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The map label for this gene is pgi [H]

Identifier: 197103797

GI number: 197103797

Start: 327031

End: 328596

Strand: Direct

Name: pgi [H]

Synonym: PHZ_c0331

Alternate gene names: 197103797

Gene position: 327031-328596 (Clockwise)

Preceding gene: 197103796

Following gene: 197103798

Centisome position: 8.18

GC content: 73.82

Gene sequence:

>1566_bases
TTGACCGACACCGACGCCGCCGCGTCCTGGCGGGCGCTTGACGCGGCCGGGGAGGCCGCCGCCCAGCGTTCGATCGCGGG
CCTGTTCGAGGCCGAGCCGGACCGGGCCTCCCGCCTGACCTTCGAGGCCGCGGGCCTGGTCCTCGACCTCTCCAAGCAGC
CCTGGTCCCAGGCCGACGTCGGGACCATGCTGGACCTCGCCCGCGCGTCGGGAGTGGAGGCGGCCCGCGCGGCCCTGTTC
GCCGGCGAGGTGGTCAACCGCTCCGAGGGGCGGCCGGCCCTGCACATGGCTCTGCGCGCGCCGGAGGGGGCCGGCTTCGC
CGCGGCGGGCGTCCCCGTTTCGGGCGAGGTCGAGACCACGCGCGCGAAGATGAAGGCCTTCGCCGGGGAGGTCCGCTCGG
GCGCCCGGCGCGGGGCGACCGGCCGGCCGTTCAAGGCCATCGTCCACATCGGCATCGGCGGCTCCGACCTCGGGCCGCGG
CTCATCTGGGAAGCGCTGCGGCCGCTAGAGCCCGCCCTCGACCTGCGCTTCGTCGCCAACGTCGATCCGGCCGAACTGGC
CCAGGCCCTGACCGGCCTCGATCCGGCGGAGACGCTGGTGGTCACCGTCTCCAAGACCTTCACCACCCTCGAGACCCTGA
CCAACGCCGAGGCCGCGCGGGCCTGGCTCCGCGCCGCGCTCGGCGAAGCGTCGGACAGCCACCTCGTCGCCGTCTCGGCC
GCGCCCGACAAGGCGCGGGGGTTCGGCGTCCCGGAGGACCAGGTGTTCGCCTTCTGGGACTGGGTCGGCGGCCGCTATTC
GCTGTGGTCGGCGGTGGGCCTCTCCTGCGCCGTCGCCCTGGGCTGGGAGGCGTTCGAGGCGCTGCACGCCGGCGCGGCGG
CGATGGACGTCCACTTCCGGGACGCCGCCCTGGACGCCAACCTGCCGGTCCTGCTGGCGCTCGCCCACGTCTTCAACCGA
AACGGCCTTGGCCGGCCGATCCGCGCGGTGGTCCCCTACGCCCAGCGCCTTCGCCTGCTGCCCCCCTTTCTCCAGCAGCT
GGAGATGGAATCGAACGGCAAGCGGGTCACCGCCGACGGCCGCCCGGTTCCGCGCCCGACCGCCGCCAGCGTGTTCGGCG
ACGCCGGCACCAACGGCCAGCACGCCTTCTTCCAGCTCCTGCACCAGGGAACCGATGTCATCCCCGTGGACATCGTCGCC
GTCCGCCAGGGCTCCGAGGGCGATCCGGCGGCCCAGCGGAAGCTGCTCGCCAACGCCGTGGCCCAGGCCGAGGCCCTGAT
GGTCGGCCGCGCGATGCCGGACGATGCCCAGCGGGACTTCCCCGGCAACCGTCCGTCCAGCTTCCTGCTGCTGGACCGCC
TGATCCCGCAGGCCCTCGGCGCGCTGATCGCCCTCTACGAGCACAAGACCTTCGTCGAGGGCGTCCTGTGGGGGATCAAC
AGCTTCGACCAGTGGGGCGTGGAGCTCGGCAAGACCCTCGCGGCCCGCATCCTCGAGGACCTGGAAGGCGCGGCCCAAAA
TCCCCACGACCCGTCGACCCAGGCGCTGATCGAGCGGCTGCGCTGA

Upstream 100 bases:

>100_bases
GTGAAGGCCGGCCGCGCCGTCGCCCAGGCTGCAACCCAACCCTACGGCTGCAGCGTTAAGTACGCCTCGGCCGACTAGCT
TTGCTGCTGAAGGGGGATGC

Downstream 100 bases:

>100_bases
CCGCCCTCCTCTCCCCCCGCGAAGCGGAGAGGGAGAGGGTAGGGAGAGGGCGGCGCGCAGCGCCGTGCGGCCGCTCCCTC
GCTCTGCTCGGGGGAGAGGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MTDTDAAASWRALDAAGEAAAQRSIAGLFEAEPDRASRLTFEAAGLVLDLSKQPWSQADVGTMLDLARASGVEAARAALF
AGEVVNRSEGRPALHMALRAPEGAGFAAAGVPVSGEVETTRAKMKAFAGEVRSGARRGATGRPFKAIVHIGIGGSDLGPR
LIWEALRPLEPALDLRFVANVDPAELAQALTGLDPAETLVVTVSKTFTTLETLTNAEAARAWLRAALGEASDSHLVAVSA
APDKARGFGVPEDQVFAFWDWVGGRYSLWSAVGLSCAVALGWEAFEALHAGAAAMDVHFRDAALDANLPVLLALAHVFNR
NGLGRPIRAVVPYAQRLRLLPPFLQQLEMESNGKRVTADGRPVPRPTAASVFGDAGTNGQHAFFQLLHQGTDVIPVDIVA
VRQGSEGDPAAQRKLLANAVAQAEALMVGRAMPDDAQRDFPGNRPSSFLLLDRLIPQALGALIALYEHKTFVEGVLWGIN
SFDQWGVELGKTLAARILEDLEGAAQNPHDPSTQALIERLR

Sequences:

>Translated_521_residues
MTDTDAAASWRALDAAGEAAAQRSIAGLFEAEPDRASRLTFEAAGLVLDLSKQPWSQADVGTMLDLARASGVEAARAALF
AGEVVNRSEGRPALHMALRAPEGAGFAAAGVPVSGEVETTRAKMKAFAGEVRSGARRGATGRPFKAIVHIGIGGSDLGPR
LIWEALRPLEPALDLRFVANVDPAELAQALTGLDPAETLVVTVSKTFTTLETLTNAEAARAWLRAALGEASDSHLVAVSA
APDKARGFGVPEDQVFAFWDWVGGRYSLWSAVGLSCAVALGWEAFEALHAGAAAMDVHFRDAALDANLPVLLALAHVFNR
NGLGRPIRAVVPYAQRLRLLPPFLQQLEMESNGKRVTADGRPVPRPTAASVFGDAGTNGQHAFFQLLHQGTDVIPVDIVA
VRQGSEGDPAAQRKLLANAVAQAEALMVGRAMPDDAQRDFPGNRPSSFLLLDRLIPQALGALIALYEHKTFVEGVLWGIN
SFDQWGVELGKTLAARILEDLEGAAQNPHDPSTQALIERLR
>Mature_520_residues
TDTDAAASWRALDAAGEAAAQRSIAGLFEAEPDRASRLTFEAAGLVLDLSKQPWSQADVGTMLDLARASGVEAARAALFA
GEVVNRSEGRPALHMALRAPEGAGFAAAGVPVSGEVETTRAKMKAFAGEVRSGARRGATGRPFKAIVHIGIGGSDLGPRL
IWEALRPLEPALDLRFVANVDPAELAQALTGLDPAETLVVTVSKTFTTLETLTNAEAARAWLRAALGEASDSHLVAVSAA
PDKARGFGVPEDQVFAFWDWVGGRYSLWSAVGLSCAVALGWEAFEALHAGAAAMDVHFRDAALDANLPVLLALAHVFNRN
GLGRPIRAVVPYAQRLRLLPPFLQQLEMESNGKRVTADGRPVPRPTAASVFGDAGTNGQHAFFQLLHQGTDVIPVDIVAV
RQGSEGDPAAQRKLLANAVAQAEALMVGRAMPDDAQRDFPGNRPSSFLLLDRLIPQALGALIALYEHKTFVEGVLWGINS
FDQWGVELGKTLAARILEDLEGAAQNPHDPSTQALIERLR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=537, Percent_Identity=42.4581005586592, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI296080693, Length=537, Percent_Identity=39.6648044692737, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1790457, Length=538, Percent_Identity=42.0074349442379, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71996708, Length=538, Percent_Identity=41.2639405204461, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71996703, Length=538, Percent_Identity=41.2639405204461, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319673, Length=538, Percent_Identity=39.5910780669145, Blast_Score=399, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651916, Length=529, Percent_Identity=41.7769376181474, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651914, Length=529, Percent_Identity=41.7769376181474, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI17737445, Length=529, Percent_Identity=41.7769376181474, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 55256; Mature: 55125

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTDAAASWRALDAAGEAAAQRSIAGLFEAEPDRASRLTFEAAGLVLDLSKQPWSQADV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCEEEECCCCCCCCCHH
GTMLDLARASGVEAARAALFAGEVVNRSEGRPALHMALRAPEGAGFAAAGVPVSGEVETT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCHHHH
RAKMKAFAGEVRSGARRGATGRPFKAIVHIGIGGSDLGPRLIWEALRPLEPALDLRFVAN
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECC
VDPAELAQALTGLDPAETLVVTVSKTFTTLETLTNAEAARAWLRAALGEASDSHLVAVSA
CCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC
APDKARGFGVPEDQVFAFWDWVGGRYSLWSAVGLSCAVALGWEAFEALHAGAAAMDVHFR
CCCHHCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEH
DAALDANLPVLLALAHVFNRNGLGRPIRAVVPYAQRLRLLPPFLQQLEMESNGKRVTADG
HHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
RPVPRPTAASVFGDAGTNGQHAFFQLLHQGTDVIPVDIVAVRQGSEGDPAAQRKLLANAV
CCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHH
AQAEALMVGRAMPDDAQRDFPGNRPSSFLLLDRLIPQALGALIALYEHKTFVEGVLWGIN
HHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SFDQWGVELGKTLAARILEDLEGAAQNPHDPSTQALIERLR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TDTDAAASWRALDAAGEAAAQRSIAGLFEAEPDRASRLTFEAAGLVLDLSKQPWSQADV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCEEEECCCCCCCCCHH
GTMLDLARASGVEAARAALFAGEVVNRSEGRPALHMALRAPEGAGFAAAGVPVSGEVETT
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCHHHH
RAKMKAFAGEVRSGARRGATGRPFKAIVHIGIGGSDLGPRLIWEALRPLEPALDLRFVAN
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECC
VDPAELAQALTGLDPAETLVVTVSKTFTTLETLTNAEAARAWLRAALGEASDSHLVAVSA
CCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC
APDKARGFGVPEDQVFAFWDWVGGRYSLWSAVGLSCAVALGWEAFEALHAGAAAMDVHFR
CCCHHCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEH
DAALDANLPVLLALAHVFNRNGLGRPIRAVVPYAQRLRLLPPFLQQLEMESNGKRVTADG
HHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
RPVPRPTAASVFGDAGTNGQHAFFQLLHQGTDVIPVDIVAVRQGSEGDPAAQRKLLANAV
CCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHH
AQAEALMVGRAMPDDAQRDFPGNRPSSFLLLDRLIPQALGALIALYEHKTFVEGVLWGIN
HHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SFDQWGVELGKTLAARILEDLEGAAQNPHDPSTQALIERLR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA