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The map label for this gene is lepA [H]

Identifier: 195977755

GI number: 195977755

Start: 642746

End: 643615

Strand: Direct

Name: lepA [H]

Synonym: Sez_0619

Alternate gene names: 195977755

Gene position: 642746-643615 (Clockwise)

Preceding gene: 195977754

Following gene: 195977756

Centisome position: 31.75

GC content: 45.98

Gene sequence:

>870_bases
ATGGATAAGCTAACAAGAATTGATGCCACGATTCATCAGTATTATGACAGGCAGTCTACTGTTTCAGCAGATCTGGAGGA
GGCCATTTTATATTCTGTTGATGGTGGTGGAAAGAGGCTCCGTCCACTCATTTTATTGGAGCTGCTGGAGGGCTTTGGTC
TTGCTTTGACGGACGCCCATTACGCGATTGCCGCTGCTATTGAGATGATTCATACAGGAAGTCTGATTCACGATGATTTG
CCTGCTATGGATAACGATGATTATCGACGCGGGCGATTAACCAGCCACAAGCAATTTGACGAAGCAACTGCTATTTTGGC
AGGAGATAGTCTTTTTTTAGACCCTTTTGCTTTAATCGCAGGGGCAGATTTGCCGGCAGACCTATTGGTGCAATTGATTC
AGCAGTTTTCCTTAGCGTCAGGAACCTTTGGCATGGTTGGTGGTCAGCTCTTGGACATGAAGGGGGAGCAGCAACTGCTG
AATATTCAGGAGCTATCTGATATTCATGCCAATAAAACAGGGAAATTGTTGACTCTTCCCTTTGTGGCTGCGGGGATCAT
AGCTGAGCAGTCGGCAGACGTTTTGTCTTGTCTGTGGGAGGCTGGTAGGCTTGTTGGACAGGCCTTTCAGATAAGAGATG
ATATTTTGGACGTTACTGCTAGCTTTGATGAGCTTGGTAAAACACCGCAAAAGGATTTGGCTGCTGATAAGTCAACCTAT
CCGAGTCTACTTGGTTTAGAGCGTTCAAGGGCTATTTTGGAGGAGTCTTTGAGTCAAGCGCTAGCTATTTTTAGCAGGCT
AGAAAGGGAAGAAGGCTTTGAGTCTCAGGCTATTATCAAAAGGATCGAGGGGTTGCGACTAAATGGCTAA

Upstream 100 bases:

>100_bases
TGGTGCTGTCAAAGGACCTTCAAAAAACCTTACAGTCAGCTGAAAAGACACTTGTTAAGGTCATGCAGGCAGATGGCACA
GAGCTAGAAATGGACGCCTA

Downstream 100 bases:

>100_bases
AGAAAGAGTAGATGTGCTAGCCTATAGACAGGGACTTTTTGAAACGCGAGAACAGGCCAAGCGCGGTGTGATGGCTGGGC
TAGTCATATCAGCTATAAGT

Product: geranyltranstransferase LepA

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDKLTRIDATIHQYYDRQSTVSADLEEAILYSVDGGGKRLRPLILLELLEGFGLALTDAHYAIAAAIEMIHTGSLIHDDL
PAMDNDDYRRGRLTSHKQFDEATAILAGDSLFLDPFALIAGADLPADLLVQLIQQFSLASGTFGMVGGQLLDMKGEQQLL
NIQELSDIHANKTGKLLTLPFVAAGIIAEQSADVLSCLWEAGRLVGQAFQIRDDILDVTASFDELGKTPQKDLAADKSTY
PSLLGLERSRAILEESLSQALAIFSRLEREEGFESQAIIKRIEGLRLNG

Sequences:

>Translated_289_residues
MDKLTRIDATIHQYYDRQSTVSADLEEAILYSVDGGGKRLRPLILLELLEGFGLALTDAHYAIAAAIEMIHTGSLIHDDL
PAMDNDDYRRGRLTSHKQFDEATAILAGDSLFLDPFALIAGADLPADLLVQLIQQFSLASGTFGMVGGQLLDMKGEQQLL
NIQELSDIHANKTGKLLTLPFVAAGIIAEQSADVLSCLWEAGRLVGQAFQIRDDILDVTASFDELGKTPQKDLAADKSTY
PSLLGLERSRAILEESLSQALAIFSRLEREEGFESQAIIKRIEGLRLNG
>Mature_289_residues
MDKLTRIDATIHQYYDRQSTVSADLEEAILYSVDGGGKRLRPLILLELLEGFGLALTDAHYAIAAAIEMIHTGSLIHDDL
PAMDNDDYRRGRLTSHKQFDEATAILAGDSLFLDPFALIAGADLPADLLVQLIQQFSLASGTFGMVGGQLLDMKGEQQLL
NIQELSDIHANKTGKLLTLPFVAAGIIAEQSADVLSCLWEAGRLVGQAFQIRDDILDVTASFDELGKTPQKDLAADKSTY
PSLLGLERSRAILEESLSQALAIFSRLEREEGFESQAIIKRIEGLRLNG

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=30.2127659574468, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786623, Length=231, Percent_Identity=44.1558441558442, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1789578, Length=223, Percent_Identity=31.8385650224215, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17505681, Length=257, Percent_Identity=25.6809338521401, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651612, Length=263, Percent_Identity=26.615969581749, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31569; Mature: 31569

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLTRIDATIHQYYDRQSTVSADLEEAILYSVDGGGKRLRPLILLELLEGFGLALTDAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
YAIAAAIEMIHTGSLIHDDLPAMDNDDYRRGRLTSHKQFDEATAILAGDSLFLDPFALIA
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
GADLPADLLVQLIQQFSLASGTFGMVGGQLLDMKGEQQLLNIQELSDIHANKTGKLLTLP
CCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHH
FVAAGIIAEQSADVLSCLWEAGRLVGQAFQIRDDILDVTASFDELGKTPQKDLAADKSTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
PSLLGLERSRAILEESLSQALAIFSRLEREEGFESQAIIKRIEGLRLNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDKLTRIDATIHQYYDRQSTVSADLEEAILYSVDGGGKRLRPLILLELLEGFGLALTDAH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
YAIAAAIEMIHTGSLIHDDLPAMDNDDYRRGRLTSHKQFDEATAILAGDSLFLDPFALIA
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
GADLPADLLVQLIQQFSLASGTFGMVGGQLLDMKGEQQLLNIQELSDIHANKTGKLLTLP
CCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHH
FVAAGIIAEQSADVLSCLWEAGRLVGQAFQIRDDILDVTASFDELGKTPQKDLAADKSTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCC
PSLLGLERSRAILEESLSQALAIFSRLEREEGFESQAIIKRIEGLRLNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]