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The map label for this gene is moeA [H]

Identifier: 197103741

GI number: 197103741

Start: 271269

End: 272459

Strand: Reverse

Name: moeA [H]

Synonym: PHZ_c0275

Alternate gene names: 197103741

Gene position: 272459-271269 (Counterclockwise)

Preceding gene: 197103742

Following gene: 197103739

Centisome position: 6.82

GC content: 77.58

Gene sequence:

>1191_bases
GTGAGGCTCCTGAGCGTCGACGAGGCCCGGGCGCGGATGCTGGCGCAGGCGCCGGCGCCGCGGGCCGAGACGGTTCCCCT
CGCCGAAGCGATCGGCCGGGTGCTCGCCGAGGACGTCGCCGCCACCCGCGACCAGCCGCCGTTCCGGGCCTCGGCCATGG
ACGGCTATGCGGTGCGCAGCGCCGATACGCCCGGCGCGCTGAGGGTCGTCGGCGAGAGCGCCGCCGGCCGCGGCTTCGAG
GGCGCCGGGGGTCCCGGCGAGGCGGTGCGGATCTTCACCGGCGCGGCCCTGCCCGACGGTTGCGACGCCGTGGTGATCCA
GGAGGACGCCGTTCGCGAAGGCGAGGCCGTGACGGTCCCGGCGGCGAGCCCCGGGCGGCACGTGCGGCCGGCCGGCGGCG
ACTTCCGCGCCGGGCAGGCGCTGCTGGCGCAAGGGACCGTGATCGACCCCTGGCGGCTCTCGCTGGCCGCGGCGGCCGGC
CGCGGCGAGCTGGCGGTCGCGCGGCGGCCGCGCGTGGCCCTGTTCTCGACCGGCGAGGAGATCGTCGAGCCGCCGGCCGC
GCCTGGCCCCTTCCAGATCTACGATTCCGGCTCGCCCGCGCTGGCGGCGCTGATCCGCGGCTGGGGGGCCGAGGTCTCCC
GCGCCCGGCCGGTGCGCGACGACCTGGAGGCCACGGTCGAGGCCCTGCGCGCGGCCGACGGCGAGCTGGTGGTCACCCTG
GGCGGGGCCTCGGTGGGCGACCACGACCTGGTGCGCAAGGCCGGCGAGGCCCTGGGGCTGGAGCTGAAGGTGGCGAGCGT
GGCGATCCGCCCCGGCAAGCCCACCTTCTTCGGGGTGCTGGGAGACGGGCGGCGGATGCTGGGCCTGCCCGGCAATCCGG
CCTCGGCCTTCGTCTGCGCCGAGCTGTTCCTGAAGCCCTACCTGATGGCCTGCCTGGGCGCCCCGGCGGCCTTGCGGACG
ATCCCCGTCCGCCTGGCCGACGACCTGCCGGCCAATGGCCCACGCGAGCACTGGATGCGCGCCAGCCTCTCGTTCGAAGG
CGGCGCCGTGACTGTGCGGCCCTTCCGGGATCAGGACTCCTCGCTGGTCAGCGTCTTCGCCGCCGCCGACGCGCTGCTGC
GCCGCGCGCCGGACGCCCCGGCGCTGTCGGCCGGCGACCTGGCCGAGGCGCTGCCGCTGTCGCGGGCGTAG

Upstream 100 bases:

>100_bases
TGACGCTCTACGACATGCTGAAGGCCGCCGAGAAGAGCATGGTCATCGAGGCCGTCCGCCTCACCGAGAAGACCGGCGGC
AAGAGCGGGGACTGGAAGGC

Downstream 100 bases:

>100_bases
CGCAGGGCGGTGATCTCGCCGATCACCGAGACCGCCACCTCGAACGGGGCCTTGCCGCCGATGTCGAGGCCGATCGGGGC
GTGCAGGCGGGCGAGGACCG

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRLLSVDEARARMLAQAPAPRAETVPLAEAIGRVLAEDVAATRDQPPFRASAMDGYAVRSADTPGALRVVGESAAGRGFE
GAGGPGEAVRIFTGAALPDGCDAVVIQEDAVREGEAVTVPAASPGRHVRPAGGDFRAGQALLAQGTVIDPWRLSLAAAAG
RGELAVARRPRVALFSTGEEIVEPPAAPGPFQIYDSGSPALAALIRGWGAEVSRARPVRDDLEATVEALRAADGELVVTL
GGASVGDHDLVRKAGEALGLELKVASVAIRPGKPTFFGVLGDGRRMLGLPGNPASAFVCAELFLKPYLMACLGAPAALRT
IPVRLADDLPANGPREHWMRASLSFEGGAVTVRPFRDQDSSLVSVFAAADALLRRAPDAPALSAGDLAEALPLSRA

Sequences:

