGGFGGYQAVERWPGRYAAASEMRKDGMALAY

Sequences:

>Translated_553_residues
MGPGDRIDGATFASRSAAWGLHGAAATAHPLATLAAIEILKAGGSAVDAAVAANAVLGFAEPIACGIGGDCFVMLWDPKQ
GKVVGLNGSGRSPRGLSLATVRARAKNGFIPSHGAISVSVPGAVDAWWSLHQRYGKLPWKSLFEPAIRHATEGAPITQNV
AYYLERSFSAFTRPGSGIEEVENFKAVWAPEGRVPVEGEVFRNPRLAATYRRIAEGGGREFYEGETARAIEAYFKRIGGW
MTRADLAAHRSEWVAPVSSSYRGVDVWALPPNSQGIATLQLLNILEQFDVKAMGFQSAAAIHHAVEAKRLAFEDRARHYA
DPAFYKAPIEHLVSKAYAKERAALIRPDRILREIAPFQAPSRGDTTYFTTADADGMMVSIIQSNYRGMGSGLSPDDLGFM
FQDRGELFALQDGHPNLYAPGKRPFQTIIPGFATREGKPWLSFGVMGGDMQPQGQAQIISNMVDHGLSLQEAGDAPRWHH
EGGSEPTGQKLDPLGLLRLETGVPARTKAALAALGWKLGEPDGGFGGYQAVERWPGRYAAASEMRKDGMALAY
>Mature_552_residues
GPGDRIDGATFASRSAAWGLHGAAATAHPLATLAAIEILKAGGSAVDAAVAANAVLGFAEPIACGIGGDCFVMLWDPKQG
KVVGLNGSGRSPRGLSLATVRARAKNGFIPSHGAISVSVPGAVDAWWSLHQRYGKLPWKSLFEPAIRHATEGAPITQNVA
YYLERSFSAFTRPGSGIEEVENFKAVWAPEGRVPVEGEVFRNPRLAATYRRIAEGGGREFYEGETARAIEAYFKRIGGWM
TRADLAAHRSEWVAPVSSSYRGVDVWALPPNSQGIATLQLLNILEQFDVKAMGFQSAAAIHHAVEAKRLAFEDRARHYAD
PAFYKAPIEHLVSKAYAKERAALIRPDRILREIAPFQAPSRGDTTYFTTADADGMMVSIIQSNYRGMGSGLSPDDLGFMF
QDRGELFALQDGHPNLYAPGKRPFQTIIPGFATREGKPWLSFGVMGGDMQPQGQAQIISNMVDHGLSLQEAGDAPRWHHE
GGSEPTGQKLDPLGLLRLETGVPARTKAALAALGWKLGEPDGGFGGYQAVERWPGRYAAASEMRKDGMALAY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=534, Percent_Identity=27.5280898876405, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI73915090, Length=534, Percent_Identity=27.5280898876405, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI73915096, Length=534, Percent_Identity=27.5280898876405, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI73915094, Length=534, Percent_Identity=27.5280898876405, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI113429324, Length=532, Percent_Identity=27.2556390977444, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI113429326, Length=540, Percent_Identity=26.4814814814815, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI109148539, Length=479, Percent_Identity=26.5135699373695, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI153266885, Length=550, Percent_Identity=22, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=21.9600725952813, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1789856, Length=547, Percent_Identity=31.0786106032907, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI193208247, Length=514, Percent_Identity=24.3190661478599, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI193208245, Length=514, Percent_Identity=24.3190661478599, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI72000294, Length=479, Percent_Identity=25.2609603340292, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI212646519, Length=479, Percent_Identity=25.2609603340292, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17542894, Length=490, Percent_Identity=25.5102040816327, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=489, Percent_Identity=24.9488752556237, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859893, Length=477, Percent_Identity=28.3018867924528, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI161077878, Length=502, Percent_Identity=24.7011952191235, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24642670, Length=502, Percent_Identity=24.7011952191235, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24642666, Length=502, Percent_Identity=24.7011952191235, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI45551474, Length=502, Percent_Identity=24.7011952191235, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI161077880, Length=502, Percent_Identity=24.7011952191235, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI161077496, Length=518, Percent_Identity=25.0965250965251, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859741, Length=482, Percent_Identity=24.6887966804979, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59526; Mature: 59395

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPGDRIDGATFASRSAAWGLHGAAATAHPLATLAAIEILKAGGSAVDAAVAANAVLGFA
CCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EPIACGIGGDCFVMLWDPKQGKVVGLNGSGRSPRGLSLATVRARAKNGFIPSHGAISVSV
CHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEC
PGAVDAWWSLHQRYGKLPWKSLFEPAIRHATEGAPITQNVAYYLERSFSAFTRPGSGIEE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
VENFKAVWAPEGRVPVEGEVFRNPRLAATYRRIAEGGGREFYEGETARAIEAYFKRIGGW
HHCCEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCH
MTRADLAAHRSEWVAPVSSSYRGVDVWALPPNSQGIATLQLLNILEQFDVKAMGFQSAAA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHCHHHHHH
IHHAVEAKRLAFEDRARHYADPAFYKAPIEHLVSKAYAKERAALIRPDRILREIAPFQAP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
SRGDTTYFTTADADGMMVSIIQSNYRGMGSGLSPDDLGFMFQDRGELFALQDGHPNLYAP
CCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCHHHCCEEEECCCCEEEEECCCCCCCCC
GKRPFQTIIPGFATREGKPWLSFGVMGGDMQPQGQAQIISNMVDHGLSLQEAGDAPRWHH
CCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCC
EGGSEPTGQKLDPLGLLRLETGVPARTKAALAALGWKLGEPDGGFGGYQAVERWPGRYAA
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHH
ASEMRKDGMALAY
HHHHHHCCCEECC
>Mature Secondary Structure 
GPGDRIDGATFASRSAAWGLHGAAATAHPLATLAAIEILKAGGSAVDAAVAANAVLGFA
CCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EPIACGIGGDCFVMLWDPKQGKVVGLNGSGRSPRGLSLATVRARAKNGFIPSHGAISVSV
CHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEC
PGAVDAWWSLHQRYGKLPWKSLFEPAIRHATEGAPITQNVAYYLERSFSAFTRPGSGIEE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
VENFKAVWAPEGRVPVEGEVFRNPRLAATYRRIAEGGGREFYEGETARAIEAYFKRIGGW
HHCCEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCH
MTRADLAAHRSEWVAPVSSSYRGVDVWALPPNSQGIATLQLLNILEQFDVKAMGFQSAAA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHCHHHHHH
IHHAVEAKRLAFEDRARHYADPAFYKAPIEHLVSKAYAKERAALIRPDRILREIAPFQAP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
SRGDTTYFTTADADGMMVSIIQSNYRGMGSGLSPDDLGFMFQDRGELFALQDGHPNLYAP
CCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCHHHCCEEEECCCCEEEEECCCCCCCCC
GKRPFQTIIPGFATREGKPWLSFGVMGGDMQPQGQAQIISNMVDHGLSLQEAGDAPRWHH
CCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCC
EGGSEPTGQKLDPLGLLRLETGVPARTKAALAALGWKLGEPDGGFGGYQAVERWPGRYAA
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHH
ASEMRKDGMALAY
HHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]