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The map label for this gene is pabA [H]

Identifier: 195978890

GI number: 195978890

Start: 1856283

End: 1858019

Strand: Direct

Name: pabA [H]

Synonym: Sez_1794

Alternate gene names: 195978890

Gene position: 1856283-1858019 (Clockwise)

Preceding gene: 195978886

Following gene: 195978891

Centisome position: 91.71

GC content: 45.25

Gene sequence:

>1737_bases
ATGCATATAAAGACGATTATTGATTTTAAGGAGCTGGGACAACGCTATATATTTCAAGCTCCTATCGTGGAATTAGTAGC
TAAGCAGATTGATCAGGTGGGACAGGTCCTTGAGCAGGTCAACCAATTTCAAGGTCTGGGCTACTATGTTGTGGGCTACC
TCAGCTATGAAGCAGCAGCCTGTTTTGACAAAAAGCTAACAACACACAATAAAAGACTTGGTCAGGAATATTTTGCTTAT
TTTACAGTGCATGACAATTGTCAGCTCGAGGACTTTCCACTCTACCACGACAGCATGACGATTCCAAACAGCTGGACAAG
TGCTACACAAGAGGAAGCCTATCAAGAGGCTATTGCACAGATTCATCAGGAGATGAAGCAGGGCAATACCTATCAGGTCA
ACTATACCATTCAGCTCAGCCAAAGGCTAAACGCTAAGGACAGCTTGGCCATTTATCATCAATTGGTCATTGAACAGGCA
GCTGGATACAATGCCTACATTGCTCACGATGACTTTGCTGTCATTTCAGCCAGTCCTGAGCTATTTTTCAAGCAAGAGAA
AAACCAGATCACCACACGCCCCATGAAAGGCACAACCAAGCGTGGTTACAATTTAGAACTAGATCAACAAGAGCATGACT
GGCTACAGGCCGATCCTAAGAACCGTTCAGAAAACATGATGATCGTTGATTTATTACGCAATGATATGAATAAGATCTGT
CAAACTGGGAGTGTCACAGTCACACAGCTCTGCCAATTGGAGCAATATTCCACCGTTTGGCAGATGACCTCTACCATTGT
CGGCACGCTGCAGGATCAGTGTCGTCTTTATGATATTTTACAGGCACTCTTTCCCTGTGGCTCCATCACAGGAGCTCCTA
AGGTGTCTACAATGGCTATTATTAACCGATTAGAGCCTAAGCCAAGGGGTGTTTACTGTGGCAGCATTGGTATTTGCCTG
CCTGATGGCAGACGTGTCTTCAATGTCGCTATTCGAACGATTCAGCTCAGCTACGATCAGGCCATCTACGGGGTAGGCGG
TGGGATTACCTGGGAAAGCCGCTGGCAGGACGAATTTGAAGAAATCAAGCAAAAATCTTCCTTTCTGCACCGTCAAAGCA
TTGATTTCACCATCAAAACCACTGCCAAGGTCGAACAACAAAGCCTAATCTATCTAGACCAACACCTCAACAGACTAAGG
GAAGCGGCGCGTTATTTTGCCTACCCTTATGATGAAGAGCTTCTGACAGATCGTTTGCAAGCCTATCTCAAGGGAAAGGA
CAGCAGCCCCTATCGTCTCACTATTGCTATTGCTAAGGACGGGCAGATTAGCCTTACAGACCAAAGCTTAGAGCCGCTTC
AAAAAGACTTTTTAAAGGCACGATTAGTTCGCCAATCAAGCGATGTCAAAAAGCTTCCCTTTACTTATTTTAAAACCAGT
CATCGACCACATCTGAGCGTCAAGCCCTATGAGCAAGTCTTTGTTGCTGCTGATGGGACCTTGCTTGAAACCTCTATTGG
TAATCTTTTTGTGCAAATCGAGCAGACCCTTTATACACCGCCTGTATCAGCCGGTATTCTATCAGGCATTTTCCGTCAAG
AATTGCTAAGGCAGGGACTGGCTCAGGAAAAAGAGCTAAGGCTTTCAGATTTAGACAAGGCCGAAGCCATTTTTGGTAGC
AATGCTGTCCGAGGACTCTACTCACTAACAATTGAGGACACCACTCTGCCTCAATAG

Upstream 100 bases:

>100_bases
AAGCCCTGCTCTCTCTTGTATTGTTGAGGTTTGCTGACAGGCTTCTTTTCAACCCTCCTCCTAATCAGTCTGAAAAGCGC
ATTTATGATATAATCAAGCT

Downstream 100 bases:

>100_bases
TACCAGGCTGATCCCTCAGCACTACTAGATGAAGGACCTTATGATACTTTTAATTGATAACTACGATTCATTTACCTATA
ATCTGGCCCAATACCTCAGT

Product: para-aminobenzoate synthase PabA

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MHIKTIIDFKELGQRYIFQAPIVELVAKQIDQVGQVLEQVNQFQGLGYYVVGYLSYEAAACFDKKLTTHNKRLGQEYFAY
FTVHDNCQLEDFPLYHDSMTIPNSWTSATQEEAYQEAIAQIHQEMKQGNTYQVNYTIQLSQRLNAKDSLAIYHQLVIEQA
AGYNAYIAHDDFAVISASPELFFKQEKNQITTRPMKGTTKRGYNLELDQQEHDWLQADPKNRSENMMIVDLLRNDMNKIC
QTGSVTVTQLCQLEQYSTVWQMTSTIVGTLQDQCRLYDILQALFPCGSITGAPKVSTMAIINRLEPKPRGVYCGSIGICL
PDGRRVFNVAIRTIQLSYDQAIYGVGGGITWESRWQDEFEEIKQKSSFLHRQSIDFTIKTTAKVEQQSLIYLDQHLNRLR
EAARYFAYPYDEELLTDRLQAYLKGKDSSPYRLTIAIAKDGQISLTDQSLEPLQKDFLKARLVRQSSDVKKLPFTYFKTS
HRPHLSVKPYEQVFVAADGTLLETSIGNLFVQIEQTLYTPPVSAGILSGIFRQELLRQGLAQEKELRLSDLDKAEAIFGS
NAVRGLYSLTIEDTTLPQ

Sequences:

>Translated_578_residues
MHIKTIIDFKELGQRYIFQAPIVELVAKQIDQVGQVLEQVNQFQGLGYYVVGYLSYEAAACFDKKLTTHNKRLGQEYFAY
FTVHDNCQLEDFPLYHDSMTIPNSWTSATQEEAYQEAIAQIHQEMKQGNTYQVNYTIQLSQRLNAKDSLAIYHQLVIEQA
AGYNAYIAHDDFAVISASPELFFKQEKNQITTRPMKGTTKRGYNLELDQQEHDWLQADPKNRSENMMIVDLLRNDMNKIC
QTGSVTVTQLCQLEQYSTVWQMTSTIVGTLQDQCRLYDILQALFPCGSITGAPKVSTMAIINRLEPKPRGVYCGSIGICL
PDGRRVFNVAIRTIQLSYDQAIYGVGGGITWESRWQDEFEEIKQKSSFLHRQSIDFTIKTTAKVEQQSLIYLDQHLNRLR
EAARYFAYPYDEELLTDRLQAYLKGKDSSPYRLTIAIAKDGQISLTDQSLEPLQKDFLKARLVRQSSDVKKLPFTYFKTS
HRPHLSVKPYEQVFVAADGTLLETSIGNLFVQIEQTLYTPPVSAGILSGIFRQELLRQGLAQEKELRLSDLDKAEAIFGS
NAVRGLYSLTIEDTTLPQ
>Mature_578_residues
MHIKTIIDFKELGQRYIFQAPIVELVAKQIDQVGQVLEQVNQFQGLGYYVVGYLSYEAAACFDKKLTTHNKRLGQEYFAY
FTVHDNCQLEDFPLYHDSMTIPNSWTSATQEEAYQEAIAQIHQEMKQGNTYQVNYTIQLSQRLNAKDSLAIYHQLVIEQA
AGYNAYIAHDDFAVISASPELFFKQEKNQITTRPMKGTTKRGYNLELDQQEHDWLQADPKNRSENMMIVDLLRNDMNKIC
QTGSVTVTQLCQLEQYSTVWQMTSTIVGTLQDQCRLYDILQALFPCGSITGAPKVSTMAIINRLEPKPRGVYCGSIGICL
PDGRRVFNVAIRTIQLSYDQAIYGVGGGITWESRWQDEFEEIKQKSSFLHRQSIDFTIKTTAKVEQQSLIYLDQHLNRLR
EAARYFAYPYDEELLTDRLQAYLKGKDSSPYRLTIAIAKDGQISLTDQSLEPLQKDFLKARLVRQSSDVKKLPFTYFKTS
HRPHLSVKPYEQVFVAADGTLLETSIGNLFVQIEQTLYTPPVSAGILSGIFRQELLRQGLAQEKELRLSDLDKAEAIFGS
NAVRGLYSLTIEDTTLPQ

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=279, Percent_Identity=36.2007168458781, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787518, Length=282, Percent_Identity=28.3687943262411, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786809, Length=226, Percent_Identity=24.7787610619469, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082077, Length=208, Percent_Identity=27.8846153846154, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=264, Percent_Identity=34.469696969697, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324361, Length=282, Percent_Identity=28.3687943262411, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 65997; Mature: 65997

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIKTIIDFKELGQRYIFQAPIVELVAKQIDQVGQVLEQVNQFQGLGYYVVGYLSYEAAA
CCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHH
CFDKKLTTHNKRLGQEYFAYFTVHDNCQLEDFPLYHDSMTIPNSWTSATQEEAYQEAIAQ
HHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IHQEMKQGNTYQVNYTIQLSQRLNAKDSLAIYHQLVIEQAAGYNAYIAHDDFAVISASPE
HHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCH
LFFKQEKNQITTRPMKGTTKRGYNLELDQQEHDWLQADPKNRSENMMIVDLLRNDMNKIC
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
QTGSVTVTQLCQLEQYSTVWQMTSTIVGTLQDQCRLYDILQALFPCGSITGAPKVSTMAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
INRLEPKPRGVYCGSIGICLPDGRRVFNVAIRTIQLSYDQAIYGVGGGITWESRWQDEFE
HHHCCCCCCEEEECCEEEECCCCCCEEEEEEEEEEEECCCEEEECCCCCCCCHHHHHHHH
EIKQKSSFLHRQSIDFTIKTTAKVEQQSLIYLDQHLNRLREAARYFAYPYDEELLTDRLQ
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AYLKGKDSSPYRLTIAIAKDGQISLTDQSLEPLQKDFLKARLVRQSSDVKKLPFTYFKTS
HHHCCCCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
HRPHLSVKPYEQVFVAADGTLLETSIGNLFVQIEQTLYTPPVSAGILSGIFRQELLRQGL
CCCCCCCCCHHEEEEEECCCEEEECCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHC
AQEKELRLSDLDKAEAIFGSNAVRGLYSLTIEDTTLPQ
CHHHHCCHHCCCHHHHHHCCHHHCCEEEEEEECCCCCC
>Mature Secondary Structure
MHIKTIIDFKELGQRYIFQAPIVELVAKQIDQVGQVLEQVNQFQGLGYYVVGYLSYEAAA
CCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHH
CFDKKLTTHNKRLGQEYFAYFTVHDNCQLEDFPLYHDSMTIPNSWTSATQEEAYQEAIAQ
HHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IHQEMKQGNTYQVNYTIQLSQRLNAKDSLAIYHQLVIEQAAGYNAYIAHDDFAVISASPE
HHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCH
LFFKQEKNQITTRPMKGTTKRGYNLELDQQEHDWLQADPKNRSENMMIVDLLRNDMNKIC
HHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
QTGSVTVTQLCQLEQYSTVWQMTSTIVGTLQDQCRLYDILQALFPCGSITGAPKVSTMAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
INRLEPKPRGVYCGSIGICLPDGRRVFNVAIRTIQLSYDQAIYGVGGGITWESRWQDEFE
HHHCCCCCCEEEECCEEEECCCCCCEEEEEEEEEEEECCCEEEECCCCCCCCHHHHHHHH
EIKQKSSFLHRQSIDFTIKTTAKVEQQSLIYLDQHLNRLREAARYFAYPYDEELLTDRLQ
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AYLKGKDSSPYRLTIAIAKDGQISLTDQSLEPLQKDFLKARLVRQSSDVKKLPFTYFKTS
HHHCCCCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCC
HRPHLSVKPYEQVFVAADGTLLETSIGNLFVQIEQTLYTPPVSAGILSGIFRQELLRQGL
CCCCCCCCCHHEEEEEECCCEEEECCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHC
AQEKELRLSDLDKAEAIFGSNAVRGLYSLTIEDTTLPQ
CHHHHCCHHCCCHHHHHHCCHHHCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]