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The map label for this gene is penA [H]

Identifier: 195977776

GI number: 195977776

Start: 658703

End: 660757

Strand: Direct

Name: penA [H]

Synonym: Sez_0640

Alternate gene names: 195977776

Gene position: 658703-660757 (Clockwise)

Preceding gene: 195977775

Following gene: 195977777

Centisome position: 32.54

GC content: 43.84

Gene sequence:

>2055_bases
ATGGCATCATGGATAAAAAAGAAAAAAGCAAGCATTCCTAGGCGAATTCATCTCCTTTTTTTGGTGATTGTTTTTTTGTT
TGTTGCCCTGATTTTGAGATTGGTACAAATGCAGATTTATGAGAAGGATTTTTACAAGGCAAAGCTGACAGCGTCAACCG
TTTACAAAGTAAAAAGCTCTATGCCAAGGGGAACCATTTTTGACCGTAATGGGAAGGTTCTAGTTTCTAATCGTATCAAG
GACGTGGTAACCTATACGAGAAGTCCCAAGGCTAGTGCTAAGGACATTAAGGCTTTGGCTCATCAGCTAGCTGCTTATAT
TAGCTATCCTGAGGCTAAAGTGACAGTCAGAGCCAAAAAGGATTATTATTTGGCAGATCCAGAGGCTTATGCTAAGACGG
TTCAAGCCTTACCCAAAAAGGACAAGGTGGATCGCTTTGGCAATAAATTAGTCGAAGCACAGATATATCAAAATGCGGCA
GCCTCTCTTAAGGAAACAGACTTGACCTATTCAGACCAAGAGCTAAAGGTTATTGCTATTTTTAACCAAATGAATGCAGC
AGCTGTTTTTAGCACTGTAAAGCTCAAGACATCAGCCTTATCTGAGCAGGATATTGCCATCATTATGGCTAATAAGTCAA
AATTACCAGGTATTTCAGTTGGGACAGACTGGGAGCGTCAGGTGGAGGAGACAAGCCTTGCTGCCATTATTGGAAGGGTC
TCTAGTGAGGAAGCCGGTCTTCCAAAGGAAGAAGCCAAGGCCTATCTTAAAAAGGGGTATTCGCTTAATGATCGTGTTGG
AACCTCTTATCTGGAAAAGCAATATGAGGAGGTCCTTCAAGGAAAGCATGAAACCAGAGAAATCAAAACGAGCAGATCTG
GTGAGGTTATTTCGGATAAAATAGTCGAAAAGGGTCAGGTGGGGCGGAACCTAAAGCTGACCATTCCACTTGATTTTCAA
CAGGATGTTGAGCAGATCCTAAATCAGCACTTGCAGACAGAGCTCAAAAATGGTCAGGCTGCTTACTCAGAAGGGATCTA
CGCTGTGGCACTTAACCCTAATACGGGAGCTATTTTAGCGATGGCAGGTCTATCACACAACCTAGAAACTGGCTCGCTTC
AAAAGGACGCTTTAGGGACCATTACTGATGTATTTACCCCTGGGTCTGTTGTCAAGGGGGCGACCTTGGCTGCTGGCTGG
CAGGCTGGAGTGATTCAAGGGAATCAGGTTTTGATTGATCAGCCGATTCAATTTGGTGGCTCCCAGCCGATTAATTCTTG
GTTTACCAGCGGTCAGCACCCTATTACTGCTAGTCAGGCGCTGGAATATTCATCAAATACTTACATGGTTCAGGTTGCCT
TGAGAATGATGGGGCAGGATTACGTGACTGGTATGACCTTGGCCAATACTGGTATGAAGGAAACCATGAAAAAATTGCGG
GCAGCCTATGCTGAATTTGGTATGGGAGTGGCAACTGGGGTTGATTTGCCTGGCGAATCCAGTGGCTACCTCACAGATCA
GTATAATACTGCAAATGTTTTGACAGAGGCCTTTGGTCAGTTTGATAACTATACAACAATGCAGCTAGCCCAATATGTCT
CAACTGTTGCTAATGGCGGCAGTCGCCTTGCGCCTCACATTGTAGAAGGCATTTATCAGGATAATGATCAGTCTGGACCA
GGCAAGCTAAGCAAGGCTATTGAGACCACCTTGTTAAATAAGGTGAACTTAGCTGCTGATAGTTTAGCGATTATTCAGGA
CGGTTTTTATCAGGTGGTTAATAGTGGTAGTGGCTATGCTACAGGTAGGGCTCTTGCAGGAGGTCCTGTTACCATTAGTG
CTAAAACCGGTACCGCAGAAACCTATGCTAAGGATAAAAATGGTCAGGTTTTATCCACCTTTAACTTGAATGTTGTGGCC
TATGGTCCGAGTGCTAGTCCTCAAATTGCTGTTGCTGTCATGTATCCTCATGCGACAGACTCTCTAGCCAAGGCACATCA
ATACGTGGCTAAGGATATCATTAATTTGTACATGAAGATGTATAAAAACCAATAA

