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The map label for this gene is galK [H]

Identifier: 195978837

GI number: 195978837

Start: 1797531

End: 1798703

Strand: Direct

Name: galK [H]

Synonym: Sez_1741

Alternate gene names: 195978837

Gene position: 1797531-1798703 (Clockwise)

Preceding gene: 195978834

Following gene: 195978838

Centisome position: 88.8

GC content: 47.4

Gene sequence:

>1173_bases
ATGGATATTGCGCAACTTAAGCAAAGCTTTACTGACGTTTTTGGCAAGGAGCCAGATGCTGTCTTTTTCTCACCGGGTCG
CATCAACCTCATTGGTGAGCACACTGATTACAATGGTGGGCATGTCTTCCCAGCTGCTATCAGTCTGGGAACCTATGGAC
TGGCCCGCAAGCGTGAGGATCAGCAGCTGCGCTTTTTCTCAGCAAATTTTGAAGAGGCTGGGATTATTGAGGTTGACTTA
AATCAGCTGACCTTTGATCAAGCTGACCTTTGGGCTAATTACCCTAAGGGAGTTCTCTCCTTTTTGCAAAAAGCTGGGCA
CCTTATTGATACGGGCTTTGAGCTTTATGTTTTTGGCAACATTCCAAATGGGTCTGGTCTGTCCTCCTCGGCATCATTGG
AGCTTTTGACAGGTATTGTGGCACAAGAGCTGTTTGGGCTTGATGTGGAACGGTTAGATCTGATTAAAATCGGTCAGCAA
GCTGAAAATCACTTTATCGGGGTGAATTCAGGTATCATGGACCAATTTGCCATAGGCATGGGAGCTGATAAGCAGGCTCT
ATACCTTGATACCAACACTTTATCCTATGAGGCTGTTCCACTTGACCTTGGTGACCACGTGATTGTCATCATGAATACCA
ACAAGCGTCGTGAGCTAGCTGATTCAAAATACAATGAACGCCGAGCAGAGTGTGAAAAAGCCCTTGAGGAATTAAATGCC
CTTCTTGATATTAAAGCACTGGGGGAATTAGACGCTCAGCGCTTTGATGAGTACAGCTACCTTATCAAAGATGGTAAACG
TCTCAAACGCGCTCGCCACGCTGTTTTGGAAAATCAACGAACACTCCAAGCAAGACAGGCCCTTGAAGCAGGAGCATTGG
AGCAATTTGGTCGTCTGATGAATGCTTCTCATGTATCCTTGGAGCATGATTATGAGGTCACAGGCCCTGAGCTGGACACA
CTGGTCCACACCGCTTGGGAGCAAGAAGGGGTCCTAGGGGCTCGCATGACAGGAGCAGGCTTTGGAGGCTGTGGCATTGC
TATCGTGGCTAAGGACAAGGTGGATAGCTTTATCGAAACAGTTGGCAAGGCCTATACTGAGGTCATTGGCTATGCTCCAG
CCTTTTATCTGGCTGAGATTGCTCAGGGAGCACGACTACTTTCAAGGAAATAA

Upstream 100 bases:

>100_bases
ATTTTTAAAAGCAATATTTAGTAAAATTTTAGTAAAAATATTGACGAGTAGTTTAGCGAAGCGTAAAATCAAGCTATCAA
CATCGTTAAAGGAGTCGCTA

Downstream 100 bases:

>100_bases
GATATGGCAAGCTTAATAGACACCTTTGTAAGGAAGGTGATTGAACACAGCGACTACACATCAGAGGACGCTATTTATAT
CCGCAATCGGGTTTTAGCAT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDIAQLKQSFTDVFGKEPDAVFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGLARKREDQQLRFFSANFEEAGIIEVDL
NQLTFDQADLWANYPKGVLSFLQKAGHLIDTGFELYVFGNIPNGSGLSSSASLELLTGIVAQELFGLDVERLDLIKIGQQ
AENHFIGVNSGIMDQFAIGMGADKQALYLDTNTLSYEAVPLDLGDHVIVIMNTNKRRELADSKYNERRAECEKALEELNA
LLDIKALGELDAQRFDEYSYLIKDGKRLKRARHAVLENQRTLQARQALEAGALEQFGRLMNASHVSLEHDYEVTGPELDT
LVHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVDSFIETVGKAYTEVIGYAPAFYLAEIAQGARLLSRK

Sequences:

>Translated_390_residues
MDIAQLKQSFTDVFGKEPDAVFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGLARKREDQQLRFFSANFEEAGIIEVDL
NQLTFDQADLWANYPKGVLSFLQKAGHLIDTGFELYVFGNIPNGSGLSSSASLELLTGIVAQELFGLDVERLDLIKIGQQ
AENHFIGVNSGIMDQFAIGMGADKQALYLDTNTLSYEAVPLDLGDHVIVIMNTNKRRELADSKYNERRAECEKALEELNA
LLDIKALGELDAQRFDEYSYLIKDGKRLKRARHAVLENQRTLQARQALEAGALEQFGRLMNASHVSLEHDYEVTGPELDT
LVHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVDSFIETVGKAYTEVIGYAPAFYLAEIAQGARLLSRK
>Mature_390_residues
MDIAQLKQSFTDVFGKEPDAVFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGLARKREDQQLRFFSANFEEAGIIEVDL
NQLTFDQADLWANYPKGVLSFLQKAGHLIDTGFELYVFGNIPNGSGLSSSASLELLTGIVAQELFGLDVERLDLIKIGQQ
AENHFIGVNSGIMDQFAIGMGADKQALYLDTNTLSYEAVPLDLGDHVIVIMNTNKRRELADSKYNERRAECEKALEELNA
LLDIKALGELDAQRFDEYSYLIKDGKRLKRARHAVLENQRTLQARQALEAGALEQFGRLMNASHVSLEHDYEVTGPELDT
LVHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVDSFIETVGKAYTEVIGYAPAFYLAEIAQGARLLSRK

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=396, Percent_Identity=38.3838383838384, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI48527957, Length=421, Percent_Identity=29.9287410926366, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI4503897, Length=419, Percent_Identity=30.0715990453461, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786972, Length=392, Percent_Identity=37.2448979591837, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71989053, Length=432, Percent_Identity=29.1666666666667, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319494, Length=259, Percent_Identity=32.046332046332, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=254, Percent_Identity=31.1023622047244, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24661292, Length=432, Percent_Identity=28.0092592592593, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21355577, Length=432, Percent_Identity=28.0092592592593, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24661285, Length=432, Percent_Identity=28.0092592592593, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42975; Mature: 42975

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIAQLKQSFTDVFGKEPDAVFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGLARKRED
CCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEHHHHHHCCHHHHCCCCC
QQLRFFSANFEEAGIIEVDLNQLTFDQADLWANYPKGVLSFLQKAGHLIDTGFELYVFGN
CCEEEEECCCCCCCEEEEEHHHHCCCHHHHHCCCHHHHHHHHHHCCCEECCCEEEEEEEC
IPNGSGLSSSASLELLTGIVAQELFGLDVERLDLIKIGQQAENHFIGVNSGIMDQFAIGM
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCEEECCCCHHHHHHHCC
GADKQALYLDTNTLSYEAVPLDLGDHVIVIMNTNKRRELADSKYNERRAECEKALEELNA
CCCCCEEEEECCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLDIKALGELDAQRFDEYSYLIKDGKRLKRARHAVLENQRTLQARQALEAGALEQFGRLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
NASHVSLEHDYEVTGPELDTLVHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVDSFIET
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHH
VGKAYTEVIGYAPAFYLAEIAQGARLLSRK
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIAQLKQSFTDVFGKEPDAVFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGLARKRED
CCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEHHHHHHCCHHHHCCCCC
QQLRFFSANFEEAGIIEVDLNQLTFDQADLWANYPKGVLSFLQKAGHLIDTGFELYVFGN
CCEEEEECCCCCCCEEEEEHHHHCCCHHHHHCCCHHHHHHHHHHCCCEECCCEEEEEEEC
IPNGSGLSSSASLELLTGIVAQELFGLDVERLDLIKIGQQAENHFIGVNSGIMDQFAIGM
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCEEECCCCHHHHHHHCC
GADKQALYLDTNTLSYEAVPLDLGDHVIVIMNTNKRRELADSKYNERRAECEKALEELNA
CCCCCEEEEECCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLDIKALGELDAQRFDEYSYLIKDGKRLKRARHAVLENQRTLQARQALEAGALEQFGRLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
NASHVSLEHDYEVTGPELDTLVHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVDSFIET
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHH
VGKAYTEVIGYAPAFYLAEIAQGARLLSRK
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA