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The map label for this gene is pheS [H]

Identifier: 195977934

GI number: 195977934

Start: 836995

End: 838038

Strand: Direct

Name: pheS [H]

Synonym: Sez_0805

Alternate gene names: 195977934

Gene position: 836995-838038 (Clockwise)

Preceding gene: 195977933

Following gene: 195977935

Centisome position: 41.35

GC content: 45.21

Gene sequence:

>1044_bases
ATGGATTTACAAGCACAATTAGAAGAACTGAAAACCAAGACACAAGAAGCGCTCAAGCAGCTAAATGGTGACCACAGCAA
GGAATTGCAGGAGCTGCGAGTTGCTGTCCTTGGGAAAAGAGGAACGCTTACCGAACTACTCAAGGGACTAAAGGATCTCT
CAAATGACCTGCGTCCTGTTGTTGGCAAACAGGTCAATGAGCTTCGTGACTTTTTGACCCAAGCCTTTGAAGAGCAGGCT
AAGGTGGTTGAGGCAGCAAAGATTCAGGCCAAGCTAGATTCTGAAAGCATTGATGTGACTTTGCCAGGCCGTCAGATGAA
GCAGGGCTATCGACATGTGCTCACTCAAATCAGTGAAGAAATTGAGGACATTTTCTTGGGCATGGGCTTTCAAATTGTTG
ATGGCTTTGAGGTTGAAAAGGATTATTATAATTTTGAACGCATGAACCTTCCAAAGGATCATCCGGCTCGTGATATGCAA
GACACCTTCTATATCACAGAGGATATTTTGCTGCGCACCCACACCAGTCCTGTACAGGCACGAACACTGGATCAGCATGA
TTTTTCAAAGGGGCCTCTCAAGATGATTTCACCTGGACGTGTTTTTCGTCGTGACACCGATGATGCCACTCATTCTCATC
AATTTCACCAAATTGAAGGCTTAGTTGTTGGCAAGTCTATCTCTATGGGAGACTTGAAGGGGACCCTTGAGATGATCATT
AAAAAGATGTTTGGTAAGGAGCGTAAGATTCGCCTGCGCCCATCCTATTTCCCTTTTACTGAGCCATCTGTTGAGGTTGA
TGTCTCATGCTTCAAATGTGGTGGTAAAGGCTGCAATGTCTGCAAAAAAACAGGCTGGATTGAAATTCTTGGAGCTGGTA
TGGTGCACCCAAGCGTTTTAGAAATGTCAGGTGTGAATGCGCAGGAGTATTCAGGCTTTGCCTTTGGGCTTGGTCAAGAG
CGTATCGCCATGCTGCGTTATGGTATCAACGATATTCGAGGCTTCTACCAAGGAGATAGTCGCTTTTCTAAGCAGTTTAA
GTAA

Upstream 100 bases:

>100_bases
TGACTAGCTGACCTAGCTGCTCACAGCTTAGCCTAAAAGGCCTATTAGCACAAGGACTGCCAGCATTAATGCAATCATTT
TCCAAACAGAAGGGAATATC

Downstream 100 bases:

>100_bases
TAGTGATCATATGGTCAAAAACCAAATCATCAGTTTGAAAAAAGAATTGACGCTCAATCTGGAGCTGTTCTTTGGGTTAG
AATCAGAAAGGAAAAAGACG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKRGTLTELLKGLKDLSNDLRPVVGKQVNELRDFLTQAFEEQA
KVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQ
DTFYITEDILLRTHTSPVQARTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMII
KKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVNAQEYSGFAFGLGQE
RIAMLRYGINDIRGFYQGDSRFSKQFK

Sequences:

>Translated_347_residues
MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKRGTLTELLKGLKDLSNDLRPVVGKQVNELRDFLTQAFEEQA
KVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQ
DTFYITEDILLRTHTSPVQARTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMII
KKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVNAQEYSGFAFGLGQE
RIAMLRYGINDIRGFYQGDSRFSKQFK
>Mature_347_residues
MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKRGTLTELLKGLKDLSNDLRPVVGKQVNELRDFLTQAFEEQA
KVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQ
DTFYITEDILLRTHTSPVQARTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMII
KKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVNAQEYSGFAFGLGQE
RIAMLRYGINDIRGFYQGDSRFSKQFK

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=268, Percent_Identity=32.8358208955224, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI5729820, Length=292, Percent_Identity=30.8219178082192, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1788007, Length=343, Percent_Identity=43.731778425656, Blast_Score=296, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17508957, Length=271, Percent_Identity=33.210332103321, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563657, Length=271, Percent_Identity=33.210332103321, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32566635, Length=247, Percent_Identity=33.6032388663968, Blast_Score=118, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321087, Length=378, Percent_Identity=29.1005291005291, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325304, Length=351, Percent_Identity=27.9202279202279, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18858079, Length=274, Percent_Identity=31.3868613138686, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17137424, Length=251, Percent_Identity=29.8804780876494, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 39390; Mature: 39390

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKRGTLTELLKGLKDLSNDLRPV
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGKQVNELRDFLTQAFEEQAKVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
IEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEDILLRTHTSPVQA
HHHHHHCCCCEEECCEEECHHHHCHHHCCCCCCCCCCCCHHHHEEHHHHHEECCCCCCHH
RTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMII
HHCCCCCCCCCCEEECCCCHHHCCCCCCCHHCCHHHHHCEEEEECCCCCHHHHHHHHHHH
KKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVL
HHHHCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCCHHHHCCCEEEEECCCCCCHHH
EMSGVNAQEYSGFAFGLGQERIAMLRYGINDIRGFYQGDSRFSKQFK
HHCCCCHHHCCCEEECCCHHHHHHHHHCHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKRGTLTELLKGLKDLSNDLRPV
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VGKQVNELRDFLTQAFEEQAKVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
IEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEDILLRTHTSPVQA
HHHHHHCCCCEEECCEEECHHHHCHHHCCCCCCCCCCCCHHHHEEHHHHHEECCCCCCHH
RTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMII
HHCCCCCCCCCCEEECCCCHHHCCCCCCCHHCCHHHHHCEEEEECCCCCHHHHHHHHHHH
KKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVL
HHHHCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCCCHHHHCCCEEEEECCCCCCHHH
EMSGVNAQEYSGFAFGLGQERIAMLRYGINDIRGFYQGDSRFSKQFK
HHCCCCHHHCCCEEECCCHHHHHHHHHCHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA