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The map label for this gene is glcK [H]

Identifier: 195977725

GI number: 195977725

Start: 612361

End: 613332

Strand: Direct

Name: glcK [H]

Synonym: Sez_0587

Alternate gene names: 195977725

Gene position: 612361-613332 (Clockwise)

Preceding gene: 195977724

Following gene: 195977726

Centisome position: 30.25

GC content: 46.19

Gene sequence:

>972_bases
ATGAGTCAAAAATTGATAGGGATTGATTTGGGCGGAACCACGATTAAATTTGGTATTTTAACCTCAGAGGGTGACGTTCA
GGAAAAATGGGCGATTGAGACAAATGTTTTAGAGGACGGTAAGCATATTGTTCCAGATATTGTCGCCTCACTCAAGCATC
GCCTTGACCTTTATGGACTGACTAAGGACGATTTTATCGGTATTGGTATGGGCTCACCTGGAGCTGTCAATCGCACAGAT
CATACTGTTACAGGGGCCTTTAACCTCAACTGGAGAGGCACCCAAGAGGTGGGATCTGTTATTGAAAGGGAGCTAGGAAT
TCCCTTTGCTATTGATAATGACGCAAATGTTGCGGCCCTCGGCGAGCGCTGGGTCGGTGCAGGTGACAATAATCCTGATG
TGGTCTTTATGACCTTAGGAACAGGTGTTGGTGGTGGTATCATCGCTGATGGGAACTTGATTCATGGTGTGGCTGGAGCT
GGTGGTGAGATTGGGCACATGATAGTAGAGCCGCTTAAGGGCTTTGCTTGCACCTGTGGCTCACAGGGCTGCCTGGAGAC
AGTGGCCTCTGCTACAGGTGTTGTTAAGGTTGCTCGCCTTTTAGCAGAAGCTTACGAAGGAGATTCAAGCATTAAGGCAG
CGATTGATAATGGAGAGGCTGTCTCAAGCAAGGACATTTTTGTTGCAGCGGAGGCTGGTGATGCCTTTGCCAACTCTGTT
GTTGAAAAGGTCAGTTATTATCTAGGACTGGCAGCGGCTAATATCTCAAATATTTTGAACCCTGATTCGATCGTTATTGG
CGGTGGTGTATCTGCTGCGGGTGAGTTTTTACGTTCACGTGTTGAAAAGTACTTTATGACTTTTACCTTTCCGCAGGTTA
GACAGTCCACTAAAATCAAAATAGCAGAGCTTGGTAATGATGCTGGTATTATTGGTGCAGCTAGCCTTGCAAGACAATTT
ATCACAGAATAG

Upstream 100 bases:

>100_bases
CTATATGATGGTGGCTTGTTGGATAAACAGGCTTATTTAACTGCTGAGCTGATTTTACGACGTGAGCATCGATTAGAGCT
AAAAAGAGAAGGGCAAGAAA

Downstream 100 bases:

>100_bases
GAGTTAATGATGTCACCACTTACAATGATTGGCTGGGTATTGCTTGCGGGAGTGATTGCCTATTACCTTTGGAATTATGT
TTCCTATAGAAGAATGGCAA

Product: glucokinase GlcK

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSQKLIGIDLGGTTIKFGILTSEGDVQEKWAIETNVLEDGKHIVPDIVASLKHRLDLYGLTKDDFIGIGMGSPGAVNRTD
HTVTGAFNLNWRGTQEVGSVIERELGIPFAIDNDANVAALGERWVGAGDNNPDVVFMTLGTGVGGGIIADGNLIHGVAGA
GGEIGHMIVEPLKGFACTCGSQGCLETVASATGVVKVARLLAEAYEGDSSIKAAIDNGEAVSSKDIFVAAEAGDAFANSV
VEKVSYYLGLAAANISNILNPDSIVIGGGVSAAGEFLRSRVEKYFMTFTFPQVRQSTKIKIAELGNDAGIIGAASLARQF
ITE

Sequences:

