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The map label for this gene is dnaX [H]

Identifier: 197103834

GI number: 197103834

Start: 372129

End: 373946

Strand: Direct

Name: dnaX [H]

Synonym: PHZ_c0368

Alternate gene names: 197103834

Gene position: 372129-373946 (Clockwise)

Preceding gene: 197103831

Following gene: 197103835

Centisome position: 9.31

GC content: 72.72

Gene sequence:

>1818_bases
ATGGCCGCGATGGTGGACGACGAAGAGATTCCCGAGCGGGATCCCAACACCGGCGACATTTTCGGGGACGCCGCGCCTGC
GGCGCCGGCGGCGTCCGCGCCTGCCTCCGGCGAGGAGTCGGCCGCCTACACCGTCATCGCCCGCAAGTACCGGCCGCGCA
CCTTCGAGGACCTCTACGGCCAGGAGGCCATGGTCCGCACCCTGCGCAACGCCTTCGCCTCGGGGCGGATCGCGCACGCC
TTCATGCTGACCGGCGTCCGCGGGGTGGGCAAGACGACCACCGCGCGCCTGCTGGCCCGGGCCCTGAACTACGAGACCGC
CACCGTCCACGAGCCGACCCTGGACCTGAAGGAAGAGGGGCTGCACTGCCGGGCCATCATCGAGGGCCGGCACATGGACG
TCCTCGAGCTGGACGCCGCCTCGCGCACCGGGGTGAACGACATCCGGGAGCTGCTGGACGGGGTGCGCTATGCGCCCGTC
GAGGCCCGCTACAAGGTCTACATCATCGACGAGGTCCACATGTTGTCGACGGGGGCGTTCAACGCGCTCCTGAAGACGCT
GGAGGAGCCGCCGCCGCACGCCAAGTTCATCTTCGCCACGACCGAGATCCGCAAGGTGCCGGTCACCATCCTCTCGCGGA
CCCAGCGGTTCGACCTGCGCCGGGTGGAGCCCGAGATGCTGGTCAAGAACCTGGAGATGATCTGCGAGAACGAGGGGGCG
CGGGTCGAGGCCGAGGGGCTGATGCTGATCGCCCGGGCCGCCGAGGGCAGCGTGCGCGACGGCCAGTCGATGCTGGACCA
GGCCATCGTCCAGGCCGAGCCCGGCCAGACGGTCACCGCCGCCACCATCCGCGACATGCTGGGCCTGGCCGACCGGGCCC
AGACCATCGGCCTGTTCGAACAGCTCATGCGCGGCCAGGCGGGCGAGGCCATCGAGACGTTCCGCACGCTCTACGGCTAC
GGCGCCAATCCCGACCAGGTGATGCTGGACCTGCTGGACCATGTGCACGGGGCCAGCGTCGCCAAGGCCATCGGGCCGCA
GGCGCTGGTGATGCCCAAGGAGCAGGCCCAGCGGCTGGCGGCGATCGGCGCGGCGGTCTCGGCGGGGGTGCTCTCGCGCC
TATGGCAGCTGACCCTGAAGGCCTACGAAGAGGTCCGGCGCGCGCCCGACGCGGCCGCGGCCGTGGACATGGCGCTGATC
CGGATGGCCTACGCCGCCGACCTGCCCGGCCCCGAGGAGGCGCTGAAGAAGCTGCAGGCGGGCGAGCCGGTGACCGGCGG
GCCGGGAGGCGGCGGCGGAGGCGGCGGCCGGGCGGTCCAGGCGCCGGGCGGCGGCGGGGCGAGCGCGGTGGCGCGCCAGA
CCATGGTCCAGCCGCAGGCGTCGGCCGAGCCGATGGCGCAGCTCGCCAGCTTCGAGGACATCCTGGCGCTGATCGAGAAG
AAGCGGGACATCACGCTGAAGCTGGATATCGAGCGCTTCGTCCGCCCGATCAGCGTGCGGCCCGGCGCCATCGAGTACGA
GCCGGCGCCCGGCGCGCCGCGCGACCTGGCGCAGCGGCTGGTGGCGCGCCTGCGCGAATGGACCGGGGAGCGCTGGCTGA
TCTCGGCCCAGGGCGGCGGCGGCGCCGAGAGCCTGTGGGAGAAGCAGAAGCGCGAGCAGCGCGAGGTGCGCGCCGCCATC
GAGCAGGACCCCTTCGTGCAGTCGGTGATGCAGGCCTTCCCCGGCGCCGAGATCGTCGGCATCCGCCAGGCGGTCCAGCC
CGCCGCGGCCGAGGGCGAGGCCCCGCCGGTCGAGGCCGACGACGAGGACGAGGACTAG

Upstream 100 bases:

>100_bases
GCGGGAGAGCGGCCGGTCCCGGTTCGTGTTTGTTCGTGGCCATGGACAGCGGGGCGTACGCGCGCCTTTCCCCTTCCGTT
CACCGGGCCCGAACCGTTAG

Downstream 100 bases:

>100_bases
CCAAGCTGAGCGCCTGCGGCGCCGGGAGTGAGTTGCGATGAAAGACCTGAATTCGCTGATGAAGCAGGCCCAGGCCATGC
AGCAGAAGCTGGCCGACGCC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MAAMVDDEEIPERDPNTGDIFGDAAPAAPAASAPASGEESAAYTVIARKYRPRTFEDLYGQEAMVRTLRNAFASGRIAHA
FMLTGVRGVGKTTTARLLARALNYETATVHEPTLDLKEEGLHCRAIIEGRHMDVLELDAASRTGVNDIRELLDGVRYAPV
EARYKVYIIDEVHMLSTGAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRTQRFDLRRVEPEMLVKNLEMICENEGA
RVEAEGLMLIARAAEGSVRDGQSMLDQAIVQAEPGQTVTAATIRDMLGLADRAQTIGLFEQLMRGQAGEAIETFRTLYGY
GANPDQVMLDLLDHVHGASVAKAIGPQALVMPKEQAQRLAAIGAAVSAGVLSRLWQLTLKAYEEVRRAPDAAAAVDMALI
RMAYAADLPGPEEALKKLQAGEPVTGGPGGGGGGGGRAVQAPGGGGASAVARQTMVQPQASAEPMAQLASFEDILALIEK
KRDITLKLDIERFVRPISVRPGAIEYEPAPGAPRDLAQRLVARLREWTGERWLISAQGGGGAESLWEKQKREQREVRAAI
EQDPFVQSVMQAFPGAEIVGIRQAVQPAAAEGEAPPVEADDEDED

Sequences:

>Translated_605_residues
MAAMVDDEEIPERDPNTGDIFGDAAPAAPAASAPASGEESAAYTVIARKYRPRTFEDLYGQEAMVRTLRNAFASGRIAHA
FMLTGVRGVGKTTTARLLARALNYETATVHEPTLDLKEEGLHCRAIIEGRHMDVLELDAASRTGVNDIRELLDGVRYAPV
EARYKVYIIDEVHMLSTGAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRTQRFDLRRVEPEMLVKNLEMICENEGA
RVEAEGLMLIARAAEGSVRDGQSMLDQAIVQAEPGQTVTAATIRDMLGLADRAQTIGLFEQLMRGQAGEAIETFRTLYGY
GANPDQVMLDLLDHVHGASVAKAIGPQALVMPKEQAQRLAAIGAAVSAGVLSRLWQLTLKAYEEVRRAPDAAAAVDMALI
RMAYAADLPGPEEALKKLQAGEPVTGGPGGGGGGGGRAVQAPGGGGASAVARQTMVQPQASAEPMAQLASFEDILALIEK
KRDITLKLDIERFVRPISVRPGAIEYEPAPGAPRDLAQRLVARLREWTGERWLISAQGGGGAESLWEKQKREQREVRAAI
EQDPFVQSVMQAFPGAEIVGIRQAVQPAAAEGEAPPVEADDEDED
>Mature_604_residues
AAMVDDEEIPERDPNTGDIFGDAAPAAPAASAPASGEESAAYTVIARKYRPRTFEDLYGQEAMVRTLRNAFASGRIAHAF
MLTGVRGVGKTTTARLLARALNYETATVHEPTLDLKEEGLHCRAIIEGRHMDVLELDAASRTGVNDIRELLDGVRYAPVE
ARYKVYIIDEVHMLSTGAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRTQRFDLRRVEPEMLVKNLEMICENEGAR
VEAEGLMLIARAAEGSVRDGQSMLDQAIVQAEPGQTVTAATIRDMLGLADRAQTIGLFEQLMRGQAGEAIETFRTLYGYG
ANPDQVMLDLLDHVHGASVAKAIGPQALVMPKEQAQRLAAIGAAVSAGVLSRLWQLTLKAYEEVRRAPDAAAAVDMALIR
MAYAADLPGPEEALKKLQAGEPVTGGPGGGGGGGGRAVQAPGGGGASAVARQTMVQPQASAEPMAQLASFEDILALIEKK
RDITLKLDIERFVRPISVRPGAIEYEPAPGAPRDLAQRLVARLREWTGERWLISAQGGGGAESLWEKQKREQREVRAAIE
QDPFVQSVMQAFPGAEIVGIRQAVQPAAAEGEAPPVEADDEDED

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=320, Percent_Identity=23.75, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31881687, Length=320, Percent_Identity=23.75, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI6677723, Length=219, Percent_Identity=26.027397260274, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI194306571, Length=222, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI194306567, Length=222, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786676, Length=375, Percent_Identity=41.3333333333333, Blast_Score=266, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17541988, Length=332, Percent_Identity=23.7951807228916, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17554730, Length=211, Percent_Identity=23.696682464455, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324478, Length=271, Percent_Identity=23.9852398523985, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=317, Percent_Identity=21.4511041009464, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18859927, Length=317, Percent_Identity=24.6056782334385, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647857, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65129; Mature: 64998

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMVDDEEIPERDPNTGDIFGDAAPAAPAASAPASGEESAAYTVIARKYRPRTFEDLYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHC
QEAMVRTLRNAFASGRIAHAFMLTGVRGVGKTTTARLLARALNYETATVHEPTLDLKEEG
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHCC
LHCRAIIEGRHMDVLELDAASRTGVNDIRELLDGVRYAPVEARYKVYIIDEVHMLSTGAF
CEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHH
NALLKTLEEPPPHAKFIFATTEIRKVPVTILSRTQRFDLRRVEPEMLVKNLEMICENEGA
HHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
RVEAEGLMLIARAAEGSVRDGQSMLDQAIVQAEPGQTVTAATIRDMLGLADRAQTIGLFE
EEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
QLMRGQAGEAIETFRTLYGYGANPDQVMLDLLDHVHGASVAKAIGPQALVMPKEQAQRLA
HHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHCCCCEEECCHHHHHHHH
AIGAAVSAGVLSRLWQLTLKAYEEVRRAPDAAAAVDMALIRMAYAADLPGPEEALKKLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GEPVTGGPGGGGGGGGRAVQAPGGGGASAVARQTMVQPQASAEPMAQLASFEDILALIEK
CCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
KRDITLKLDIERFVRPISVRPGAIEYEPAPGAPRDLAQRLVARLREWTGERWLISAQGGG
CCCEEEEEEHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GAESLWEKQKREQREVRAAIEQDPFVQSVMQAFPGAEIVGIRQAVQPAAAEGEAPPVEAD
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCCC
DEDED
CCCCC
>Mature Secondary Structure 
AAMVDDEEIPERDPNTGDIFGDAAPAAPAASAPASGEESAAYTVIARKYRPRTFEDLYG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHC
QEAMVRTLRNAFASGRIAHAFMLTGVRGVGKTTTARLLARALNYETATVHEPTLDLKEEG
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHCC
LHCRAIIEGRHMDVLELDAASRTGVNDIRELLDGVRYAPVEARYKVYIIDEVHMLSTGAF
CEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHH
NALLKTLEEPPPHAKFIFATTEIRKVPVTILSRTQRFDLRRVEPEMLVKNLEMICENEGA
HHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
RVEAEGLMLIARAAEGSVRDGQSMLDQAIVQAEPGQTVTAATIRDMLGLADRAQTIGLFE
EEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
QLMRGQAGEAIETFRTLYGYGANPDQVMLDLLDHVHGASVAKAIGPQALVMPKEQAQRLA
HHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHCCCCEEECCHHHHHHHH
AIGAAVSAGVLSRLWQLTLKAYEEVRRAPDAAAAVDMALIRMAYAADLPGPEEALKKLQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GEPVTGGPGGGGGGGGRAVQAPGGGGASAVARQTMVQPQASAEPMAQLASFEDILALIEK
CCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
KRDITLKLDIERFVRPISVRPGAIEYEPAPGAPRDLAQRLVARLREWTGERWLISAQGGG
CCCEEEEEEHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GAESLWEKQKREQREVRAAIEQDPFVQSVMQAFPGAEIVGIRQAVQPAAAEGEAPPVEAD
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCCCCCCC
DEDED
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]