>Translated_396_residues
MRLLSVDEARARMLAQAPAPRAETVPLAEAIGRVLAEDVAATRDQPPFRASAMDGYAVRSADTPGALRVVGESAAGRGFE
GAGGPGEAVRIFTGAALPDGCDAVVIQEDAVREGEAVTVPAASPGRHVRPAGGDFRAGQALLAQGTVIDPWRLSLAAAAG
RGELAVARRPRVALFSTGEEIVEPPAAPGPFQIYDSGSPALAALIRGWGAEVSRARPVRDDLEATVEALRAADGELVVTL
GGASVGDHDLVRKAGEALGLELKVASVAIRPGKPTFFGVLGDGRRMLGLPGNPASAFVCAELFLKPYLMACLGAPAALRT
IPVRLADDLPANGPREHWMRASLSFEGGAVTVRPFRDQDSSLVSVFAAADALLRRAPDAPALSAGDLAEALPLSRA
>Mature_396_residues
MRLLSVDEARARMLAQAPAPRAETVPLAEAIGRVLAEDVAATRDQPPFRASAMDGYAVRSADTPGALRVVGESAAGRGFE
GAGGPGEAVRIFTGAALPDGCDAVVIQEDAVREGEAVTVPAASPGRHVRPAGGDFRAGQALLAQGTVIDPWRLSLAAAAG
RGELAVARRPRVALFSTGEEIVEPPAAPGPFQIYDSGSPALAALIRGWGAEVSRARPVRDDLEATVEALRAADGELVVTL
GGASVGDHDLVRKAGEALGLELKVASVAIRPGKPTFFGVLGDGRRMLGLPGNPASAFVCAELFLKPYLMACLGAPAALRT
IPVRLADDLPANGPREHWMRASLSFEGGAVTVRPFRDQDSSLVSVFAAADALLRRAPDAPALSAGDLAEALPLSRA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=362, Percent_Identity=36.4640883977901, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI10880983, Length=362, Percent_Identity=36.4640883977901, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=36.8146214099217, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147659, Length=391, Percent_Identity=32.4808184143223, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=387, Percent_Identity=25.5813953488372, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=385, Percent_Identity=31.1688311688312, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24638841, Length=385, Percent_Identity=31.1688311688312, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 40811; Mature: 40811

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLSVDEARARMLAQAPAPRAETVPLAEAIGRVLAEDVAATRDQPPFRASAMDGYAVRS
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
ADTPGALRVVGESAAGRGFEGAGGPGEAVRIFTGAALPDGCDAVVIQEDAVREGEAVTVP
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEC
AASPGRHVRPAGGDFRAGQALLAQGTVIDPWRLSLAAAAGRGELAVARRPRVALFSTGEE
CCCCCCCCCCCCCCCCCCCHHHHCCCEECHHHHHHEECCCCCCEEEECCCCEEEEECCHH
IVEPPAAPGPFQIYDSGSPALAALIRGWGAEVSRARPVRDDLEATVEALRAADGELVVTL
HHCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
GGASVGDHDLVRKAGEALGLELKVASVAIRPGKPTFFGVLGDGRRMLGLPGNPASAFVCA
CCCCCCHHHHHHHHHHHHCEEEEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHHHHHH
ELFLKPYLMACLGAPAALRTIPVRLADDLPANGPREHWMRASLSFEGGAVTVRPFRDQDS
HHHHHHHHHHHHCCCHHHHEECEEECCCCCCCCCHHHHEEEEEEECCCEEEEEECCCCCH
SLVSVFAAADALLRRAPDAPALSAGDLAEALPLSRA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MRLLSVDEARARMLAQAPAPRAETVPLAEAIGRVLAEDVAATRDQPPFRASAMDGYAVRS
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
ADTPGALRVVGESAAGRGFEGAGGPGEAVRIFTGAALPDGCDAVVIQEDAVREGEAVTVP
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEC
AASPGRHVRPAGGDFRAGQALLAQGTVIDPWRLSLAAAAGRGELAVARRPRVALFSTGEE
CCCCCCCCCCCCCCCCCCCHHHHCCCEECHHHHHHEECCCCCCEEEECCCCEEEEECCHH
IVEPPAAPGPFQIYDSGSPALAALIRGWGAEVSRARPVRDDLEATVEALRAADGELVVTL
HHCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
GGASVGDHDLVRKAGEALGLELKVASVAIRPGKPTFFGVLGDGRRMLGLPGNPASAFVCA
CCCCCCHHHHHHHHHHHHCEEEEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHHHHHH
ELFLKPYLMACLGAPAALRTIPVRLADDLPANGPREHWMRASLSFEGGAVTVRPFRDQDS
HHHHHHHHHHHHCCCHHHHEECEEECCCCCCCCCHHHHEEEEEEECCCEEEEEECCCCCH
SLVSVFAAADALLRRAPDAPALSAGDLAEALPLSRA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA