| Definition | Streptococcus equi subsp. zooepidemicus MGCS10565, complete genome. |
|---|---|
| Accession | NC_011134 |
| Length | 2,024,171 |
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The map label for this gene is polA [H]
Identifier: 195977329
GI number: 195977329
Start: 196567
End: 199266
Strand: Direct
Name: polA [H]
Synonym: Sez_0182
Alternate gene names: 195977329
Gene position: 196567-199266 (Clockwise)
Preceding gene: 195977327
Following gene: 195977330
Centisome position: 9.71
GC content: 45.15
Gene sequence:
>2700_bases TTGCAAAAAGCGAAGCTGGTCAGAGCAAAGCAGGTCACTGTGTGGTATAATAAAGGCATGGAAAACAAGAATAAATTACT TTTGATTGATGGCTCCTCAGTGGCCTTTCGTGCCTTTTTTGCCCTCTATAACCAGATTGACCGCTTTAAAAATCACAGCG GTCTTCACACTAATGCGATTTATGGCTTTCATTTGATGCTAGACCACATGATGAAGCGTGTTCAGCCGACGCATGTCCTA GTGGCCTTTGACGCGGGTAAAACAACCTTTCGGACAGAGCTTTTTGCTGATTACAAGGCAGGACGTGCTAAGACGCCTGA TGAATTTCGAGAGCAGTTTCCTTATATTCGTGATATGCTGGGAGCGCTTGGTATTGCCTTTTATGAGCTAGAGCATTACG AGGCAGACGATATTATCGGAACGCTTGATAAAATGGCAGAGCGCACAGAGCTTCCTTTTGATGTGACTATTGTTAGCGGT GACAAGGATTTGATTCAGCTGACAGATGCAAATACCGTTGTTGAGATTTCTAAAAAAGGAGTTGCTGAGTTTGAAGAGTT TACCCCAGCCTACCTCATGGACAAAATGGGGCTTACGCCAGAGCAATTCATTGACTTGAAAGCGCTCATGGGAGACAAGT CTGATAATATTCCAGGAGTGACCAAAATTGGGGAAAAAACAGGTTTAAAGCTCTTGCACGAATATGGCAGCCTAGAAGGC ATCTACCAGCATGTGGATAGCTTTAAGCCATCAAAAATGAAGGAAAACTTGCTTCATGATAAGGAGCAGGCCTTCCTCTC AAAGACACTTGCTACTATCAACACCAGTGCTCCGATTACGATTGGATTGGAGGATATTGTCTATCAGGGTCCAGATCTAG ATCGCTTGTCACAATTTTATGATGAGATGGATTTTGTTCAACTAAAAAATGCCTTAGCTAGTCAGCTGCCACAGGAGCCG GTAGCTGAGATTGCTTATCAGGAAGTCACTGACATAAGAGCGGACATGTTTTCAGATGATACAGTGTTTTATTTTGAGGC TTTGAGGGATAATTATCACCGCGAGGAGCTGATTGGCTTTGCTTGGGGCAACCAAGGCCAGATTTATGCTTCAGCAGATA TTAGCCTCCTCACAACAGAGCTCTTTAAAAAGGTTCTTGAGCAGCCGATTGCTACCTATGATTTTAAGCGCAGTAAGGTG CTGCTTAGTCACCTAGGGCTTGATTTGCCGGCTGCCAGTTATGATGCCCGCTTAGCTAATTACCTCTTATCAACTGTAGA GGACAATGAAATGGCTACTTTGGCACGTCTTTACACCACTATACCACTGGATACAGATGAGGTGGTTTATGGTAAGGGGG TCAAGCGTGCTGTGCCTGACAAGGCTGTTTTGTTAGGACATCTGGCGCGTAAGGTTCAGGTCTTGCTGGATAGTAGACCA GTCATGCTTGATAAGCTGGCAGAGCATGAGCAGGCTGATCTCTACACAGACATTGAATTGCCGCTTGCCAATGTTCTTGC GAAAATGGAAATCGAAGGCATTGCTGTCAATCAAGATAGCCTGCAGGAAATGGCAGAGCAAAATAAGGTGGTCATTGAGG AACTGACACAGGAAATCTATGAAATGGCTGGTGAGGTCTTTAATATTAATTCTCCCAAGCAGCTAGGAGTGATACTCTTT GAGAAAATGCAGCTCCCTCTTCATTTGACAAAGAAAACCAAGACAGGCTATTCAACGGCTGTTGATGTCTTGGAGCGCTT AGCGCCAATTGCGCCAATCGTGGCTAAGATCTTGGACTATCGTCAAATTACTAAGCTGCAATCAACCTATGTGATTGGAC TGCAGGATTACATCATGGCTGATGGCAGGATCCACACCCGCTATTTACAGGATTTAACCCAGACAGGCCGACTTTCCAGT GTTGATCCTAACCTGCAAAATATCCCGATTCGTCTGGAGCAGGGGCGCTTGATTCGTAAGGCCTTTACTCCATCTCATGA TGATGCTGTTTTGCTTAGCTCGGATTATTCGCAAATTGAATTGCGTGTTTTAGCACATATTTCAGGAGATGAGCATTTGA TTGCTGCTTTTAAGGAGGGAGCGGATATCCATACCTCAACGGCAATGCGTGTCTTTGGCATTGAAAAGCCAGAGGACGTC ACTGCCAATGATCGTCGGAATGCTAAGGCTGTTAACTTTGGCATTGTGTATGGGATTTCTGACTTTGGCTTGTCTAATAA CCTTGGAATTCCAAGAAAGCAGGCCAAGGCTTATATTGACACCTACTTTGAGCGCTACCCTGGTATCAAGGCTTACATGG AAAGGGTTGTGCGTGAAGCCAAGGATAAGGGCTATGTTGAGACGCTCTTTAAGCGCCGTCGTCAATTGCCAGATATCAAT TCTCGTCAATTTAACCTTCGTTCATTTGCGGAGCGTACAGCCATTAATTCACCAATTCAGGGCAGTGCAGCCGATATTCT CAAAATTGCGATGATAAATCTTGACCAAGCCCTAGTAGCTGGTGGCTTTGAGACCAAAATGCTGCTTCAGGTGCATGATG AGATTGTGCTTGAGGTGCCAAGCCATGAGCTAGCGGCTGTTAAAGAGCTGGTCAAAGAAACAATGGAATCAGCTGTCAAT CTGGCAGTTCCGCTGCGTGTGGACGAAAGTGCTGGTAAGAGCTGGTATGAGGCCAAGTAG
Upstream 100 bases:
>100_bases GGTAGAAATGTCTTGCTGATAAAGCAAGATCGATCATTTGTTTCTCCTCAAGCAGCTTGGACCTTTGATCAAGCTGCTGG TGAGCTGCGCTTGCTGGTGC
Downstream 100 bases:
>100_bases ACTAGATTAGCACTGGTGCTAAGTGGTAGTTTGCTTGGCTGCTGTTACATGATAGACGCGTGAAGGATTTTAAGTAAGAA AAGAAAGCTTTTTTATATTT
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 899; Mature: 899
Protein sequence:
>899_residues MQKAKLVRAKQVTVWYNKGMENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVQPTHVL VAFDAGKTTFRTELFADYKAGRAKTPDEFREQFPYIRDMLGALGIAFYELEHYEADDIIGTLDKMAERTELPFDVTIVSG DKDLIQLTDANTVVEISKKGVAEFEEFTPAYLMDKMGLTPEQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEYGSLEG IYQHVDSFKPSKMKENLLHDKEQAFLSKTLATINTSAPITIGLEDIVYQGPDLDRLSQFYDEMDFVQLKNALASQLPQEP VAEIAYQEVTDIRADMFSDDTVFYFEALRDNYHREELIGFAWGNQGQIYASADISLLTTELFKKVLEQPIATYDFKRSKV LLSHLGLDLPAASYDARLANYLLSTVEDNEMATLARLYTTIPLDTDEVVYGKGVKRAVPDKAVLLGHLARKVQVLLDSRP VMLDKLAEHEQADLYTDIELPLANVLAKMEIEGIAVNQDSLQEMAEQNKVVIEELTQEIYEMAGEVFNINSPKQLGVILF EKMQLPLHLTKKTKTGYSTAVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYIMADGRIHTRYLQDLTQTGRLSS VDPNLQNIPIRLEQGRLIRKAFTPSHDDAVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIEKPEDV TANDRRNAKAVNFGIVYGISDFGLSNNLGIPRKQAKAYIDTYFERYPGIKAYMERVVREAKDKGYVETLFKRRRQLPDIN SRQFNLRSFAERTAINSPIQGSAADILKIAMINLDQALVAGGFETKMLLQVHDEIVLEVPSHELAAVKELVKETMESAVN LAVPLRVDESAGKSWYEAK
Sequences:
>Translated_899_residues MQKAKLVRAKQVTVWYNKGMENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVQPTHVL VAFDAGKTTFRTELFADYKAGRAKTPDEFREQFPYIRDMLGALGIAFYELEHYEADDIIGTLDKMAERTELPFDVTIVSG DKDLIQLTDANTVVEISKKGVAEFEEFTPAYLMDKMGLTPEQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEYGSLEG IYQHVDSFKPSKMKENLLHDKEQAFLSKTLATINTSAPITIGLEDIVYQGPDLDRLSQFYDEMDFVQLKNALASQLPQEP VAEIAYQEVTDIRADMFSDDTVFYFEALRDNYHREELIGFAWGNQGQIYASADISLLTTELFKKVLEQPIATYDFKRSKV LLSHLGLDLPAASYDARLANYLLSTVEDNEMATLARLYTTIPLDTDEVVYGKGVKRAVPDKAVLLGHLARKVQVLLDSRP VMLDKLAEHEQADLYTDIELPLANVLAKMEIEGIAVNQDSLQEMAEQNKVVIEELTQEIYEMAGEVFNINSPKQLGVILF EKMQLPLHLTKKTKTGYSTAVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYIMADGRIHTRYLQDLTQTGRLSS VDPNLQNIPIRLEQGRLIRKAFTPSHDDAVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIEKPEDV TANDRRNAKAVNFGIVYGISDFGLSNNLGIPRKQAKAYIDTYFERYPGIKAYMERVVREAKDKGYVETLFKRRRQLPDIN SRQFNLRSFAERTAINSPIQGSAADILKIAMINLDQALVAGGFETKMLLQVHDEIVLEVPSHELAAVKELVKETMESAVN LAVPLRVDESAGKSWYEAK >Mature_899_residues MQKAKLVRAKQVTVWYNKGMENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVQPTHVL VAFDAGKTTFRTELFADYKAGRAKTPDEFREQFPYIRDMLGALGIAFYELEHYEADDIIGTLDKMAERTELPFDVTIVSG DKDLIQLTDANTVVEISKKGVAEFEEFTPAYLMDKMGLTPEQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEYGSLEG IYQHVDSFKPSKMKENLLHDKEQAFLSKTLATINTSAPITIGLEDIVYQGPDLDRLSQFYDEMDFVQLKNALASQLPQEP VAEIAYQEVTDIRADMFSDDTVFYFEALRDNYHREELIGFAWGNQGQIYASADISLLTTELFKKVLEQPIATYDFKRSKV LLSHLGLDLPAASYDARLANYLLSTVEDNEMATLARLYTTIPLDTDEVVYGKGVKRAVPDKAVLLGHLARKVQVLLDSRP VMLDKLAEHEQADLYTDIELPLANVLAKMEIEGIAVNQDSLQEMAEQNKVVIEELTQEIYEMAGEVFNINSPKQLGVILF EKMQLPLHLTKKTKTGYSTAVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYIMADGRIHTRYLQDLTQTGRLSS VDPNLQNIPIRLEQGRLIRKAFTPSHDDAVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIEKPEDV TANDRRNAKAVNFGIVYGISDFGLSNNLGIPRKQAKAYIDTYFERYPGIKAYMERVVREAKDKGYVETLFKRRRQLPDIN SRQFNLRSFAERTAINSPIQGSAADILKIAMINLDQALVAGGFETKMLLQVHDEIVLEVPSHELAAVKELVKETMESAVN LAVPLRVDESAGKSWYEAK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=443, Percent_Identity=34.9887133182844, Blast_Score=234, Evalue=4e-61, Organism=Homo sapiens, GI139394648, Length=640, Percent_Identity=27.5, Blast_Score=212, Evalue=2e-54, Organism=Escherichia coli, GI1790294, Length=938, Percent_Identity=38.3795309168444, Blast_Score=534, Evalue=1e-152, Organism=Escherichia coli, GI226510970, Length=223, Percent_Identity=32.2869955156951, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI86563272, Length=392, Percent_Identity=28.8265306122449, Blast_Score=171, Evalue=1e-42, Organism=Drosophila melanogaster, GI17933644, Length=516, Percent_Identity=32.3643410852713, Blast_Score=242, Evalue=8e-64,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 101386; Mature: 101386
Theoretical pI: Translated: 5.25; Mature: 5.25
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQKAKLVRAKQVTVWYNKGMENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAI CCCCHHHHHEEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHH YGFHLMLDHMMKRVQPTHVLVAFDAGKTTFRTELFADYKAGRAKTPDEFREQFPYIRDML HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHH GALGIAFYELEHYEADDIIGTLDKMAERTELPFDVTIVSGDKDLIQLTDANTVVEISKKG HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCEEEEEHHCC VAEFEEFTPAYLMDKMGLTPEQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEYGSLEG HHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHCCHHH IYQHVDSFKPSKMKENLLHDKEQAFLSKTLATINTSAPITIGLEDIVYQGPDLDRLSQFY HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCHHHHHHHH DEMDFVQLKNALASQLPQEPVAEIAYQEVTDIRADMFSDDTVFYFEALRDNYHREELIGF HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEEE AWGNQGQIYASADISLLTTELFKKVLEQPIATYDFKRSKVLLSHLGLDLPAASYDARLAN EECCCCCEEEECCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHH YLLSTVEDNEMATLARLYTTIPLDTDEVVYGKGVKRAVPDKAVLLGHLARKVQVLLDSRP HHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC VMLDKLAEHEQADLYTDIELPLANVLAKMEIEGIAVNQDSLQEMAEQNKVVIEELTQEIY HHHHHHHHHHHCCCEEECCCCHHHHHHHHEECEEEECHHHHHHHHHCCCHHHHHHHHHHH EMAGEVFNINSPKQLGVILFEKMQLPLHLTKKTKTGYSTAVDVLERLAPIAPIVAKILDY HHCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH RQITKLQSTYVIGLQDYIMADGRIHTRYLQDLTQTGRLSSVDPNLQNIPIRLEQGRLIRK HHHHHHHHHEEEEHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHH AFTPSHDDAVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIEKPEDV HCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEHHHHCCCCCCCCCEEEEECCCCCCCC TANDRRNAKAVNFGIVYGISDFGLSNNLGIPRKQAKAYIDTYFERYPGIKAYMERVVREA CCCCCCCCEEEEEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH KDKGYVETLFKRRRQLPDINSRQFNLRSFAERTAINSPIQGSAADILKIAMINLDQALVA HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC GGFETKMLLQVHDEIVLEVPSHELAAVKELVKETMESAVNLAVPLRVDESAGKSWYEAK CCCCHHHHHHHHCHHEEECCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCC >Mature Secondary Structure MQKAKLVRAKQVTVWYNKGMENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAI CCCCHHHHHEEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHH YGFHLMLDHMMKRVQPTHVLVAFDAGKTTFRTELFADYKAGRAKTPDEFREQFPYIRDML HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHHH GALGIAFYELEHYEADDIIGTLDKMAERTELPFDVTIVSGDKDLIQLTDANTVVEISKKG HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCEEEEEHHCC VAEFEEFTPAYLMDKMGLTPEQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEYGSLEG HHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHCCHHH IYQHVDSFKPSKMKENLLHDKEQAFLSKTLATINTSAPITIGLEDIVYQGPDLDRLSQFY HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHCCCCCHHHHHHHH DEMDFVQLKNALASQLPQEPVAEIAYQEVTDIRADMFSDDTVFYFEALRDNYHREELIGF HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHEEE AWGNQGQIYASADISLLTTELFKKVLEQPIATYDFKRSKVLLSHLGLDLPAASYDARLAN EECCCCCEEEECCHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHH YLLSTVEDNEMATLARLYTTIPLDTDEVVYGKGVKRAVPDKAVLLGHLARKVQVLLDSRP HHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC VMLDKLAEHEQADLYTDIELPLANVLAKMEIEGIAVNQDSLQEMAEQNKVVIEELTQEIY HHHHHHHHHHHCCCEEECCCCHHHHHHHHEECEEEECHHHHHHHHHCCCHHHHHHHHHHH EMAGEVFNINSPKQLGVILFEKMQLPLHLTKKTKTGYSTAVDVLERLAPIAPIVAKILDY HHCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH RQITKLQSTYVIGLQDYIMADGRIHTRYLQDLTQTGRLSSVDPNLQNIPIRLEQGRLIRK HHHHHHHHHEEEEHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHH AFTPSHDDAVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIEKPEDV HCCCCCCCEEEEECCCCCEEEEEEEECCCCCCEEHHHHCCCCCCCCCEEEEECCCCCCCC TANDRRNAKAVNFGIVYGISDFGLSNNLGIPRKQAKAYIDTYFERYPGIKAYMERVVREA CCCCCCCCEEEEEEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH KDKGYVETLFKRRRQLPDINSRQFNLRSFAERTAINSPIQGSAADILKIAMINLDQALVA HCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC GGFETKMLLQVHDEIVLEVPSHELAAVKELVKETMESAVNLAVPLRVDESAGKSWYEAK CCCCHHHHHHHHCHHEEECCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916 [H]