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The map label for this gene is saeR [H]

Identifier: 195977456

GI number: 195977456

Start: 327973

End: 328659

Strand: Direct

Name: saeR [H]

Synonym: Sez_0311

Alternate gene names: 195977456

Gene position: 327973-328659 (Clockwise)

Preceding gene: 195977455

Following gene: 195977457

Centisome position: 16.2

GC content: 39.45

Gene sequence:

>687_bases
ATGACCTACAAGATATTATTGGTGGATGATGAATTGGAAATTATTGATATTAACGAACGTTATTTGCAACAGGCAGGGTA
TCGTGTTACCACTGCAAGCGATGGTAGTCAAGCCTTGGAGCTTTTTCATAAGGATCAGTACGATTTGATTATTAGTGATG
TTATGATGCCCAATATGGATGGCTATGATTTTATTGGGGAGGTTTTACTGGAAAAGCCAGATCAGCCCTTTCTCTTTATC
ACTGCAAAAACATCTGAGCCTGACAAGATTTATTCCTTGAGCTTGGGAGCAGATGATTTTATTTCCAAGCCCTTTAGTCC
ACGTGAATTAGTCTTACGGGTCAAAAATATTTTGAATCGGATTTATGGTAAGGCTAACCAAGCTGACTCCTTAGTTATTG
GGGATTTGGTCATGGATCACAGCACTCGAAGGGTTACAGTGGCAAATCAAGATCTGAATCTGACCAACAAGGCTTTTGAT
TTGTTGTGGATTTTGGCCAATCATTTGAATCATGTCTTTTCAAAAACAGAGCTTTATGAGCGTGTGTGGGAGGAGGAGTA
TTTAGATGATACCAATACCTTAAATGTTCACATTCATTCCCTACGCAATGACTTGGCAAAATACAGTACCGAGCAAACAC
CAACCATTAAAACGGTTTGGGGACTAGGCTATAAATTAGAGGAGTAG

Upstream 100 bases:

>100_bases
ATGATTGATGAGTTAATGAGATTAGAATTATTTGGCTAAGTTAAGAATTAGTGTTATACTTGAGAGAGTGTAGCACTAAT
TTTTTAATCAAGGAGGAAGC

Downstream 100 bases:

>100_bases
TATGCGACTAAGAACATACATTGTTATCGGCTATTTAATGTCTATGCTGATTACTATTGCAGGTCTGATTGTTGGGTTAA
ACCAAATGCTCATTACCATT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTYKILLVDDELEIIDINERYLQQAGYRVTTASDGSQALELFHKDQYDLIISDVMMPNMDGYDFIGEVLLEKPDQPFLFI
TAKTSEPDKIYSLSLGADDFISKPFSPRELVLRVKNILNRIYGKANQADSLVIGDLVMDHSTRRVTVANQDLNLTNKAFD
LLWILANHLNHVFSKTELYERVWEEEYLDDTNTLNVHIHSLRNDLAKYSTEQTPTIKTVWGLGYKLEE

Sequences:

>Translated_228_residues
MTYKILLVDDELEIIDINERYLQQAGYRVTTASDGSQALELFHKDQYDLIISDVMMPNMDGYDFIGEVLLEKPDQPFLFI
TAKTSEPDKIYSLSLGADDFISKPFSPRELVLRVKNILNRIYGKANQADSLVIGDLVMDHSTRRVTVANQDLNLTNKAFD
LLWILANHLNHVFSKTELYERVWEEEYLDDTNTLNVHIHSLRNDLAKYSTEQTPTIKTVWGLGYKLEE
>Mature_227_residues
TYKILLVDDELEIIDINERYLQQAGYRVTTASDGSQALELFHKDQYDLIISDVMMPNMDGYDFIGEVLLEKPDQPFLFIT
AKTSEPDKIYSLSLGADDFISKPFSPRELVLRVKNILNRIYGKANQADSLVIGDLVMDHSTRRVTVANQDLNLTNKAFDL
LWILANHLNHVFSKTELYERVWEEEYLDDTNTLNVHIHSLRNDLAKYSTEQTPTIKTVWGLGYKLEE

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=31.6017316017316, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.070796460177, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.7354260089686, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.5291479820628, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.4561403508772, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=32.5991189427313, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.6283185840708, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=36.1233480176211, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=34.8017621145374, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=30.8370044052863, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=27.8969957081545, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=29.3333333333333, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1787229, Length=214, Percent_Identity=27.1028037383178, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=30, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788905, Length=107, Percent_Identity=33.6448598130841, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=36.6336633663366, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=36.7924528301887, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=31.0344827586207, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=104, Percent_Identity=31.7307692307692, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26308; Mature: 26177

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYKILLVDDELEIIDINERYLQQAGYRVTTASDGSQALELFHKDQYDLIISDVMMPNMD
CEEEEEEEECCEEEEECCHHHHHHCCCEEEECCCHHHHHHHHHCCCHHEEEHHHHCCCCC
GYDFIGEVLLEKPDQPFLFITAKTSEPDKIYSLSLGADDFISKPFSPRELVLRVKNILNR
CHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHH
IYGKANQADSLVIGDLVMDHSTRRVTVANQDLNLTNKAFDLLWILANHLNHVFSKTELYE
HCCCCCCCCCEEEEHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVWEEEYLDDTNTLNVHIHSLRNDLAKYSTEQTPTIKTVWGLGYKLEE
HHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEECCCEEECC
>Mature Secondary Structure 
TYKILLVDDELEIIDINERYLQQAGYRVTTASDGSQALELFHKDQYDLIISDVMMPNMD
EEEEEEEECCEEEEECCHHHHHHCCCEEEECCCHHHHHHHHHCCCHHEEEHHHHCCCCC
GYDFIGEVLLEKPDQPFLFITAKTSEPDKIYSLSLGADDFISKPFSPRELVLRVKNILNR
CHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHH
IYGKANQADSLVIGDLVMDHSTRRVTVANQDLNLTNKAFDLLWILANHLNHVFSKTELYE
HCCCCCCCCCEEEEHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RVWEEEYLDDTNTLNVHIHSLRNDLAKYSTEQTPTIKTVWGLGYKLEE
HHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA