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The map label for this gene is map [H]

Identifier: 197103859

GI number: 197103859

Start: 395694

End: 396443

Strand: Reverse

Name: map [H]

Synonym: PHZ_c0393

Alternate gene names: 197103859

Gene position: 396443-395694 (Counterclockwise)

Preceding gene: 197103860

Following gene: 197103858

Centisome position: 9.92

GC content: 73.47

Gene sequence:

>750_bases
ATGACCATCGGCAGCGAAGACGACCTCGAGAAGCTGAAGGCGGCCGGCCGCCTCGTGGCGCGCACGCTGAAGGCCATGGG
CGAGGCGCTGGAGCCCGGGATCACCACCCGCGAGCTGGACCGCCTGGGCCGCAAGATGCTGGAGGACGCCGGCGCCCGCT
CGGCGCCCGAGCTGACCTACGCCTTCCCTGGCGCCACCTGCATCTCGATCGGCCCCGACGTGGCCCACGGCGTCCCGGAC
GACCGCAAGGTCGAGGCGGGCGACCTGATCAACATCGACGTCTCGGCCGAGCTGGACGGCTTCTTCGCCGACACCGGGGC
CAGCTTCGCCGTGCCGCCGACGGCGCCGAAGGTGGAGCGCCTGTGCCGCGACGGGCGCCGCGCCATGTGGGCCGGCATCC
GCGCCGTCCGCCCCGGCGGGCCGCTGAACGCCATCGGCAAGTCGATCGAGGCCTTCGCCGACCGCAACGGCTACAGCCTC
GTGCGCAACCTCGCGAGCCACGGCGTGGGCAGGAGCCTGCACGAGGAGCCGACCGAGATCGCCACCTGGTGGGAGCCGTC
CGACCGCCGGACGATCACCGAGGGCCTGGTCTTCACCATCGAGCCCTTCCTGTCCCTCGGGGCGGACTGGGTCGAAGAGG
CCGGCGACGGCTGGACCCTGCGCCCGCCCGGCGGCCAGCCGACGGTCCAGTACGAGCACACCCTGGTCGCCACCCGCCGC
GGGCCGGTGGTGGTCACGCTCGCTGAGTGA

Upstream 100 bases:

>100_bases
GCTGGACGACTGGCGCGCCGCGTTCGAGACGCTGGCGAACCGCACCGTCGTCGGCAAGACGATCATCCGCCCAGACCTCT
AGTTTCCGGACCTCCAGACC

Downstream 100 bases:

>100_bases
CTTGGCCGACCGACTTCGCCCATTGACTTAGCCGGTCAATTTGGCCGATTGAGCCGAGCGATCGAACGGGGCGCGGTTGA
CAGGCCCTCCCCGTTCCACT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 2 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTIGSEDDLEKLKAAGRLVARTLKAMGEALEPGITTRELDRLGRKMLEDAGARSAPELTYAFPGATCISIGPDVAHGVPD
DRKVEAGDLINIDVSAELDGFFADTGASFAVPPTAPKVERLCRDGRRAMWAGIRAVRPGGPLNAIGKSIEAFADRNGYSL
VRNLASHGVGRSLHEEPTEIATWWEPSDRRTITEGLVFTIEPFLSLGADWVEEAGDGWTLRPPGGQPTVQYEHTLVATRR
GPVVVTLAE

Sequences:

>Translated_249_residues
MTIGSEDDLEKLKAAGRLVARTLKAMGEALEPGITTRELDRLGRKMLEDAGARSAPELTYAFPGATCISIGPDVAHGVPD
DRKVEAGDLINIDVSAELDGFFADTGASFAVPPTAPKVERLCRDGRRAMWAGIRAVRPGGPLNAIGKSIEAFADRNGYSL
VRNLASHGVGRSLHEEPTEIATWWEPSDRRTITEGLVFTIEPFLSLGADWVEEAGDGWTLRPPGGQPTVQYEHTLVATRR
GPVVVTLAE
>Mature_248_residues
TIGSEDDLEKLKAAGRLVARTLKAMGEALEPGITTRELDRLGRKMLEDAGARSAPELTYAFPGATCISIGPDVAHGVPDD
RKVEAGDLINIDVSAELDGFFADTGASFAVPPTAPKVERLCRDGRRAMWAGIRAVRPGGPLNAIGKSIEAFADRNGYSLV
RNLASHGVGRSLHEEPTEIATWWEPSDRRTITEGLVFTIEPFLSLGADWVEEAGDGWTLRPPGGQPTVQYEHTLVATRRG
PVVVTLAE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=31.5789473684211, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI164420681, Length=243, Percent_Identity=29.6296296296296, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=36.9477911646586, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=30.3643724696356, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=31.7073170731707, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=32.520325203252, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=31.1475409836066, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26754; Mature: 26623

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGSEDDLEKLKAAGRLVARTLKAMGEALEPGITTRELDRLGRKMLEDAGARSAPELTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
AFPGATCISIGPDVAHGVPDDRKVEAGDLINIDVSAELDGFFADTGASFAVPPTAPKVER
ECCCCEEEECCCHHHCCCCCCCEECCCCEEEEEECCCCCCEEECCCCCCCCCCCCHHHHH
LCRDGRRAMWAGIRAVRPGGPLNAIGKSIEAFADRNGYSLVRNLASHGVGRSLHEEPTEI
HHHHCHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHCCCCHH
ATWWEPSDRRTITEGLVFTIEPFLSLGADWVEEAGDGWTLRPPGGQPTVQYEHTLVATRR
EECCCCCCCCCHHHHHHEEEHHHHHCCHHHHHHCCCCCEECCCCCCCCEEEEEEEEEECC
GPVVVTLAE
CCEEEEECC
>Mature Secondary Structure 
TIGSEDDLEKLKAAGRLVARTLKAMGEALEPGITTRELDRLGRKMLEDAGARSAPELTY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
AFPGATCISIGPDVAHGVPDDRKVEAGDLINIDVSAELDGFFADTGASFAVPPTAPKVER
ECCCCEEEECCCHHHCCCCCCCEECCCCEEEEEECCCCCCEEECCCCCCCCCCCCHHHHH
LCRDGRRAMWAGIRAVRPGGPLNAIGKSIEAFADRNGYSLVRNLASHGVGRSLHEEPTEI
HHHHCHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHCCCCHH
ATWWEPSDRRTITEGLVFTIEPFLSLGADWVEEAGDGWTLRPPGGQPTVQYEHTLVATRR
EECCCCCCCCCHHHHHHEEEHHHHHCCHHHHHHCCCCCEECCCCCCCCEEEEEEEEEECC
GPVVVTLAE
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9272861; 9384377 [H]