Upstream 100 bases:

>100_bases
ATATTTTTAGACTGGGAGACCTTATTCTCAGTCTTATTTTTATATTTTGTGATAAAATAGGAAACGACGTTTAAAAAGGA
GGAGTTGATAAGCATCTAAT

Downstream 100 bases:

>100_bases
AGGAGAAACGAGTGCTTTACCCTATACCAATCGCAAAATTAATTGAAAGCTATTCTAAATTACCAGGGATTGGTGTTAAA
ACAGCGACAAGATTGGCTTT

Product: cell division protein FtsI

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MASWIKKKKASIPRRIHLLFLVIVFLFVALILRLVQMQIYEKDFYKAKLTASTVYKVKSSMPRGTIFDRNGKVLVSNRIK
DVVTYTRSPKASAKDIKALAHQLAAYISYPEAKVTVRAKKDYYLADPEAYAKTVQALPKKDKVDRFGNKLVEAQIYQNAA
ASLKETDLTYSDQELKVIAIFNQMNAAAVFSTVKLKTSALSEQDIAIIMANKSKLPGISVGTDWERQVEETSLAAIIGRV
SSEEAGLPKEEAKAYLKKGYSLNDRVGTSYLEKQYEEVLQGKHETREIKTSRSGEVISDKIVEKGQVGRNLKLTIPLDFQ
QDVEQILNQHLQTELKNGQAAYSEGIYAVALNPNTGAILAMAGLSHNLETGSLQKDALGTITDVFTPGSVVKGATLAAGW
QAGVIQGNQVLIDQPIQFGGSQPINSWFTSGQHPITASQALEYSSNTYMVQVALRMMGQDYVTGMTLANTGMKETMKKLR
AAYAEFGMGVATGVDLPGESSGYLTDQYNTANVLTEAFGQFDNYTTMQLAQYVSTVANGGSRLAPHIVEGIYQDNDQSGP
GKLSKAIETTLLNKVNLAADSLAIIQDGFYQVVNSGSGYATGRALAGGPVTISAKTGTAETYAKDKNGQVLSTFNLNVVA
YGPSASPQIAVAVMYPHATDSLAKAHQYVAKDIINLYMKMYKNQ

Sequences:

>Translated_684_residues
MASWIKKKKASIPRRIHLLFLVIVFLFVALILRLVQMQIYEKDFYKAKLTASTVYKVKSSMPRGTIFDRNGKVLVSNRIK
DVVTYTRSPKASAKDIKALAHQLAAYISYPEAKVTVRAKKDYYLADPEAYAKTVQALPKKDKVDRFGNKLVEAQIYQNAA
ASLKETDLTYSDQELKVIAIFNQMNAAAVFSTVKLKTSALSEQDIAIIMANKSKLPGISVGTDWERQVEETSLAAIIGRV
SSEEAGLPKEEAKAYLKKGYSLNDRVGTSYLEKQYEEVLQGKHETREIKTSRSGEVISDKIVEKGQVGRNLKLTIPLDFQ
QDVEQILNQHLQTELKNGQAAYSEGIYAVALNPNTGAILAMAGLSHNLETGSLQKDALGTITDVFTPGSVVKGATLAAGW
QAGVIQGNQVLIDQPIQFGGSQPINSWFTSGQHPITASQALEYSSNTYMVQVALRMMGQDYVTGMTLANTGMKETMKKLR
AAYAEFGMGVATGVDLPGESSGYLTDQYNTANVLTEAFGQFDNYTTMQLAQYVSTVANGGSRLAPHIVEGIYQDNDQSGP
GKLSKAIETTLLNKVNLAADSLAIIQDGFYQVVNSGSGYATGRALAGGPVTISAKTGTAETYAKDKNGQVLSTFNLNVVA
YGPSASPQIAVAVMYPHATDSLAKAHQYVAKDIINLYMKMYKNQ
>Mature_683_residues
ASWIKKKKASIPRRIHLLFLVIVFLFVALILRLVQMQIYEKDFYKAKLTASTVYKVKSSMPRGTIFDRNGKVLVSNRIKD
VVTYTRSPKASAKDIKALAHQLAAYISYPEAKVTVRAKKDYYLADPEAYAKTVQALPKKDKVDRFGNKLVEAQIYQNAAA
SLKETDLTYSDQELKVIAIFNQMNAAAVFSTVKLKTSALSEQDIAIIMANKSKLPGISVGTDWERQVEETSLAAIIGRVS
SEEAGLPKEEAKAYLKKGYSLNDRVGTSYLEKQYEEVLQGKHETREIKTSRSGEVISDKIVEKGQVGRNLKLTIPLDFQQ
DVEQILNQHLQTELKNGQAAYSEGIYAVALNPNTGAILAMAGLSHNLETGSLQKDALGTITDVFTPGSVVKGATLAAGWQ
AGVIQGNQVLIDQPIQFGGSQPINSWFTSGQHPITASQALEYSSNTYMVQVALRMMGQDYVTGMTLANTGMKETMKKLRA
AYAEFGMGVATGVDLPGESSGYLTDQYNTANVLTEAFGQFDNYTTMQLAQYVSTVANGGSRLAPHIVEGIYQDNDQSGPG
KLSKAIETTLLNKVNLAADSLAIIQDGFYQVVNSGSGYATGRALAGGPVTISAKTGTAETYAKDKNGQVLSTFNLNVVAY
GPSASPQIAVAVMYPHATDSLAKAHQYVAKDIINLYMKMYKNQ

