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The map label for this gene is xseA

Identifier: 195977753

GI number: 195977753

Start: 641213

End: 642553

Strand: Direct

Name: xseA

Synonym: Sez_0617

Alternate gene names: 195977753

Gene position: 641213-642553 (Clockwise)

Preceding gene: 195977752

Following gene: 195977754

Centisome position: 31.68

GC content: 46.38

Gene sequence:

>1341_bases
ATGGCAGACTATTTATCCGTCACTCAGCTGACAAAATATTTAAAATTGAAATTTGATCGAGACCCTTATCTGGAGCGTGT
CTATCTCACTGGTCAGGTGTCCAATTTCAGAAAAAGACCAAATCACCAATATTTTTCCTTAAAGGACGAGGGGGCGGTGA
TTCAGGCCACCATGTGGGCAGGAGCTTATAAAAAGCTTGGCTTTGATTTAGAAGAAGGCATGAAGCTCAATGTGGTCGGG
CGTATTCAGCTCTATGAACCAAACGGCTCGTATTCCATCATCATTGAAAAGGCTGAGCCAGATGGTATTGGTGCTTTGGC
GCTGCAATTTGAGCAGCTCAGGCAAAAGCTGGCTGGTGAAGGCTTCTTTGATGAGAGGCATAAGCAGGCTCTGCCACAAT
TTGTGACAAAGGTAGGTGTTGTGACGAGTCCAAGTGGGGCTGTGATTCGTGATATTATCACAACCATTTCAAGGCGTTTT
CCTGGGGTGAGCATTCTTTTGTTTCCAACAAAGGTTCAGGGCGAGGGGGCAGCTCAAGAGGTTGCTGCTAATATTGCTAG
GGCTAACCAGCGTGAGGATCTGGATTTGTTGATTGTTGGGCGCGGCGGTGGCTCGATTGAGGACCTGTGGGCTTTCAATG
AGGAAATCGTTGTTCAGGCTATTTTTGAGTCTCGCTTGCCTGTTATTTCTAGTGTGGGGCATGAGACAGATACGACCTTG
GCTGATTTTGTGGCTGATCGCAGAGCTGCTACCCCAACCGCAGCTGCTGAGCTAGCGACACCTATTACAAAAACAGATAT
TGTTTCTTGGATTGCTGAGCAACAGAATCGTTCCTATCAGGCCTGTTTGCGCTATATCAGACAAGGGCAGGAGCGAGTGG
ATAAGCTGTCTTATTCTGTTATGTTCAGGCAGCCAGAGAGGCTCTATGATGCTTATAGCCAACGCCTAGATAGGCTTACG
ACCTCCTTGATGACTACCTTTAAGGAGACATTATCAGAAGCTAAGCAAGAGCATCTGATTTTGGAGCATCGCTTAGCTTC
TGTCAACGTACAAGCAAGGCTTGAGCGTTATCAGGATCGTCTGGCAACTGCACATCGTCTCTTGATAGCCAATATGACTA
ATCAATACGATAGTAAGCTAGCAGGCTTTGAGCGAGCTCAAGCTGCCTTGCTGTCGCTTGATACGAGTCGTATCATTGCC
CGCGGCTATGCCTTGTTAAAAAAGGACGGTGCAGTAGCTGCCTGTGTTAAGGACATTAAAAAGGGAGATCATCTTAGCAT
TGTCATGCGTGATGGTCAATTAGAAGTAGAGGTAGAAGATGTCAACGAAAAAAACATTTGA

Upstream 100 bases:

>100_bases
TTTTTGTCTCTTTTTTGCTCACTATTTATGTGGAAACATGATATAATTGCATTAGTATACAGTTGGAGCCGTTAGGCTTC
ATGAAGTGAAAGGTAAACTG

Downstream 100 bases:

>100_bases
AGAACGTTTACAAGAATTAGAGGCCATTGTGACGAGGCTAGAAAATGGTGATGTGCCGCTAGAAGAGGCCATCTCTGAAT
TTCAAAAGGGTATGGTGCTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MADYLSVTQLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDEGAVIQATMWAGAYKKLGFDLEEGMKLNVVG
RIQLYEPNGSYSIIIEKAEPDGIGALALQFEQLRQKLAGEGFFDERHKQALPQFVTKVGVVTSPSGAVIRDIITTISRRF
PGVSILLFPTKVQGEGAAQEVAANIARANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESRLPVISSVGHETDTTL
ADFVADRRAATPTAAAELATPITKTDIVSWIAEQQNRSYQACLRYIRQGQERVDKLSYSVMFRQPERLYDAYSQRLDRLT
TSLMTTFKETLSEAKQEHLILEHRLASVNVQARLERYQDRLATAHRLLIANMTNQYDSKLAGFERAQAALLSLDTSRIIA
RGYALLKKDGAVAACVKDIKKGDHLSIVMRDGQLEVEVEDVNEKNI

Sequences:

>Translated_446_residues
MADYLSVTQLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDEGAVIQATMWAGAYKKLGFDLEEGMKLNVVG
RIQLYEPNGSYSIIIEKAEPDGIGALALQFEQLRQKLAGEGFFDERHKQALPQFVTKVGVVTSPSGAVIRDIITTISRRF
PGVSILLFPTKVQGEGAAQEVAANIARANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESRLPVISSVGHETDTTL
ADFVADRRAATPTAAAELATPITKTDIVSWIAEQQNRSYQACLRYIRQGQERVDKLSYSVMFRQPERLYDAYSQRLDRLT
TSLMTTFKETLSEAKQEHLILEHRLASVNVQARLERYQDRLATAHRLLIANMTNQYDSKLAGFERAQAALLSLDTSRIIA
RGYALLKKDGAVAACVKDIKKGDHLSIVMRDGQLEVEVEDVNEKNI
>Mature_445_residues
ADYLSVTQLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDEGAVIQATMWAGAYKKLGFDLEEGMKLNVVGR
IQLYEPNGSYSIIIEKAEPDGIGALALQFEQLRQKLAGEGFFDERHKQALPQFVTKVGVVTSPSGAVIRDIITTISRRFP
GVSILLFPTKVQGEGAAQEVAANIARANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESRLPVISSVGHETDTTLA
DFVADRRAATPTAAAELATPITKTDIVSWIAEQQNRSYQACLRYIRQGQERVDKLSYSVMFRQPERLYDAYSQRLDRLTT
SLMTTFKETLSEAKQEHLILEHRLASVNVQARLERYQDRLATAHRLLIANMTNQYDSKLAGFERAQAALLSLDTSRIIAR
GYALLKKDGAVAACVKDIKKGDHLSIVMRDGQLEVEVEDVNEKNI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=439, Percent_Identity=35.0797266514806, Blast_Score=271, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_STREM (B4U1W7)

Other databases:

- EMBL:   CP001129
- RefSeq:   YP_002122997.1
- EnsemblBacteria:   EBSTRT00000009776
- GeneID:   6761016
- GenomeReviews:   CP001129_GR
- KEGG:   sez:Sez_0617
- GeneTree:   EBGT00050000027533
- HOGENOM:   HBG634411
- OMA:   RLLIANM
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50094; Mature: 49963

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADYLSVTQLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDEGAVIQATMWA
CCCHHHHHHHHHHHHEECCCCCCCEEEEEEEEHHHHHCCCCCCEEEECCCCCEEEEEHHH
GAYKKLGFDLEEGMKLNVVGRIQLYEPNGSYSIIIEKAEPDGIGALALQFEQLRQKLAGE
HHHHHCCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GFFDERHKQALPQFVTKVGVVTSPSGAVIRDIITTISRRFPGVSILLFPTKVQGEGAAQE
CCHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH
VAANIARANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESRLPVISSVGHETDTTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH
ADFVADRRAATPTAAAELATPITKTDIVSWIAEQQNRSYQACLRYIRQGQERVDKLSYSV
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MFRQPERLYDAYSQRLDRLTTSLMTTFKETLSEAKQEHLILEHRLASVNVQARLERYQDR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LATAHRLLIANMTNQYDSKLAGFERAQAALLSLDTSRIIARGYALLKKDGAVAACVKDIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHC
KGDHLSIVMRDGQLEVEVEDVNEKNI
CCCCEEEEEECCEEEEEEECCCCCCC
>Mature Secondary Structure 
ADYLSVTQLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPNHQYFSLKDEGAVIQATMWA
CCHHHHHHHHHHHHEECCCCCCCEEEEEEEEHHHHHCCCCCCEEEECCCCCEEEEEHHH
GAYKKLGFDLEEGMKLNVVGRIQLYEPNGSYSIIIEKAEPDGIGALALQFEQLRQKLAGE
HHHHHCCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GFFDERHKQALPQFVTKVGVVTSPSGAVIRDIITTISRRFPGVSILLFPTKVQGEGAAQE
CCHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH
VAANIARANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESRLPVISSVGHETDTTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH
ADFVADRRAATPTAAAELATPITKTDIVSWIAEQQNRSYQACLRYIRQGQERVDKLSYSV
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MFRQPERLYDAYSQRLDRLTTSLMTTFKETLSEAKQEHLILEHRLASVNVQARLERYQDR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LATAHRLLIANMTNQYDSKLAGFERAQAALLSLDTSRIIARGYALLKKDGAVAACVKDIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHC
KGDHLSIVMRDGQLEVEVEDVNEKNI
CCCCEEEEEECCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA