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The map label for this gene is gyrB [H]

Identifier: 195977899

GI number: 195977899

Start: 798900

End: 800852

Strand: Direct

Name: gyrB [H]

Synonym: Sez_0769

Alternate gene names: 195977899

Gene position: 798900-800852 (Clockwise)

Preceding gene: 195977898

Following gene: 195977900

Centisome position: 39.47

GC content: 45.06

Gene sequence:

>1953_bases
ATGGTTGAAGAAAATAAACAATTAGAAGACAAGGCTCAAGAGTATGACGCTAGCCAGATTCAGGTCTTAGAGGGGCTAGA
GGCTGTTCGCATGCGTCCTGGAATGTATATCGGCTCAACTGCCAAGGAGGGCTTACATCACCTAGTTTGGGAGATCGTTG
ATAATTCTATCGATGAAGCCTTGGCAGGCTTTGCCAGCCATATTCAGGTTTTTATTGAGGCAGATAATTCCATTACAGTT
ATTGATGACGGACGTGGTATCCCAGTTGATATTCAAGCCAAGACAGGCCGGCCTGCTGTAGAGACTGTTTTTACAGTTTT
GCATGCTGGTGGAAAGTTTGGCGGTGGTGGCTACAAGGTTTCTGGAGGACTTCATGGTGTAGGTTCCTCAGTTGTTAATG
CCTTATCCACACAGCTTGATGTTCGTGTCTATAAAAATGGGCATATCCACTATCAGGAGTTTAGGCGTGGTGCTGTAGTA
GATGATCTAGCCATCATTGGAACGACTGATGTTACAGGAACAACAGTGCATTTTACACCTGATCCAGAGATCTTTACAGA
AACAACAGAATTTGATTATCAAGTCCTGGCAAAGCGTATTCAAGAGCTAGCCTTTCTTAATCGTGGCTTAAAAATCTCAA
TTACAGATAAACGAGCTGGTCTTGAAAGAGAAGAGCATTTCCATTACGAGGGTGGTATTGGCTCTTATGTTGCCTTTTTA
AATGATAAAAAGGACGTCATCTTCGATACTCCGATTTATTCTGATGGTGAGCTGGAGGGGATAACAGTTGAGGTGGCGAT
GCAGTACACTACAGGTTACCATGAGACTGTTATGAGCTTTGCCAACAATATTCACACACATGAGGGTGGTACCCATGAGC
AGGGCTTTAGAACAGCTCTGACGCGCGTGATTAATGACTATGCTAAGAAGGCTAAGATTCTCAAGGAAAACGAGGACAAT
CTGACAGGTGAGGACGTCCGCGAGGGATTGACCGCTGTTATTTCTGTCAAGCACCCAAATCCACAATTTGAAGGGCAAAC
AAAGACAAAGTTAGGAAATTCTGAGGTTGTTAAGATTACCAATCGCTTGTTTAGCGAAGCTCTTCAGCGCTTTCTATTAG
AGAATCCGCAGGTTGCCCGTAAGATTGTTGAAAAGGGGATTCTAGCCTCTAAGGCTCGCATTGCTGCCAAGAGAGCGCGT
GAAGTAACCCGCAAAAAATCAGGCCTAGAGATTTCCAATTTGCCAGGGAAGCTGGCTGACTGCTCCTCAAATGATGCTAG
TCAAAATGAGCTTTTTATCGTGGAGGGGGATTCGGCTGGTGGATCAGCGAAGTCAGGCCGCAATCGTGAGTTTCAGGCTA
TTCTGCCTATTCGTGGTAAAATTTTAAACGTTGAAAAAGCAACGATGGATAAAATCCTTGCTAACGAAGAAATCAGAAGC
CTCTTTACTGCTATGGGGACAGGCTTTGGAGCGGATTTTGATGTTTCTAGAGCTCGCTATCAAAAGCTGGTCATCATGAC
TGATGCAGATGTCGATGGAGCTCATATCAGAACGCTTTTGTTAACGTTGATTTATCGCTTCATGCGACCAGTATTAGAGG
CTGGCTATGTTTACATTGCTCAGCCACCGATTTATGGTGTTAAGGTTGGCAGCGAGATTAAGGAATACATTCAACCGGGA
GTCAACCAAGAAGAGGAGCTAAAGGCTGCTCTTGAAAGACACAGCACAGGGCGCTCAAGGCCGACTATTCAACGCTATAA
GGGTCTAGGAGAGATGGACGATCACCAGCTTTGGGAAACAACAATGGACCCTGATAATCGTCTAATGGCACGTGTGACCG
TAGATGATGCGGCAGAGGCTGATCGGATTTTTGACATGCTGATGGGCGATCGCGTTGAGCCAAGGCGTGAATTTATTGAG
GAAAATGCGGTCTATAGTACGCTTGACATTTAG

Upstream 100 bases:

>100_bases
GATTGGTGATCGCAGACTTGATATAGAAGCAGGACAAGCAGCAGGCTTTGATACCCTGCTTGTTGATGGTAGAAAAAACC
TATTGGAGATAGTAGATTAG

Downstream 100 bases:

>100_bases
TCAAATATATTTTGAAAAGCACCTAAAAGTATGTTATAATCGTAACGTTATAGTGTATTTTTGATAATATAATAAAAGGC
GATTCTTGCTAGTTGTTCCT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MVEENKQLEDKAQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEADNSITV
IDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVYKNGHIHYQEFRRGAVV
DDLAIIGTTDVTGTTVHFTPDPEIFTETTEFDYQVLAKRIQELAFLNRGLKISITDKRAGLEREEHFHYEGGIGSYVAFL
NDKKDVIFDTPIYSDGELEGITVEVAMQYTTGYHETVMSFANNIHTHEGGTHEQGFRTALTRVINDYAKKAKILKENEDN
LTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEALQRFLLENPQVARKIVEKGILASKARIAAKRAR
EVTRKKSGLEISNLPGKLADCSSNDASQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRS
LFTAMGTGFGADFDVSRARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPG
VNQEEELKAALERHSTGRSRPTIQRYKGLGEMDDHQLWETTMDPDNRLMARVTVDDAAEADRIFDMLMGDRVEPRREFIE
ENAVYSTLDI

Sequences:

>Translated_650_residues
MVEENKQLEDKAQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEADNSITV
IDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVYKNGHIHYQEFRRGAVV
DDLAIIGTTDVTGTTVHFTPDPEIFTETTEFDYQVLAKRIQELAFLNRGLKISITDKRAGLEREEHFHYEGGIGSYVAFL
NDKKDVIFDTPIYSDGELEGITVEVAMQYTTGYHETVMSFANNIHTHEGGTHEQGFRTALTRVINDYAKKAKILKENEDN
LTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEALQRFLLENPQVARKIVEKGILASKARIAAKRAR
EVTRKKSGLEISNLPGKLADCSSNDASQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRS
LFTAMGTGFGADFDVSRARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPG
VNQEEELKAALERHSTGRSRPTIQRYKGLGEMDDHQLWETTMDPDNRLMARVTVDDAAEADRIFDMLMGDRVEPRREFIE
ENAVYSTLDI
>Mature_650_residues
MVEENKQLEDKAQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEADNSITV
IDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVYKNGHIHYQEFRRGAVV
DDLAIIGTTDVTGTTVHFTPDPEIFTETTEFDYQVLAKRIQELAFLNRGLKISITDKRAGLEREEHFHYEGGIGSYVAFL
NDKKDVIFDTPIYSDGELEGITVEVAMQYTTGYHETVMSFANNIHTHEGGTHEQGFRTALTRVINDYAKKAKILKENEDN
LTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEALQRFLLENPQVARKIVEKGILASKARIAAKRAR
EVTRKKSGLEISNLPGKLADCSSNDASQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRS
LFTAMGTGFGADFDVSRARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPG
VNQEEELKAALERHSTGRSRPTIQRYKGLGEMDDHQLWETTMDPDNRLMARVTVDDAAEADRIFDMLMGDRVEPRREFIE
ENAVYSTLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=676, Percent_Identity=26.7751479289941, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI19913406, Length=651, Percent_Identity=25.3456221198157, Blast_Score=126, Evalue=8e-29,
Organism=Escherichia coli, GI48994957, Length=549, Percent_Identity=54.0983606557377, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1789408, Length=646, Percent_Identity=39.6284829721362, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17535065, Length=669, Percent_Identity=24.6636771300448, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI212645845, Length=604, Percent_Identity=24.5033112582781, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324241, Length=640, Percent_Identity=23.90625, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136538, Length=653, Percent_Identity=25.8805513016845, Blast_Score=132, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 72173; Mature: 72173

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEENKQLEDKAQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEA
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
LAGFASHIQVFIEADNSITVIDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKV
HHHHHHHEEEEEECCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEE
SGGLHGVGSSVVNALSTQLDVRVYKNGHIHYQEFRRGAVVDDLAIIGTTDVTGTTVHFTP
CCCCCHHHHHHHHHHHHHEEEEEEECCCEEHHHHHCCCCCCCEEEEECCCCCCCEEEECC
DPEIFTETTEFDYQVLAKRIQELAFLNRGLKISITDKRAGLEREEHFHYEGGIGSYVAFL
CCCCEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHCEEECCCHHHHHEEE
NDKKDVIFDTPIYSDGELEGITVEVAMQYTTGYHETVMSFANNIHTHEGGTHEQGFRTAL
CCCCCEEEECCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TRVINDYAKKAKILKENEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKIT
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCHHHHHH
NRLFSEALQRFLLENPQVARKIVEKGILASKARIAAKRAREVTRKKSGLEISNLPGKLAD
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
CSSNDASQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRS
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECHHHHHHHHHHHHHHHH
LFTAMGTGFGADFDVSRARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIA
HHHHHCCCCCCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEE
QPPIYGVKVGSEIKEYIQPGVNQEEELKAALERHSTGRSRPTIQRYKGLGEMDDHQLWET
CCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHC
TMDPDNRLMARVTVDDAAEADRIFDMLMGDRVEPRREFIEENAVYSTLDI
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MVEENKQLEDKAQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEA
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
LAGFASHIQVFIEADNSITVIDDGRGIPVDIQAKTGRPAVETVFTVLHAGGKFGGGGYKV
HHHHHHHEEEEEECCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEE
SGGLHGVGSSVVNALSTQLDVRVYKNGHIHYQEFRRGAVVDDLAIIGTTDVTGTTVHFTP
CCCCCHHHHHHHHHHHHHEEEEEEECCCEEHHHHHCCCCCCCEEEEECCCCCCCEEEECC
DPEIFTETTEFDYQVLAKRIQELAFLNRGLKISITDKRAGLEREEHFHYEGGIGSYVAFL
CCCCEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHCEEECCCHHHHHEEE
NDKKDVIFDTPIYSDGELEGITVEVAMQYTTGYHETVMSFANNIHTHEGGTHEQGFRTAL
CCCCCEEEECCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TRVINDYAKKAKILKENEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKIT
HHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCHHHCCCCCHHHHHH
NRLFSEALQRFLLENPQVARKIVEKGILASKARIAAKRAREVTRKKSGLEISNLPGKLAD
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCC
CSSNDASQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRS
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEECHHHHHHHHHHHHHHHH
LFTAMGTGFGADFDVSRARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIA
HHHHHCCCCCCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEE
QPPIYGVKVGSEIKEYIQPGVNQEEELKAALERHSTGRSRPTIQRYKGLGEMDDHQLWET
CCCCEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCHHHHC
TMDPDNRLMARVTVDDAAEADRIFDMLMGDRVEPRREFIEENAVYSTLDI
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]