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The map label for this gene is hutH

Identifier: 197103932

GI number: 197103932

Start: 481983

End: 483518

Strand: Direct

Name: hutH

Synonym: PHZ_c0466

Alternate gene names: 197103932

Gene position: 481983-483518 (Clockwise)

Preceding gene: 197103931

Following gene: 197103933

Centisome position: 12.06

GC content: 73.96

Gene sequence:

>1536_bases
TTGACCGACATCGTCCTGGAGCCCGGCGCTGCGCCGCTGTCCGTCTGGCGCGAGATCTGGCGCGGGGCGGGGGTGCGCCT
CGATCCCGCCGCCCACGCCGTGGTGGCGCAGAGCGCCGAGGCGGTGACGCGCATCCTGGCCAGGGGCGAGCCGGTCTACG
GGATCAACACCGGCTTCGGGAAGCTGGCGACCGTCCGCATCGAGGACGCCGACCTCGCCACCCTGCAGAGGAACCTGGTG
CTGAGCCATGCGGCCGGGGTGGGCGAGGCCTCGCCGCGCGCCGTCGTGCGGCTGATGATGGCTCTGAAGCTGGCGAGCCT
GGCCCAGGGCGCCTCGGGCGTGCGGCCAGTCACGGTCCAGCTGCTGGAGCGGATGATCGCGCAGGACCTGATCCCCGTGG
TGCCGGGGCAGGGGTCGGTGGGCGCCTCGGGCGACCTCGCGCCACTCGCCCACATGGCCGCGGCGATGCTGGGGGTGGGC
GAGATCGAGACCGCCGGCCAGCGCCTGCCGGCGGGCGAGGCGCTGGCGGCCGCCGGGCTCGCGCCGCTGGCCCTGGGGCC
CAAGGAGGGCTTGGCGTTGCTGAACGGCACCCAGTTCTCGACGGCCAATGCGCTGGCCGGCCTGTTCGAGGCCGAGCGGC
TGTTCCGCTCGGCCCTGGTGACGGGAGCCCTCTCCACCGAAGCGGCGAAGGGGTCGGACACACCGTTCGACGCCCGCATC
CACGCCCTGCGCCGCCAGCCGGGCCAGGTCGAGGCGGCGCGGGCGCTGCGGGAGCTGATGGCGGGCTCTGCGATCCGCGC
CTCGCACCTGAAGGACGACGAGCGGGTGCAGGATCCCTACTGCCTGCGCTGCCAGCCGCAGGTGATGGGCGCGGCGCTGG
ACGTGCTGCGCCAGGCCGCGGCGACGCTGGGCTTCGAGGCCAACGGCGTCTCGGACAATCCGCTGATCTTCGCCGGCGAC
ACGAACAATGGCGAGGACGAGGCGCTGTCGGGCGGCAACTTCCACGCCGAGCCGGTGGCCTTCGCGGCCGACATGATCGC
CCTGGCGGTCTGCGAGATCGGCTCCATCGCCGAGCGGCGGATCGCCATGCTGGTGGACCCGGCGCTCTCGGGCCTGCCGG
CGTTCCTGACGCCCAAGCCGGGGCTGAACTCGGGCTTCATGATCCCGCAGGTGACCGCCGCCGCCTTGGTCTCGGAGAAC
AAGCAGCTCGCCCACCCCGCCAGCGTCGATTCCATCCCGACCAGCGCCAACCAGGAGGACCACGTCTCCATGGCCGCGCA
CGGCGCCCGCCGCCTGCTCGCCATGACTGCCAACCTGGAAGGGGTGGTGGCCATCGAGCTGCTGGCGGCCGCGCAGGGCT
GCGACTTCCACGCGCCGCTGACGTCGAGCGAGGCCCTGGAGCGGGTCCGCGCGCGCCTGCGGCGGGACGTGCCCTCGCTG
GACCACGACCGGCACTTCGCCCCCGACATCGCCGCGGCCCAGGCGATCGTGCGAGCCGGCGAGCTCGCCTTCCCCGACCT
GCCGGGCGTCGCCTGA

Upstream 100 bases:

>100_bases
GCAAGCGCTGCGATCTCGCCATCTGGGACGTCGAGCGGCCCGCCGAGCTCGTCTACCGCATGGGATTCAATCCGCTGCAC
GCCCGCGTCTGGAGGGGCCG

Downstream 100 bases:

>100_bases
TGGACTGGCTGCAGGTCGTCCGGGGCGAGGCCCCGCTGGTGGTGAGCTTTCCGCATACGGGCACGGACATTCCGGCGGAT
ATCGAGGGGCGGCTCGTCTC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTDIVLEPGAAPLSVWREIWRGAGVRLDPAAHAVVAQSAEAVTRILARGEPVYGINTGFGKLATVRIEDADLATLQRNLV
LSHAAGVGEASPRAVVRLMMALKLASLAQGASGVRPVTVQLLERMIAQDLIPVVPGQGSVGASGDLAPLAHMAAAMLGVG
EIETAGQRLPAGEALAAAGLAPLALGPKEGLALLNGTQFSTANALAGLFEAERLFRSALVTGALSTEAAKGSDTPFDARI
HALRRQPGQVEAARALRELMAGSAIRASHLKDDERVQDPYCLRCQPQVMGAALDVLRQAAATLGFEANGVSDNPLIFAGD
TNNGEDEALSGGNFHAEPVAFAADMIALAVCEIGSIAERRIAMLVDPALSGLPAFLTPKPGLNSGFMIPQVTAAALVSEN
KQLAHPASVDSIPTSANQEDHVSMAAHGARRLLAMTANLEGVVAIELLAAAQGCDFHAPLTSSEALERVRARLRRDVPSL
DHDRHFAPDIAAAQAIVRAGELAFPDLPGVA

Sequences:

>Translated_511_residues
MTDIVLEPGAAPLSVWREIWRGAGVRLDPAAHAVVAQSAEAVTRILARGEPVYGINTGFGKLATVRIEDADLATLQRNLV
LSHAAGVGEASPRAVVRLMMALKLASLAQGASGVRPVTVQLLERMIAQDLIPVVPGQGSVGASGDLAPLAHMAAAMLGVG
EIETAGQRLPAGEALAAAGLAPLALGPKEGLALLNGTQFSTANALAGLFEAERLFRSALVTGALSTEAAKGSDTPFDARI
HALRRQPGQVEAARALRELMAGSAIRASHLKDDERVQDPYCLRCQPQVMGAALDVLRQAAATLGFEANGVSDNPLIFAGD
TNNGEDEALSGGNFHAEPVAFAADMIALAVCEIGSIAERRIAMLVDPALSGLPAFLTPKPGLNSGFMIPQVTAAALVSEN
KQLAHPASVDSIPTSANQEDHVSMAAHGARRLLAMTANLEGVVAIELLAAAQGCDFHAPLTSSEALERVRARLRRDVPSL
DHDRHFAPDIAAAQAIVRAGELAFPDLPGVA
>Mature_510_residues
TDIVLEPGAAPLSVWREIWRGAGVRLDPAAHAVVAQSAEAVTRILARGEPVYGINTGFGKLATVRIEDADLATLQRNLVL
SHAAGVGEASPRAVVRLMMALKLASLAQGASGVRPVTVQLLERMIAQDLIPVVPGQGSVGASGDLAPLAHMAAAMLGVGE
IETAGQRLPAGEALAAAGLAPLALGPKEGLALLNGTQFSTANALAGLFEAERLFRSALVTGALSTEAAKGSDTPFDARIH
ALRRQPGQVEAARALRELMAGSAIRASHLKDDERVQDPYCLRCQPQVMGAALDVLRQAAATLGFEANGVSDNPLIFAGDT
NNGEDEALSGGNFHAEPVAFAADMIALAVCEIGSIAERRIAMLVDPALSGLPAFLTPKPGLNSGFMIPQVTAAALVSENK
QLAHPASVDSIPTSANQEDHVSMAAHGARRLLAMTANLEGVVAIELLAAAQGCDFHAPLTSSEALERVRARLRRDVPSLD
HDRHFAPDIAAAQAIVRAGELAFPDLPGVA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=489, Percent_Identity=44.5807770961145, Blast_Score=364, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17567831, Length=474, Percent_Identity=44.5147679324894, Blast_Score=335, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_PHEZH (B4RED8)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129309.1
- GeneID:   6789957
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0466
- HOGENOM:   HBG510887
- OMA:   HIEGDER
- ProtClustDB:   PRK09367
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 52941; Mature: 52810

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIVLEPGAAPLSVWREIWRGAGVRLDPAAHAVVAQSAEAVTRILARGEPVYGINTGFG
CCCEEECCCCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
KLATVRIEDADLATLQRNLVLSHAAGVGEASPRAVVRLMMALKLASLAQGASGVRPVTVQ
CEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLERMIAQDLIPVVPGQGSVGASGDLAPLAHMAAAMLGVGEIETAGQRLPAGEALAAAGL
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCC
APLALGPKEGLALLNGTQFSTANALAGLFEAERLFRSALVTGALSTEAAKGSDTPFDARI
CHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HALRRQPGQVEAARALRELMAGSAIRASHLKDDERVQDPYCLRCQPQVMGAALDVLRQAA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCEEECCCHHHHHHHHHHHHHHH
ATLGFEANGVSDNPLIFAGDTNNGEDEALSGGNFHAEPVAFAADMIALAVCEIGSIAERR
HHCCCCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAMLVDPALSGLPAFLTPKPGLNSGFMIPQVTAAALVSENKQLAHPASVDSIPTSANQED
HHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
HVSMAAHGARRLLAMTANLEGVVAIELLAAAQGCDFHAPLTSSEALERVRARLRRDVPSL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DHDRHFAPDIAAAQAIVRAGELAFPDLPGVA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDIVLEPGAAPLSVWREIWRGAGVRLDPAAHAVVAQSAEAVTRILARGEPVYGINTGFG
CCEEECCCCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
KLATVRIEDADLATLQRNLVLSHAAGVGEASPRAVVRLMMALKLASLAQGASGVRPVTVQ
CEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLERMIAQDLIPVVPGQGSVGASGDLAPLAHMAAAMLGVGEIETAGQRLPAGEALAAAGL
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCC
APLALGPKEGLALLNGTQFSTANALAGLFEAERLFRSALVTGALSTEAAKGSDTPFDARI
CHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
HALRRQPGQVEAARALRELMAGSAIRASHLKDDERVQDPYCLRCQPQVMGAALDVLRQAA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCEEECCCHHHHHHHHHHHHHHH
ATLGFEANGVSDNPLIFAGDTNNGEDEALSGGNFHAEPVAFAADMIALAVCEIGSIAERR
HHCCCCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IAMLVDPALSGLPAFLTPKPGLNSGFMIPQVTAAALVSENKQLAHPASVDSIPTSANQED
HHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
HVSMAAHGARRLLAMTANLEGVVAIELLAAAQGCDFHAPLTSSEALERVRARLRRDVPSL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
DHDRHFAPDIAAAQAIVRAGELAFPDLPGVA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA