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The map label for this gene is fhs1 [H]

Identifier: 195978072

GI number: 195978072

Start: 982555

End: 984225

Strand: Direct

Name: fhs1 [H]

Synonym: Sez_0945

Alternate gene names: 195978072

Gene position: 982555-984225 (Clockwise)

Preceding gene: 195978066

Following gene: 195978073

Centisome position: 48.54

GC content: 44.52

Gene sequence:

>1671_bases
ATGAAATCAGATATCGAAATTGCTCAAAGCGTCCCCTTAAAGCCGATTACAGAAATCGTTAAAAAGGTGGGGATTGATGG
TGATGATTTGGAGCTGTACGGTAATTATAAGGCCAAATTATCCTTCGAAAAAATCAAATCAGTAAAGGGCAATAAGCCTG
GTAAGCTCATTTTAGTGACTGCTATAAATCCAACGCCAGCAGGTGAGGGCAAATCAACCATGTCTATTGGTTTGGCAGAT
GCCTTGACTAAGATCGGTAAAAAAACCATGCTGGCCTTGCGTGAGCCCTCTCTAGGACCAGTTATGGGGATCAAGGGTGG
TGCTGCAGGTGGCGGCTACGCTCAGGTTCTTCCGATGGAAGATATTAATCTTCATTTCACTGGAGATATGCATGCCATTA
CCACAGCTCATAACGCTTTATCAGCCCTTATTGATAATCACCTTCAGCAAGGCAATGAGCTTGGTATTGACCCGCGTCGT
ATCATCTGGAAGCGTGTGCTTGATTTGAATGATCGTTCTCTTAGGCAGGTCATTGTTGGTTTGGGGAGTCCTGTCAATGG
TGTGCCACGAGAAGATGGCTTTGATATTACAGTAGCCTCTGAAGTGATGGCTATCCTTTGCTTGGCGACTGATCTCAAGG
ACTTGAAGGCTCGTTTAGCTAATATTGTGATTGCCTACCGCTATGATAAATCACCTGTATATGTGCGTGATTTAAAGGTA
GAAGGGGCATTAGCCTTGATTTTGAAGGACGCCATCAAGCCTAACCTTGTTCAAACGATCTACGGTACACCAGCCTTTGT
GCATGGTGGCCCCTTTGCCAATATTGCTCATGGCTGTAATTCTGTTCTGGCGACATCAACAGCTCTACGGTTGGCAGATT
ATACTGTTACAGAGGCAGGCTTTGGAGCAGATCTTGGAGCAGAAAAATTCCTTAACATCAAAACACCGAATCTGCCTAAG
GCTCCTGATGCAGTTGTTATTGTCGCAACACTTCGTGCCTTGAAGATGCATGGTGGTGTTGCTAAGGCGGATTTAACCTT
TGAAAATACAGCTGCGGTCCGGTCTGGCTTTGCTAATTTAAAGCGTCATGTTGAGAATATTCGAAAATTCAATATTCCGG
TTGTTGTAGCTATCAACGAATTTGTGACAGATACTAAAGCAGAAATTCAAGTCTTAAAAGAATTGTGTGCAGAAATAGCT
GTTCCGGTTGAATTGGCAAGTGTGTGGGCCAAGGGAGCTGATGGCGGTATTGCTCTTGCCAATGCTGTTGTCAGTGCTAT
TGCAGAAGAAAGCGCAGCCTATAAGCGTCTATATGCAGATAAGGATAGCTTAGAGGAGAAACTTAGGGCAATTGTGACTG
AAATCTATGGTGGCAGGACTGTGCAATTCGGACCTAAAGCTAAAAATCAGCTCAAGCAATTTGCCCAATATGGCTGGGAT
CAATTGCCTGTTTGCATGGCCAAAACCCAATATAGCTTTTCAGACGATCCATCTCTCCTAGGTGCGCCAGATCAGTTTGA
CATTACCATTCGTGAATTAGTGCCTAAGACTGGGGCTGGTTTTATCGTTGCCTTAACTGGAGATGTGATGACAATGCCAG
GCTTGCCAAAGATTCCTGCAGCTATGAAGATGGATGTCACCGAAGACGGTACAGCAGTAGGATTGTTTTGA

Upstream 100 bases:

>100_bases
CATTGCAAAAGCGAACGTTTTTGAAATGGAAATAAATAAATATACGTTTAAGATAGAGTGTGATATAATGATACTATCAA
GTAAGAGTCAAGGAGTTTTC

Downstream 100 bases:

>100_bases
TTTATTTGTTATAGCCAGAATCAGGATTGAAGAAAGCTTCAGAAAGGGGTTTTCTTCAATCTTTTTTAATGTCTAAGGAT
AAGCTGATAACAATAGCTCA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKSDIEIAQSVPLKPITEIVKKVGIDGDDLELYGNYKAKLSFEKIKSVKGNKPGKLILVTAINPTPAGEGKSTMSIGLAD
ALTKIGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTAHNALSALIDNHLQQGNELGIDPRR
IIWKRVLDLNDRSLRQVIVGLGSPVNGVPREDGFDITVASEVMAILCLATDLKDLKARLANIVIAYRYDKSPVYVRDLKV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKTPNLPK
APDAVVIVATLRALKMHGGVAKADLTFENTAAVRSGFANLKRHVENIRKFNIPVVVAINEFVTDTKAEIQVLKELCAEIA
VPVELASVWAKGADGGIALANAVVSAIAEESAAYKRLYADKDSLEEKLRAIVTEIYGGRTVQFGPKAKNQLKQFAQYGWD
QLPVCMAKTQYSFSDDPSLLGAPDQFDITIRELVPKTGAGFIVALTGDVMTMPGLPKIPAAMKMDVTEDGTAVGLF

Sequences:

>Translated_556_residues
MKSDIEIAQSVPLKPITEIVKKVGIDGDDLELYGNYKAKLSFEKIKSVKGNKPGKLILVTAINPTPAGEGKSTMSIGLAD
ALTKIGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTAHNALSALIDNHLQQGNELGIDPRR
IIWKRVLDLNDRSLRQVIVGLGSPVNGVPREDGFDITVASEVMAILCLATDLKDLKARLANIVIAYRYDKSPVYVRDLKV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKTPNLPK
APDAVVIVATLRALKMHGGVAKADLTFENTAAVRSGFANLKRHVENIRKFNIPVVVAINEFVTDTKAEIQVLKELCAEIA
VPVELASVWAKGADGGIALANAVVSAIAEESAAYKRLYADKDSLEEKLRAIVTEIYGGRTVQFGPKAKNQLKQFAQYGWD
QLPVCMAKTQYSFSDDPSLLGAPDQFDITIRELVPKTGAGFIVALTGDVMTMPGLPKIPAAMKMDVTEDGTAVGLF
>Mature_556_residues
MKSDIEIAQSVPLKPITEIVKKVGIDGDDLELYGNYKAKLSFEKIKSVKGNKPGKLILVTAINPTPAGEGKSTMSIGLAD
ALTKIGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTAHNALSALIDNHLQQGNELGIDPRR
IIWKRVLDLNDRSLRQVIVGLGSPVNGVPREDGFDITVASEVMAILCLATDLKDLKARLANIVIAYRYDKSPVYVRDLKV
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAGFGADLGAEKFLNIKTPNLPK
APDAVVIVATLRALKMHGGVAKADLTFENTAAVRSGFANLKRHVENIRKFNIPVVVAINEFVTDTKAEIQVLKELCAEIA
VPVELASVWAKGADGGIALANAVVSAIAEESAAYKRLYADKDSLEEKLRAIVTEIYGGRTVQFGPKAKNQLKQFAQYGWD
QLPVCMAKTQYSFSDDPSLLGAPDQFDITIRELVPKTGAGFIVALTGDVMTMPGLPKIPAAMKMDVTEDGTAVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=42.6494345718901, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=42.443729903537, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI310124614, Length=82, Percent_Identity=36.5853658536585, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=614, Percent_Identity=43.485342019544, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17568739, Length=614, Percent_Identity=43.485342019544, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=41.6798732171157, Blast_Score=443, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.85303514377, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=41.0339256865913, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=41.0339256865913, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=41.0339256865913, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=41.0339256865913, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59435; Mature: 59435

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQSVPLKPITEIVKKVGIDGDDLELYGNYKAKLSFEKIKSVKGNKPGKLILVT
CCCCCCHHHCCCCHHHHHHHHHHCCCCCCEEEEECEEEEEEHHHHHHCCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALTKIGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTAHNALSALIDNHLQQGNELGIDPRRIIWKRVLDLNDRSLRQVIVG
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEVMAILCLATDLKDLKARLANIVIAYRYDKSPVYVRDLKV
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKTPNLPKAPDAVVIVATLRALKMHGGVAKADLTFENTAAVRSGFANL
CCCCCCCHHEEECCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHH
KRHVENIRKFNIPVVVAINEFVTDTKAEIQVLKELCAEIAVPVELASVWAKGADGGIALA
HHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHH
NAVVSAIAEESAAYKRLYADKDSLEEKLRAIVTEIYGGRTVQFGPKAKNQLKQFAQYGWD
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCC
QLPVCMAKTQYSFSDDPSLLGAPDQFDITIRELVPKTGAGFIVALTGDVMTMPGLPKIPA
CCCHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCEEEEEECCEEECCCCCCCCC
AMKMDVTEDGTAVGLF
CEEEECCCCCCEECCC
>Mature Secondary Structure
MKSDIEIAQSVPLKPITEIVKKVGIDGDDLELYGNYKAKLSFEKIKSVKGNKPGKLILVT
CCCCCCHHHCCCCHHHHHHHHHHCCCCCCEEEEECEEEEEEHHHHHHCCCCCCCCEEEEE
AINPTPAGEGKSTMSIGLADALTKIGKKTMLALREPSLGPVMGIKGGAAGGGYAQVLPME
EECCCCCCCCCCEEEHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCCCCEEEEEEC
DINLHFTGDMHAITTAHNALSALIDNHLQQGNELGIDPRRIIWKRVLDLNDRSLRQVIVG
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
LGSPVNGVPREDGFDITVASEVMAILCLATDLKDLKARLANIVIAYRYDKSPVYVRDLKV
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEEE
EGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTVTEAG
CCHHHHHHHHHCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCC
FGADLGAEKFLNIKTPNLPKAPDAVVIVATLRALKMHGGVAKADLTFENTAAVRSGFANL
CCCCCCCHHEEECCCCCCCCCCCCEEHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHH
KRHVENIRKFNIPVVVAINEFVTDTKAEIQVLKELCAEIAVPVELASVWAKGADGGIALA
HHHHHHHHHCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHH
NAVVSAIAEESAAYKRLYADKDSLEEKLRAIVTEIYGGRTVQFGPKAKNQLKQFAQYGWD
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCC
QLPVCMAKTQYSFSDDPSLLGAPDQFDITIRELVPKTGAGFIVALTGDVMTMPGLPKIPA
CCCHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCCCCCCEEEEEECCEEECCCCCCCCC
AMKMDVTEDGTAVGLF
CEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA