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The map label for this gene is comEB [H]

Identifier: 195977496

GI number: 195977496

Start: 372824

End: 373285

Strand: Direct

Name: comEB [H]

Synonym: Sez_0351

Alternate gene names: 195977496

Gene position: 372824-373285 (Clockwise)

Preceding gene: 195977495

Following gene: 195977497

Centisome position: 18.42

GC content: 44.81

Gene sequence:

>462_bases
ATGACAGATAGGCTATCATGGCAAGATTATTTTATGGCAAATGCAGAGCTGATATCTAAGCGCTCGACCTGCGATCGAGC
ATTTGTCGGTGCGGTCCTAGTCAAGGATAATCGCATTATTGCGACAGGCTATAACGGTGGCGTATCAGCGACTGATAACT
GTAACGAAGCTGGTCATTATATGGAAGAGGGGCATTGTATCAGGACTGTTCATGCAGAGATGAATGCTTTGATTCAATGT
GCTAAGGAGGGCATTTCAACTGCTGGAACAGAGATTTATGTCACACACTTTCCTTGTATCAATTGCACCAAGGCCCTCCT
TCAGGCTGGTATTTGCAAAATTACCTATAAATCCCATTATCGTCCCCACCCTTTTGCCATTGAGCTAATGGATAAAAAAG
GGGTTGGCTATGTTCAGCATGATGTGCCTCAGATTATCTTGGGTGGCGCTGTTGAGCCTTAG

Upstream 100 bases:

>100_bases
AGAGACAGGCTGTCAGGTCTTAACCAAGGCACCAAAGGAATTGATTGTTTTAACGTAGGCTTGTTAGCTGCTGTGAGCTA
GGAGGAATTAGGAGACAAAA

Downstream 100 bases:

>100_bases
GTCCAAGGCCAATAATGGTCATAAAACATTTGAGCCTACAGCTCTTTTGTGGTAAAATAAGACGATAACTATTTTAGTAA
GAGGTAATAACAAATGATTG

Product: dCMP deaminase; late competence protein ComEB

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MTDRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSATDNCNEAGHYMEEGHCIRTVHAEMNALIQC
AKEGISTAGTEIYVTHFPCINCTKALLQAGICKITYKSHYRPHPFAIELMDKKGVGYVQHDVPQIILGGAVEP

Sequences:

>Translated_153_residues
MTDRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSATDNCNEAGHYMEEGHCIRTVHAEMNALIQC
AKEGISTAGTEIYVTHFPCINCTKALLQAGICKITYKSHYRPHPFAIELMDKKGVGYVQHDVPQIILGGAVEP
>Mature_152_residues
TDRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSATDNCNEAGHYMEEGHCIRTVHAEMNALIQCA
KEGISTAGTEIYVTHFPCINCTKALLQAGICKITYKSHYRPHPFAIELMDKKGVGYVQHDVPQIILGGAVEP

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742821, Length=121, Percent_Identity=34.7107438016529, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI61742819, Length=121, Percent_Identity=34.7107438016529, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321938, Length=153, Percent_Identity=32.0261437908497, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667298, Length=154, Percent_Identity=36.3636363636364, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667302, Length=154, Percent_Identity=36.3636363636364, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 16837; Mature: 16706

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSATDNCNEAGHY
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHEEEEEECCEEEEECCCCCCCCCCCCCCCCCH
MEEGHCIRTVHAEMNALIQCAKEGISTAGTEIYVTHFPCINCTKALLQAGICKITYKSHY
HHCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCC
RPHPFAIELMDKKGVGYVQHDVPQIILGGAVEP
CCCCEEEEEECCCCCCEEHHCCCCEEECCCCCC
>Mature Secondary Structure 
TDRLSWQDYFMANAELISKRSTCDRAFVGAVLVKDNRIIATGYNGGVSATDNCNEAGHY
CCCCCCHHHHHHHHHHHHCCCCCCHHHHEEEEEECCEEEEECCCCCCCCCCCCCCCCCH
MEEGHCIRTVHAEMNALIQCAKEGISTAGTEIYVTHFPCINCTKALLQAGICKITYKSHY
HHCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCC
RPHPFAIELMDKKGVGYVQHDVPQIILGGAVEP
CCCCEEEEEECCCCCCEEHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]