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The map label for this gene is pgcA [H]

Identifier: 195977749

GI number: 195977749

Start: 637418

End: 639112

Strand: Direct

Name: pgcA [H]

Synonym: Sez_0613

Alternate gene names: 195977749

Gene position: 637418-639112 (Clockwise)

Preceding gene: 195977748

Following gene: 195977750

Centisome position: 31.49

GC content: 43.72

Gene sequence:

>1695_bases
ATGGACTACAAAGCTGTTTATCAGGAGTGGCTGCACAATGATTTTTTCAATGAAGAAATCAAGGCAGATTTAGAGGCGAT
TAAGCATGATGAGGCTGAGATTCAAGATCGTTTTTATAAGGTGCTTGAGTTTGGGACAGCAGGGCTTCGAGGCAAGCTGG
GTGCTGGAACCAACCGCATGAATATTTATATGGTTGGTAAGGCTGCTCAGGCTTTAGCTAATACCATTATTGATCATGGA
CCAGAAGCAGTCTCACGCGGGATTGCCATCAGCTATGATGTGCGCTACAAGTCTAAAGAGTTCGCAGAATTGACCTGCTC
TATCATGGCAGCTAATGGGATTAAGTCTTATATCTACAAGGGTATTCGTCCGACACCAATGTGCTCTTATGCGATTCGTG
CCTTGAATTGTATCTCTGGTGTTATGATTACTGCTAGTCACAATCCTCAGGCCTATAATGGCTACAAGGCTTATTGGGAA
GAGGGGTCACAGATCCTAGATGACATCGCTAATCAGATAGCAGCTCATATGGACGCTATTGAGCGTTTTGAGGACGTTAA
GCAAATACCATTTGAGGAGGCATTGGCAAGTGGTTTGACCAGCTATATTGATGACAGCATAGAGGAAGCCTATAAAAAAG
AGGTTCTAGGCTTGACCATCAATGATACTGATATTGATAAATCAGTGCGTGTGGTTTATACGCCTTTGAATGGCGTTGGT
AATTTGCCTGTTCGTGAGGTATTGAAGAGACGAGGCTTTGATCATGTCTTTGTAGTGCCGGAGCAGGAAATGCCAGACCC
AGACTTCACAACAGTTGGTTATCCAAATCCAGAGGTGCCAAAGGCCTTTGCTTATTCAGAAAGACTAGGGCAAGAAGTAG
GAGCAGATATTTTGATTGCGACTGATCCGGACTGTGATCGTGTGGCACTAGAAGTTCGAGCTGCTGACGGTAGTTATGTC
TTTCTTAATGGTAATAAGATTGGTGCTTTGTTGTCCTACTATATCTTTTCACAGCGCCATGCTAGGCATAACCTTCCTGA
CAATCCTGTCCTTGTCAAATCCATTGTGACAGGGGATTTGTCAAAGGCTATTGCCGCTAAATATGGCATTGAAACGGTTG
AGACCCTTACAGGCTTTAAAAACATCTGTGGCAAGGCTAATGACTATGACATCACAAAGGAGAAGACCTATGTCTTTGGC
TATGAGGAAAGCATTGGTTTTTGTTACGGTACCTTTGTGCGTGATAAGGATGCGGTCAGTGCCTCAATGATGGTGGTAGA
GATGGCTGCCTACTACAAGCAAAGAGGTCAGTCACTCTTGGACGTGCTTCAAGATATTTACAAGGAATTTGGTTATTACA
ATGAGCGTCAGGTAGCGCTTGAATTAGAGGGTGTTGAGGGGCAAAAGCGTATTGCACGTATCATGGAGGACTTTAGAAAT
AAGCCTATTGAGCGTGCAGGTGCTATGAGCTTAAAGACCGTTGTGGACTTTAAGGACGGCTACCTTGATTTTCCAAAGCA
AAATTGTTTGAAATATTATTTTGATGATGGGTCATGGTATGCGCTGAGACCATCTGGAACAGAGCCTAAGATCAAGCTTT
ACATCTATACTATTGGTGAAACAGAGGCAGACAGCATTGCTAAGCTAGACGCTATTGAGTCAGCCTGTCAAGCAAAGATG
GACAGTGTCAGCTAA

Upstream 100 bases:

>100_bases
AGAAAGCGCTTTGCTTTTTGGTGATGGCAATCATTATCATATGATCAAATCTTAAGTAAATGTTGATGTCAACATGGTGG
TCTAAAAGTAGGAGGATAAT

Downstream 100 bases:

>100_bases
TTGTTCAAGCTCTGCAACAGAAAATCAGCTAATCAATAAGCAAAAAGGAAAAGGAAGTGACAGTGCTTCCTTTTTTCGTT
ATAATAGTTAAAAAATTAGC

Product: probable phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MDYKAVYQEWLHNDFFNEEIKADLEAIKHDEAEIQDRFYKVLEFGTAGLRGKLGAGTNRMNIYMVGKAAQALANTIIDHG
PEAVSRGIAISYDVRYKSKEFAELTCSIMAANGIKSYIYKGIRPTPMCSYAIRALNCISGVMITASHNPQAYNGYKAYWE
EGSQILDDIANQIAAHMDAIERFEDVKQIPFEEALASGLTSYIDDSIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
NLPVREVLKRRGFDHVFVVPEQEMPDPDFTTVGYPNPEVPKAFAYSERLGQEVGADILIATDPDCDRVALEVRAADGSYV
FLNGNKIGALLSYYIFSQRHARHNLPDNPVLVKSIVTGDLSKAIAAKYGIETVETLTGFKNICGKANDYDITKEKTYVFG
YEESIGFCYGTFVRDKDAVSASMMVVEMAAYYKQRGQSLLDVLQDIYKEFGYYNERQVALELEGVEGQKRIARIMEDFRN
KPIERAGAMSLKTVVDFKDGYLDFPKQNCLKYYFDDGSWYALRPSGTEPKIKLYIYTIGETEADSIAKLDAIESACQAKM
DSVS

Sequences:

>Translated_564_residues
MDYKAVYQEWLHNDFFNEEIKADLEAIKHDEAEIQDRFYKVLEFGTAGLRGKLGAGTNRMNIYMVGKAAQALANTIIDHG
PEAVSRGIAISYDVRYKSKEFAELTCSIMAANGIKSYIYKGIRPTPMCSYAIRALNCISGVMITASHNPQAYNGYKAYWE
EGSQILDDIANQIAAHMDAIERFEDVKQIPFEEALASGLTSYIDDSIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
NLPVREVLKRRGFDHVFVVPEQEMPDPDFTTVGYPNPEVPKAFAYSERLGQEVGADILIATDPDCDRVALEVRAADGSYV
FLNGNKIGALLSYYIFSQRHARHNLPDNPVLVKSIVTGDLSKAIAAKYGIETVETLTGFKNICGKANDYDITKEKTYVFG
YEESIGFCYGTFVRDKDAVSASMMVVEMAAYYKQRGQSLLDVLQDIYKEFGYYNERQVALELEGVEGQKRIARIMEDFRN
KPIERAGAMSLKTVVDFKDGYLDFPKQNCLKYYFDDGSWYALRPSGTEPKIKLYIYTIGETEADSIAKLDAIESACQAKM
DSVS
>Mature_564_residues
MDYKAVYQEWLHNDFFNEEIKADLEAIKHDEAEIQDRFYKVLEFGTAGLRGKLGAGTNRMNIYMVGKAAQALANTIIDHG
PEAVSRGIAISYDVRYKSKEFAELTCSIMAANGIKSYIYKGIRPTPMCSYAIRALNCISGVMITASHNPQAYNGYKAYWE
EGSQILDDIANQIAAHMDAIERFEDVKQIPFEEALASGLTSYIDDSIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
NLPVREVLKRRGFDHVFVVPEQEMPDPDFTTVGYPNPEVPKAFAYSERLGQEVGADILIATDPDCDRVALEVRAADGSYV
FLNGNKIGALLSYYIFSQRHARHNLPDNPVLVKSIVTGDLSKAIAAKYGIETVETLTGFKNICGKANDYDITKEKTYVFG
YEESIGFCYGTFVRDKDAVSASMMVVEMAAYYKQRGQSLLDVLQDIYKEFGYYNERQVALELEGVEGQKRIARIMEDFRN
KPIERAGAMSLKTVVDFKDGYLDFPKQNCLKYYFDDGSWYALRPSGTEPKIKLYIYTIGETEADSIAKLDAIESACQAKM
DSVS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=561, Percent_Identity=32.2638146167558, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI31377548, Length=579, Percent_Identity=31.7789291882556, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71993870, Length=585, Percent_Identity=29.9145299145299, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=316, Percent_Identity=30.379746835443, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323934, Length=458, Percent_Identity=33.1877729257642, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323752, Length=535, Percent_Identity=23.5514018691589, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129809, Length=582, Percent_Identity=31.4432989690722, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24651977, Length=465, Percent_Identity=33.3333333333333, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24653722, Length=467, Percent_Identity=28.6937901498929, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17864244, Length=530, Percent_Identity=23.7735849056604, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63218; Mature: 63218

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKAVYQEWLHNDFFNEEIKADLEAIKHDEAEIQDRFYKVLEFGTAGLRGKLGAGTNRM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
NIYMVGKAAQALANTIIDHGPEAVSRGIAISYDVRYKSKEFAELTCSIMAANGIKSYIYK
EEEEECHHHHHHHHHHHHCCHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GIRPTPMCSYAIRALNCISGVMITASHNPQAYNGYKAYWEEGSQILDDIANQIAAHMDAI
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ERFEDVKQIPFEEALASGLTSYIDDSIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCC
NLPVREVLKRRGFDHVFVVPEQEMPDPDFTTVGYPNPEVPKAFAYSERLGQEVGADILIA
CCCHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCEEEE
TDPDCDRVALEVRAADGSYVFLNGNKIGALLSYYIFSQRHARHNLPDNPVLVKSIVTGDL
CCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
SKAIAAKYGIETVETLTGFKNICGKANDYDITKEKTYVFGYEESIGFCYGTFVRDKDAVS
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEHCCCCHHHH
ASMMVVEMAAYYKQRGQSLLDVLQDIYKEFGYYNERQVALELEGVEGQKRIARIMEDFRN
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
KPIERAGAMSLKTVVDFKDGYLDFPKQNCLKYYFDDGSWYALRPSGTEPKIKLYIYTIGE
CCCHHHCCCHHHHHEECCCCCCCCCHHHCEEEEEECCCEEEECCCCCCCEEEEEEEECCC
TEADSIAKLDAIESACQAKMDSVS
CCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYKAVYQEWLHNDFFNEEIKADLEAIKHDEAEIQDRFYKVLEFGTAGLRGKLGAGTNRM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
NIYMVGKAAQALANTIIDHGPEAVSRGIAISYDVRYKSKEFAELTCSIMAANGIKSYIYK
EEEEECHHHHHHHHHHHHCCHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GIRPTPMCSYAIRALNCISGVMITASHNPQAYNGYKAYWEEGSQILDDIANQIAAHMDAI
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ERFEDVKQIPFEEALASGLTSYIDDSIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCC
NLPVREVLKRRGFDHVFVVPEQEMPDPDFTTVGYPNPEVPKAFAYSERLGQEVGADILIA
CCCHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCEEEE
TDPDCDRVALEVRAADGSYVFLNGNKIGALLSYYIFSQRHARHNLPDNPVLVKSIVTGDL
CCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHH
SKAIAAKYGIETVETLTGFKNICGKANDYDITKEKTYVFGYEESIGFCYGTFVRDKDAVS
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEHCCCCHHHH
ASMMVVEMAAYYKQRGQSLLDVLQDIYKEFGYYNERQVALELEGVEGQKRIARIMEDFRN
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHC
KPIERAGAMSLKTVVDFKDGYLDFPKQNCLKYYFDDGSWYALRPSGTEPKIKLYIYTIGE
CCCHHHCCCHHHHHEECCCCCCCCCHHHCEEEEEECCCEEEECCCCCCCEEEEEEEECCC
TEADSIAKLDAIESACQAKMDSVS
CCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]