>Translated_323_residues
MSQKLIGIDLGGTTIKFGILTSEGDVQEKWAIETNVLEDGKHIVPDIVASLKHRLDLYGLTKDDFIGIGMGSPGAVNRTD
HTVTGAFNLNWRGTQEVGSVIERELGIPFAIDNDANVAALGERWVGAGDNNPDVVFMTLGTGVGGGIIADGNLIHGVAGA
GGEIGHMIVEPLKGFACTCGSQGCLETVASATGVVKVARLLAEAYEGDSSIKAAIDNGEAVSSKDIFVAAEAGDAFANSV
VEKVSYYLGLAAANISNILNPDSIVIGGGVSAAGEFLRSRVEKYFMTFTFPQVRQSTKIKIAELGNDAGIIGAASLARQF
ITE
>Mature_322_residues
SQKLIGIDLGGTTIKFGILTSEGDVQEKWAIETNVLEDGKHIVPDIVASLKHRLDLYGLTKDDFIGIGMGSPGAVNRTDH
TVTGAFNLNWRGTQEVGSVIERELGIPFAIDNDANVAALGERWVGAGDNNPDVVFMTLGTGVGGGIIADGNLIHGVAGAG
GEIGHMIVEPLKGFACTCGSQGCLETVASATGVVKVARLLAEAYEGDSSIKAAIDNGEAVSSKDIFVAAEAGDAFANSVV
EKVSYYLGLAAANISNILNPDSIVIGGGVSAAGEFLRSRVEKYFMTFTFPQVRQSTKIKIAELGNDAGIIGAASLARQFI
TE

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=278, Percent_Identity=31.294964028777, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI298566325, Length=278, Percent_Identity=31.294964028777, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI298566315, Length=278, Percent_Identity=31.294964028777, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4885285, Length=278, Percent_Identity=31.294964028777, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI298566312, Length=125, Percent_Identity=36.8, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786891, Length=320, Percent_Identity=29.375, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787878, Length=218, Percent_Identity=28.8990825688073, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787363, Length=324, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082127, Length=224, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=28.8819875776398, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1790522, Length=323, Percent_Identity=26.9349845201238, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082230, Length=280, Percent_Identity=26.4285714285714, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33574; Mature: 33443

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKLIGIDLGGTTIKFGILTSEGDVQEKWAIETNVLEDGKHIVPDIVASLKHRLDLYGL
CCCEEEEEECCCCEEEEEEEECCCCCCHHHEEEHHHHHCCCHHHHHHHHHHHHHHHHCCC
TKDDFIGIGMGSPGAVNRTDHTVTGAFNLNWRGTQEVGSVIERELGIPFAIDNDANVAAL
CCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCEEEE
GERWVGAGDNNPDVVFMTLGTGVGGGIIADGNLIHGVAGAGGEIGHMIVEPLKGFACTCG
CCHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCEECCC
SQGCLETVASATGVVKVARLLAEAYEGDSSIKAAIDNGEAVSSKDIFVAAEAGDAFANSV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCEEEEECCCCHHHHHH
VEKVSYYLGLAAANISNILNPDSIVIGGGVSAAGEFLRSRVEKYFMTFTFPQVRQSTKIK
HHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEECHHHHCCCCEE
IAELGNDAGIIGAASLARQFITE
EEECCCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
SQKLIGIDLGGTTIKFGILTSEGDVQEKWAIETNVLEDGKHIVPDIVASLKHRLDLYGL
CCEEEEEECCCCEEEEEEEECCCCCCHHHEEEHHHHHCCCHHHHHHHHHHHHHHHHCCC
TKDDFIGIGMGSPGAVNRTDHTVTGAFNLNWRGTQEVGSVIERELGIPFAIDNDANVAAL
CCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCEEEE
GERWVGAGDNNPDVVFMTLGTGVGGGIIADGNLIHGVAGAGGEIGHMIVEPLKGFACTCG
CCHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCEECCC
SQGCLETVASATGVVKVARLLAEAYEGDSSIKAAIDNGEAVSSKDIFVAAEAGDAFANSV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCCCEEEEECCCCHHHHHH
VEKVSYYLGLAAANISNILNPDSIVIGGGVSAAGEFLRSRVEKYFMTFTFPQVRQSTKIK
HHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEECHHHHCCCCEE
IAELGNDAGIIGAASLARQFITE
EEECCCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]