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The map label for this gene is endA [H]

Identifier: 195977932

GI number: 195977932

Start: 835187

End: 836080

Strand: Direct

Name: endA [H]

Synonym: Sez_0803

Alternate gene names: 195977932

Gene position: 835187-836080 (Clockwise)

Preceding gene: 195977931

Following gene: 195977933

Centisome position: 41.26

GC content: 45.3

Gene sequence:

>894_bases
ATGATAAGAGGAAAGATGATCAAAAAGAAGAAAGACATTAGGCTGCTTAATGCCTTTTTAGCGCTCTTGCTTGTTCTTGG
AACAGGTTATTTGGCAGGACATGATGACCTGGCAGCTGATAATCCGATCAAGCAGGTCTACCAAAGGATTTTTGGCTCTG
ACCCGCAGCAAGCCGAGTCACCAAAGGCAAGCAGAGACTGGGACACTCCCTCCAAGGCCTTGGCGGATTCGGTCATGACA
GCTGCCATCAAACAGCAATTAGGTGATGTGATTACTTGGAATGGCACCGGTGCCTATATTATTAACCATAATAAAACGAC
GCTAAATGCAAAGGTAGCTAGTCTCCCCTATGCCAATAATAAAACAAAGATGGTACAAGGGCAAAGCGTTCCTACCGTAG
CCAATGCCCTGCTAACCAAGTCAACCCGACAATATCAGAAGCGCAATGACACTGGAAATGGTTATAGCTCATGGAAGCCT
GCTGGCTGGCATCAGGTTCAGGGGTTAAAGGGAAGGTATAGTCACGCAGTGGATAGAGGGCATCTTCTAGGCTATGCGCT
TGTTGGCGGGCTAAAAGGCTTTGATGCCTCAATGGCTAATCCTAGTAATATCGCTACTCAAACCGCATGGGCTAACCAAG
CAGCTAACGAGAGATCAACCGGACAAAACTATTATGAAACAAAAATTCGCAAAGCCCTAGATAGCAATAAGCGTGTCCGC
TATCGTGTAACTTTGCTTTATGAGGGAAATAATCTCTTAGCAAGCGGCAGTCATCTTGAGGCAAAGTCATCAGATGGTAG
CTTAGAATTTAACGTCTTTATCCCTAATGTACAGGCTGGATTACAGATTGATTATCAAAGAGGTCAGATCACTGTAGCTT
CTTCCCAGCCTTAG

Upstream 100 bases:

>100_bases
CTTATCGGTGATGGCCAAAATCCCTTAGCGATTTTATCACCAGATAAGTGGGCTGAACTGATTCATAAATTTACGGGAAA
GTAGGCATGGCCTGCTTTTT

Downstream 100 bases:

>100_bases
TGAGGCACATCACATGGCAAAAGCTGATCACGTAGCTAGCCATCATGGCAGAGAAGCGTTAATCCTTGTAGTCCCTCAAA
GAAAGGTGCTAACAATATTT

Product: DNA-entry nuclease EndA

Products: NA

Alternate protein names: Competence-specific nuclease [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIRGKMIKKKKDIRLLNAFLALLLVLGTGYLAGHDDLAADNPIKQVYQRIFGSDPQQAESPKASRDWDTPSKALADSVMT
AAIKQQLGDVITWNGTGAYIINHNKTTLNAKVASLPYANNKTKMVQGQSVPTVANALLTKSTRQYQKRNDTGNGYSSWKP
AGWHQVQGLKGRYSHAVDRGHLLGYALVGGLKGFDASMANPSNIATQTAWANQAANERSTGQNYYETKIRKALDSNKRVR
YRVTLLYEGNNLLASGSHLEAKSSDGSLEFNVFIPNVQAGLQIDYQRGQITVASSQP

Sequences:

>Translated_297_residues
MIRGKMIKKKKDIRLLNAFLALLLVLGTGYLAGHDDLAADNPIKQVYQRIFGSDPQQAESPKASRDWDTPSKALADSVMT
AAIKQQLGDVITWNGTGAYIINHNKTTLNAKVASLPYANNKTKMVQGQSVPTVANALLTKSTRQYQKRNDTGNGYSSWKP
AGWHQVQGLKGRYSHAVDRGHLLGYALVGGLKGFDASMANPSNIATQTAWANQAANERSTGQNYYETKIRKALDSNKRVR
YRVTLLYEGNNLLASGSHLEAKSSDGSLEFNVFIPNVQAGLQIDYQRGQITVASSQP
>Mature_297_residues
MIRGKMIKKKKDIRLLNAFLALLLVLGTGYLAGHDDLAADNPIKQVYQRIFGSDPQQAESPKASRDWDTPSKALADSVMT
AAIKQQLGDVITWNGTGAYIINHNKTTLNAKVASLPYANNKTKMVQGQSVPTVANALLTKSTRQYQKRNDTGNGYSSWKP
AGWHQVQGLKGRYSHAVDRGHLLGYALVGGLKGFDASMANPSNIATQTAWANQAANERSTGQNYYETKIRKALDSNKRVR
YRVTLLYEGNNLLASGSHLEAKSSDGSLEFNVFIPNVQAGLQIDYQRGQITVASSQP

Specific function: By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA/RNA non-specific endonuclease family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018524
- InterPro:   IPR001604 [H]

Pfam domain/function: PF01223 Endonuclease_NS [H]

EC number: NA

Molecular weight: Translated: 32498; Mature: 32498

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGKMIKKKKDIRLLNAFLALLLVLGTGYLAGHDDLAADNPIKQVYQRIFGSDPQQAES
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCC
PKASRDWDTPSKALADSVMTAAIKQQLGDVITWNGTGAYIINHNKTTLNAKVASLPYANN
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCEEEEEEEEECCCCCC
KTKMVQGQSVPTVANALLTKSTRQYQKRNDTGNGYSSWKPAGWHQVQGLKGRYSHAVDRG
CCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHCCC
HLLGYALVGGLKGFDASMANPSNIATQTAWANQAANERSTGQNYYETKIRKALDSNKRVR
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
YRVTLLYEGNNLLASGSHLEAKSSDGSLEFNVFIPNVQAGLQIDYQRGQITVASSQP
EEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCEEEEECCCC
>Mature Secondary Structure
MIRGKMIKKKKDIRLLNAFLALLLVLGTGYLAGHDDLAADNPIKQVYQRIFGSDPQQAES
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCC
PKASRDWDTPSKALADSVMTAAIKQQLGDVITWNGTGAYIINHNKTTLNAKVASLPYANN
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEECCCEEEEEEEEECCCCCC
KTKMVQGQSVPTVANALLTKSTRQYQKRNDTGNGYSSWKPAGWHQVQGLKGRYSHAVDRG
CCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHCCC
HLLGYALVGGLKGFDASMANPSNIATQTAWANQAANERSTGQNYYETKIRKALDSNKRVR
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
YRVTLLYEGNNLLASGSHLEAKSSDGSLEFNVFIPNVQAGLQIDYQRGQITVASSQP
EEEEEEECCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2359120; 11463916 [H]