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=529, Percent_Identity=25.5198487712665, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1786272, Length=419, Percent_Identity=26.7303102625298, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74496; Mature: 74365

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASWIKKKKASIPRRIHLLFLVIVFLFVALILRLVQMQIYEKDFYKAKLTASTVYKVKSS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPRGTIFDRNGKVLVSNRIKDVVTYTRSPKASAKDIKALAHQLAAYISYPEAKVTVRAKK
CCCCCEEECCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
DYYLADPEAYAKTVQALPKKDKVDRFGNKLVEAQIYQNAAASLKETDLTYSDQELKVIAI
CEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
FNQMNAAAVFSTVKLKTSALSEQDIAIIMANKSKLPGISVGTDWERQVEETSLAAIIGRV
ECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
SSEEAGLPKEEAKAYLKKGYSLNDRVGTSYLEKQYEEVLQGKHETREIKTSRSGEVISDK
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHH
IVEKGQVGRNLKLTIPLDFQQDVEQILNQHLQTELKNGQAAYSEGIYAVALNPNTGAILA
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCEEEE
MAGLSHNLETGSLQKDALGTITDVFTPGSVVKGATLAAGWQAGVIQGNQVLIDQPIQFGG
EECCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCEEECCCCCCEEECCEEEEECCCCCCC
SQPINSWFTSGQHPITASQALEYSSNTYMVQVALRMMGQDYVTGMTLANTGMKETMKKLR
CCCCHHHHCCCCCCCCHHHHHHCCCCCEEHHHHHHHHCCHHHCCEEECCCCHHHHHHHHH
AAYAEFGMGVATGVDLPGESSGYLTDQYNTANVLTEAFGQFDNYTTMQLAQYVSTVANGG
HHHHHHCCCCEECCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SRLAPHIVEGIYQDNDQSGPGKLSKAIETTLLNKVNLAADSLAIIQDGFYQVVNSGSGYA
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TGRALAGGPVTISAKTGTAETYAKDKNGQVLSTFNLNVVAYGPSASPQIAVAVMYPHATD
CCCEECCCCEEEEECCCCHHHHCCCCCCCEEEEEEEEEEEECCCCCCCEEEEEEECCCCH
SLAKAHQYVAKDIINLYMKMYKNQ
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASWIKKKKASIPRRIHLLFLVIVFLFVALILRLVQMQIYEKDFYKAKLTASTVYKVKSS
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPRGTIFDRNGKVLVSNRIKDVVTYTRSPKASAKDIKALAHQLAAYISYPEAKVTVRAKK
CCCCCEEECCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
DYYLADPEAYAKTVQALPKKDKVDRFGNKLVEAQIYQNAAASLKETDLTYSDQELKVIAI
CEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
FNQMNAAAVFSTVKLKTSALSEQDIAIIMANKSKLPGISVGTDWERQVEETSLAAIIGRV
ECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
SSEEAGLPKEEAKAYLKKGYSLNDRVGTSYLEKQYEEVLQGKHETREIKTSRSGEVISDK
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHH
IVEKGQVGRNLKLTIPLDFQQDVEQILNQHLQTELKNGQAAYSEGIYAVALNPNTGAILA
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCEEEE
MAGLSHNLETGSLQKDALGTITDVFTPGSVVKGATLAAGWQAGVIQGNQVLIDQPIQFGG
EECCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCEEECCCCCCEEECCEEEEECCCCCCC
SQPINSWFTSGQHPITASQALEYSSNTYMVQVALRMMGQDYVTGMTLANTGMKETMKKLR
CCCCHHHHCCCCCCCCHHHHHHCCCCCEEHHHHHHHHCCHHHCCEEECCCCHHHHHHHHH
AAYAEFGMGVATGVDLPGESSGYLTDQYNTANVLTEAFGQFDNYTTMQLAQYVSTVANGG
HHHHHHCCCCEECCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SRLAPHIVEGIYQDNDQSGPGKLSKAIETTLLNKVNLAADSLAIIQDGFYQVVNSGSGYA
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TGRALAGGPVTISAKTGTAETYAKDKNGQVLSTFNLNVVAYGPSASPQIAVAVMYPHATD
CCCEECCCCEEEEECCCCHHHHCCCCCCCEEEEEEEEEEEECCCCCCCEEEEEEECCCCH
SLAKAHQYVAKDIINLYMKMYKNQ
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]