Click here to switch to the map view.

The map label for this gene is ubiH [H]

Identifier: 197103488

GI number: 197103488

Start: 18046

End: 19308

Strand: Reverse

Name: ubiH [H]

Synonym: PHZ_c0022

Alternate gene names: 197103488

Gene position: 19308-18046 (Counterclockwise)

Preceding gene: 197103492

Following gene: 197103483

Centisome position: 0.48

GC content: 75.14

Gene sequence:

>1263_bases
ATGAGCGGACCGTCCGAGGCGTTCGACGCCGACGTCATCATCGCCGGCGCCGGCATGGCGGGCGCCACCCTGGCCCTGGC
CCTCCAGCAAGGGGGCCTGAGGCCCCTGCTGATCGATCCTGTGGCCTTCGAGGCCCAGACGGCGCCGACGTTCGACGGCC
GCGCCTCGGCCATCGCCTACGCGGCCTACCGGCAGTGGCGGGCCCTGGGTCTTGCCGAGGCCTTCGACCCGCACGCCCAG
CGGATCGAGCAGATCCTGGTGACCGACGGGCGCACGCCGGGCGCCTCGACCGGCGCCCCGACCCCGTTCTTCCTGCGCTT
CGACTCCGCCGAAATCTCGGACCGGTCCGAAGGCGAGCCGCTGGGCTACCTGATCGAGAACCGCCACACCCGGGCGGGCC
TGGCCGCCGCGGTGCAGGCCGCCGGCATCGAGGTGCTGGCCCCCGCCCGCGTGGTCGGCTGCGAGTTCACGCCCCGCGCC
GCCACGGTGATCCTGGCCGACCGCCGGCGGCTGTCCGCCCCGCTGGTCGTGGGGGCCGAGGGCCGCGGCTCGGCGGTGCG
CGAGGCCGCCGGCATCGGGGTGGTCGGCTGGCCCTACGCCCAGACCGGCGTCGTCGCCACCGTGCGGCTGGAGCGGCCGC
ACGAGGGCGTCGCCCACGAATACTTCCTGCCCGGCGGGCCCTTCGCCATCCTGCCGCTGACCGACAATCGCGCCAGCCTC
GTCTGGACCGAGAGCACGGCCCGCGCCGAGGCGCTCAAGACCGCCCGGCTCGAGGTGTTCCAGGCCCACCTGGAGCGCCG
CTTCGGCGAGTTCCTGGGCGGGATCACGGTCGAGGGTCCGGTGTTCACCTATCCGCTGTCGCTGCAGCTCGCCGAGCGCT
TCGCCGGTCCGCGGGTCGCGCTGCTGGGCGACGCCGCCCACGGGGTGCACCCGATCGCCGGCCAAGGGCTGAACCTCGGC
CTGAAGGGCGCCGCGGCGCTGGCCGAGGTGCTGGTGGACGCCGCGCGCCTGGGCGAGGACATCGGCTCCGAGACGGTGCT
GGAGCGCTACGCCGCCTGGCGGCGCTTCGACACCGTGACCCTGTCGGCGGGCATGGACGCCTTCGTGCGGCTGTTCTCCA
ACGACAACCCGCTGGTCCGCATGGTGCGCGGGGTCGGCATGGCCGCGGTGAACCGGGTGGGTCCGGCCCGGCGGTTCTTC
ATGCACGAGGCCGGCGGCGCGGTCGGCGACCTGCCCCGCCTGCTGCGCGGCGAGGCGCTGTAG

Upstream 100 bases:

>100_bases
TAAGCTGCTCCCGGTCCTCCGGCAAGCGAACTTTGGACGGCGGCGTCCATTTTTCGATGCCGGCTGGCGGCGGAGCGCCG
GGGCGCGTAATCGTCGCCGC

Downstream 100 bases:

>100_bases
CTACTCGCCCTCGCCCAGCTCGCGGGCTTCCTCGGGCAGCATGATCGGCACGCCGTCGCGGATCGGATAGGCGAGCCGGG
CCGAGCGGCTGACCAGCTCG

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSGPSEAFDADVIIAGAGMAGATLALALQQGGLRPLLIDPVAFEAQTAPTFDGRASAIAYAAYRQWRALGLAEAFDPHAQ
RIEQILVTDGRTPGASTGAPTPFFLRFDSAEISDRSEGEPLGYLIENRHTRAGLAAAVQAAGIEVLAPARVVGCEFTPRA
ATVILADRRRLSAPLVVGAEGRGSAVREAAGIGVVGWPYAQTGVVATVRLERPHEGVAHEYFLPGGPFAILPLTDNRASL
VWTESTARAEALKTARLEVFQAHLERRFGEFLGGITVEGPVFTYPLSLQLAERFAGPRVALLGDAAHGVHPIAGQGLNLG
LKGAAALAEVLVDAARLGEDIGSETVLERYAAWRRFDTVTLSAGMDAFVRLFSNDNPLVRMVRGVGMAAVNRVGPARRFF
MHEAGGAVGDLPRLLRGEAL

Sequences:

>Translated_420_residues
MSGPSEAFDADVIIAGAGMAGATLALALQQGGLRPLLIDPVAFEAQTAPTFDGRASAIAYAAYRQWRALGLAEAFDPHAQ
RIEQILVTDGRTPGASTGAPTPFFLRFDSAEISDRSEGEPLGYLIENRHTRAGLAAAVQAAGIEVLAPARVVGCEFTPRA
ATVILADRRRLSAPLVVGAEGRGSAVREAAGIGVVGWPYAQTGVVATVRLERPHEGVAHEYFLPGGPFAILPLTDNRASL
VWTESTARAEALKTARLEVFQAHLERRFGEFLGGITVEGPVFTYPLSLQLAERFAGPRVALLGDAAHGVHPIAGQGLNLG
LKGAAALAEVLVDAARLGEDIGSETVLERYAAWRRFDTVTLSAGMDAFVRLFSNDNPLVRMVRGVGMAAVNRVGPARRFF
MHEAGGAVGDLPRLLRGEAL
>Mature_419_residues
SGPSEAFDADVIIAGAGMAGATLALALQQGGLRPLLIDPVAFEAQTAPTFDGRASAIAYAAYRQWRALGLAEAFDPHAQR
IEQILVTDGRTPGASTGAPTPFFLRFDSAEISDRSEGEPLGYLIENRHTRAGLAAAVQAAGIEVLAPARVVGCEFTPRAA
TVILADRRRLSAPLVVGAEGRGSAVREAAGIGVVGWPYAQTGVVATVRLERPHEGVAHEYFLPGGPFAILPLTDNRASLV
WTESTARAEALKTARLEVFQAHLERRFGEFLGGITVEGPVFTYPLSLQLAERFAGPRVALLGDAAHGVHPIAGQGLNLGL
KGAAALAEVLVDAARLGEDIGSETVLERYAAWRRFDTVTLSAGMDAFVRLFSNDNPLVRMVRGVGMAAVNRVGPARRFFM
HEAGGAVGDLPRLLRGEAL

Specific function: Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967307, Length=333, Percent_Identity=33.033033033033, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI32967305, Length=333, Percent_Identity=33.033033033033, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1786883, Length=394, Percent_Identity=35.0253807106599, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789274, Length=402, Percent_Identity=35.5721393034826, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789273, Length=411, Percent_Identity=34.3065693430657, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25146631, Length=449, Percent_Identity=27.6169265033408, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321694, Length=468, Percent_Identity=26.2820512820513, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19920760, Length=455, Percent_Identity=28.1318681318681, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 44342; Mature: 44211

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSEAFDADVIIAGAGMAGATLALALQQGGLRPLLIDPVAFEAQTAPTFDGRASAIAY
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCEEECCCCCCCCCCCHHHHHH
AAYRQWRALGLAEAFDPHAQRIEQILVTDGRTPGASTGAPTPFFLRFDSAEISDRSEGEP
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
LGYLIENRHTRAGLAAAVQAAGIEVLAPARVVGCEFTPRAATVILADRRRLSAPLVVGAE
CCHHCCCCCCHHHHHHHHHHCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCCEEEECC
GRGSAVREAAGIGVVGWPYAQTGVVATVRLERPHEGVAHEYFLPGGPFAILPLTDNRASL
CCCHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEEECCCCEEE
VWTESTARAEALKTARLEVFQAHLERRFGEFLGGITVEGPVFTYPLSLQLAERFAGPRVA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEHHHHHHHHCCCCEEE
LLGDAAHGVHPIAGQGLNLGLKGAAALAEVLVDAARLGEDIGSETVLERYAAWRRFDTVT
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEE
LSAGMDAFVRLFSNDNPLVRMVRGVGMAAVNRVGPARRFFMHEAGGAVGDLPRLLRGEAL
EECCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SGPSEAFDADVIIAGAGMAGATLALALQQGGLRPLLIDPVAFEAQTAPTFDGRASAIAY
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCEEECCCCCCCCCCCHHHHHH
AAYRQWRALGLAEAFDPHAQRIEQILVTDGRTPGASTGAPTPFFLRFDSAEISDRSEGEP
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
LGYLIENRHTRAGLAAAVQAAGIEVLAPARVVGCEFTPRAATVILADRRRLSAPLVVGAE
CCHHCCCCCCHHHHHHHHHHCCEEEECCCEEECCCCCCCCEEEEEECCCCCCCCEEEECC
GRGSAVREAAGIGVVGWPYAQTGVVATVRLERPHEGVAHEYFLPGGPFAILPLTDNRASL
CCCHHHHHHCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEEECCCCEEE
VWTESTARAEALKTARLEVFQAHLERRFGEFLGGITVEGPVFTYPLSLQLAERFAGPRVA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEHHHHHHHHCCCCEEE
LLGDAAHGVHPIAGQGLNLGLKGAAALAEVLVDAARLGEDIGSETVLERYAAWRRFDTVT
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCEEE
LSAGMDAFVRLFSNDNPLVRMVRGVGMAAVNRVGPARRFFMHEAGGAVGDLPRLLRGEAL
EECCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydroxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10802164 [H]