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The map label for this gene is dnaX [H]

Identifier: 195977810

GI number: 195977810

Start: 699357

End: 701033

Strand: Direct

Name: dnaX [H]

Synonym: Sez_0676

Alternate gene names: 195977810

Gene position: 699357-701033 (Clockwise)

Preceding gene: 195977809

Following gene: 195977811

Centisome position: 34.55

GC content: 44.54

Gene sequence:

>1677_bases
ATGTATCAAGCCCTTTACCGGAAGTATCGTAGCCAGACCTTTGCTGAAATGGTTGGGCAGTCAGTTATTTCGACCACCTT
AAAGCAGGCTGTTGAGTCGGGAAAGATAAGTCACGCCTACCTCTTTTCAGGTCCAAGAGGAACTGGTAAAACCAGCGCAG
CCAAAATTTTTGCCAAGGCAATGAACTGCCCTAATCAGGTCAAGGGAGAGCCCTGCAATCATTGTGATATTTGCCGAGAT
ATTACAACTGGCAGTCTGGAGGACGTGATTGAAATTGATGCCGCCTCTAATAATGGTGTTGATGAAATTCGCGATATTCG
AGATAAGTCAACCTATGCCCCGAGTCGGGCAACCTACAAGGTTTATATTATTGATGAGGTCCATATGCTGTCAACAGGAG
CCTTCAATGCGCTCCTAAAGACCCTAGAAGAGCCGAGTGACAATGTGGTTTTTATCCTAGCCACAACAGAATTACACAAG
ATTCCAGCTACTATTTTGTCTAGAGTCCAGCGATTTGAGTTTAAAGCCATTAAGCAGGCGGCTATTTGTGAGCATTTGGC
AGCGATACTGGACAAAGAGGGCATAGCTTATGAAACAGAGGCGCTTCATTTAATTGCAAGACGGGCTGAAGGTGGCATGC
GTGATGCCCTATCCATTTTAGATCAGGCCTTGAGCCTATCCTTTGACAATCGAGTGACGCTTGCTATTGCCGAAGAAATT
ACAGGCTCTATTTCCATTTCAGCCTTGGACGACTACGTTCAGCATCTCATCAGGCAAAAAACAAGTCAGGCCTTAGCTAA
TCTAGAAACGATTTATGATAGTGGCAAGAGCATGAGTCGCTTTGCAACGGACCTGTTAACCTATTTTAGAGACCTGCTCA
TTGTGAAATCAGGTGGTGATCATCACAGGCAGTCCCCTCTTTTTGATGACAATCTTGCAGTGTCTTTTGATCAGCTTTTT
ACCATGATTGCTACAGTAACCAAGCATTTGCCTGAGATCAAAAAAGGAACCCACCCTAGAATATACGCTGAAATGATGAC
CATTCAGCTGGCAGAGCAGGGACAGGTAACAGACACTGCAATACCATCTAGCCTGCTAGCTGATGTTGATGGCTTAAAGC
ATGAAATTAGCCAGTTGAGGGAGACGATATCACAGCTACAGGCTCAAAAAGGTCTAACTGCACAGGCTACGCCAGCTCAT
TCTATCAAGCCAAAGGCCTTTACCTACAAGGTTGATCGGGAAAAGATATTGAAAATCATGGAGGAAACTGTTCAAGATAG
CCAGCAGTCACGACAATATTTAGAAGCGCTAAAAAGTGCTTGGAATGAGATTTTAGATAGTATTTCTGCACAGGATCGAG
CTTTGTTACTAGGCTCGGAGCCTGTTTTAGCCAATAGTGAAAATGCTATTTTGGCCTTTGAGGCCGCCTTTAACGCTGAG
CAGGCCATGAAGCGTCAGGATTTGAATGATATGTTTGGGAATATCATGAGTAAGGCAGCAGGGTTTTCTCCTCATATCTT
GGCAGTACCAAAGGCAGACTTCCACCATATTCGCTCGGAGTTTGCCATGACCATCAAAACCAAAAAAGAGACAGCCAAAG
AGCCTGAGCAAGCGACCTTTGACATGCCTGAGGGGTTTGACTTTTTAACTGATAAGATTCATCTCATAGAGGATTAG

Upstream 100 bases:

>100_bases
CTGATTATGATCAGATAGATCAAGACTATTTAGAGCAATTTGTAGCCTTATTACTAGAAAATACATCTTTTCGTTTTGAC
ATGTTTGGAGTTGAGGATTA

Downstream 100 bases:

>100_bases
CGCTAGCTGATGATTAGTAGTGTATCAATTGTCTAGAATAAGGAGATGAAAAGGCTCATTGTCAGCAAAAATGGATCGCT
GACAAGCCAAGCTAGAGAGG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MYQALYRKYRSQTFAEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVKGEPCNHCDICRD
ITTGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPSDNVVFILATTELHK
IPATILSRVQRFEFKAIKQAAICEHLAAILDKEGIAYETEALHLIARRAEGGMRDALSILDQALSLSFDNRVTLAIAEEI
TGSISISALDDYVQHLIRQKTSQALANLETIYDSGKSMSRFATDLLTYFRDLLIVKSGGDHHRQSPLFDDNLAVSFDQLF
TMIATVTKHLPEIKKGTHPRIYAEMMTIQLAEQGQVTDTAIPSSLLADVDGLKHEISQLRETISQLQAQKGLTAQATPAH
SIKPKAFTYKVDREKILKIMEETVQDSQQSRQYLEALKSAWNEILDSISAQDRALLLGSEPVLANSENAILAFEAAFNAE
QAMKRQDLNDMFGNIMSKAAGFSPHILAVPKADFHHIRSEFAMTIKTKKETAKEPEQATFDMPEGFDFLTDKIHLIED

Sequences:

>Translated_558_residues
MYQALYRKYRSQTFAEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVKGEPCNHCDICRD
ITTGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPSDNVVFILATTELHK
IPATILSRVQRFEFKAIKQAAICEHLAAILDKEGIAYETEALHLIARRAEGGMRDALSILDQALSLSFDNRVTLAIAEEI
TGSISISALDDYVQHLIRQKTSQALANLETIYDSGKSMSRFATDLLTYFRDLLIVKSGGDHHRQSPLFDDNLAVSFDQLF
TMIATVTKHLPEIKKGTHPRIYAEMMTIQLAEQGQVTDTAIPSSLLADVDGLKHEISQLRETISQLQAQKGLTAQATPAH
SIKPKAFTYKVDREKILKIMEETVQDSQQSRQYLEALKSAWNEILDSISAQDRALLLGSEPVLANSENAILAFEAAFNAE
QAMKRQDLNDMFGNIMSKAAGFSPHILAVPKADFHHIRSEFAMTIKTKKETAKEPEQATFDMPEGFDFLTDKIHLIED
>Mature_558_residues
MYQALYRKYRSQTFAEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKAMNCPNQVKGEPCNHCDICRD
ITTGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPSDNVVFILATTELHK
IPATILSRVQRFEFKAIKQAAICEHLAAILDKEGIAYETEALHLIARRAEGGMRDALSILDQALSLSFDNRVTLAIAEEI
TGSISISALDDYVQHLIRQKTSQALANLETIYDSGKSMSRFATDLLTYFRDLLIVKSGGDHHRQSPLFDDNLAVSFDQLF
TMIATVTKHLPEIKKGTHPRIYAEMMTIQLAEQGQVTDTAIPSSLLADVDGLKHEISQLRETISQLQAQKGLTAQATPAH
SIKPKAFTYKVDREKILKIMEETVQDSQQSRQYLEALKSAWNEILDSISAQDRALLLGSEPVLANSENAILAFEAAFNAE
QAMKRQDLNDMFGNIMSKAAGFSPHILAVPKADFHHIRSEFAMTIKTKKETAKEPEQATFDMPEGFDFLTDKIHLIED

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=263, Percent_Identity=26.615969581749, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI194306571, Length=266, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI194306567, Length=266, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4506491, Length=340, Percent_Identity=23.8235294117647, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI31881687, Length=340, Percent_Identity=23.8235294117647, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI31563534, Length=224, Percent_Identity=28.125, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786676, Length=243, Percent_Identity=51.440329218107, Blast_Score=254, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=24.496644295302, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=222, Percent_Identity=27.4774774774775, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=218, Percent_Identity=28.4403669724771, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=225, Percent_Identity=31.1111111111111, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322528, Length=303, Percent_Identity=23.4323432343234, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=218, Percent_Identity=26.605504587156, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859927, Length=257, Percent_Identity=27.6264591439689, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921076, Length=227, Percent_Identity=27.3127753303965, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647857, Length=216, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61969; Mature: 61969

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQALYRKYRSQTFAEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
MNCPNQVKGEPCNHCDICRDITTGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYK
HCCCCCCCCCCCCCHHHHHCCCCCCHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPSDNVVFILATTELHKIPATILSRVQRFEFKAIKQA
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AICEHLAAILDKEGIAYETEALHLIARRAEGGMRDALSILDQALSLSFDNRVTLAIAEEI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHH
TGSISISALDDYVQHLIRQKTSQALANLETIYDSGKSMSRFATDLLTYFRDLLIVKSGGD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCC
HHRQSPLFDDNLAVSFDQLFTMIATVTKHLPEIKKGTHPRIYAEMMTIQLAEQGQVTDTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
IPSSLLADVDGLKHEISQLRETISQLQAQKGLTAQATPAHSIKPKAFTYKVDREKILKIM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHH
EETVQDSQQSRQYLEALKSAWNEILDSISAQDRALLLGSEPVLANSENAILAFEAAFNAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEEEEECCCHH
QAMKRQDLNDMFGNIMSKAAGFSPHILAVPKADFHHIRSEFAMTIKTKKETAKEPEQATF
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHEECCHHHCCCCCCCCC
DMPEGFDFLTDKIHLIED
CCCCCCHHHHCCEEECCC
>Mature Secondary Structure
MYQALYRKYRSQTFAEMVGQSVISTTLKQAVESGKISHAYLFSGPRGTGKTSAAKIFAKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHH
MNCPNQVKGEPCNHCDICRDITTGSLEDVIEIDAASNNGVDEIRDIRDKSTYAPSRATYK
HCCCCCCCCCCCCCHHHHHCCCCCCHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPSDNVVFILATTELHKIPATILSRVQRFEFKAIKQA
EEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AICEHLAAILDKEGIAYETEALHLIARRAEGGMRDALSILDQALSLSFDNRVTLAIAEEI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHH
TGSISISALDDYVQHLIRQKTSQALANLETIYDSGKSMSRFATDLLTYFRDLLIVKSGGD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCC
HHRQSPLFDDNLAVSFDQLFTMIATVTKHLPEIKKGTHPRIYAEMMTIQLAEQGQVTDTA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHH
IPSSLLADVDGLKHEISQLRETISQLQAQKGLTAQATPAHSIKPKAFTYKVDREKILKIM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHH
EETVQDSQQSRQYLEALKSAWNEILDSISAQDRALLLGSEPVLANSENAILAFEAAFNAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCEEEEEECCCHH
QAMKRQDLNDMFGNIMSKAAGFSPHILAVPKADFHHIRSEFAMTIKTKKETAKEPEQATF
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHEECCHHHCCCCCCCCC
DMPEGFDFLTDKIHLIED
CCCCCCHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]